{"id":68951,"date":"2019-10-31T10:31:34","date_gmt":"2019-10-31T09:31:34","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=68951"},"modified":"2019-10-31T13:14:39","modified_gmt":"2019-10-31T12:14:39","slug":"libec-rep-financament-per-a-tres-projectes-de-la-ma-de-la-marato-2018","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/libec-rep-financament-per-a-tres-projectes-de-la-ma-de-la-marato-2018\/","title":{"rendered":"L’IBEC rep finan\u00e7ament per a tres projectes de la m\u00e0 de la Marat\u00f3 2018"},"content":{"rendered":"

La Marat\u00f3 de TV3, juntament amb Catalunya R\u00e0dio, emet la seva telemarat\u00f3 anual per recaptar fons per a la recerca cient\u00edfica de malalties diverses i t\u00e9 una tem\u00e0tica diferent cada any. L’edici\u00f3 del 2018 va recaptar un total de 15 milions d’euros que s’han destinat a 43 projectes i 96 equips.<\/a><\/p>\n

El projecte titulat “Comprensi\u00f3 de la mecanotransducci\u00f3 mitjan\u00e7ada per YAP en c\u00e0ncer de p\u00e0ncrees” liderat des de l’IBEC per Pere Roca-Cusacs i co-liderat per Miguel \u00c1ngel del Pozo Barriuso (Centro Nacional de Investigaciones Cardiovasculares, CNIC) ha rebut un finan\u00e7ament de 300.000 per als tres pr\u00f2xims anys. El projecte persegueix entendre com la rigidesa dels teixits afecta el c\u00e0ncer de p\u00e0ncrees. Concretament, se centrar\u00e0 a estudiar el paper de la mol\u00e8cula YAP, que \u00e9s un activador de gens espec\u00edfics i se sap que t\u00e9 un paper tant en el c\u00e0ncer de p\u00e0ncrees com en la resposta cel\u00b7lular a la rigidesa. Gr\u00e0cies a aquest projecte, es desenvoluparan eines per entendre els mecanismes moleculars pels quals els tumors de p\u00e0ncrees responen a la rigidesa a trav\u00e9s de YAP i quines s\u00f3n les implicacions i aix\u00ed poder dissenyar nous medicaments contra el c\u00e0ncer de p\u00e0ncrees. El c\u00e0ncer de p\u00e0ncrees \u00e9s la quarta causa de mort relacionada amb el c\u00e0ncer a tot el m\u00f3n. Un cop diagnosticat, t\u00e9 la taxa de superviv\u00e8ncia m\u00e9s baixa de tots els c\u00e0ncers, ja que nom\u00e9s entre el 2-10% de les persones diagnosticades sobreviuen despr\u00e9s de cinc anys. Tot i que les ter\u00e0pies de quimioter\u00e0pia i radioter\u00e0pia estan ben establertes, les taxes de superviv\u00e8ncia segueixen sent extremadament baixes, i la majoria de pacients experimenten una recaiguda tumoral i la resist\u00e8ncia a les ter\u00e0pies \u00e9s molt freq\u00fcent.<\/p>\n

D’altra banda, Xavier trepat, \u00e9s co-l\u00edder del projecte “Exclusi\u00f3 de les c\u00e8l\u00b7lules T durant l’evasi\u00f3 sistema immunitari i la manca de resposta a la immunoter\u00e0pia del c\u00e0ncer: tipus cel\u00b7lulars, programes transcripcionals i biomec\u00e0nica”. Juntament amb Eduard Batlle de l’Insitut de Recerca Biom\u00e8dica de Barcelona, coordinador del projecte i Holger Heyn del Centre de Regulaci\u00f3 Gen\u00f2mica, investigaran quins mecanismes utilitzen les c\u00e8l\u00b7lules tumorals per impedir la migraci\u00f3 i la funci\u00f3 de les c\u00e8l\u00b7lules immunit\u00e0ries en el c\u00e0ncer colorectal. Aquest coneixement ser\u00e0 utilitzat per desenvolupar una nova classe d’immunoter\u00e0pia per tractar aquest tipus de tumor, i potencialment altres que facin servir estrat\u00e8gies semblants. Molts tipus de tumors com el c\u00e0ncer colorectal inhibeixen la capacitat del sistema immunitari per eliminar aquesta malaltia impedint el moviment de les c\u00e8l\u00b7lules immunit\u00e0ries dins el tumor, el que provoca una resist\u00e8ncia a les immunoter\u00e0pies actuals. El projecte t\u00e9 una duraci\u00f3 de 3 anys i compta amb un pressupost de 400.000 euros.<\/p>\n

Per \u00faltim, N\u00faria Montserrat co-lidera el projecte “Identificaci\u00f3 de noves dianes terap\u00e8utiques i biomarcadors de progressi\u00f3 del c\u00e0ncer de rony\u00f3 a trav\u00e9s de models organoids i xenoempelts gen\u00e8ticament dissenyats per CRISPR” juntament amb la Laura Izquierdo de l’Institut d’Investigacions Biom\u00e8diques August Pi i Sunyer i amb l’Oriol Casanovas de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge com a coordinador del projecte. El projecte t\u00e9 com a objectiu abordar la progressi\u00f3 del carcinoma de c\u00e8l\u00b7lules renals de subtipus c\u00e8l\u00b7lula clara (ccRCC) des d’un angle \u00fanic i innovador, anir\u00e0 un pas m\u00e9s ennll\u00e0 en la generaci\u00f3 d’organoides renals gen\u00e8ticament modificats o mini-ronyons i els seus models animals derivats per a la identificaci\u00f3 de noves vies i dianes de la progressi\u00f3 de ccRCC. Posteriorment, permetr\u00e0 la validaci\u00f3 cl\u00ednica completa en dues s\u00e8ries de pacients amb ccRCC per determinar el paper de les mol\u00e8cules identificades com a dianes terap\u00e8utiques. Aquest coneixement permetr\u00e0 implementar aquestes mol\u00e8cules com a eines per al tractament d’un ccRCC avan\u00e7at en l’entorn cl\u00ednic. El carcinoma de c\u00e8l\u00b7lules renals \u00e9s un tipus agressiu de c\u00e0ncer i el subtipus de c\u00e8l\u00b7lula clara (ccRCC) \u00e9s el m\u00e9s freq\u00fcent. Tot i que aquest tipus de c\u00e0ncer ha estat \u00e0mpliament estudiat hi ha una important manca de ter\u00e0pies dirigides que siguin efectives per a aquesta malaltia. Per tant, hi ha una important necessitat m\u00e8dica d’identificaci\u00f3 de noves vies moleculars i nous marcadors per millorar l’efic\u00e0cia terap\u00e8utica i el pron\u00f2stic d’aquesta malaltia. El projecte t\u00e9 una duraci\u00f3 de 3 anys i compta amb un pressupost de 400.000 euros.<\/p>\n

La comissi\u00f3 d’obertura de la cerim\u00f2nia va estar presidida per les conselleres de Presid\u00e8ncia i de Salut, Meritxell Bud\u00f3 i Alba Verg\u00e9s va comptar tamb\u00e9 amb la pres\u00e8ncia de N\u00faria Llorach, vicepresidenta de la Corporaci\u00f3 Catalana de Mitjans Audiovisuals i del Patronat de la Fundaci\u00f3 La Marat\u00f3 de TV3; Joan Sala, president de l’Acad\u00e8mia de Ci\u00e8ncies M\u00e8diques i de la Salut de Catalunya i de Balears; Llu\u00eds Bernab\u00e9, director de la Fundaci\u00f3 La Marat\u00f3 de TV3, i de Robert Fabregat Barber\u00e0, director general de Recerca i Innovaci\u00f3 del Departament de Salut.<\/p>\n

L\u2019edici\u00f3 del 2019 de La Marat\u00f3<\/a>\u00a0estar\u00e0 dedicada a recaptar fons per a projectes contra el c\u00e0ncer i se celebrar\u00e0 el 15 de desembre del 2019.<\/p>\n

\"\"
Investigadors guardonats durant la celebraci\u00f3 (Foto: TV3)<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"

\"\"Tres projectes en els quals participa l’IBEC han estat seleccionats per rebre finan\u00e7ament de La Marat\u00f3 2018 “Contra el c\u00e0ncer”. Un dels projectes \u00e9s liderat per l’investigador Pere Roca-Cusachs i els altres dos s\u00f3n co-liderats pels investigadors Xavier Trepat i N\u00faria Montserrat. <\/h3>\n<\/p>\n

La cerim\u00f2nia d’entrega dels diplomes acreditatius va tenir lloc el 30 d’octubre a l’Auditori de l’Acad\u00e8mia de Ci\u00e8ncies M\u00e8diques i de la Salut de Catalunya i de Balears. En aquesta edici\u00f3 s’han escollit 43 projectes dels 188 avaluats per un comit\u00e8 d’experts en c\u00e0ncer d’\u00e0mbit internacional, en funci\u00f3 de la seva excel\u00b7l\u00e8ncia, metodologia i rellev\u00e0ncia.<\/p>\n","protected":false},"author":4,"featured_media":68961,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[561,325],"post_formats":[],"class_list":["post-68951","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-marato","tag-tv3-ca"],"yoast_head":"\nL'IBEC rep finan\u00e7ament per a tres projectes de la m\u00e0 de la Marat\u00f3 2018 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/libec-rep-financament-per-a-tres-projectes-de-la-ma-de-la-marato-2018\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'IBEC rep finan\u00e7ament per a tres projectes de la m\u00e0 de la Marat\u00f3 2018 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Tres projectes en els quals participa l'IBEC han estat seleccionats per rebre finan\u00e7ament de La Marat\u00f3 2018 "Contra el c\u00e0ncer". 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