{"id":6801,"date":"2013-01-22T15:42:44","date_gmt":"2013-01-22T15:42:44","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/un-pas-cap-a-la-reparacio-del-sistema-nervios-central\/"},"modified":"2015-01-08T15:12:31","modified_gmt":"2015-01-08T15:12:31","slug":"un-pas-cap-a-la-reparacio-del-sistema-nervios-central","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/un-pas-cap-a-la-reparacio-del-sistema-nervios-central\/","title":{"rendered":"Un pas cap a la reparaci\u00f3 del sistema nervi\u00f3s central"},"content":{"rendered":"<\/h3>\n

Malgrat els recents aven\u00e7os en la comprensi\u00f3 dels mecanismes de les lesions nervioses, a l\u2019enginyeria de teixits encara li costa trobar solucions per reparar danys en el sistema nervi\u00f3s central, a causa del paper crucial i complex que hi tenen els n\u00ednxols de c\u00e8l\u00b7lules mare neurals. Aquestes zones, en qu\u00e8 les c\u00e8l\u00b7lules mare queden reservades despr\u00e9s del desenvolupament embrionari per a la producci\u00f3 de noves c\u00e8l\u00b7lules, exerceixen un control molt estricte sobre moltes tasques crucials, com ara la promoci\u00f3 del creixement i la recreaci\u00f3 dels senyals bioqu\u00edmics i f\u00edsics essencials per a la diferenciaci\u00f3 cel\u00b7lular neural.<\/p>\n

Cultius de c\u00e8l\u00b7lules neuronals vistos a trav\u00e9s d\u2019un microscopi confocal. El citoesquelet est\u00e0 tintat en vermell, els nuclis en blau i els nuclis proliferatius en verd<\/span><\/p>\n

Segons explica la primera autora de l\u2019article, Zaida \u00c1lvarez, del grup de Biomaterials per a Ter\u00e0pies Regeneratives, \u00abper poder desenvolupar estrat\u00e8gies d\u2019enginyeria de teixits que permetin reparar els danys en el sistema nervi\u00f3s central, \u00e9s essencial dissenyar biomaterials que imitin amb molta precisi\u00f3 els n\u00ednxols de c\u00e8l\u00b7lules mare neurals i les seves caracter\u00edstiques qu\u00edmiques i bioqu\u00edmiques\u00bb.<\/p>\n

En l\u2019estudi, liderat per la investigadora de la Universitat de Barcelona Soledad Alc\u00e1ntara, l\u2019equip va provar diferents tipus d\u2019\u00e0cid polil\u00e0ctic (PLA) amb diferents proporcions d\u2019is\u00f2mers L i D\/L, un material biodegradable que permet l\u2019adhesi\u00f3 i el creixement cel\u00b7lular neural. Aix\u00ed, es va descobrir que un d\u2019ells, el PLA amb una proporci\u00f3 d\u2019is\u00f2mers 70\/30 (PLA70\/30), mantenia els grups de c\u00e8l\u00b7lules progenitores neuronals i glials in vitro. El PLA70\/30 era m\u00e9s amorf, es degradava m\u00e9s de pressa i, encara m\u00e9s important, alliberava grans quantitats d\u2019L-lactat, essencial per al manteniment de les c\u00e8l\u00b7lules progenitores neurals. \u00abL\u2019objectiu del treball era trobar un biomaterial capa\u00e7 de mantenir la poblaci\u00f3 de c\u00e8l\u00b7lules progenitores neurals i de generar noves c\u00e8l\u00b7lules diferenciades amb la finalitat d\u2019iniciar el desenvolupament d\u2019un implant que permeti la regeneraci\u00f3 cerebral\u00bb, apunta la Dra. Alc\u00e1ntara.<\/p>\n

\u00abLes propietats mec\u00e0niques i de superf\u00edcie del PLA70\/30, que usem aqu\u00ed en forma de pel\u00b7l\u00edcules microprimes, fan que sigui un bon substrat per a l\u2019adhesi\u00f3, proliferaci\u00f3 i diferenciaci\u00f3 de les c\u00e8l\u00b7lules neurals\u00bb, indica Zaida. \u00abLes propietats f\u00edsiques del material i l\u2019alliberament d\u2019L-lactat en degradar-se proporciona un substrat oxidatiu alternatiu per a les c\u00e8l\u00b7lules neurals que actua sinerg\u00edsticament modulant fenotips progenitors\u00bb, conclou la investigadora.<\/p>\n

Els resultats suggereixen que la introducci\u00f3 de patrons 3D imitant l\u2019arquitectura dels n\u00ednxols de c\u00e8l\u00b7lules mare neurals embrion\u00e0ries en estructures fetes amb PLA70\/30 pot ser un bon punt de partida per dissenyar dispositius implantables al cervell. \u00abAquests podran activar o induir c\u00e8l\u00b7lules progenitores neurals ja existents a autorenovar-se i produir neurones noves, de manera que es potenciaria la resposta regenerativa del sistema nervi\u00f3s central in situ\u00bb, afegeix Zaida.<\/p>\n

Aconseguir que el sistema nervi\u00f3s central es regeneri podria obrir la porta a noves i prometedores estrat\u00e8gies amb la finalitat d\u2019afrontar els danys causats per accidents, a m\u00e9s dels que provoquen nombroses afeccions com els vessaments cerebrals i malalties degeneratives com el Parkinson i l\u2019Alzheimer.<\/p>\n

—<\/p>\n

Alvarez, Z., Mateos-Timoneda, M.A., Hyro\u0161\u0161ov\u00e1, P., Casta\u00f1o, O., Planell, J.A., Perales, J.C., Engel, E. and Alc\u00e1ntara, S. (2013). The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche<\/a>. Biomaterials 34, 9, 2221\u20132233<\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l\u2019IBEC i de la Universitat de Barcelona revelen, en un article publicat a la revista Biomaterials<\/em>, una nova i prometedora estrat\u00e8gia per regenerar el sistema nervi\u00f3s central. <\/p>\n","protected":false},"author":4,"featured_media":6797,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-6801","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nUn pas cap a la reparaci\u00f3 del sistema nervi\u00f3s central - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/un-pas-cap-a-la-reparacio-del-sistema-nervios-central\/\" \/>\n<meta property=\"og:locale\" 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