{"id":68258,"date":"2019-09-12T11:45:27","date_gmt":"2019-09-12T09:45:27","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=68258"},"modified":"2020-06-15T11:34:23","modified_gmt":"2020-06-15T09:34:23","slug":"el-aceite-de-oliva-ofrece-dos-poderosas-armas-en-la-lucha-contra-la-resistencia-bacteriana","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/el-aceite-de-oliva-ofrece-dos-poderosas-armas-en-la-lucha-contra-la-resistencia-bacteriana\/","title":{"rendered":"L’oli d’oliva ofereix dues poderoses armes en la lluita contra la resist\u00e8ncia bacteriana"},"content":{"rendered":"

\"\" \u2013l\u2019\u00e0cid olean\u00f2lic i l’\u00e0cid masl\u00ednic- dos derivats amb un enorme potencial antimicrobi\u00e0.<\/p>\n

L’estudi, publicat a la revista ACS Infectious Diseases<\/em>, revela per primera vegada com les propietats antibacterianes de les mol\u00e8cules obtingudes superen amb escreix a les dels compostos originals<\/strong>.<\/p>\n

“Les propietats antimicrobianes dels \u00e0cids olean\u00f2lic i masl\u00ednic es coneixen des de fa anys. De fet, aquests \u00e0cids presents en les olives no nom\u00e9s no s\u00f3n nocius per a les c\u00e8l\u00b7lules del nostre organisme, sin\u00f3 que a m\u00e9s, els bacteris no s\u00f3n resistents a la seva actuaci\u00f3”, comenta Eduard Torrents, investigador principal del grup d’Infeccions Bacterianes: Ter\u00e0pies Antimicrobianes<\/a> de l\u2019IBEC i col\u00edder de l’estudi. “No obstant aix\u00f2, tot i aquests avantatges, la seva activitat antimicrobiana nom\u00e9s s’ha provat in vitro<\/em> i, fins ara, no s’havien trobat derivats que milloressin la seva activitat.”<\/p>\n

Despr\u00e9s sintetitzar i estudiar catorze derivats dels \u00e0cids olean\u00f2lic i masl\u00ednic, l’equip investigador va trobar dos, anomenats OA-HDA i MA-HDA, que van superar l’activitat antimicrobiana dels compostos originals tant in vitro<\/em> com en model animal. I el m\u00e9s rellevant: els bacteris no van mostrar ser capa\u00e7os de generar resist\u00e8ncia davant cap dels dos compostos. “L’\u00fas inadequat dels antibi\u00f2tics ha provocat l’aparici\u00f3 de bacteris multiresistents, capa\u00e7os de sobreviure davant l’acci\u00f3 dels medicaments. Es tracta d’un problema de salut global que cada vegada causa la mort a m\u00e9s persones”, explica Eduard Torrents (IBEC). “Trobar alternatives als antibi\u00f2tics comuns, com els derivats OA-HDA i MA-HDA, \u00e9s, avui dia, una prioritat. \u00c9s una necessitat urgent.”<\/p>\n

Contra les infeccions als hospitals<\/strong><\/p>\n

Al voltant del 5% de tots els pacients adquireix una infecci\u00f3 durant la seva estada a l’hospital. Aquestes infeccions, denominades infeccions nosocomials, solen estar causades pel bacteri Staphylococcus aureus<\/em>, i comporten una elevada morbiditat i mortalitat, a m\u00e9s d’un gran impacte econ\u00f2mic per al sistema sanitari.<\/p>\n

“La majoria de les infeccions nosocomials s’originen durant procediments invasius, com l’aplicaci\u00f3 de cat\u00e8ters o pr\u00f2tesis. Per desgr\u00e0cia, les superf\u00edcies d’aquests dispositius afavoreixen la formaci\u00f3 de biofilms, ecosistemes bacterians amb taxes de resist\u00e8ncia a antibi\u00f2tics fins a 1.000 vegades superiors als bacteris habituals”, explica Torrents.<\/p>\n

Els biofilms de Staphylococcus aureus<\/em> poden generar infeccions perilloses, de vegades arribant a la s\u00e8psia, una afecci\u00f3 m\u00e8dica potencialment letal en la qual el sistema immunitari d\u00f3na una resposta aclaparadora i fulminant davant la infecci\u00f3. “L’\u00fanic tractament efica\u00e7 contra una infecci\u00f3 causada per biofilms \u00e9s la retirada del dispositiu m\u00e8dic i una ter\u00e0pia antibi\u00f2tica a llarg termini, que pot promoure bacteris resistents als antibi\u00f2tics”, afegeix l’expert. En una situaci\u00f3 d’aquest tipus, els compostos desenvolupats pels investigadors serien de gran utilitat, ja que la seva activitat antimicrobiana en els biofilms de cat\u00e8ters tamb\u00e9 ha estat provada, tot donant resultats positius<\/strong>.<\/p>\n

Dos compostos accessibles i de f\u00e0cil obtenci\u00f3<\/strong><\/p>\n

L’estudi assenyala la import\u00e0ncia d’utilitzar una mat\u00e8ria primera natural per crear compostos terap\u00e8utics. “Vam escollir els \u00e0cids olean\u00f2lic i masl\u00ednic per dos motius. En primer lloc, perqu\u00e8 s\u00f3n abundants en un producte natural tan quotidi\u00e0 com l’oliva. Els residus industrials de l’oli oliva, per tant, s\u00f3n una font immillorable d’ambd\u00f3s \u00e0cids”, comenta Luis \u00c1lvarez de Cienfuegos. “En segon lloc, els derivats que hem sintetitzat requereixen molt poques transformacions qu\u00edmiques, pel que la seva obtenci\u00f3 a partir dels \u00e0cids originals \u00e9s relativament senzilla”.<\/p>\n

Amb aquesta troballa, els investigadors obren la porta a la creaci\u00f3 de nous f\u00e0rmacs antimicrobians que actuen de forma efica\u00e7 sense el perill de provocar resist\u00e8ncia bacteriana. “En un futur, els compostos OA-HDA i MA-HDA podrien ser els integrants principals de ter\u00e0pies antibacterianes que no deixin lloc per a la resist\u00e8ncia”, conclou Torrents.<\/p>\n

 <\/p>\n

\n

Art\u00edculo referenciado:<\/strong> Blanco-Cabra,N., Vega-Granados,K., Moya-And\u00e9rico, L., Vukomanovic, M., Parra, A., \u00c1lvarez de Cienfuegos, L., Torrents, E. \u00a0<\/em>Novel Oleanolic and Maslinic Acid Derivatives as a Promising Treatment against Bacterial Biofilm in Nosocomial Infections: An in Vitro and in Vivo Study<\/em><\/a>. ACS Infect. Dis., DOI 10.1021\/acsinfecdis.9b00125<\/em><\/p>\n

 <\/p>\n

Per a m\u00e9s informaci\u00f3, si us plau, contacti amb \u00c0ngels L\u00f3pez del departament de Comunicaci\u00f3:\u00a0alopez@ibecbarcelona.eu<\/strong><\/p>\n

\n","protected":false},"excerpt":{"rendered":"

Investigadors del grup d’Infeccions Bacterianes: Ter\u00e0pies Antimicrobianes de l’IBEC i de la Universitat de Granada han creat dos potents antimicrobians a partir de l’\u00e0cid olean\u00f2lic i l’\u00e0cid masl\u00ednic, tots dos presents a l’oli d’oliva.<\/h3>\n

L’estudi, publicat a la revista ACS Infectious Diseases, ha demostrat l’efecte d’aquests derivats sobre el bacteri Staphylococcus aureus<\/em>, un dels principals causants d’infeccions en cat\u00e8ters i pr\u00f2tesis hospital\u00e0ries<\/strong>
\nOr l\u00edquid. Aix\u00ed \u00e9s com totes les cultures mediterr\u00e0nies s’han referit a l’oli d’oliva al llarg de la hist\u00f2ria. El seu sabor captivador, la seva textura i el seu paper en la gastronomia han estat algunes de les qualitats que hi han contribu\u00eft. Per\u00f2 l’oli d’oliva tamb\u00e9 \u00e9s un gran aliat quan parlem de salut: des de propietats antiinflamat\u00f2ries fins beneficis per al sistema cardiovascular, passant per efectes antitumorals recentment descoberts.  
\nAra, cient\u00edfics de l’Institut de Bioenginyeria de Catalunya (IBEC) i de la Universitat de Granada (UGR) s’han proposat incrementar les ja conegudes propietats antimicrobianes de l’oli d’oliva. Per a aix\u00f2, han sintetitzat a partir de dos compostos presents en l’oli d’oliva<\/p>\n","protected":false},"author":4,"featured_media":68243,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[603,1141,158,539,601],"post_formats":[],"class_list":["post-68258","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-acs-infectious-diseases-ca","tag-eduard-torrents-ca","tag-ibec-ca","tag-ibec-es-ca","tag-oli"],"yoast_head":"\nL'oli d'oliva ofereix dues poderoses armes en la lluita contra la resist\u00e8ncia bacteriana - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/el-aceite-de-oliva-ofrece-dos-poderosas-armas-en-la-lucha-contra-la-resistencia-bacteriana\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'oli d'oliva ofereix dues poderoses armes en la lluita contra la resist\u00e8ncia bacteriana - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors del grup d'Infeccions Bacterianes: Ter\u00e0pies Antimicrobianes de l'IBEC i de la Universitat de Granada han creat dos potents antimicrobians a partir de l'\u00e0cid olean\u00f2lic i l'\u00e0cid masl\u00ednic, tots dos presents a l'oli d'oliva. L'estudi, publicat a la revista ACS Infectious Diseases, ha demostrat l'efecte d'aquests derivats sobre el bacteri Staphylococcus aureus, un dels principals causants d'infeccions en cat\u00e8ters i pr\u00f2tesis hospital\u00e0ries Or l\u00edquid. Aix\u00ed \u00e9s com totes les cultures mediterr\u00e0nies s'han referit a l'oli d'oliva al llarg de la hist\u00f2ria. El seu sabor captivador, la seva textura i el seu paper en la gastronomia han estat algunes de les qualitats que hi han contribu\u00eft. Per\u00f2 l'oli d'oliva tamb\u00e9 \u00e9s un gran aliat quan parlem de salut: des de propietats antiinflamat\u00f2ries fins beneficis per al sistema cardiovascular, passant per efectes antitumorals recentment descoberts.   Ara, cient\u00edfics de l'Institut de Bioenginyeria de Catalunya (IBEC) i de la Universitat de Granada (UGR) s'han proposat incrementar les ja conegudes propietats antimicrobianes de l'oli d'oliva. 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