{"id":66058,"date":"2019-03-20T09:48:00","date_gmt":"2019-03-20T08:48:00","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=66058"},"modified":"2020-06-15T11:37:34","modified_gmt":"2020-06-15T09:37:34","slug":"un-pas-endavant-en-lus-de-nanoparticules-per-combatre-la-resistencia-bacteriana","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/un-pas-endavant-en-lus-de-nanoparticules-per-combatre-la-resistencia-bacteriana\/","title":{"rendered":"Un pas endavant en l\u2019\u00fas de nanopart\u00edcules per combatre la resist\u00e8ncia bacteriana"},"content":{"rendered":"

En conseq\u00fc\u00e8ncia, els antibi\u00f2tics perden efic\u00e0cia.<\/p>\n

En aquest context, calen estrat\u00e8gies terap\u00e8utiques innovadores, capaces d’impedir que els microorganismes desenvolupin mecanismes de resist\u00e8ncia. Des de fa uns anys, els cient\u00edfics estudien les anomenades nanopart\u00edcules met\u00e0l\u00b7liques, part\u00edcules d\u2019una mida inferior a la mil\u00b7l\u00e8sima part d\u2019un cabell hum\u00e0 formades per \u00e0toms de metall com l\u2019or o la plata, entre d\u2019altres. Aquestes part\u00edcules s’adhereixen a les membranes dels bacteris i, per aquest motiu, els experts estan sintetitzant f\u00e0rmacs antimicrobians que les inclouen en la seva estructura, amb l\u2019objectiu d\u2019augmentar l\u2019efic\u00e0cia del tractament i reduir l\u2019aparici\u00f3 de resist\u00e8ncies bacterianes.<\/p>\n

Si b\u00e9 aquest enfocament terap\u00e8utic \u00e9s molt prometedor, encara no ha arribat al mercat. Per quin motiu? Hi ha una dificultat enorme a l\u2019hora de validar la seva efic\u00e0cia: en ser met\u00e0l\u00b7liques, les nanopart\u00edcules alteren els resultats de les validacions biol\u00f2giques, fent impossible comprovar si el f\u00e0rmac funciona o no.<\/p>\n

Per primera vegada, cient\u00edfics de l’Institut d’Enginyeria Biom\u00e8dica de Catalunya (IBEC) han dissenyat una t\u00e8cnica que permet avaluar l’efic\u00e0cia dels f\u00e0rmacs units a nanopart\u00edcules de manera precisa i fiable.<\/strong><\/p>\n

Trencant la barrera existent en les validacions biol\u00f2giques<\/strong><\/h2>\n

\u201cActualment, hi ha una \u00e0mplia gamma de nanopart\u00edcules dirigides a enriquir la propera generaci\u00f3 d’antimicrobians. Per\u00f2 la majoria d’aquestes estructures posseeixen unes propietats \u00f2ptiques que alteren els resultats de la validaci\u00f3 biol\u00f2gica\u201d, explica Eduard Torrents, cap del grup d’Infeccions Bacterianes: Ter\u00e0pies Antimicrobianes<\/a> de l’IBEC i col\u00edder de l’estudi. I afegeix, \u201cLa creaci\u00f3 de tractaments innovadors ha d’anar de la m\u00e0 del desenvolupament de nous m\u00e8todes de validaci\u00f3, perqu\u00e8 els antics no s\u00f3n \u00fatils.\u201d<\/p>\n

La nova metodologia ha estat testada amb nanopart\u00edcules d’or unides a f\u00e0rmacs que atacaven tres esp\u00e8cies diferents de bacteris: Escherichia coli<\/em>, responsable de m\u00faltiples infeccions com algunes gastroenteritis, cistitis i meningitis; Staphylococcus aureus<\/em>, culpable de la majoria de les intoxicacions aliment\u00e0ries, i Pseudomonas aeruginosa<\/em>, causant d’infeccions en el tracte respiratori. En tots els casos, la nova t\u00e8cnica ha perm\u00e8s validar l’efic\u00e0cia dels antimicrobians amb nanopart\u00edcules.<\/p>\n

\u201cA m\u00e9s de ser barata, aquesta t\u00e8cnica t\u00e9 una alta resoluci\u00f3 i una elevada sensibilitat. Amb ella, vam obrir les portes a l’\u00fas de nanopart\u00edcules per tractar infeccions bacterianes, un objectiu que perseguim des de fa anys\u201d, comenta Torrents. I conclou, \u201cLa possibilitat d’aplicar ter\u00e0pies noves i efectives que ens alliberin de la problem\u00e0tica de les resist\u00e8ncies bacterianes tindr\u00e0 un elevat impacte en la salut global de les persones.\u201d<\/p>\n

Imagen:\u00a0<\/em><\/strong><\/p>\n

 <\/p>\n

\n

Article de refer\u00e8ncia: <\/strong>Vukomanovic M, Torrents E. High time resolution and high signal-to-noise monitoring of the bacterial growth kinetics in the presence of plasmonic nanoparticles. <\/em>Journal of Nanobiotechnology, 2019. https:\/\/doi.org\/10.1186\/s12951-019-0459-1<\/a><\/p>\n

\n

Sobre l\u2019IBEC
\n<\/strong>L’Institut de Bioenginyeria de Catalunya (IBEC) \u00e9s centre d’Excel\u00b7l\u00e8ncia Severo Ochoa i membre de l’Institut de Ci\u00e8ncia i Tecnologia de Barcelona (BIST). Porta a terme recerca interdisciplin\u00e0ria d’excel\u00b7l\u00e8ncia en la frontera de l’enginyeria i les ci\u00e8ncies de la vida per tal de generar nous coneixements integrant camps com la nanomedicina, la biof\u00edsica, la biotecnologia l\u2019enginyeria de teixits i les aplicacions de tecnologia de la informaci\u00f3 en l\u2019\u00e0mbit de la salut. L\u2019IBEC va ser creat el 2005 per la Generalitat de Catalunya, la Universitat de Barcelona (UB) i la Universitat Polit\u00e8cnica de Catalunya (UPC).<\/p>\n

\u00a0<\/strong><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"El grup d’Infeccions Bacterianes: Ter\u00e0pies Antimicrobianes, liderat per Eduard Torrents, ha dissenyat un nou m\u00e8tode que permet, per primera vegada, comprovar l’efic\u00e0cia dels f\u00e0rmacs antimicrobians que inclouen nanopart\u00edcules en la seva estructura. Aquesta nova t\u00e8cnica, s’ha publicat recentment en la revista Journal of Nanobiotechnology.<\/h3>\n

La resist\u00e8ncia bacteriana \u00e9s una de les majors amenaces a qu\u00e8 s\u2019enfronta la salut global en l\u2019actualitat. Segons dades de l\u2019OMS, cada vegada hi ha m\u00e9s infeccions (pneum\u00f2nia, tuberculosi, gonorrea) el tractament de les quals s\u2019ha complicat a causa de la p\u00e8rdua d’efic\u00e0cia de molts antibi\u00f2tics. L\u2019origen d’aquest problema es troba en l\u2019\u00fas indegut i abusiu dels antibi\u00f2tics, que provoca que els bacteris es tornin resistents a ells. <\/p>\n","protected":false},"author":4,"featured_media":66049,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1141],"post_formats":[],"class_list":["post-66058","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-eduard-torrents-ca"],"yoast_head":"\nUn pas endavant en l\u2019\u00fas de nanopart\u00edcules per combatre la resist\u00e8ncia bacteriana - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/un-pas-endavant-en-lus-de-nanoparticules-per-combatre-la-resistencia-bacteriana\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un pas endavant en l\u2019\u00fas de nanopart\u00edcules per combatre la resist\u00e8ncia bacteriana - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grup d'Infeccions Bacterianes: Ter\u00e0pies Antimicrobianes, liderat per Eduard Torrents, ha dissenyat un nou m\u00e8tode que permet, per primera vegada, comprovar l'efic\u00e0cia dels f\u00e0rmacs antimicrobians que inclouen nanopart\u00edcules en la seva estructura. 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