{"id":68051,"date":"2019-09-03T13:29:08","date_gmt":"2019-09-03T11:29:08","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=68051"},"modified":"2020-06-15T11:34:34","modified_gmt":"2020-06-15T09:34:34","slug":"investigadors-de-libec-desenvolupen-una-plataforma-de-bioenginyeria-que-permet-detectar-moleules-pro-inflamatories-presents-en-desordres-musculars","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-desenvolupen-una-plataforma-de-bioenginyeria-que-permet-detectar-moleules-pro-inflamatories-presents-en-desordres-musculars\/","title":{"rendered":"Investigadors de l&#8217;IBEC desenvolupen una plataforma de bioenginyeria que permet detectar mol\u00e8ules pro-inflamat\u00f2ries presents en desordres musculars"},"content":{"rendered":"<figure id=\"attachment_68055\" aria-describedby=\"caption-attachment-68055\" style=\"width: 490px\" class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"size-full wp-image-68055 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/09\/Figura1.jpg\" alt=\"\" width=\"500\" height=\"332\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/09\/Figura1.jpg 500w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/09\/Figura1-300x199.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/09\/Figura1-196x130.jpg 196w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/09\/Figura1-150x100.jpg 150w\" data-sizes=\"(max-width: 500px) 100vw, 500px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/332;\" \/><figcaption id=\"caption-attachment-68055\" class=\"wp-caption-text\">Schematic overview of the configuration and function of the muscle-on-a-chip. The flow passes through the microdevice where 3D SM tissue is electrically (ITO-IDA electrodes) or biologically (LPS) stimulated. As a consequence of this stimulation cytokines are secreted and detected in situ by the sensing platform which allows its quantification.<\/figcaption><\/figure>\n<p>En aquest context, la comprensi\u00f3 de la din\u00e0mica de secreci\u00f3 de prote\u00efnes dels teixits \u00e9s un factor cr\u00edtic per a avan\u00e7ar cap a una millor detecci\u00f3 d&#8217;anomalies i nous tractaments per a malalties com la\u00a0distr\u00f2fia\u00a0muscular de\u00a0<span class=\"hiddenSpellError\">Duchenne<\/span>\u00a0i la\u00a0miopatia\u00a0inflamat\u00f2ria.\u00a0No obstant aix\u00f2, la determinaci\u00f3 de la velocitat d&#8217;alliberament d&#8217;aquestes mol\u00e8cules d&#8217;un teixit in vivo representa un repte important\u00a0a causa de\u00a0les contribucions incontrolades d&#8217;altres teixits.<\/p>\n<p>Investigadors de l&#8217;<span class=\"hiddenSpellError\">IBEC<\/span>\u00a0han desenvolupat una plataforma que permet localitzar la font de\u00a0<span class=\"hiddenSpellError\">citoquines<\/span>. Despr\u00e9s de cultivar teixits biomim\u00e8tics en 3D, els investigadors van\u00a0connectar\u00a0el &#8220;m\u00fascul en un xip&#8221; a una plataforma de detecci\u00f3 de prote\u00efnes d&#8217;alta sensibilitat amb la finalitat de mesurar la seva activitat biol\u00f2gica.<\/p>\n<p>Mitjan\u00e7ant aquest enfocament, els cient\u00edfics ara poden monitorar la\u00a0secreci\u00f3\u00a0temporal de les mol\u00e8cules\u00a0<span class=\"hiddenSpellError\">IL<\/span>-6\u00a0<span class=\"hiddenGrammarError\">y<\/span>\u00a0<span class=\"hiddenSpellError\">TNF<\/span>\u2014<span class=\"hiddenSpellError\">\u03b1<\/span>\u00a0resultants de l&#8217;estimulaci\u00f3 el\u00e8ctrica i qu\u00edmica dels teixits musculars esquel\u00e8tics.<\/p>\n<p>Segons els autors, aquesta metodologia\u00a0podria\u00a0contribuir no nom\u00e9s a una millor comprensi\u00f3 de la contribuci\u00f3 de les mol\u00e8cules\u00a0<span class=\"hiddenSpellError\">IL<\/span>-6\u00a0<span class=\"hiddenGrammarError\">y<\/span>\u00a0<span class=\"hiddenSpellError\">TNF<\/span>\u2014<span class=\"hiddenSpellError\">\u03b1<\/span>\u00a0en el proc\u00e9s d&#8217;inflamaci\u00f3 relacionat amb el m\u00fascul\u00a0sin\u00f3\u00a0que tamb\u00e9 es pot aplicar en futurs estudis sobre el\u00a0trastorn\u00a0metab\u00f2lic. Aquesta revolucion\u00e0ria tecnologia es pot exportar a\u00a0qualsevol\u00a0entorn de laboratori i pot tenir un gran impacte en el proc\u00e9s de detecci\u00f3 de drogues per a qualsevol sistema d&#8217;\u00f2rgans.<\/p>\n<p><strong>Art\u00edcle de refer\u00e8ncia;\u00a0<\/strong>M. A. Ortega, X. Fern\u00e1ndez-Garibay, A. G. Casta\u00f1o, F. De Chiara, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590137019300159#!\" target=\"_blank\" rel=\"noopener noreferrer\">A. Hern\u00e1ndez-Albors<\/a>, J. Balaguer-Trias and J. Ramon-Azcon. Muscle-on-a-chip with an on-site multiplexed biosensing system for in situ monitoring of secreted IL-6 and TNF-\u03b1. <em>Lab Chip, 2019,19, 2568-2580. 10.1039\/C9LC00285E.<\/em><\/p>\n<p><strong>Persona de contacte per a m\u00e9s informaci\u00f3: \u00c0ngels L\u00f3pez, Departament de Comunicaci\u00f3.\u00a0<\/strong><\/p>\n<p><strong>E-Mail: <\/strong><a href=\"mailto:alopez@ibecbarcelona.eu\">alopez@ibecbarcelona.eu<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<h3>El grup de recerca de Biosensors per a la bioenginyeria liderat per Javier Ram\u00f3n ha desenvolupat una plataforma de detecci\u00f3 per a la captaci\u00f3 in-situ de mol\u00e8cules pro-inflamat\u00f2ries segregades pels teixits, conegudes com a citoquines. Aquesta nova metodologia obre una porta a la comprensi\u00f3 dels desordres metab\u00f2lics presents en les malalties musculars a m\u00e9s a m\u00e9s del desenvolupament d&#8217;aplicacions de detecci\u00f3 de drogues.<\/h3>\n<\/p>\n<p>Tot i que el 40% del total de massa corporal \u00e9s teixit muscular esquel\u00e8tic, segons l&#8217;Associaci\u00f3 M\u00e8dica Estatunidenca, no existeix un perfil m\u00e8dic cl\u00ednic especialitzat en el tractament de malalties musculars. \u00c9s precisament en aquesta \u00e0rea que des de fa uns anys, el grup de recerca del Dr. Javier Ram\u00f3n a l&#8217;IBEC, treballa per omplir l&#8217;escletxa entre els trastorns musculars i les ter\u00e0pies m\u00e8diques espec\u00edfiques.<\/p>\n","protected":false},"author":4,"featured_media":68055,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1131],"post_formats":[],"class_list":["post-68051","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-javier-ramon-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigadors de l&#039;IBEC desenvolupen una plataforma de bioenginyeria que permet detectar mol\u00e8ules pro-inflamat\u00f2ries presents en desordres musculars - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-desenvolupen-una-plataforma-de-bioenginyeria-que-permet-detectar-moleules-pro-inflamatories-presents-en-desordres-musculars\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors de l&#039;IBEC desenvolupen una plataforma de bioenginyeria que permet detectar mol\u00e8ules pro-inflamat\u00f2ries presents en desordres musculars - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grup de recerca de Biosensors per a la bioenginyeria liderat per Javier Ram\u00f3n ha desenvolupat una plataforma de detecci\u00f3 per a la captaci\u00f3 in-situ de mol\u00e8cules pro-inflamat\u00f2ries segregades pels teixits, conegudes com a citoquines. 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Tot i que el 40% del total de massa corporal \u00e9s teixit muscular esquel\u00e8tic, segons l&#039;Associaci\u00f3 M\u00e8dica Estatunidenca, no existeix un perfil m\u00e8dic cl\u00ednic especialitzat en el tractament de malalties musculars. \u00c9s precisament en aquesta \u00e0rea que des de fa uns anys, el grup de recerca del Dr. Javier Ram\u00f3n a l&#039;IBEC, treballa per omplir l&#039;escletxa entre els trastorns musculars i les ter\u00e0pies m\u00e8diques espec\u00edfiques.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-desenvolupen-una-plataforma-de-bioenginyeria-que-permet-detectar-moleules-pro-inflamatories-presents-en-desordres-musculars\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-03T11:29:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-15T09:34:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/09\/Figura1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"332\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-desenvolupen-una-plataforma-de-bioenginyeria-que-permet-detectar-moleules-pro-inflamatories-presents-en-desordres-musculars\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-desenvolupen-una-plataforma-de-bioenginyeria-que-permet-detectar-moleules-pro-inflamatories-presents-en-desordres-musculars\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Investigadors de l&#8217;IBEC desenvolupen una plataforma de bioenginyeria que permet detectar mol\u00e8ules pro-inflamat\u00f2ries presents en desordres musculars\",\"datePublished\":\"2019-09-03T11:29:08+00:00\",\"dateModified\":\"2020-06-15T09:34:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-desenvolupen-una-plataforma-de-bioenginyeria-que-permet-detectar-moleules-pro-inflamatories-presents-en-desordres-musculars\\\/\"},\"wordCount\":384,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-desenvolupen-una-plataforma-de-bioenginyeria-que-permet-detectar-moleules-pro-inflamatories-presents-en-desordres-musculars\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2019\\\/09\\\/Figura1.jpg\",\"keywords\":[\"Javier Ram\u00f3n\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-desenvolupen-una-plataforma-de-bioenginyeria-que-permet-detectar-moleules-pro-inflamatories-presents-en-desordres-musculars\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-desenvolupen-una-plataforma-de-bioenginyeria-que-permet-detectar-moleules-pro-inflamatories-presents-en-desordres-musculars\\\/\",\"name\":\"Investigadors de l'IBEC desenvolupen una plataforma de bioenginyeria que permet detectar mol\u00e8ules pro-inflamat\u00f2ries presents en desordres musculars - 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