{"id":71504,"date":"2020-01-28T15:20:32","date_gmt":"2020-01-28T14:20:32","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=71504"},"modified":"2020-06-15T11:21:44","modified_gmt":"2020-06-15T09:21:44","slug":"nous-avancos-en-la-millora-del-disseny-de-farmacs-contra-la-taupatia-globular-glial","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/nous-avancos-en-la-millora-del-disseny-de-farmacs-contra-la-taupatia-globular-glial\/","title":{"rendered":"Nous avan\u00e7os en la millora del disseny de f\u00e0rmacs contra la taupat\u00eda globular glial"},"content":{"rendered":"<p>Dins d&#8217;aquest grup de malalties, trobem les taupaties globulars glials, com l&#8217;Alzheimer, que es distingeixen per l&#8217;aglomeraci\u00f3 de la prote\u00efna tau fosforilada en neurones, formant agregats en les c\u00e8l\u00b7lules glials.<\/p>\n<p>En aquest estudi es posa en evid\u00e8ncia que no sols tau \u00e9s la causant\/responsable d&#8217;aquestes patologies com es creia fins al moment, sin\u00f3 que moltes altres prote\u00efnes es troben anormalment fosforilades, la qual cosa condueix a la formaci\u00f3 d&#8217;aquests dip\u00f2sits proteics. Aquestes troballes demostren tamb\u00e9 que aquestes acumulacions no sols afecten les neurones, sin\u00f3 tamb\u00e9 a les c\u00e8l\u00b7lules glials que les acompanyen, la qual cosa pot provocar que certes determinades connexions neuronals es trenquin. A m\u00e9s, aquests agregats s\u00f3n capa\u00e7os de viatjar d&#8217;una neurona a una altra, provocant la propagaci\u00f3 del mal cap a les c\u00e8l\u00b7lules sanes, com si es tract\u00e9s d&#8217;una infecci\u00f3.<\/p>\n<p>Per a realitzar l&#8217;estudi, s&#8217;han analitzat els casos de diversos pacients amb aquesta mena de taupat\u00eda, gr\u00e0cies a la participaci\u00f3 de l&#8217;Hospital de Navarra, que s&#8217;ha encarregat d&#8217;analitzar els nivells de fosforilaci\u00f3 i de les prote\u00efnes implicades.<\/p>\n<p>Aquests descobriments obren una nova via de recerca per al disseny de nous f\u00e0rmacs que parin la progressi\u00f3 de la malaltia. Per a aix\u00f2, primer caldr\u00e0 tenir en compte que l&#8217;addici\u00f3 de grups fosfato no sols afecta tau, sin\u00f3 que tamb\u00e9 a altres prote\u00efnes i, d&#8217;altra banda, no sols estan implicades les neurones sin\u00f3 tamb\u00e9 les c\u00e8l\u00b7lules gliars, que a m\u00e9s afavoreixen la transmissi\u00f3 i expansi\u00f3 de la malaltia.<\/p>\n<p>Aquest estudi ha estat finan\u00e7at per el \u201cMinisterio de Economia y Competitividad\u201d, la Fundaci\u00f3 \u201cLa Caixa\u201d i \u201cEuropean Regional Development Fund\u201d.<\/p>\n<hr \/>\n<p><strong>Article de refer\u00e8ncia: <\/strong><em>Isidro Ferrer, Pol Andr\u00e9s-Benito, Maria Victoria Zelaya, Maria Elena Erro Aguirre, Margarita Carmona, Karina Aus\u00edn, Mercedes Lach\u00e9n-Montes, Joaqu\u00edn Fern\u00e1ndez-Irigoyen, Enrique Santamar\u00eda &amp; Jos\u00e9 Antonio del Rio.<\/em> <strong><a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs00401-019-02122-9\" target=\"_blank\" rel=\"noopener noreferrer\">Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy<\/a><\/strong><em>Acta Neuropathologica (2020) DOI: https:\/\/doi.org\/10.1007\/s00401-019-02122-9\u00a0<\/em><\/p>\n<p><strong>Font: <\/strong><a href=\"http:\/\/www.idibell.cat\/en\/whats-on\/noticies\/new-aspects-globular-glial-tauopathy-could-help-design-more-effective-drugs\" target=\"_blank\" rel=\"noopener noreferrer\">IDIBELL\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"alignnone size-full wp-image-66903 lazyload\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2019\/06\/delrio_ibec.jpg\" alt=\"\" width=\"500\" height=\"398\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/06\/delrio_ibec.jpg 500w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/06\/delrio_ibec-300x239.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/06\/delrio_ibec-163x130.jpg 163w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/06\/delrio_ibec-150x119.jpg 150w\" data-sizes=\"(max-width: 500px) 100vw, 500px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/398;\" \/>Jos\u00e9 Antonio del R\u00edo, investigador principal a l&#8217;Institut de Bioenginyeria de Catalunya (IBEC) juntament amb el Dr. Isidre Ferrer de l&#8217;Institut d&#8217;Investigacions Biom\u00e8diques de Bellvitge (IDIBELL) han liderat un estudi on han descobert que la patologia que mostren els pacients amb taupatia globular glial \u00e9s deguda a la generaci\u00f3 de dip\u00f2sits proteics nocius per a les neurones i les c\u00e8l\u00b7lules glials.<\/h3>\n<p>Les taupat\u00edas es caracteritzen per l&#8217;acumulaci\u00f3 de la prote\u00efna tau fosforilada, \u00e9s a dir, unida a grups fosfat. Aquesta acumulaci\u00f3 provoca la disfunci\u00f3 de les prote\u00efnes i acaba danyant les c\u00e8l\u00b7lules. <\/p>\n","protected":false},"author":4,"featured_media":66904,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1132],"post_formats":[],"class_list":["post-71504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-jose-antonio-del-rio-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nous avan\u00e7os en la millora del disseny de f\u00e0rmacs contra la taupat\u00eda globular glial - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/nous-avancos-en-la-millora-del-disseny-de-farmacs-contra-la-taupatia-globular-glial\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nous avan\u00e7os en la millora del disseny de f\u00e0rmacs contra la taupat\u00eda globular glial - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Jos\u00e9 Antonio del R\u00edo, investigador principal a l&#039;Institut de Bioenginyeria de Catalunya (IBEC) juntament amb el Dr. Isidre Ferrer de l&#039;Institut d&#039;Investigacions Biom\u00e8diques de Bellvitge (IDIBELL) han liderat un estudi on han descobert que la patologia que mostren els pacients amb taupatia globular glial \u00e9s deguda a la generaci\u00f3 de dip\u00f2sits proteics nocius per a les neurones i les c\u00e8l\u00b7lules glials. 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