{"id":65661,"date":"2019-02-18T19:49:06","date_gmt":"2019-02-18T18:49:06","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=65661"},"modified":"2020-06-15T11:38:45","modified_gmt":"2020-06-15T09:38:45","slug":"investigadors-de-libec-generen-mini-ronyons-vascularitzats-a-partir-de-cel%c2%b7lules-mare-humanes","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-generen-mini-ronyons-vascularitzats-a-partir-de-cel%c2%b7lules-mare-humanes\/","title":{"rendered":"Investigadors de l\u2019IBEC generen mini-ronyons vascularitzats a partir de c\u00e8l\u00b7lules mare humanes"},"content":{"rendered":"<p>i mostra com aquests cultius tridimensionals mimetitzen aspectes fonamentals durant la formaci\u00f3 del rony\u00f3, com la distribuci\u00f3, la funcionalitat i l&#8217;organitzaci\u00f3 espec\u00edfica de les c\u00e8l\u00b7lules.<\/p>\n<p>La investigaci\u00f3, liderada per la Dra. N\u00faria Montserrat, investigadora principal d&#8217;ICREA a l&#8217;IBEC, i en el que tamb\u00e9 han col\u00b7laborat l&#8217;Hospital Cl\u00ednic de Barcelona, el Consejo Superior de Investigaciones Cient\u00edficas, la Universitat de Barcelona i el Salk Institute for Biological Studies als EE.UU, permet generar coneixement fonamental sobre com es desenvolupa aquest \u00f2rgan, i a la vegada, facilita el disseny d&#8217;experiments focalitzats en el cribratge de compostos terap\u00e8utics destinats a la regeneraci\u00f3 renal.<\/p>\n<p>Per a dur a terme aquest proc\u00e9s, els investigadors han utilitzat c\u00e8l\u00b7lules mare pluripotents, amb les que han aconseguit recapitular el desenvolupament embrionari del rony\u00f3 \u2013 fins al segon trimestre de gestaci\u00f3-, i han generat els mini ronyons simulant la duresa del micro ambient embrionari mitjan\u00e7ant l&#8217;\u00fas de biomaterials.<\/p>\n<figure id=\"attachment_65624\" aria-describedby=\"caption-attachment-65624\" style=\"width: 390px\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"wp-image-65624 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/minirrin\u0303o\u0301n-ibec.png\" alt=\"\" width=\"400\" height=\"400\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/minirrin\u0303o\u0301n-ibec.png 470w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/minirrin\u0303o\u0301n-ibec-150x150.png 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/minirrin\u0303o\u0301n-ibec-300x300.png 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/minirrin\u0303o\u0301n-ibec-130x130.png 130w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/minirrin\u0303o\u0301n-ibec-45x45.png 45w\" data-sizes=\"(max-width: 400px) 100vw, 400px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/400;\" \/><figcaption id=\"caption-attachment-65624\" class=\"wp-caption-text\">Mini-rony\u00f3 derivat a partir de c\u00e8l\u00b7lules mare pluripotents humanes<\/figcaption><\/figure>\n<p>&#8220;Un dels aspectes crucials de la investigaci\u00f3 amb organoides consisteix en desenvolupar una metodologia que permeti la seva maduraci\u00f3 en una placa de cultiu, i que aquests s&#8217;assemblin a l&#8217;\u00f2rgan adult, per a aix\u00f2, \u00e9s essencial proveir a aquests mini \u00f2rgans, entre altres coses, d&#8217;una xarxa vascular, essencial per a facilitar l&#8217;intercanvi de nutrients i assegurar la seva funcionalitat&#8221;, comenta N\u00faria Montserrat.<\/p>\n<p>Per a superar aquest obstacle, els investigadors han implantat els mini ronyons a la vasculatura embrion\u00e0ria del pollastre i han observat que, al cap de pocs dies, els mini ronyons presentaven c\u00e8l\u00b7lules endotelials i evid\u00e8ncies estructurals que indicaven una millor diferenciaci\u00f3 dins d&#8217;aquestes estructures tridimensionals.<\/p>\n<p>Aquest tipus d&#8217;abordatge representa una estrat\u00e8gia prometedora per al desenvolupament de teixits bio funcionals, que puguin ser utilitzats tant per a la detecci\u00f3 de drogues com per al desenvolupament de medicina personalitzada. &#8220;Anticipem que aquest procediment que presentem pot ser aplicat immediatament als laboratoris que treballin en el modelatge de malalties de rony\u00f3&#8221;, comenta N\u00faria Montserrat. &#8220;Necessitem entendre com es generen els teixits per poder abordar q\u00fcestions relacionades amb la seva disfunci\u00f3&#8221;, afegeix el Dr. Josep M. Campistol de l&#8217;Hospital Cl\u00ednic de Barcelona.<\/p>\n<p>L\u2019estudi en el qual han participat investigadors de tres grups d\u2019investigaci\u00f3 de l\u2019IBEC, l\u2019Hospital Cl\u00ednic en Barcelona, el Consejo Superior de Investigaciones, la Universitat de Barcelona i el Salk Institute for Biological Studies als EE.UU., ha estat finan\u00e7at parcialment pel European Research Council i la Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer, entre d\u2019altres institucions.<\/p>\n<hr \/>\n<p><em><strong>Source article:\u00a0<\/strong>Garreta, Elena, Prado, Patricia, Tarantino, Carolina, Oria, Roger, Fanlo, Lucia, Mart\u00ed, Elisa, Zalvidea, Dobryna, Trepat, Xavier, Roca-Cusachs, Pere, Gavald\u00e0\u00a0-Navarro, Aleix, Cozzuto, Luca, Campistol, Josep M., Izpis\u00faa Belmonte, Juan Carlos, Hurtado del Pozo, Carmen, Montserrat, Nuria, (2018).\u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41563-019-0287-6\" target=\"_blank\" rel=\"noopener noreferrer\">Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells.\u00a0<\/a><i>Nature Materials\u00a0<\/i>Ahead<\/em><\/p>\n<hr \/>\n<p>Algunes aparicions en premsa escrita:<\/p>\n<ul>\n<li><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/0021OG4Y_Ibec_Creen-ronyons-artificials-amb-reg-sanguini.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Creen ronyons artificials amb reg sanguini<\/a> &#8211; El Punt Avui<\/li>\n<li><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/0021OGH8_Ibec_Microronyons-al-laboratori-un-\u00e8xit-esperan\u00e7ador.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Microronyons al laboratori, un \u00e8xit esperan\u00e7ador<\/a> &#8211; Diari Ara<\/li>\n<li><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/0021OH74_Montserrat_Crean-en-solo-20-d\u00edas-minirri\u00f1ones-a-partir-de-c\u00e9lulas-madre.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Crean en s\u00f3lo 20 d\u00edas miniri\u00f1ones a partir de c\u00e9lulas madre<\/a> &#8211; Abc<\/li>\n<li><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/0021OIT7_Ibec_Investigadores-catalanes-crean-minirri\u00f1ones-con-c\u00e9lulas-madre.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Investigadores catalanes crean miniri\u00f1ones con c\u00e9lulas madre<\/a> &#8211; El Peri\u00f3dico<\/li>\n<li><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/0021P16T_Ibec_La-ciencia-crea-minirri\u00f1ones-parecidos-a-los-de-un-feto-de-6-meses-con-c\u00e9lulas-madre.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">La ciencia crea miniri\u00f1ones parecidos a los de un feto de 6 meses con c\u00e9lulas madre<\/a> &#8211; La Raz\u00f3n<\/li>\n<\/ul>\n<p><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/prensa-escrita.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Dossier de premsa escrita complet<\/a><\/p>\n<p>Aparicions en r\u00e0dio:<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ccma.cat\/catradio\/alacarta\/catalunya-vespre\/creen-amb-cellules-mare-minironyons-similars-als-del-segon-trimestre-de-gestacio\/audio\/1030573\/\" target=\"_blank\" rel=\"noopener noreferrer\">Catalunya R\u00e0dio\u00a0<\/a><\/li>\n<li>Onda Cero &#8211; <a href=\"https:\/\/www.ondacero.es\/programas\/julia-en-la-onda\/audios-podcast\/mesa-redaccion\/cientificos-consiguen-crear-en-20-dias-minirrinones-a-partir-de-celulas-madre_201902195c6c22380cf2717239dce1bc.html\" target=\"_blank\" rel=\"noopener noreferrer\">Julia en la Onda<\/a><\/li>\n<li>Onda Cero &#8211; <a href=\"https:\/\/www.ondacero.es\/emisoras\/catalunya\/audios-podcast\/nits-radio\/creacio-de-miniorgans-en-laboratori-a-casa-nostra_201902275c763f410cf252a9eda8bb4a.html\" target=\"_blank\" rel=\"noopener noreferrer\">Nits de r\u00e0dio amb Carles Lamelo<\/a><\/li>\n<li>La COPE &#8211; <a href=\"https:\/\/www.cope.es\/programas\/la-linterna\/horas-completas\" target=\"_blank\" rel=\"noopener noreferrer\">La Linterna\u00a0<\/a><\/li>\n<\/ul>\n<p>Aparicions en TV:<\/p>\n<ul>\n<li><a href=\"https:\/\/beteve.cat\/terricoles\/nuria-montserrat\/\" target=\"_blank\" rel=\"noopener noreferrer\">Betev\u00e9<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-medium wp-image-64079 lazyload\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/nuriamontserrat_grupo_web-1.jpg\" alt=\"\" width=\"500\" height=\"\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/>Investigadors de l&#8217;IBEC han creat per primer cop cultius tridimensionals -organoides- a partir de c\u00e8l\u00b7lules mare pluripotents, que s&#8217;assemblen al teixit embrionari de rony\u00f3 hum\u00e0 durant el segon trimestre de gestaci\u00f3.<\/h3>\n<p>Mitjan\u00e7ant l&#8217;\u00fas de biomaterials que mimetitzen el micro ambient embrionari els investigadors tamb\u00e9 han aconseguit que aquests mini ronyons presentin caracter\u00edstiques rellevants per al seu \u00fas immediat en el modelatge de patologies renals.<br \/>\nEn un estudi publicat ahir en la revista Nature Materials es descriu com investigadors de l&#8217;IBEC han generat organoides, o mini \u00f2rgans, que s&#8217;assemblen al rony\u00f3 embrionari hum\u00e0 durant el segon trimestre de gestaci\u00f3,<\/p>\n","protected":false},"author":4,"featured_media":65632,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1123],"post_formats":[],"class_list":["post-65661","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-nuria-montserrat-ca-2"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigadors de l\u2019IBEC generen mini-ronyons vascularitzats a partir de c\u00e8l\u00b7lules mare humanes - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-generen-mini-ronyons-vascularitzats-a-partir-de-cel\u00b7lules-mare-humanes\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors de l\u2019IBEC generen mini-ronyons vascularitzats a partir de c\u00e8l\u00b7lules mare humanes - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l&#039;IBEC han creat per primer cop cultius tridimensionals -organoides- a partir de c\u00e8l\u00b7lules mare pluripotents, que s&#039;assemblen al teixit embrionari de rony\u00f3 hum\u00e0 durant el segon trimestre de gestaci\u00f3.Mitjan\u00e7ant l&#039;\u00fas de biomaterials que mimetitzen el micro ambient embrionari els investigadors tamb\u00e9 han aconseguit que aquests mini ronyons presentin caracter\u00edstiques rellevants per al seu \u00fas immediat en el modelatge de patologies renals. En un estudi publicat ahir en la revista Nature Materials es descriu com investigadors de l&#039;IBEC han generat organoides, o mini \u00f2rgans, que s&#039;assemblen al rony\u00f3 embrionari hum\u00e0 durant el segon trimestre de gestaci\u00f3,\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-generen-mini-ronyons-vascularitzats-a-partir-de-cel\u00b7lules-mare-humanes\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2019-02-18T18:49:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-15T09:38:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/nuriamontserrat_grupo_web-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"338\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-generen-mini-ronyons-vascularitzats-a-partir-de-cel%c2%b7lules-mare-humanes\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-generen-mini-ronyons-vascularitzats-a-partir-de-cel%c2%b7lules-mare-humanes\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Investigadors de l\u2019IBEC generen mini-ronyons vascularitzats a partir de c\u00e8l\u00b7lules mare humanes\",\"datePublished\":\"2019-02-18T18:49:06+00:00\",\"dateModified\":\"2020-06-15T09:38:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-generen-mini-ronyons-vascularitzats-a-partir-de-cel%c2%b7lules-mare-humanes\\\/\"},\"wordCount\":629,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-generen-mini-ronyons-vascularitzats-a-partir-de-cel%c2%b7lules-mare-humanes\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2019\\\/02\\\/nuriamontserrat_grupo_web-1.jpg\",\"keywords\":[\"Nuria Montserrat\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-generen-mini-ronyons-vascularitzats-a-partir-de-cel%c2%b7lules-mare-humanes\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-generen-mini-ronyons-vascularitzats-a-partir-de-cel%c2%b7lules-mare-humanes\\\/\",\"name\":\"Investigadors de l\u2019IBEC generen mini-ronyons vascularitzats a partir de c\u00e8l\u00b7lules mare humanes - 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