{"id":71716,"date":"2020-02-25T09:41:35","date_gmt":"2020-02-25T08:41:35","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=71716"},"modified":"2020-06-15T11:21:23","modified_gmt":"2020-06-15T09:21:23","slug":"investigadors-de-libec-desxifren-com-els-patogens-sadapten-als-canvis-doxigen","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-desxifren-com-els-patogens-sadapten-als-canvis-doxigen\/","title":{"rendered":"Investigadors de l\u2019IBEC desxifren com els pat\u00f2gens s\u2019adapten als canvis d\u2019oxigen"},"content":{"rendered":"

Un “antibiograma” \u00e9s una prova microbiol\u00f2gica que mesura la sensibilitat d’un bacteri davant de diferents agents antimicrobians. Es realitza en pacients que se sospita que poden tenir algun tipus d’infecci\u00f3 per saber quins antibi\u00f2tics cal receptar-los i s\u2019acostuma a dur a terme en un ambient aer\u00f2bic, \u00e9s a dir, en pres\u00e8ncia d’oxigen. No obstant aix\u00f2, sovint les infeccions es produeixen en llocs on la pres\u00e8ncia d’oxigen \u00e9s escassa o nul\u00b7la i, a m\u00e9s a m\u00e9s, no \u00e9s constant.<\/p>\n

\"\"Un exemple clar d’aix\u00f2 \u00e9s el del menjar contaminat, ja que durant la ingesta els bacteris estan en contacte amb l’aire, si b\u00e9 quan viatgen a trav\u00e9s dels intestins van trobant-se amb cada vegada menys oxigen. Molts agents infecciosos s\u00f3n capa\u00e7os d’adaptar-se a aquests canvis d’oxigen<\/strong>, per\u00f2 al mateix temps aix\u00f2 dificulta saber com aquests infecten a les persones<\/p>\n

Per superar aquesta dificultat, investigadors de l’IBEC liderats per l\u2019Eduard Torrents, investigador principal del grup \u2018Infeccions Bacterianes: Ter\u00e0pies Antimicrobianes<\/a>\u2019 de l’IBEC i professor de la Universitat de Barcelona (UB), han desenvolupat una soluci\u00f3 basada en la bioenginyeria gr\u00e0cies a la qual es poden controlar i monitoritzar les concentracions d’oxigen a les que estan exposats els pat\u00f2gens<\/strong>. Es tracta de la t\u00e8cnica AnaeroTrans<\/em> i, de moment, s’ha fet servir per estudiar dos bacteris molt comuns: E. coli<\/em> i P. aeruginosa<\/em>, segons recull un estudi<\/a> publicat recentment en el FASEB Journal<\/em> de la Federaci\u00f3 de Societats Americanes de Biologia Experimental (FASEB, per les sigles en angl\u00e8s).<\/p>\n

Gr\u00e0cies a la t\u00e8cnica AnaeroTrans<\/em> els experts han simulat com s’adapten aquestes dues esp\u00e8cies a ambients amb poc oxigen, que \u00e9s on viuen normalment. En el cas de l\u2019E.coli<\/em>, per exemple, es troba a la part baixa de l’intest\u00ed de l’\u00e9sser hum\u00e0 i pot provocar infeccions tant intra com extra intestinals. Per aix\u00f2, poder estudiar aquest patogen en condicions m\u00e9s realistes \u00e9s de gran ajuda per als experts.<\/p>\n

Aix\u00ed mateix, mitjan\u00e7ant aquesta nova soluci\u00f3 els investigadors han aconseguit descriure l’anomenat “perfil RNR”, que \u00e9s el de les ribonucle\u00f2tid reductases o RNR, uns enzims que es fan servir com a dianes per a tractaments antimicrobians. Per fer-ho s\u2019han considerat diferents escenaris i, gr\u00e0cies a aix\u00f2, els experts han descobert que aquests enzims s’adapten mitjan\u00e7ant diferents mecanismes a ambients amb diferents concentracions d\u2019oxigen.<\/p>\n

El treball ofereix tamb\u00e9 una imatge global de com es comporten diferents pat\u00f2gens anaerobis facultatius entre la aerobiosi i la anaerobiosi i descriu els estats intermedis, anomenats rang mico aer\u00f2bic.<\/strong><\/p>\n

La nova t\u00e8cnica AnaeroTrans<\/em> permetr\u00e0 als investigadors crear entorns de laboratori que reprodueixin aquells que es donen en situacions reals, com la fibrosi qu\u00edstica<\/strong>, amb l’objectiu de descobrir noves solucions sanit\u00e0ries<\/p>\n

 <\/p>\n

\n

Article de refer\u00e8ncia<\/strong>:
\nL. Pedraz, N. Blanco\u2010Cabra, E. Torrents (2019). Gradual adaptation of facultative anaerobic pathogens to microaerobic and anaerobic conditions<\/a> The FASEB journal, volume 34, Issue 2<\/em><\/p>\n

\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

El grup de \u2018Infeccions Bacterianes: Ter\u00e0pies Antimicrobianes\u2019 de l’IBEC, liderat per Eduard Torrents, ha desenvolupat un sistema capa\u00e7 d’investigar com s’adapten els pat\u00f2gens als canvis d’oxigen. <\/h3>\n

Utilitzant aquesta t\u00e8cnica, han descobert que els bacteris E. coli <\/em>i Pseudomonas aeruginosa <\/em>poden adaptar-se als canvis ambientals a trav\u00e9s de diferents mecanismes, la qual cosa obre la porta a un millor coneixement i tractament de les infeccions.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1141,158,539],"post_formats":[],"class_list":["post-71716","post","type-post","status-publish","format-standard","hentry","category-noticies-de-recerca","tag-eduard-torrents-ca","tag-ibec-ca","tag-ibec-es-ca"],"yoast_head":"\nInvestigadors de l\u2019IBEC desxifren com els pat\u00f2gens s\u2019adapten als canvis d\u2019oxigen - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"description\" content=\"l grup de \u2018Infeccions Bacterianes: Ter\u00e0pies Antimicrobianes\u2019 de l'IBEC, liderat per Eduard 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