{"id":69823,"date":"2019-12-10T16:00:09","date_gmt":"2019-12-10T15:00:09","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=69823"},"modified":"2019-12-10T16:29:53","modified_gmt":"2019-12-10T15:29:53","slug":"un-equip-dinvestigadors-desenvolupa-biotransistors-capacos-descoltar-petits-batecs-de-vida","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/un-equip-dinvestigadors-desenvolupa-biotransistors-capacos-descoltar-petits-batecs-de-vida\/","title":{"rendered":"Un equip d’investigadors desenvolupa biotransistors capa\u00e7os d’escoltar petits batecs de vida"},"content":{"rendered":"

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Una de les proves que gaireb\u00e9 tots els pacients han d’afrontar abans d’una cirurgia o qualsevol altra intervenci\u00f3 sanit\u00e0ria \u00e9s un electrocardiograma. Per dur a terme aquest control, els metges acostumen a utilitzar un conjunt d’el\u00e8ctrodes capa\u00e7os d’enregistrar l’activitat el\u00e8ctrica del cor. La q\u00fcesti\u00f3\u00a0 \u00e9s: qu\u00e8 passa quan aquest senyal \u00e9s molt m\u00e9s baix, com, per exemple, quan volem escoltar el batec de petites agrupacions de c\u00e8l\u00b7lules o de grups de c\u00e8l\u00b7lules dins de teixits?<\/p>\n

La comunitat cient\u00edfica fa anys que est\u00e0 intentant solucionar aquest problema, ja que facilitaria el cam\u00ed pel desenvolupament i el control dels f\u00e0rmacs. El desenvolupament d’aquestes t\u00e8cniques, juntament amb l’\u00fas de derivats de c\u00e8l\u00b7lules mare pluripotents, obre la porta, no nom\u00e9s a trobar aplicacions immediates en el camp card\u00edac, sin\u00f3 tamb\u00e9 en altres \u00e0rees de recerca crucials, com el neural.<\/p>\n

Ara, experts de l’Institut de Bioenginyeria de Catalunya (IBEC), en col\u00b7laboraci\u00f3 amb l’Institut de Ci\u00e8ncia de Materials de Barcelona (ICMAB-CSIC), han assolit una nova fita. Han desenvolupat una plataforma biol\u00f2gica que integra un dispositiu electr\u00f2nic org\u00e0nic anomenat “transistor org\u00e0nic d’efecte de camp de porta electrol\u00edtica” (EGOFET) al nucli. D\u2019aquesta manera, els investigadors han pogut monitorar el senyal el\u00e8ctric de c\u00e8l\u00b7lules i microteixits durant llargs per\u00edodes de temps. Aquest treball \u00e9s el resultat d’una profitosa col\u00b7laboraci\u00f3 multidisciplin\u00e0ria entre un equip de dispositius electr\u00f2nics org\u00e0nics (dirigit per la doctora Marta Mas-Torrent de l’ICMAB), un equip de bioenginyeria (dirigit pel professor de la UB Gabriel Gomila, a l’IBEC) i un equip d’enginyeria tissular de c\u00e8l\u00b7lules mare (dirigit per la professora de recerca ICREA N\u00faria Montserrat, a l’IBEC), amb la col\u00b7laboraci\u00f3 en desenvolupament d’instrumentaci\u00f3 del doctor Tobias Cramer, de la Universitat de Bolonya a It\u00e0lia.<\/p>\n

\u201cHa estat incre\u00efble veure com la plataforma electrofisiol\u00f2gica desenvolupada amb c\u00e8l\u00b7lules card\u00edaques sembrades es mantenia en funcionament durant diverses setmanes sense que se’n degrad\u00e9s el rendiment. Aquesta capacitat obre la porta a incomptables aplicacions en biologia i biomedicina.\u201d<\/strong><\/p>\n

Dr. Adrica Kyndiah, autora principal de l’informe i investigadora de l’IBEC.<\/p>\n

Els transistors impresos en substrats flexibles van ser fabricats pel grup de la doctora Marta Mas-Torrent a l’ICMAB-CSIC. Posteriorment, la superf\u00edcie de l’EGOFET i tota la plataforma es van adaptar perqu\u00e8 interactuessin amb agrupacions de c\u00e8l\u00b7lules card\u00edaques derivades de c\u00e8l\u00b7lules mare humanes pluripotents durant per\u00edodes llargs de temps (diverses setmanes). Segons els autors de l’informe, publicat a la revista Biosensors and Bioelectronics<\/em>, l’avantatge principal d’utilitzar aquests EGOFET per a l’enregistrament bioelectr\u00f2nic \u00e9s triple:<\/p>\n

En primer lloc, els EGOFET s’elaboren amb material org\u00e0nic sobre un substrat mec\u00e0nicament flexible, s\u00f3n biocompatibles i mostren un rendiment consolidat quan es fan funcionar en un entorn fisiol\u00f2gic. En segon lloc, un transistor produeix l’ampliaci\u00f3 intr\u00ednseca del senyal sense que calguin amplificadors externs, en comparaci\u00f3 amb els el\u00e8ctrodes convencionals, i aix\u00f2 comporta un alt nivell de senyal en relaci\u00f3 amb el soroll. I, en tercer lloc, funciona a baix voltatge, de manera que evita danys cel\u00b7lulars o un est\u00edmul no desitjat en la c\u00e8l\u00b7lula.<\/p>\n

Els investigadors de l’IBEC no nom\u00e9s van provar el dispositiu en c\u00e8l\u00b7lules i teixits card\u00edacs sin\u00f3 que tamb\u00e9 van investigar l’efecte de dos f\u00e0rmacs coneguts que afecten el rendiment card\u00edac. Aix\u00ed, ara seria possible controlar nous compostos en els cardiomi\u00f2cits i altres c\u00e8l\u00b7lules el\u00e8ctriques derivades de c\u00e8l\u00b7lules mare pluripotents (com les neurones). Aquest aven\u00e7, per la seva banda, afavoriria la reducci\u00f3 de l’\u00fas de models animals per a aquestes aplicacions.<\/p>\n

Segons l’equip multidisciplinari, els resultats podrien ampliar-se de l’estudi in vitro<\/em> a l’enregistrament in vivo<\/em> d’\u00f2rgans i teixits i a dispositius implantables per monitorar la salut.<\/p>\n

 <\/p>\n

\n

Article de refer\u00e8ncia:
\n<\/em><\/strong>Kyndiah A,\u00a0Leonardi F,\u00a0Tarantino C,\u00a0Cramer T,\u00a0Millan-Solsona R,\u00a0Garreta E,\u00a0Montserrat N,\u00a0Mas-Torrent M,\u00a0Gomila G. Bioelectronic Recordings of Cardiomyocytes with Accumulation Mode Electrolyte Gated Organic Field Effect Transistors<\/a>. Biosens Bioelectron. 2019 Nov 6:111844. doi: 10.1016\/j.bios.2019.111844 \u00a0\u00a0\u00a0<\/em><\/p>\n

\n

 <\/p>\n

 <\/p>\n

Contacte per a m\u00e9s informaci\u00f3n:
\n<\/em>\u00c0ngels L\u00f3pez \u00b7 Departament de Comunicaci\u00f3
\n<\/em>alopez@ibecbarcelona.eu<\/em><\/a> \u00b7 934 037 299<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l’IBEC i l’ICMAB han desenvolupat una plataforma de transistors biocompatibles, flexibles i econ\u00f2mics capa\u00e7os d’enregistrar un electrocardiograma en c\u00e8l\u00b7lules i microteixits durant per\u00edodes llargs de temps.<\/h3>\n

La plataforma, basada en transistors org\u00e0nics de tipus EGOFET, tamb\u00e9 pot mesurar l’efecte dels f\u00e0rmacs en c\u00e8l\u00b7lules amb batec, com ara els cardiomi\u00f2cits, fet que obre la porta a diverses aplicacions, per exemple, de dispositius implantables per millorar la salut.<\/p>\n","protected":false},"author":4,"featured_media":69818,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1114],"post_formats":[],"class_list":["post-69823","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-gabriel-gomila-ca"],"yoast_head":"\nUn equip d'investigadors desenvolupa biotransistors capa\u00e7os d'escoltar petits batecs de vida - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/un-equip-dinvestigadors-desenvolupa-biotransistors-capacos-descoltar-petits-batecs-de-vida\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un equip d'investigadors desenvolupa biotransistors capa\u00e7os d'escoltar petits batecs de vida - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l'IBEC i l'ICMAB han desenvolupat una plataforma de transistors biocompatibles, flexibles i econ\u00f2mics capa\u00e7os d'enregistrar un electrocardiograma en c\u00e8l\u00b7lules i microteixits durant per\u00edodes llargs de temps. 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