{"id":72412,"date":"2019-07-12T16:24:07","date_gmt":"2019-07-12T14:24:07","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=72412"},"modified":"2020-06-15T11:35:52","modified_gmt":"2020-06-15T09:35:52","slug":"una-nova-tecnologia-de-cultiu-per-a-assajos-funcionals-intestinals","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/una-nova-tecnologia-de-cultiu-per-a-assajos-funcionals-intestinals\/","title":{"rendered":"Una nova tecnologia de cultiu per a assajos funcionals intestinals"},"content":{"rendered":"

Investigadors de l’IBEC dirigits per la Dra. Elena Mart\u00ednez, en col\u00b7laboraci\u00f3 amb l’IRB, van descriure en un article publicat a Scientific Reports un m\u00e8tode simple per generar monocapes epitelials intestinals en pel\u00b7l\u00edcules primes de Matrigel\u00ae.<\/p>\n

Aquestes monocapes repliquen la composici\u00f3 i organitzaci\u00f3 cel\u00b7lular in vivo en un format de cultiu de teixits que permet l’acc\u00e9s independent als compartiments apical i basolateral. Com a caracter\u00edstica \u00fanica, aquestes monocapes epitelials formen barreres epitelials funcionals amb una superf\u00edcie accessible i propietats el\u00e8ctriques fisiol\u00f2gicament rellevants.<\/p>\n

Aquesta tecnologia ofereix un m\u00e8tode actualitzat de cultiu intestinal fisiol\u00f2gicament rellevant compatible amb assajos funcionals com l’absorci\u00f3 de f\u00e0rmacs, el tr\u00e0fic intracel\u00b7lular i els assajos d’interacci\u00f3 microbi-epiteli.<\/p>\n

Article de refer\u00e8ncia: <\/strong>Altay<\/a> et al. (2019). Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function. Scientific Reports<\/em><\/a> volume9, 10140.<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Durant l’\u00faltima d\u00e8cada, els organoides intestinals s’han convertit en una eina crucial per estudiar la biologia intestinal in vitro. No obstant aix\u00f2, la seva geometria en forma d’esfera limita l’acc\u00e9s de llum de l’organoide, el que dificulta el seu \u00fas en molts experiments funcionals en els quals es requereix acc\u00e9s independent als diferents costats de l’epiteli.<\/h3>\n","protected":false},"author":4,"featured_media":72383,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[820],"post_formats":[],"class_list":["post-72412","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-elena-martinez-ca"],"yoast_head":"\nUna nova tecnologia de cultiu per a assajos funcionals intestinals - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/una-nova-tecnologia-de-cultiu-per-a-assajos-funcionals-intestinals\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Una nova tecnologia de cultiu per a assajos funcionals intestinals - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Durant l'\u00faltima d\u00e8cada, els organoides intestinals s'han convertit en una eina crucial per estudiar la biologia intestinal in vitro. No obstant aix\u00f2, la seva geometria en forma d'esfera limita l'acc\u00e9s de llum de l'organoide, el que dificulta el seu \u00fas en molts experiments funcionals en els quals es requereix acc\u00e9s independent als diferents costats de l'epiteli.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/una-nova-tecnologia-de-cultiu-per-a-assajos-funcionals-intestinals\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2019-07-12T14:24:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-15T09:35:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/03\/EMartinez_web.png\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"219\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minut\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/una-nova-tecnologia-de-cultiu-per-a-assajos-funcionals-intestinals\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/una-nova-tecnologia-de-cultiu-per-a-assajos-funcionals-intestinals\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Una nova tecnologia de cultiu per a assajos funcionals intestinals\",\"datePublished\":\"2019-07-12T14:24:07+00:00\",\"dateModified\":\"2020-06-15T09:35:52+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/una-nova-tecnologia-de-cultiu-per-a-assajos-funcionals-intestinals\\\/\"},\"wordCount\":157,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/una-nova-tecnologia-de-cultiu-per-a-assajos-funcionals-intestinals\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/03\\\/EMartinez_web.png\",\"keywords\":[\"Elena Martinez\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/una-nova-tecnologia-de-cultiu-per-a-assajos-funcionals-intestinals\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/una-nova-tecnologia-de-cultiu-per-a-assajos-funcionals-intestinals\\\/\",\"name\":\"Una nova tecnologia de cultiu per a assajos funcionals intestinals - 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