{"id":68031,"date":"2019-08-09T09:24:08","date_gmt":"2019-08-09T07:24:08","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=68031"},"modified":"2020-06-15T11:35:13","modified_gmt":"2020-06-15T09:35:13","slug":"els-nanovectors-podrien-millorar-ladministracio-combinada-de-farmacs-contra-la-malaria","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/els-nanovectors-podrien-millorar-ladministracio-combinada-de-farmacs-contra-la-malaria\/","title":{"rendered":"Els nanovectors podrien millorar l\u2019administraci\u00f3 combinada de f\u00e0rmacs contra la mal\u00e0ria"},"content":{"rendered":"<p>Per superar aquest obstacle, l\u2019equip de Fern\u00e1ndez-Busquets ha desenvolupat un nanovector \u2013que consisteix en petites esferes o liposomes\u2013 capa\u00e7 de\u00a0<strong>transportar simult\u00e0niament mol\u00e8cules solubles en aigua<\/strong>\u00a0(hidrof\u00edlics)\u00a0<strong>i en l\u00edpids<\/strong>\u00a0(lipof\u00edlics).<\/p>\n<p>\u201cA l&#8217;encapsular els dos f\u00e0rmacs en el mateix nanovector ens assegurem que tots dos perduraran el mateix temps dins l\u2019organisme\u201d, explica Fern\u00e1ndez-Busquets. Com a prova de concepte, l\u2019equip investigador va introduir el f\u00e0rmac hidrosoluble pironaridina a la cavitat interna del liposoma, i el f\u00e0rmac liposoluble atovaquona a la membrana del mateix. A m\u00e9s, van envoltar el liposoma d\u2019un antic\u00f2s que reconeix una prote\u00efna expressada per gl\u00f2buls vermells (estiguin infectats o no) i gamet\u00f2cits (la fase sexual del par\u00e0sit responsable de la transmissi\u00f3 entre hostes). D\u2019aqu\u00ed el nom de immunoliposoma.<\/p>\n<p>Els resultats mostren que ambd\u00f3s f\u00e0rmacs, quan son encapsulats, van ser capa\u00e7os\u00a0<strong>d\u2019inhibir el creixement del par\u00e0sit<\/strong>\u00a0<em>in vitro<\/em>\u00a0a concentracions que no tenien cap efecte quan eren lliures. Gr\u00e0cies als anticossos, els immunoliposomes\u00a0<strong>van unir-se r\u00e0pidament a la c\u00e8l\u00b7lula diana i van administrar el f\u00e0rmac\u00a0<\/strong>de manera molt eficient.<\/p>\n<p>Els autors assenyalen que aquesta estrat\u00e8gia podria aplicar-se en un futur proper a casos de mal\u00e0ria greu que ingressin a l\u2019hospital, on l\u2019administraci\u00f3 intravenosa del liposoma \u00e9s factible. El repte ser\u00e0 desenvolupar nanovectors d\u2019administraci\u00f3 oral per tractar la mal\u00e0ria no greu, una l\u00ednia de treball que el mateix grup de recerca est\u00e0 tamb\u00e9 explorant.<\/p>\n<p>\u201cEls tractaments actuals actuen majorit\u00e0riament sobre les fases asexuals del par\u00e0sit. Aquesta nova estrat\u00e8gia actuaria tamb\u00e9 sobre la fase sexual o gamet\u00f2cit, l\u2019\u00fanica fase del par\u00e0sit que es pot transmetre d\u2019humans a mosquits, i ajudaria a reduir l\u2019emerg\u00e8ncia i la propagaci\u00f3 de resist\u00e8ncies\u201d, afegeix l\u2019investigador.<\/p>\n<p><strong>Article de refer\u00e8ncia: <\/strong>Biosca A, Dirscherl L, Moles E, Imperial S, Fern\u00e0ndez-Busquets X. An ImmunoPEGliposome for Targeted Antimalarial Combination Therapy at the Nanoscale. Pharmaceutics. 2019 Jul 16;11(7). pii: E341.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31315185\" target=\"_blank\" rel=\"noopener noreferrer\">doi: 10.3390\/pharmaceutics11070341<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"alignnone wp-image-68028 size-medium lazyload\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2019\/08\/Nanovectors-malaria-300x142.jpg\" alt=\"Nanovector_IBEC\" width=\"300\" height=\"142\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/08\/Nanovectors-malaria-300x142.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/08\/Nanovectors-malaria-768x363.jpg 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/08\/Nanovectors-malaria-1024x484.jpg 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/08\/Nanovectors-malaria-230x109.jpg 230w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/08\/Nanovectors-malaria-150x71.jpg 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/08\/Nanovectors-malaria.jpg 1600w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/142;\" \/>Segons indica l\u2019estudi, l\u2019estrat\u00e8gia t\u00e9, a m\u00e9s, l&#8217;avantatge de recon\u00e8ixer al gametocist, la fase transmissible del par\u00e0sit. Encapsular dos f\u00e0rmacs amb propietats diferents en nanoves\u00edcules envoltades per anticossos millora notablement la seva especificitat i efic\u00e0cia, segons un estudi liderat per Xavier Fern\u00e1ndez-Busquets, director de la unitat mixta de Nanomal\u00e0ria de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i l\u2019Institut de Salut Global de Barcelona (ISGlobal), centre impulsat per \u201dla Caixa\u201d.<\/h3>\n<\/p>\n<p>La combinaci\u00f3 de dos f\u00e0rmacs que difereixen en el seu mecanisme d\u2019acci\u00f3 \u00e9s la base de les ter\u00e0pies m\u00e9s reeixides avui dia per tractar la mal\u00e0ria. Tot i aix\u00f2, la difer\u00e8ncia en propietats fisicoqu\u00edmiques dels f\u00e0rmacs (solubilitat, vida mitjana, etc.) afecta moltes vegades a l\u2019efic\u00e0cia del tractament.<\/p>\n","protected":false},"author":4,"featured_media":68028,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[157,1112],"post_formats":[],"class_list":["post-68031","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-malaria-ca","tag-xavier-fernandez-busquets-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Els nanovectors podrien millorar l\u2019administraci\u00f3 combinada de f\u00e0rmacs contra la mal\u00e0ria - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/els-nanovectors-podrien-millorar-ladministracio-combinada-de-farmacs-contra-la-malaria\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Els nanovectors podrien millorar l\u2019administraci\u00f3 combinada de f\u00e0rmacs contra la mal\u00e0ria - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Segons indica l\u2019estudi, l\u2019estrat\u00e8gia t\u00e9, a m\u00e9s, l&#039;avantatge de recon\u00e8ixer al gametocist, la fase transmissible del par\u00e0sit. Encapsular dos f\u00e0rmacs amb propietats diferents en nanoves\u00edcules envoltades per anticossos millora notablement la seva especificitat i efic\u00e0cia, segons un estudi liderat per Xavier Fern\u00e1ndez-Busquets, director de la unitat mixta de Nanomal\u00e0ria de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i l\u2019Institut de Salut Global de Barcelona (ISGlobal), centre impulsat per \u201dla Caixa\u201d.  La combinaci\u00f3 de dos f\u00e0rmacs que difereixen en el seu mecanisme d\u2019acci\u00f3 \u00e9s la base de les ter\u00e0pies m\u00e9s reeixides avui dia per tractar la mal\u00e0ria. 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