{"id":72944,"date":"2020-03-27T13:18:54","date_gmt":"2020-03-27T12:18:54","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=72944"},"modified":"2020-06-09T15:22:26","modified_gmt":"2020-06-09T13:22:26","slug":"un-investigador-del-ibec-desarrolla-un-modelo-para-la-nanomedicina-de-precision","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/un-investigador-del-ibec-desarrolla-un-modelo-para-la-nanomedicina-de-precision\/","title":{"rendered":"Un investigador de lIBEC desenvolupa un model per a la nanomedicina de precisi\u00f3"},"content":{"rendered":"

Despr\u00e9s de provar centenars de productes qu\u00edmics, el metge i bacteri\u00f2leg alemany Paul\u00a0Ehrlich<\/span>, guanyador\u00a0del\u00a0premi Nobel de Medicina el 1908, va descobrir un compost que podia matar de forma selectiva als bacteris de l’esp\u00e8cie Treponema\u00a0pallidum<\/span><\/em>, les causants de la s\u00edfilis.<\/p>\n

L’expert va seguir investigant en aquesta mateixa l\u00ednia durant els anys que van venir amb l’objectiu de descobrir m\u00e9s “bales m\u00e0giques” capa\u00e7os d’atacar als pat\u00f2gens invasors sense causar danys en les c\u00e8l\u00b7lules de l’hoste. No ho sabia, per\u00f2 estava establint les bases de les bases de la farmacologia. De fet, la seva idea que existeixen agents terap\u00e8utics “ideals” que actuen de manera espec\u00edfica contra els agents infecciosos segueix sent v\u00e0lida avui dia.<\/p>\n

Ara, un grup d’investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC<\/span>) liderats per\u00a0Giuseppe<\/span>\u00a0Battaglia<\/span>, investigador principal en el grup de Bi\u00f2nica\u00a0Molecuar<\/span>\u00a0de l’IBEC<\/span>, ha desenvolupat un model per a la medicina de precisi\u00f3 basat tamb\u00e9 en aquesta idea de “selectivitat” que defensava\u00a0Ehrlich<\/span>.<\/p>\n

En el seu treball, publicat recentment a la revista especialitzada Science\u00a0Advances<\/a>, els<\/span>\u00a0autors relaten que el que fa que les nanopart\u00edcules s’adhereixin a altres part\u00edcules s\u00f3n les caracter\u00edstiques de la corona de vellositats que les recobreix.<\/span><\/p>\n

Per aix\u00f2, el model que proposen els investigadors t\u00e9 en compte tant la mida de les nanopart\u00edcules com la llargada i el nombre de vellositats que les recobreixen. Aix\u00ed mateix, els experts afegeixen\u00a0al\u00a0model un terme addicional,\u00a0l'”afinitat”, que juntament amb els altres tres, permet la “superselectivitat<\/span>” de les nanopart\u00edcules.<\/p>\n

Segons els experts, el model permet dissenyar nanopart\u00edcules a mida per a cada pacient, el que pot ser de gran ajuda per personalitzar les ter\u00e0pies. A m\u00e9s, el model aporta algunes de les claus per entendre com interaccionen en els sistemes biol\u00f2gics les c\u00e8l\u00b7lules, els virus, els bacteris o les prote\u00efnes entre elles.<\/p>\n

\n

Article de refer\u00e8ncia:<\/strong> X.\u00a0<\/span>Tian<\/span>, S.\u00a0<\/span>Ang<\/span>ioletti-Uberti<\/span>\u00a0and G.\u00a0<\/span>Battaglia<\/span>\u00a0(2020).\u00a0<\/span>On the design of precision\u00a0<\/span>nanomedicines<\/span>.<\/span>\u00a0<\/span>Science\u00a0<\/span><\/i>Advances<\/span><\/i><\/a>, volume 6, issue 4.<\/span> DOI: 10.1126\/sciadv.aat0919<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC) han proposat un model que ofereix informaci\u00f3 important sobre com les nanopart\u00edcules interactuen amb c\u00e8l\u00b7lules, virus, bacteris o prote\u00efnes, entre d’altres.
\n<\/h3>\n

El model t\u00e9 en compte els diferents factors que determinen l’afinitat de les nanopart\u00edcules amb c\u00e8l\u00b7lules, virus, bacteris o prote\u00efnes, el que \u00e9s clau per elaborar f\u00e0rmacs a mida per a cada pacient.<\/p>\n","protected":false},"author":4,"featured_media":72934,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1104,915],"post_formats":[],"class_list":["post-72944","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-giuseppe-battaglia-ca","tag-nanoparticules"],"yoast_head":"\nUn investigador de lIBEC desenvolupa un model per a la nanomedicina de precisi\u00f3 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/un-investigador-del-ibec-desarrolla-un-modelo-para-la-nanomedicina-de-precision\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un investigador de lIBEC desenvolupa un model per a la nanomedicina de precisi\u00f3 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l'Institut de Bioenginyeria de Catalunya (IBEC) han proposat un model que ofereix informaci\u00f3 important sobre com les nanopart\u00edcules interactuen amb c\u00e8l\u00b7lules, virus, bacteris o prote\u00efnes, entre d'altres. 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