{"id":6768,"date":"2012-12-20T10:23:18","date_gmt":"2012-12-20T10:23:18","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/una-estrategia-prometedora-contra-la-malaria\/"},"modified":"2015-01-08T15:14:15","modified_gmt":"2015-01-08T15:14:15","slug":"una-estrategia-prometedora-contra-la-malaria","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/una-estrategia-prometedora-contra-la-malaria\/","title":{"rendered":"Una estrat\u00e8gia prometedora contra la mal\u00e0ria"},"content":{"rendered":"

A l’article \u201cDemonstration of specific binding of heparin to Plasmodium falciparum<\/em>-infected vs non-infected red blood cells by single-molecule force spectroscopy\u201d, per Valle-Delgado, Urb\u00e1n iFern\u00e0ndez-Busquets, publicat al darrer n\u00famero de la revista Nanoscale<\/em>, els investigadors es van centrar en els canvis a l’estructura de les c\u00e9l\u00b7lules sangu\u00ednies vermelles (RBCs) infectades pel par\u00e0sit de la mal\u00e0ria Plasmodium falciparum. <\/p>\n

Imatge: L’adhesi\u00f3 de l’heparina als eritrocits infectats pel par\u00e0sit de la mal\u00e0ria, el Plasmodium falciparum<\/em>, ha estat demostrada per la espectrosc\u00f2pia de for\u00e7a at\u00f2mica de mol\u00e8cules individuals.<\/span><\/p>\n

No nom\u00e9s els RBCs parasitats (pRBCs) tenen m\u00e9s probabilitats d’adherir-se als gl\u00f2buls vermells normals i a d’altres c\u00e8l\u00b7lules com elles, formant c\u00famuls anomenats rosetes, sin\u00f3 que tamb\u00e9 es poden adherir a les parets dels capil\u00b7lars, estretant-los. Aix\u00f2 es caracter\u00edstic de la mal\u00e0ria greu i pot ser mortal. Es sap que una prote\u00efna particular que s’expressa a la superf\u00edcie de les pRBCs, la PfEMP1, est\u00e0 implicada en facilitar la seva adhesi\u00f3 entre s\u00ed i amb les parets dels capil\u00b7lars, i destorbar aquesta prote\u00efna podria ajudar a prevenir-ho.<\/p>\n

\u201cVam fer servir heparina, un glicosaminoglyc\u00e0 (GAG, una mena de polisac\u00e0rid), junt amb pRBCs, com a model per estudiar les interaccions GAG-pRBC a nivell de mol\u00e8cules individuals per primera vegada,\u201d diu el Dr. Xavier Fern\u00e0ndez-Busquets, un dels investigadors s\u00e8niors del grup de Nanobioenginyeria. \u201cFent servir microscopia de fluoresc\u00e8ncia, selecci\u00f3 cel\u00b7lular assistida per fluoresc\u00e8ncia, i espectrosc\u00f2pia de pot\u00e8ncia de mol\u00e8cules individuals, varem trobar que l’heparina es lliga espec\u00edficament amb les RBCs infectades, per\u00f2 no amb les que estan lliures d’infecci\u00f3.\u201d<\/p>\n

Aix\u00f2 podria permetre el desenvolupament de ter\u00e0pies antimal\u00e0riques espec\u00edfiques per a les pRBCs basades en l’heparina o una mol\u00e8cula similar com a element actiu. “Podria ser una aproximaci\u00f3 molt m\u00e9s barata que l’alternativa de fer servir anticossos,” diu en Xavier. “Aix\u00f2 \u00e9s especialment important ja que la mal\u00e0ria es troba principalment als pa\u00efsos en desenvolupament.”<\/p>\n

—<\/p>\n

IBEC als Mitjans: <\/strong>La revista ha seleccionat aquest article \u2018candent\u2019 per apar\u00e8ixer en el seu pack de premsa semanal de la Royal Society of Chemistry Publishing, que s’envia a periodistes cient\u00edfics. Tamb\u00e9 ha aparegut un article sobre aquesta recerca en la secci\u00f3 de not\u00edcies online del Chemistry World<\/em> (www.rsc.org\/ChemistryWorld<\/a>), i apareix al blog i la p\u00e0gina web de la revista a http:\/\/blogs.rsc.org\/nr<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Un article publicat pel grup de Nanobioenginyeria revela una nova estrat\u00e8gia per al tractament localitzat de la mal\u00e0ria que no es basa en l’\u00fas d’anticossos d’elevat cost.<\/h3>\n","protected":false},"author":4,"featured_media":6764,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-6768","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nUna estrat\u00e8gia prometedora contra la mal\u00e0ria - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/una-estrategia-prometedora-contra-la-malaria\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Una estrat\u00e8gia prometedora contra la mal\u00e0ria - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un article publicat pel grup de Nanobioenginyeria revela una nova estrat\u00e8gia per al tractament localitzat de la mal\u00e0ria que no es basa en l'\u00fas d'anticossos d'elevat cost.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/una-estrategia-prometedora-contra-la-malaria\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2012-12-20T10:23:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-01-08T15:14:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2012\/12\/tocrevision_2sm.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"300\" \/>\n\t<meta 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