{"id":7236,"date":"2013-03-21T10:59:18","date_gmt":"2013-03-21T10:59:18","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/canvi-de-marxa-en-la-comprensio-de-la-funcio-celmlular\/"},"modified":"2015-10-20T14:44:22","modified_gmt":"2015-10-20T14:44:22","slug":"canvi-de-marxa-en-la-comprensio-de-la-funcio-celmlular","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/canvi-de-marxa-en-la-comprensio-de-la-funcio-celmlular\/","title":{"rendered":"Canvi de marxa en la comprensi\u00f3 de la funci\u00f3 cel\u00b7lular"},"content":{"rendered":"

Imagineu que condu\u00efu un cotxe per una carretera de muntanya i us trobeu amb un fort pendent. Per assegurar-vos de que podreu pujar-la, redu\u00efu la marxa per millorar la transmissi\u00f3 de for\u00e7a del motor a les rodes.<\/p>\n

Potser penseu que les c\u00e8l\u00b7lules del nostre cos no tenen gaire a veure amb els cotxes, per\u00f2 resulta que les c\u00e8l\u00b7lules fan servir un mecanisme molt semblant per transmetre les forces que els permeten complir importants funcions com la migraci\u00f3 cel\u00b7lular, moure els m\u00fasculs o simplement mantenir la integritat dels teixits. Per\u00f2 en lloc de fer servir marxes, les c\u00e8l\u00b7lules fan servir mol\u00e8cules.<\/p>\n

C\u00e8l\u00b7lula marcada amb tots dos tipus de mol\u00e8cules, alfa-actinina (verd) i talina (vermell). Una altra mol\u00e8cula, integrina, apareix en blau.<\/h6>\n

Un equip dirigit pel Dr. Pere Roca-Cusachs de l\u2019Institut de Bioenginyeria de Catalunya (IBEC), ha descobert com les c\u00e8l\u00b7lules fan servir dues d\u2019aquestes mol\u00e8cules, la talina i l\u2019alfa-actinina, per connectar i transmetre forces a all\u00f2 que les envolta. Fent servir nanotecnologies que poden detectar i aplicar forces sobre les c\u00e8l\u00b7lules, els investigadors han descobert un mecanisme indispensable pel qual les c\u00e8l\u00b7lules \u201ccanvien de marxa\u201d fent servir una mol\u00e8cula o l\u2019altra, regulant la transmissi\u00f3 de forces i la connexi\u00f3 amb el seu entorn.<\/p>\n

\u201cCom les forces cel\u00b7lulars s\u00f3n essencials per processos tan importants com el desenvolupament embrionari o la cicatritzaci\u00f3 de ferides, i tamb\u00e9 per processos indesitjables com la progressi\u00f3 del c\u00e0ncer, aquest descobriment representa un pas important en la nostra comprensi\u00f3 de la funci\u00f3 cel\u00b7lular, amb implicacions tant per la salut com per la malaltia,\u201d explica en Pere.<\/p>\n

—<\/p>\n

Roca-Cusachs, P., del Rio, A., Faucher, E., Gauthier, N.C., Biais, N. & Sheetz, M.P. (2013). Integrin-dependent force transmission to the extracellular matrix by \u03b1-actinin triggers adhesion maturation<\/a>. PNAS<\/em>, 110(15): E1361-70<\/p>\n","protected":false},"excerpt":{"rendered":"

Un investigador de l\u2019IBEC i els seus col\u00b7laboradors descobreixen el paper crucial de dues mol\u00e8cules en permetre que les c\u00e8l\u00b7lules es comuniquin amb el seu entorn. <\/h3>\n","protected":false},"author":4,"featured_media":7232,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-7236","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nCanvi de marxa en la comprensi\u00f3 de la funci\u00f3 cel\u00b7lular - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/canvi-de-marxa-en-la-comprensio-de-la-funcio-celmlular\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta 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