{"id":65787,"date":"2019-02-28T13:00:36","date_gmt":"2019-02-28T12:00:36","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=65787"},"modified":"2020-06-15T11:38:33","modified_gmt":"2020-06-15T09:38:33","slug":"nanomotors-propulsats-amb-urea-un-tractament-prometedor-per-al-cancer-de-bufeta","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/nanomotors-propulsats-amb-urea-un-tractament-prometedor-per-al-cancer-de-bufeta\/","title":{"rendered":"Nanomotors propulsats amb urea, un tractament prometedor per al c\u00e0ncer de bufeta"},"content":{"rendered":"<p>&#8220;Els nostres <span class=\"hiddenSpellError\">nanomotors<\/span> carregats amb els anticossos han estat capa\u00e7os de &#8216;nedar&#8217; tant en orina simulada com en orina real,&#8221; afirma l&#8217;investigador <span class=\"hiddenSpellError\">ICREA<\/span> a l&#8217;<span class=\"hiddenSpellError\">IBEC<\/span>\u00a0Samuel S\u00e1nchez, investigador principal del grup\u00a0<span class=\"hiddenSpellError\">Smart<\/span>\u00a0Nano-Bio\u00a0<span class=\"hiddenSpellError\">Devices<\/span>\u00a0de l&#8217;<span class=\"hiddenSpellError\">IBEC<\/span>. &#8220;Observem una millor supressi\u00f3 de les c\u00e8l\u00b7lules del c\u00e0ncer de bufeta que en utilitzar\u00a0<span class=\"hiddenSpellError\">nanomotors<\/span>\u00a0sense la modificaci\u00f3 de l&#8217;antic\u00f2s, i encara m\u00e9s en comparaci\u00f3 amb les nanopart\u00edcules passives, que podrien apar\u00e8ixer tant de la producci\u00f3 d&#8217;amon\u00edac local com de l&#8217;efecte terap\u00e8utic de l&#8217;<span class=\"hiddenSpellError\">anti<\/span>&#8211;<span class=\"hiddenSpellError\">FGFR3<\/span>&#8220;.<\/p>\n<p>El c\u00e0ncer de bufeta \u00e9s el nov\u00e8 c\u00e0ncer m\u00e9s com\u00fa en el m\u00f3n i presenta un elevat \u00edndex de superviv\u00e8ncia, per\u00f2 tamb\u00e9 nivells de recurr\u00e8ncia importants, per la qual cosa exigeix una millora dels tractaments existents.<\/p>\n<p>Els\u00a0<span class=\"hiddenSpellError\">nanomotors<\/span>\u00a0presenten una forma prometedora d&#8217;atacar espec\u00edficament els teixits tumorals que poden actuar millorant l&#8217;efic\u00e0cia del tractament del c\u00e0ncer i minimitzant els efectes col\u00b7laterals. &#8220;Futurs estudi\u00efs que utilitzin\u00a0<span class=\"hiddenSpellError\">nanomotors<\/span>\u00a0modificats amb anticossos que transportin agents d&#8217;<span class=\"hiddenSpellError\">imagenologia<\/span>, podran obrir vies que millorin l&#8217;efici\u00e8ncia en el diagn\u00f2stic i el tractament del c\u00e0ncer&#8221;, diu\u00a0<span class=\"hiddenSpellError\">Ana<\/span>\u00a0<span class=\"hiddenSpellError\">Hortel\u00e3o<\/span>, estudiant de doctorat i autora principal de l&#8217;article.<\/p>\n<hr \/>\n<p>Ana C. Hortel\u00e3o, Rafael Carrascosa, Nerea Murillo-Cremaes, Tania Pati\u00f1o, and Samuel S\u00e1nchez (2018). <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.8b06610\" target=\"_blank\" rel=\"noopener noreferrer\">Targeting 3D Bladder Cancer Spheroids with Urease-Powered Nanomotors<\/a>. ACS Nano, epub ahead of print<\/p>\n<hr \/>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"alignnone size-full wp-image-65748 lazyload\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/acsnano_ibec_web.png\" alt=\"\" width=\"500\" height=\"504\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/acsnano_ibec_web.png 500w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/acsnano_ibec_web-150x150.png 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/acsnano_ibec_web-298x300.png 298w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/acsnano_ibec_web-129x130.png 129w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/acsnano_ibec_web-45x45.png 45w\" data-sizes=\"(max-width: 500px) 100vw, 500px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/504;\" \/>El grup Smart Nano-Bio Devices de l&#8217;IBEC ha publicat un article que descriu com els nanomotors ataquen els esferoides 3D del c\u00e0ncer de bufeta in vitro. <\/h3>\n<p> Els nanomotors transporten l&#8217;anti-FGFR3 en la seva superf\u00edcie exterior, un antic\u00f2s que no nom\u00e9s permet identificar les c\u00e8l\u00b7lules canceroses de forma espec\u00edfica, sin\u00f3 que tamb\u00e9 inhibeix la via de senyalitzaci\u00f3 del factor de creixement del fibroblast, suprimint el creixement tumoral. B\u00e0sicament, el combustible que permet als nanomotors despla\u00e7ar-se de forma aut\u00f2noma \u00e9s la urea, que es troba en la bufeta en elevades concentracions, convertint a aquests nanomotors en particular, en una via prometedora per a aquest tipus de c\u00e0ncer.<\/p>\n","protected":false},"author":4,"featured_media":65748,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1140],"post_formats":[],"class_list":["post-65787","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-samuel-sanchez-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nanomotors propulsats amb urea, un tractament prometedor per al c\u00e0ncer de bufeta - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/nanomotors-propulsats-amb-urea-un-tractament-prometedor-per-al-cancer-de-bufeta\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nanomotors propulsats amb urea, un tractament prometedor per al c\u00e0ncer de bufeta - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grup Smart Nano-Bio Devices de l&#039;IBEC ha publicat un article que descriu com els nanomotors ataquen els esferoides 3D del c\u00e0ncer de bufeta in vitro. Els nanomotors transporten l&#039;anti-FGFR3 en la seva superf\u00edcie exterior, un antic\u00f2s que no nom\u00e9s permet identificar les c\u00e8l\u00b7lules canceroses de forma espec\u00edfica, sin\u00f3 que tamb\u00e9 inhibeix la via de senyalitzaci\u00f3 del factor de creixement del fibroblast, suprimint el creixement tumoral. 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