{"id":66812,"date":"2019-06-04T13:07:45","date_gmt":"2019-06-04T11:07:45","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=66812"},"modified":"2020-06-15T11:36:59","modified_gmt":"2020-06-15T09:36:59","slug":"les-cel%c2%b7lules-amb-dos-nuclis-podrien-ser-clau-en-la-regeneracio-del-cor","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/les-cellules-amb-dos-nuclis-podrien-ser-clau-en-la-regeneracio-del-cor\/","title":{"rendered":"Les c\u00e8l\u00b7lules amb dos nuclis podrien ser clau en la regeneraci\u00f3 del cor"},"content":{"rendered":"

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C\u00e8l\u00b7lules de l’epicardi del peix zebra a on s\u2019observen algunes c\u00e8l\u00b7lules amb dos nuclis (en blau).<\/figcaption><\/figure> Aquesta capacitat regenerativa extraordin\u00e0ria ha atret l\u2019atenci\u00f3 d\u2019investigadors de tot el m\u00f3n, que veuen el ventall de possibilitats que s\u2019obririen si aquest mecanisme de regeneraci\u00f3 es pogu\u00e9s aplicar en ter\u00e0pies dirigides a humans.<\/p>\n

En un article publicat avui a la revista Nature Materials, un equip d\u2019investigadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) dirigit per Xavier Trepat, en col\u00b7laboraci\u00f3 amb el Centre de Medicina Regenerativa de Barcelona (CMR[B]), han descobert un sorprenent mecanisme pel qual les c\u00e8l\u00b7lules card\u00edaques del peix zebra es mouen i divideixen durant la regeneraci\u00f3.<\/p>\n

Els investigadors s\u2019han centrat en l\u2019epicardi, que \u00e9s la capa de c\u00e8l\u00b7lules que recobreix el cor. Malgrat que les c\u00e8l\u00b7lules de l\u2019epicardi representen nom\u00e9s una petita fracci\u00f3 de la massa del cor, juguen un paper fonamental en la seva regeneraci\u00f3. \u201cL\u2019epicardi \u00e9s l\u2019origen de diversos tipus cel\u00b7lulars del cor, i secreta senyals bioqu\u00edmiques que indiquen a la resta de c\u00e8l\u00b7lules qu\u00e8 han de fer en cada moment. \u00c9s una mena de \u2018hub\u2019 de la regeneraci\u00f3\u201d, indica Angel Raya, Investigador ICREA i director del CMRB.
\n

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Marina Uroz i Xavier Trepat<\/figcaption><\/figure><\/p>\n

Despr\u00e9s d\u2019una lesi\u00f3, les c\u00e8l\u00b7lules de l\u2019epicardi comencen a dividir-se i moure\u2019s en massa per recobrir la ferida. Els investigadors han observat que durant aquest proc\u00e9s les c\u00e8l\u00b7lules esdevenen bi-nucleades: dupliquen el material gen\u00e8tic i el separen en dos nuclis, per\u00f2 no s\u2019arriben a dividir en dues c\u00e8l\u00b7lules independents. \u201cEns va sorprendre molt descobrir c\u00e8l\u00b7lules que en comptes de tenir un nucli, com \u00e9s habitual en la majoria de teixits, en tenen dos, i cadascun d\u2019ells cont\u00e9 una c\u00f2pia de l\u2019ADN de la c\u00e8l\u00b7lula\u201d afirma Trepat, investigador ICREA a l\u2019IBEC i professor associat de la Universitat de Barcelona.<\/p>\n

Els investigadors han descobert que el mecanisme pel qual les c\u00e8l\u00b7lules esdevenen bi-nucleades \u00e9s d\u2019origen biomec\u00e0nic. Un cop l\u2019ADN ja s\u2019ha separat en dos nuclis, la majoria de c\u00e8l\u00b7lules animals formen un anell contr\u00e0ctil al seu equador. A mesura que es va contraient, aquest anell divideix la c\u00e8l\u00b7lula mare en dues c\u00e8l\u00b7lules filles. En el cas de les c\u00e8l\u00b7lules del cor del peix zebra, l\u2019estudi mostra que l\u2019anell s\u2019adhereix a les fibres del seu entorn de manera que no es pot contraure. El resultat \u00e9s que les dues c\u00e8l\u00b7lules filles no poden arribar a separar-se malgrat haver duplicat correctament el seu ADN.<\/p>\n

\u201cLa multinucleaci\u00f3 \u00e9s un fenomen ben conegut en c\u00e0ncer, perqu\u00e8 \u00e9s una causa d\u2019inestabilitat gen\u00f2mica. \u00c9s a dir, les c\u00e8l\u00b7lules canceroses perden el control de les prote\u00efnes que sintetitzen i es comporten patol\u00f2gicament. En el cas del cor peix zebra, la multinucleaci\u00f3 \u00e9s fisiol\u00f2gica i no sembla causar cap problema\u201d, afirma Marina Uroz, primer autora de l\u2019article. El seg\u00fcent pas ser\u00e0 estudiar quin paper tenen les c\u00e8l\u00b7lules multi-nucleades durant la regeneraci\u00f3 del cor i altres \u00f2rgans.<\/p>\n

El Dr. Trepat i el Dr. Raya formen part del CIBER-BBN (Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina).<\/p>\n

 <\/p>\n

\n

 <\/p>\n

Article referenciat: <\/em><\/strong>M. Uroz, A. Garcia-Puig, I. Tekeli, A. Elosegui-Artola, J. F. Abenza, A. Mar\u00edn-Llaurad\u00f3, S. Pujals, V. Conte, L. Albertazzi, P. Roca-Cusachs, A. Raya and X. Trepat. Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium<\/a>. Nature Materials, DOI: 10.1038\/s41563-019-0381-9\u00a0<\/strong>(2019)\u00a0<\/em><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Un equip d’investigadors de l’IBEC liderat per Xavier Trepat, en col\u00b7laboraci\u00f3 amb el CMR[B], ha descobert un mecanisme que genera c\u00e8l\u00b7lules de dos nuclis. Aquest mecanisme s\u2019ha identificat durant la regeneraci\u00f3 del cor del peix zebra, i podria estar associat a l\u2019extraordinari poder regeneratiu d\u2019aquest animal. <\/H3><\/p>\n

Despr\u00e9s d\u2019una lesi\u00f3 aguda, com un infart de miocardi, el cor hum\u00e0 \u00e9s incapa\u00e7 de regenerar-se. Les c\u00e8l\u00b7lules card\u00edaques adultes no poden cr\u00e9ixer i dividir-se per substituir les danyades, i la lesi\u00f3 esdev\u00e9 irreversible. Per\u00f2 aix\u00f2 no passa en tots els animals. Un peix d\u2019aigua dol\u00e7a originari del Sud-est d\u2019\u00c0sia, conegut com a peix zebra, pot regenerar per complet el seu cor fins i tot despr\u00e9s de l\u2019amputaci\u00f3 del 20% del seu ventricle. <\/p>\n","protected":false},"author":4,"featured_media":66793,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1143],"post_formats":[],"class_list":["post-66812","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-xavier-trepat-ca"],"yoast_head":"\nLes c\u00e8l\u00b7lules amb dos nuclis podrien ser clau en la regeneraci\u00f3 del cor - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/les-cellules-amb-dos-nuclis-podrien-ser-clau-en-la-regeneracio-del-cor\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les c\u00e8l\u00b7lules amb dos nuclis podrien ser clau en la regeneraci\u00f3 del cor - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un equip d'investigadors de l'IBEC liderat per Xavier Trepat, en col\u00b7laboraci\u00f3 amb el CMR[B], ha descobert un mecanisme que genera c\u00e8l\u00b7lules de dos nuclis. 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