{"id":6555,"date":"2012-07-12T15:34:37","date_gmt":"2012-07-12T15:34:37","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/descobert-un-nou-tipus-dona-en-teixits-vius-2\/"},"modified":"2015-01-08T15:26:36","modified_gmt":"2015-01-08T15:26:36","slug":"descobert-un-nou-tipus-dona-en-teixits-vius-2","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/descobert-un-nou-tipus-dona-en-teixits-vius-2\/","title":{"rendered":"Descobert un nou tipus d’ona en teixits vius"},"content":{"rendered":"

En estudiar el moviment de ra\u00efms de c\u00e8l\u00b7lules, els cient\u00edfics van trobar proves de l\u2019aparici\u00f3 de crestes de deformaci\u00f3 similars a onades, llen\u00e7ades als extrems dels ra\u00efms i que es propaguen de c\u00e8l\u00b7lula a c\u00e8l\u00b7lula a aproximadament el doble de la velocitat amb qu\u00e8 es movien les c\u00e8l\u00b7lules.<\/p>\n

\u201cImagina veure un emb\u00fas de tr\u00e0fic des de dalt,\u201d diu el responsable del grup Xavier Trepat, el treball del qual apareix tamb\u00e9 com a recerca destacada a Nature<\/em>. \u201cVeur\u00e0s un efecte d\u2019onatge similar quan alguns cotxes avancen i altres els segueixen despr\u00e9s d\u2019un lleuger retard per omplir els forats. Per\u00f2 a difer\u00e8ncia dels cotxes, les c\u00e8l\u00b7lules del nostre estudi poden emp\u00e8nyer i tibar les unes de les altres, aix\u00ed que el fenomen \u00e9s molt m\u00e9s intens.\u201d<\/p>\n

Fa molt que es sap com funcionen les ones mec\u00e0niques en la mat\u00e8ria inert, per\u00f2 \u00e9s el primer cop que s\u2019observen en mat\u00e8ria viva. \u201cAquestes onades avancen a aproximadament un mil\u00b7l\u00edmetre per dia, i estan entre les ones m\u00e9s lentes mai descobertes,\u201d afegeix en Xavier.<\/p>\n

Els descobriments del grup estableixen un patr\u00f3 d\u2019estr\u00e8s i tensi\u00f3 reiterats en el temps i l\u2019espai al llarg d\u2019un teixit multicel\u00b7lular, una cosa que mai s\u2019havia observat abans, i que \u00e9s un probable candidat a \u00e9sser la for\u00e7a impulsora darrera de l\u2019activaci\u00f3 de les xarxes responsables de la invasi\u00f3 cel\u00b7lular t\u00edpica del c\u00e0ncer. \u201c\u00c9s sabut que les forces f\u00edsiques poden actuar com senyals intracel\u00b7lulars per activar xarxes locals de prote\u00efnes reguladores \u2013 els processos necessaris per a que tinguin lloc els esdeveniments biol\u00f2gics, siguin bons o dolents,\u201d diu en Xavier. \u201cAix\u00ed doncs, la nostra \u201conada\u201d recent descoberta podria jugar un paper primordial en provocar les vies requerides.\u201d<\/p>\n

Amb aquests darrers resultats, els cient\u00edfics estan un pas m\u00e9s a prop de comprendre com migren les c\u00e8l\u00b7lules, i una etapa m\u00e9s a prop d\u2019entendre les din\u00e0miques de les c\u00e8l\u00b7lules tumorals i els mecanismes f\u00edsics que fan servir per separar-se i metastatitzar.<\/p>\n

Imatge: Onades d’estirament cel\u00b7lular (en rosa) es propaguen de c\u00e8l\u00b7lula en c\u00e8l\u00b7lula al llarg d’una monocapa en migraci\u00f3.<\/p>\n

—<\/p>\n

Serra-Picamal, X.<\/a>, Conte, V.<\/a>, Vincent, R.<\/a>, A\u00f1\u00f3n, E.<\/a>, Tambe, D., Bazelli\u00e8res, E.<\/a>, Butler, J., Fredberg, J. & Trepat, X<\/a>. (2012). Mechanical waves during tissue expansion<\/a><\/strong>. Nature Physics.<\/p>\n","protected":false},"excerpt":{"rendered":"

El grup de Din\u00e0miques Interactives Cel\u00b7lulars i Tissulars ha publicat a la revista\u00a0Nature Physics<\/em> els darrers resultats que han obtingut tot cercant com comprendre la migraci\u00f3 col\u00b7lectiva de les c\u00e8l\u00b7lules del nostre cos.<\/p>\n","protected":false},"author":4,"featured_media":6534,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-6555","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nDescobert un nou tipus d'ona en teixits vius - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/descobert-un-nou-tipus-dona-en-teixits-vius-2\/\" \/>\n<meta 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