{"id":72527,"date":"2020-03-17T12:28:20","date_gmt":"2020-03-17T11:28:20","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=72527"},"modified":"2020-06-15T11:20:06","modified_gmt":"2020-06-15T09:20:06","slug":"mes-a-prop-del-tractament-d-algunes-malalties-pulmonars-croniques","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/mes-a-prop-del-tractament-d-algunes-malalties-pulmonars-croniques\/","title":{"rendered":"M\u00e9s a prop del tractament d’ algunes malalties pulmonars cr\u00f2niques"},"content":{"rendered":"

\"\"<\/p>\n

La comunitat cient\u00edfica<\/span>\u00a0porta<\/span>\u00a0anys intentant reproduir<\/span>\u00a0<\/span>in vitro<\/span><\/i>\u00a0<\/span>les condicions en qu\u00e8 creixen aquestes bact\u00e8ries. Fins ara, les investigacions s\u2019han centrat en l\u2019estudi de diferents pat\u00f2gens per separat, per\u00f2 el cert \u00e9s que en aquest tipus d\u2019infeccions<\/span>\u00a0acostumen a coexistir di<\/span>ferents esp\u00e8cies de bact\u00e8ries.<\/span>\u00a0<\/span><\/p>\n

Aquestes e<\/span>stan relacionades entre elles<\/span>\u00a0a trav\u00e9s d\u2019interaccions complexes que en determinen, entre d\u2019altres, la seva toler\u00e0ncia als antibi\u00f2tics i la seva resist\u00e8ncia a les c\u00e8l\u00b7lules del sistema immunol\u00f2gic. No obstant aix\u00f2, les condicions id\u00f2nies per al creixement de cada<\/span>scuna s\u00f3n diferents, el que\u00a0<\/span>dificulta<\/span>\u00a0<\/span>la reproducci\u00f3 del seu h\u00e0bitat natural<\/span>\u00a0i<\/span>\u00a0el seu cultiu\u00a0<\/span>in vitro<\/span><\/i>. De fet, quan es duen a terme cultius mixtes acaba dominant sempre una esp\u00e8cie per sobre de l\u2019<\/span>altra<\/span>\u00a0o de les altres.<\/span>\u00a0<\/span>\u00a0<\/span><\/p>\n

Entre l<\/span>e<\/span>s\u00a0<\/span>bact\u00e8ries<\/span>\u00a0m\u00e9<\/span>s estudia<\/span>des figuren les esp\u00e8<\/span>cies\u00a0<\/span>Pseudomonas<\/span><\/i>\u00a0<\/span><\/i>aeruginosa<\/span><\/i>\u00a0y\u00a0<\/span>Staphylococcus<\/span><\/i>\u00a0<\/span><\/i>aureus<\/span><\/i>, que son\u00a0<\/span>especialment<\/span>\u00a0<\/span>freq\u00fcents en malalties pulmonar<\/span>s\u00a0<\/span>infeccioses<\/span>\u00a0como la Fibrosis Qu\u00edstica<\/span>\u00a0o\u00a0<\/span>la\u00a0<\/span>Malaltia<\/span>\u00a0pulmonar obstructiva\u00a0<\/span>cr\u00f2nica<\/span>\u00a0(EPOC)\u00a0<\/span>y<\/span>\u00a0<\/span>cre<\/span>ix<\/span>en<\/span>\u00a0<\/span>de\u00a0<\/span>manera<\/span>\u00a0<\/span>simult\u00e0nia<\/span>\u00a0<\/span>in vitro<\/span><\/i>.<\/span>\u00a0<\/span><\/p>\n

Ara, investigadors de l\u2019Institut<\/span>\u00a0de Bio<\/span>enginyeria de Catalunya (IBEC) i<\/span>\u00a0de la\u00a0<\/span>Universitat<\/span>\u00a0de Barcelona (UB) que\u00a0<\/span>estudien<\/span>\u00a0la\u00a0<\/span>coexist\u00e8ncia<\/span>\u00a0de\u00a0<\/span>P.\u00a0<\/span><\/i>aeruginosa<\/span><\/i>\u00a0y\u00a0<\/span>S.\u00a0<\/span><\/i>aureus<\/span><\/i>\u00a0<\/span>han\u00a0<\/span>descobert<\/span> que la <\/span>resist\u00e8ncia<\/span>\u00a0al<\/span>s\u00a0<\/span>antibi\u00f2tics<\/span>\u00a0<\/span>d\u2019aquestes\u00a0<\/span>dues<\/span>\u00a0<\/span>especies\u00a0<\/span>augmenta<\/span>\u00a0<\/span>substancialment<\/span>\u00a0<\/span>amb el creixement del biofilm<\/span> en el que creixen de manera simult\u00e0nia.<\/span>\u00a0<\/span><\/p>\n

Tot aix\u00f2 es recull en un article cient\u00edfic publicat recentment a la\u00a0<\/span>revista\u00a0<\/span>especialitzada<\/span>\u00a0<\/span>Scientific<\/span><\/i>\u00a0Reports<\/span><\/i>.\u00a0<\/span>Al treball els experts detallen que la superviv\u00e8ncia de\u00a0<\/span>S.\u00a0<\/span><\/i>aureus<\/span><\/i>\u00a0<\/span>dep\u00e8n estrictament de la difusi\u00f3 d\u2019oxigen, el que permet la formaci\u00f3 d\u2019una\u00a0<\/span>biopel\u00b7l\u00edcula<\/span>\u00a0mixta amb una poblaci\u00f3<\/span>\u00a0estable<\/span>\u00a0de\u00a0<\/span>P.\u00a0<\/span><\/i>aeruginosa<\/span><\/i>\u00a0i una de<\/span>\u00a0<\/span>S.\u00a0<\/span><\/i>aureus<\/span><\/i>.<\/span>\u00a0<\/span><\/p>\n

El treball recull tamb\u00e9 les condicions \u00f2ptimes de cultiu i els requisits ambientals que permeten el creixe<\/span>ment simultani i estable<\/span>\u00a0de les esp\u00e8cies\u00a0<\/span>P.\u00a0<\/span><\/i>aeruginosa<\/span><\/i>\u00a0y\u00a0<\/span>S.\u00a0<\/span><\/i>aureus<\/span><\/i>\u00a0en\u00a0<\/span>biope<\/span>l\u00b7l\u00edcules<\/span>\u00a0mixte<\/span>s.<\/span>\u00a0<\/span>\u00a0Segons els resultats de l\u2019estudi, aquestes condicions varien segons si les esp\u00e8cies creixen juntes i separades a les\u00a0<\/span>biolpel\u00b7l\u00edcules<\/span>.\u00a0<\/span>\u00a0<\/span><\/p>\n

\u201cLa nostra investigaci\u00f3 ajudar\u00e0 a\u00a0<\/span>avaluar<\/span>\u00a0i a escollir la millor ter\u00e0pia antimicrobiana per a tractar infeccions cr\u00f2niques bacterianes\u201d, celebra l\u2019Eduard Torrents,\u00a0<\/span>investigador principal del grup d\u2019<\/span>Infeccions Bacterian<\/span>e<\/span>s: Ter\u00e0pies Antimicrobians<\/span>\u00a0de l\u2019IBEC i<\/span>\u00a0<\/span>un dels autors de l\u2019estudi.\u00a0<\/span>\u00a0<\/span><\/p>\n

Finalment, l\u2019expert conclou que \u201cestudis com aquest s\u00f3n de gran ajuda per a pacients amb malalties com la\u00a0<\/span>F<\/span>ibrosis\u00a0<\/span>Q<\/span>u\u00edstica\u00a0<\/span>o la\u00a0<\/span>Malaltia<\/span>\u00a0pulmonar obstructiva\u00a0<\/span>cr\u00f2<\/span>nica<\/span>\u00a0(EPOC)<\/span>,\u00a0<\/span>ja que poden contribuir a identificar quin \u00e9s en cada cas el millor tractament antibi\u00f2tic\u201d.\u00a0<\/span>\u00a0<\/span><\/p>\n

Art\u00edcle de refer\u00e8ncia: <\/strong>Cendra<\/span>,\u00a0<\/span>M.d.M.<\/span>, Blanco-Cabra, N.,\u00a0<\/span>Pedraz<\/span>, L.\u00a0 and Torrents, E. (2019) Optimal environmental and culture conditions allow the in vitro coexistence of Pseudomonas aeruginosa and Staphylococcus aureus in stable biofilms. Sci Rep 9, 16284, https:\/\/doi.org\/10.1038\/s41598-019-52726-0<\/a><\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Un grup d\u2019investigadors de l\u2019IBEC ha aconseguit recrear les condicions de cultiu i ambientals que permeten el creixement simultani i estable de les bact\u00e8ries Pseudomonas aeruginosa i Staphylococcus aureus, que s\u00f3n especialment freq\u00fcents en malalties pulmonars cr\u00f2niques com la EPOC o la Fibrosis Qu\u00edstica. <\/h3>\n

Gran part de les infeccions que s\u00f3n cr\u00f2niques es produeixen degut a la capacitat inherent d\u2019algunes bact\u00e8ries de crear biopel\u00b7l\u00edcules. Aquestes infeccions associades a biofilms s\u2019han convertit en una amena\u00e7a global, si b\u00e9 encara se\u2019n coneixen pocs detalls.<\/p>\n","protected":false},"author":4,"featured_media":72534,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1141,885],"post_formats":[],"class_list":["post-72527","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-eduard-torrents-ca","tag-malalties-pulmonars-croniques"],"yoast_head":"\nM\u00e9s a prop del tractament d' algunes malalties pulmonars cr\u00f2niques - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/mes-a-prop-del-tractament-d-algunes-malalties-pulmonars-croniques\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"M\u00e9s a prop del tractament d' algunes malalties pulmonars cr\u00f2niques - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un grup d\u2019investigadors de l\u2019IBEC ha aconseguit recrear les condicions de cultiu i ambientals que permeten el creixement simultani i estable de les bact\u00e8ries Pseudomonas aeruginosa i Staphylococcus aureus, que s\u00f3n especialment freq\u00fcents en malalties pulmonars cr\u00f2niques com la EPOC o la Fibrosis Qu\u00edstica. 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