{"id":72196,"date":"2020-03-06T13:47:36","date_gmt":"2020-03-06T12:47:36","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=72196"},"modified":"2020-03-06T14:49:06","modified_gmt":"2020-03-06T13:49:06","slug":"identifiquen-un-nou-mecanisme-de-reparacio-del-sistema-nervios-periferic-aplicant-tecniques-de-bioenginyeria","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-un-nou-mecanisme-de-reparacio-del-sistema-nervios-periferic-aplicant-tecniques-de-bioenginyeria\/","title":{"rendered":"Identifiquen un nou mecanisme de reparaci\u00f3 del sistema nervi\u00f3s perif\u00e8ric aplicant t\u00e8cniques de bioenginyeria"},"content":{"rendered":"<p>Les lesions del sistema nervi\u00f3s perif\u00e8ric representen un important problema de salut i un repte per a la medicina. Actualment, la major part de les ter\u00e0pies es basen en la cirurgia despr\u00e9s de la lesi\u00f3. No obstant aix\u00f2, aquestes intervencions gaudeixen d&#8217;una efici\u00e8ncia moderada a l&#8217;hora de restablir les funcions perdudes.<\/p>\n<p>Ara, un grup d&#8217;investigadors de l&#8217;Institut de\u00a0Bioingenieria\u00a0de Catalunya (IBEC) liderats per Jos\u00e9 Antonio del R\u00edo, investigador principal del Grup de\u00a0Neurobiologia\u00a0Molecular i Cel\u00b7lular de l&#8217;IBEC, i Arnau\u00a0Hervera, investigador postdoctoral del mateix grup, han desenvolupat un dispositiu \u2013<em>lab-on-a-xip<\/em>\u2013\u00a0per a estudiar i reparar lesions del sistema nervi\u00f3s combinat dues tecnologies basades en la\u00a0bioingenieria.<\/p>\n<p>Es tracta de la\u00a0microfluidica\u00a0-que utilitza sistemes que processen o manipulen quantitats petites de fluids mitjan\u00e7ant canals amb l&#8217;objectiu d&#8217;estudiar la resposta a diferents est\u00edmuls- i de la\u00a0optogen\u00e8tica\u00a0\u2013que combina la gen\u00e8tica i l&#8217;\u00f2ptica per a controlar l&#8217;activitat de les neurones-. Aquesta \u00faltima \u00e9s especialment \u00fatil en\u00a0neurobiologia\u00a0perqu\u00e8 permet modelar l&#8217;activitat cel\u00b7lular nom\u00e9s mitjan\u00e7ant canvis de llum, sense necessitat d&#8217;usar l&#8217;estimulaci\u00f3 el\u00e8ctrica, que \u00e9s m\u00e9s inespec\u00edfica i pot danyar les c\u00e8l\u00b7lules.<\/p>\n<p>Gr\u00e0cies a la combinaci\u00f3 d&#8217;ambdues els experts han descobert que el m\u00fascul envia senyals regeneratius a les neurones amb la finalitat de promoure la seva\u00a0reconnexi\u00f3\u00a0i restablir les funcions i el control de la contracci\u00f3 perdut despr\u00e9s d&#8217;una lesi\u00f3.<\/p>\n<p>Segons Arnau\u00a0Hervera, aquest descobriment \u201cpermet entendre millor els mecanismes subjacents a les lesions de\u00a0motoneurones\u201d, un tipus de c\u00e8l\u00b7lules encarregades de produir els est\u00edmuls que provoquen la contracci\u00f3 dels diferents grups musculars de l&#8217;organisme. En aquest sentit, l&#8217;investigador afegeix que la troballa \u201cobre una finestra perqu\u00e8 en un futur es puguin millorar els efectes de les ter\u00e0pies de rehabilitaci\u00f3 actuals\u201d.<\/p>\n<p>Tot aix\u00f2 es recull en un estudi realitzat amb c\u00e8l\u00b7lules de ratolins i publicat recentment en la revista especialitzada\u00a0<em>Cells<\/em>\u00a0del qual es despr\u00e8n que un augment de l&#8217;activitat muscular \u00e9s capa\u00e7 d&#8217;induir la regeneraci\u00f3\u00a0axonal, imprescindible perqu\u00e8 es restableixin les funcions perdudes despr\u00e9s d&#8217;una lesi\u00f3.<\/p>\n<div style=\"width: 640px;\" class=\"wp-video\"><!--[if lt IE 9]><script>document.createElement('video');<\/script><![endif]-->\n<video class=\"wp-video-shortcode\" id=\"video-72196-1\" width=\"640\" height=\"360\" loop autoplay preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/03\/Video4.mp4?_=1\" \/><a href=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/03\/Video4.mp4\">https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/03\/Video4.mp4<\/a><\/video><\/div>\n<p>Els autors del treball, en el qual tamb\u00e9 ha participat el Grup de\u00a0Nanobioingenieria\u00a0de l&#8217;IBEC, liderat per Josep\u00a0Samitier, el director de l&#8217;Institut, subratllen la possible utilitzaci\u00f3 de la metodologia per a\u00a0modelitzar\u00a0l&#8217;estudi d&#8217;altres malalties del sistema nervi\u00f3s com l&#8217;esclerosi lateral amiotr\u00f2fica (ELA), l&#8217;origen del qual es relaciona amb la mort de\u00a0motoneurones.<\/p>\n<p>\u201cLa plataforma que hem dissenyat ens permet posar en un mateix dispositiu dos tipus de c\u00e8l\u00b7lules diferents -les neuronals i les musculars- i modular la seva activitat mitjan\u00e7ant est\u00edmuls de llum\u201d, apunta del R\u00edo, que a m\u00e9s de ser un dels investigadors principals de l&#8217;IBEC \u00e9s catedr\u00e0tic del Departament de Biologia Cel\u00b7lular, Fisiologia i Immunologia de la Universitat de Barcelona (UB), membre de l&#8217;Institut de Neuroci\u00e8ncia de la UB (UBNeuro)\u00a0i del Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED).<\/p>\n<p>Finalment, el catedr\u00e0tic destaca que mitjan\u00e7ant l&#8217;\u00fas d&#8217;aquesta mena de plataformes es redueix en gran manera la necessitat d&#8217;experimentar amb animals, perqu\u00e8 aquest tipus d&#8217;experimentaci\u00f3 se substitueix per l\u00ednies cel\u00b7lulars a l&#8217;hora de dur a terme els experiments. De fet, l&#8217;expert espera que aviat es pugui \u201chumanitzar\u201d el sistema, \u00e9s a dir, fer que funcioni amb c\u00e8l\u00b7lules humanes, la qual cosa acostaria els resultats m\u00e9s cap a la seva possible utilitzaci\u00f3 en pacients.<\/p>\n<hr \/>\n<p><strong>Article de refer\u00e8nci<\/strong>a: <em>Sala-Jarque, F. Mesquida-Veny, M. Badiola-Mateos, J. Samitier, A. Hervera, J. A. del R\u00edo (2020).<\/em> <a href=\"https:\/\/www.mdpi.com\/2073-4409\/9\/2\/302\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Neuromuscular Activity Induces Paracrine Signaling and Triggers Axonal Regrowth after Injury in Microfluidic Lab<\/em><em>\u2010<\/em><em>On<\/em><em>\u2010<\/em><em>Chip Devices<\/em><em>.<\/em><\/a><em> Cells, volume 9, issue 2<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"alignnone size-full wp-image-72180 lazyload\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2020\/03\/Hervera-DelRio_web.jpg\" alt=\"\" width=\"500\" height=\"327\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/03\/Hervera-DelRio_web.jpg 500w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/03\/Hervera-DelRio_web-300x196.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/03\/Hervera-DelRio_web-150x98.jpg 150w\" data-sizes=\"(max-width: 500px) 100vw, 500px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/327;\" \/>El grup de Neurobiotecnologia molecular i celular amb la colaboraci\u00f3 amb el grup de Nanobioenginyeria, tots dos de l\u2019IBEC, han aplicat una t\u00e8cnica basada en l&#8217;estimulaci\u00f3 amb llum per a modular l&#8217;activitat muscular i aix\u00ed estimular la regeneraci\u00f3 de c\u00e8l\u00b7lules del sistema nervi\u00f3s perif\u00e8ric.<\/h3>\n<p>Com a resultat d&#8217;aquesta recerca han descobert que l&#8217;activitat del m\u00fascul \u00e9s capa\u00e7 d&#8217;activar les neurones i accelerar la seva regeneraci\u00f3 despr\u00e9s d&#8217;una lesi\u00f3.<\/p>\n<p>\n","protected":false},"author":4,"featured_media":72181,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[866,865],"post_formats":[],"class_list":["post-72196","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-bioenginyeria-ca","tag-neurones"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Identifiquen un nou mecanisme de reparaci\u00f3 del sistema nervi\u00f3s perif\u00e8ric aplicant t\u00e8cniques de bioenginyeria - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-un-nou-mecanisme-de-reparacio-del-sistema-nervios-periferic-aplicant-tecniques-de-bioenginyeria\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identifiquen un nou mecanisme de reparaci\u00f3 del sistema nervi\u00f3s perif\u00e8ric aplicant t\u00e8cniques de bioenginyeria - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"El grup de Neurobiotecnologia molecular i celular amb la colaboraci\u00f3 amb el grup de Nanobioenginyeria, tots dos de l\u2019IBEC, han aplicat una t\u00e8cnica basada en l&#039;estimulaci\u00f3 amb llum per a modular l&#039;activitat muscular i aix\u00ed estimular la regeneraci\u00f3 de c\u00e8l\u00b7lules del sistema nervi\u00f3s perif\u00e8ric. Com a resultat d&#039;aquesta recerca han descobert que l&#039;activitat del m\u00fascul \u00e9s capa\u00e7 d&#039;activar les neurones i accelerar la seva regeneraci\u00f3 despr\u00e9s d&#039;una lesi\u00f3.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-un-nou-mecanisme-de-reparacio-del-sistema-nervios-periferic-aplicant-tecniques-de-bioenginyeria\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-06T12:47:36+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-03-06T13:49:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/03\/Hervera-DelRio_web.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"327\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-un-nou-mecanisme-de-reparacio-del-sistema-nervios-periferic-aplicant-tecniques-de-bioenginyeria\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-un-nou-mecanisme-de-reparacio-del-sistema-nervios-periferic-aplicant-tecniques-de-bioenginyeria\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Identifiquen un nou mecanisme de reparaci\u00f3 del sistema nervi\u00f3s perif\u00e8ric aplicant t\u00e8cniques de bioenginyeria\",\"datePublished\":\"2020-03-06T12:47:36+00:00\",\"dateModified\":\"2020-03-06T13:49:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-un-nou-mecanisme-de-reparacio-del-sistema-nervios-periferic-aplicant-tecniques-de-bioenginyeria\\\/\"},\"wordCount\":663,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-un-nou-mecanisme-de-reparacio-del-sistema-nervios-periferic-aplicant-tecniques-de-bioenginyeria\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/03\\\/Hervera-DelRio_web.jpg\",\"keywords\":[\"bioenginyeria\",\"Neurones\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-un-nou-mecanisme-de-reparacio-del-sistema-nervios-periferic-aplicant-tecniques-de-bioenginyeria\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-un-nou-mecanisme-de-reparacio-del-sistema-nervios-periferic-aplicant-tecniques-de-bioenginyeria\\\/\",\"name\":\"Identifiquen un nou mecanisme de reparaci\u00f3 del sistema nervi\u00f3s perif\u00e8ric aplicant t\u00e8cniques de bioenginyeria - 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