{"id":73000,"date":"2020-03-31T12:03:09","date_gmt":"2020-03-31T10:03:09","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=73000"},"modified":"2020-03-31T12:05:36","modified_gmt":"2020-03-31T10:05:36","slug":"linvestigador-xavier-trepat-rep-una-erc-advanced-grant-per-a-crear-les-bases-duna-nova-generacio-de-robots-biologics","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/linvestigador-xavier-trepat-rep-una-erc-advanced-grant-per-a-crear-les-bases-duna-nova-generacio-de-robots-biologics\/","title":{"rendered":"L\u2019investigador Xavier Trepat rep una ERC Advanced Grant per a crear les bases d\u2019una nova generaci\u00f3 de robots biol\u00f2gics"},"content":{"rendered":"

El Consell Europeu de Recerca (ERC, per les seves inicials en angl\u00e8s)\u2014una organitzaci\u00f3 p\u00fablica europea que finan\u00e7a projectes de recerca\u2014ha atorgat a Xavier Trepat, professor ICREA i investigador principal a<\/span>\u00a0l\u2019Institut de Bioenginyeria de Catalunya<\/span>\u00a0<\/span>(<\/span>IBEC<\/span>)<\/span>, la prestigiosa beca ERC Advanced\u00a0<\/span>Grant<\/span>, dotada amb 2,5 M\u20ac. Abans d’<\/span>aconseguir<\/span>\u00a0aquesta beca, l’investigador<\/span>\u00a0tamb\u00e9<\/span>\u00a0va obtenir les subvencions “<\/span>Starging<\/span>\u00a0<\/span>G<\/span>rant<\/span>“, “<\/span>Consolidator<\/span>\u00a0<\/span>G<\/span>rant<\/span>” i “<\/span>Proof<\/span>\u00a0of\u00a0<\/span>Concept<\/span>“, totes elles atorgades per l’ERC.<\/span>\u00a0<\/span><\/p>\n

Gr\u00e0cies a aquest reconeixement, l’expert podr\u00e0 desenvolupar durant cinc anys el projecte “<\/span>EpiFold<\/span>“, que se centrar\u00e0 en la comprensi\u00f3 dels principis i les propietats mec\u00e0niques de l’epiteli en 3D. Aix\u00ed mateix, Trepat i el seu equip aniran un pas m\u00e9s enll\u00e0 i desenvoluparan una nova tecnologia per establir les bases d’una nova generaci\u00f3 de dispositius\u00a0<\/span>bioh\u00edbr<\/span>ids<\/span>\u00a0que tindrien una capacitat \u00fanica per potenciar funcions en robots biol\u00f2gics.<\/span>\u00a0<\/span><\/p>\n

Totes les superf\u00edcies del nostre cos, tant internes com externes, estan cobertes per primes capes cel\u00b7lulars anomenades epiteli. El teixit epitelial t\u00e9 un paper crucial en les funcions fisiol\u00f2giques humanes fonamentals, com\u00a0<\/span>per exemple,<\/span>\u00a0la morfog\u00e8nesi, la filtraci\u00f3, el transport o la protecci\u00f3 davant pat\u00f2gens. Per estudiar com funciona aquest teixit \u00e9s important comprendre primer la seva forma tridimensional i la seva mec\u00e0nica i, per aix\u00f2, cal treballar amb models\u00a0<\/span>in vitro<\/span><\/i>\u00a0capa\u00e7os d’imitar les condicions que es troben en el nostre cos.<\/span>\u00a0<\/span><\/p>\n

En l’actualitat, aix\u00f2 \u00e9s possible gr\u00e0cies als diferents models 3D desenvolupats fins\u00a0<\/span>avui<\/span>. No obstant aix\u00f2, els principis d’enginyeria que regeixen la forma i la\u00a0<\/span>mec\u00e0nica epitelial en 3D segueixen sent desconeguts. Per aix\u00f2, el projecte de “<\/span>EpiFold<\/span>” tindr\u00e0 un paper crucial per desvetllar aquests principis.<\/span>\u00a0<\/span><\/p>\n

En concret, el projecte t\u00e9 com a objectiu revelar els principis mec\u00e0nics pels quals el teixit epitelial adopta i mant\u00e9 la seva forma. Mitjan\u00e7ant l’enginyeria de teixits\u00a0<\/span>in vitro<\/span><\/i>, Xavier Trepat i el seu equip esperen comprendre com aquestes estructures 3D es construeixen\u00a0<\/span>in<\/span><\/i>\u00a0<\/span><\/i>vivo<\/span><\/i>, per aix\u00ed poder dirigir la seva formaci\u00f3. A m\u00e9s, el projecte tamb\u00e9 tindr\u00e0 un gran impacte en l’emergent camp dels\u00a0<\/span>organoides<\/span>, ja que estudiar\u00e0 la forma i la mec\u00e0nica dels\u00a0<\/span>organoides<\/span>\u00a0intestinals.<\/span>\u00a0<\/span><\/p>\n

Desenvolupant una tecnologia completament nova<\/span><\/b>\u00a0<\/span><\/h3>\n

El m\u00e9s innovador i ambici\u00f3s d’aquest projecte \u00e9s que aquests principis s’han d’aplicar per al disseny d’una nova generaci\u00f3 de dispositius\u00a0<\/span>bioh\u00edbri<\/span>ds<\/span>\u00a0obtinguts a partir de teixit epitelial que posseiran una capacitat \u00fanica per potenciar funcions com la filtraci\u00f3, la secreci\u00f3, l’auto<\/span>–<\/span>regeneraci\u00f3 o la propulsi\u00f3 en robots tous.<\/span>\u00a0<\/span><\/p>\n

Aquest projecte ser\u00e0 el punt de partida d’una tecnologia completament nova anomenada “<\/span>Epiflu\u00eddica<\/span>” que explotar\u00e0 la capacitat excepcional de detecci\u00f3 i actuaci\u00f3 de les c\u00e8l\u00b7lules epitelials per dissenyar aquests dispositius\u00a0<\/span>bioh\u00edbrid<\/span>s<\/span>.<\/span>\u00a0<\/span><\/p>\n

Aquests micro-robots \u00fanics constru\u00efts amb hidrogels i capes epitelials seran capa\u00e7os de mantenir les propietats multifuncionals i a<\/span>uto-<\/span>regeneratives de l’epiteli, a m\u00e9s de poder de detectar, absorbir, secretar, filtrar i realitzar activitats enzim\u00e0tiques.<\/span>\u00a0<\/span><\/p>\n

“Quan una pe\u00e7a d’un robot actual es trenca no tenim altra opci\u00f3 que substituir-la. En canvi, amb robots biol\u00f2gics podem aconseguir que les peces\u00a0<\/span>s’auto<\/span>-reparin, ja que els teixits vius tenen capacitat de regeneraci\u00f3 gr\u00e0cies a les seves c\u00e8l\u00b7lules mare”, exposa Trepat.<\/span>\u00a0<\/span><\/p>\n

En aquest mateix sentit, l’expert afegeix que “gr\u00e0cies a milers d’anys d’evoluci\u00f3, els teixits vius s\u00f3n capa\u00e7os d’executar tasques m\u00e9s precises i eficients que els dispositius dissenyats per humans”, per aix\u00f2, “volem explotar aquesta capacitat natural dels teixits per desenvolupar robots multifuncionals “<\/span>, conclou Trepat.<\/span>\u00a0<\/span><\/p>\n

Les cobejades ERC Advanced\u00a0<\/span>G<\/span>rants<\/span>\u00a0s’atorguen a investigadors de la UE<\/span>\u00a0amb un ampli historial d’\u00e8xits cient\u00edfics en els \u00faltims 10 anys, amb l’objectiu de donar suport a projectes d’avantguarda de diferents tem\u00e0tiques.<\/span>\u00a0Es premien projectes amb un fort component de\u00a0<\/span>multidisciplinarietat<\/span>\u00a0i amb aplicacions innovadores en camps emergents. En aquesta convocat\u00f2ria, es van presentar<\/span>\u00a0un total de<\/span>\u00a0<\/span>1881<\/span>\u00a0propostes, de les quals\u00a0<\/span>185<\/span>\u00a0han estat seleccionades per al seu finan\u00e7ament.\u00a0<\/span>A<\/span>mb aquesta nova beca, avui dia, l’IBEC ha rebut finan\u00e7ament de l’ERC per al desenvolupament de 19 projectes d’investigaci\u00f3.<\/span>\u00a0<\/span><\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"L\u2019investigador de l\u2019Institut de Bioenginyeria de Catalunya (IBEC), Xavier Trepat, ha rebut la prestigiosa beca ERC Advanced Grant concedida pel Consell Europeu de Recerca (ERC) i dotada amb 2.5 milions d\u2019euros.<\/h3>\n

L\u2019expert i el seu grup destinaran aquests recursos a estudiar les propietats mec\u00e0niques de l\u2019epiteli en 3D i a assentar les bases d\u2019una tecnologia pionera anomenada \u201cEpiflu\u00eddica\u201d, que permetr\u00e0 dissenyar els robots biol\u00f2gics.<\/p>\n","protected":false},"author":4,"featured_media":73023,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[919,1411,821,918,175],"post_formats":[],"class_list":["post-73000","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-advanced-grant-ca","tag-erc-grant","tag-european-research-council-ca","tag-robot-biologic","tag-xavier-trepat"],"yoast_head":"\nL\u2019investigador Xavier Trepat rep una ERC Advanced Grant per a crear les bases d\u2019una nova generaci\u00f3 de robots biol\u00f2gics - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/xavier-trepat-receives-the-erc-advanced-grant-to-lay-the-basis-of-a-new-generation-of-biological-robots\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L\u2019investigador Xavier Trepat rep una ERC Advanced Grant per a crear les bases d\u2019una nova generaci\u00f3 de robots biol\u00f2gics - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"L\u2019investigador de l\u2019Institut de Bioenginyeria de Catalunya (IBEC), Xavier Trepat, ha rebut la prestigiosa beca ERC Advanced Grant concedida pel Consell Europeu de Recerca (ERC) i dotada amb 2.5 milions d\u2019euros. 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