{"id":67263,"date":"2019-07-16T15:25:24","date_gmt":"2019-07-16T13:25:24","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=67263"},"modified":"2019-07-16T15:26:37","modified_gmt":"2019-07-16T13:26:37","slug":"un-equip-de-recerca-desenvolupa-una-minifabrica-de-teixit-cardiac-huma","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/un-equip-de-recerca-desenvolupa-una-minifabrica-de-teixit-cardiac-huma\/","title":{"rendered":"Un equip de recerca desenvolupa una minif\u00e0brica de teixit card\u00edac hum\u00e0"},"content":{"rendered":"<p>\u00c9s per aix\u00f2 que, disposar de models de laboratori que ajudin a comprendre millor la fisiologia del cor o a avaluar la cardiotoxicitat dels f\u00e0rmacs, pot resultar de gran ajuda a l&#8217;hora de desenvolupar nous medicaments o ter\u00e0pies com per exemple, la medicina regenerativa. No obstant aix\u00f2, la producci\u00f3 al laboratori de teixits capa\u00e7os de comportar-se de manera similar al cor hum\u00e0 segueix suposant un repte.<\/p>\n<p>En aquest context, investigadors de l&#8217;Institut de Bioenginyeria de Catalunya (IBEC), en col\u00b7laboraci\u00f3 amb el Centre de Medicina Regenerativa de Barcelona (CMR[B]), han donat a con\u00e8ixer mitjan\u00e7ant un article publicat recentment a la revista Stem Cell Reports, un nou sistema de bioenginyeria que podria suposar un important aven\u00e7 en aquest camp.<\/p>\n<div style=\"width: 400px;\" class=\"wp-video\"><!--[if lt IE 9]><script>document.createElement('video');<\/script><![endif]-->\n<video class=\"wp-video-shortcode\" id=\"video-67263-1\" width=\"400\" height=\"250\" loop autoplay preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/07\/IBEC_tejido-card\u00edaco-1.mp4?_=1\" \/><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/07\/IBEC_tejido-card\u00edaco-1.mp4\">https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/07\/IBEC_tejido-card\u00edaco-1.mp4<\/a><\/video><\/div>\n<p>&nbsp;<\/p>\n<p>La nova plataforma, batejada amb el nom de CardioSlice, \u00e9s capa\u00e7 de produir, a partir de c\u00e8l\u00b7lules mare pluripotents humanes (PSC) i de matrius tridimensionals, teixits card\u00edacs amb propietats molt especials. I \u00e9s que, segons detallen els investigadors, els teixits card\u00edacs amb problemes especials. I \u00e9s que, segons detallen els investigadors, els teixits artificials que obtenen amb CardioSlice s\u00f3n capaces de bategar de manera aut\u00f2noma, produeixen un senyal el\u00e8ctric similar a un electrocardiograma i responen a f\u00e0rmacs de la mateixa manera que ho fa un cor hum\u00e0. Per a aconseguir-ho, els investigadors i enginyers de l&#8217;IBEC i el CMR[B] han dissenyat i constru\u00eft una cadena en paral\u00b7lel de bioreactors que permetin l&#8217;estimulaci\u00f3, observaci\u00f3 i estudi in situ de l&#8217;electrofisiologia del teixit resultant, aix\u00ed com de l&#8217;impacte de factors externs com per exemple, medicaments amb efectes cardiot\u00f2xics.<\/p>\n<p>En paraules de l&#8217;Elena Mart\u00ednez, investigadora principal a l&#8217;IBEC i professora a la Universitat de Barcelona (UB): &#8220;CardioSlice \u00e9s com una mini f\u00e0brica de teixits que ens podria ajudar a discernir quins medicaments poden danyar el nostre cor&#8221;.<\/p>\n<p>Els investigadors mostren en diversos v\u00eddeos que el nivell de complexitat dels teixits que CardioSlice permet obtenir, s&#8217;observa en l&#8217;activitat espont\u00e0nia dels mateixos en forma de contraccions i de senyals an\u00e0logues a les d&#8217;un electrocardiograma (ECG). &#8220;L&#8217;an\u00e0lisi avan\u00e7ada del senyal electrofisiol\u00f2gic de CardioSlice permet quantificar canvis en l&#8217;ECG deguts a l&#8217;efecte d&#8217;un f\u00e0rmac, identificant canvis com el ritme card\u00edac, aparici\u00f3 de QRS ect\u00f2pics o perllongaci\u00f3 de l&#8217;interval QT&#8221;, explica Raim\u00f3n Jan\u00e9, investigador principal del grup de Processos i interpretaci\u00f3 de senyals biom\u00e8diques de l&#8217;IBEC i professor a la Universitat Polit\u00e8cnica de Catalunya (UPC).<\/p>\n<p>Segons els autors de l&#8217;article &#8220;La rellev\u00e0ncia fisiol\u00f2gica dels teixits produ\u00efts per CardioSlice, juntament amb la seva naturalesa escalable i la funci\u00f3 de monitoratge electrofisiol\u00f2gic en l\u00ednia, fan que la nostra tecnologia \u00e9s situ\u00ef a l&#8217;avantguarda de la producci\u00f3 de macro-teixits card\u00edacs humans dissenyats fins avui dia&#8221;<\/p>\n<p>Aquest estudi s&#8217;ha realitzat en col\u00b7laboraci\u00f3 amb cient\u00edfics de tres grups de l&#8217;Institut de Bioenginyeria de Catalunya (IBEC), investigadors del Centre de Medicina Regenerativa de Barcelona (CMR[B]), la Universitat de Barcelona (UB), la Universitat Polit\u00e8cnica de Catalunya (UPC) i Centro de Investigaci\u00f3n Biom\u00e9dica en Red en el \u00e0rea tem\u00e0tica de Bioingenieria, Biomaterials i Nanomedicina (CIBER-BBN).<\/p>\n<hr \/>\n<p>Art\u00edcle referenciat: Valls-Margarit et al<em>., <\/em><a href=\"https:\/\/www.cell.com\/stem-cell-reports\/fulltext\/S2213-6711(19)30192-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213671119301924%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Engineered macroscale cardiac constructs elicit human myocardial tissue-like functionality<\/em><\/a>. Stem Cells Report, volumen 13, issue 1, p207-220 (2019).<\/p>\n","protected":false},"excerpt":{"rendered":"<h3>Un sistema desenvolupat per investigadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i del Centre de Medicina Regenerativa de Barcelona (CMR[B]) \u00e9s capa\u00e7 de produir al laboratori teixits que simulen el comportament del cor hum\u00e0. Els teixits produ\u00efts per aquest sistema de bioenginyeria podrien servir per a preavaluar la toxicitat de medicaments en el cor sense necessitat d\u2019utilitzar models animals. <\/h3>\n<\/p>\n<p>Les malalties cardiovasculars suposen actualment una de les primeres causes de mort a escala mundial. No obstant aix\u00f2, els factors que motiven o accentuen aquestes malalties del cor s&#8217;amaguen, a vegades, darrere d&#8217;elements no coneguts. Entre altres causes, els medicaments que s\u00f3n \u00fatils per a curar o pal\u00b7liar determinades malalties poden, al mateix temps, presentar efectes secundaris sobre altres \u00f2rgans com el cor, el que els experts coneixen com a cardiotoxicitat.<\/p>\n","protected":false},"author":4,"featured_media":67268,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[820],"post_formats":[],"class_list":["post-67263","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-elena-martinez-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Un equip de recerca desenvolupa una minif\u00e0brica de teixit card\u00edac hum\u00e0 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/un-equip-de-recerca-desenvolupa-una-minifabrica-de-teixit-cardiac-huma\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un equip de recerca desenvolupa una minif\u00e0brica de teixit card\u00edac hum\u00e0 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un sistema desenvolupat per investigadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i del Centre de Medicina Regenerativa de Barcelona (CMR[B]) \u00e9s capa\u00e7 de produir al laboratori teixits que simulen el comportament del cor hum\u00e0. Els teixits produ\u00efts per aquest sistema de bioenginyeria podrien servir per a preavaluar la toxicitat de medicaments en el cor sense necessitat d\u2019utilitzar models animals.   Les malalties cardiovasculars suposen actualment una de les primeres causes de mort a escala mundial. No obstant aix\u00f2, els factors que motiven o accentuen aquestes malalties del cor s&#039;amaguen, a vegades, darrere d&#039;elements no coneguts. 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