{"id":73138,"date":"2020-04-02T22:09:43","date_gmt":"2020-04-02T20:09:43","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=73138"},"modified":"2020-06-15T11:19:17","modified_gmt":"2020-06-15T09:19:17","slug":"experts-de-libec-contribueixen-a-identificar-un-farmac-en-fase-clinica-que-bloqueja-els-efectes-de-la-malaltia-del-coronavirus","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/experts-de-libec-contribueixen-a-identificar-un-farmac-en-fase-clinica-que-bloqueja-els-efectes-de-la-malaltia-del-coronavirus\/","title":{"rendered":"Experts de l&#8217;IBEC contribueixen a identificar un f\u00e0rmac en fase cl\u00ednica que bloqueja els efectes del virus SARS-Co-V2"},"content":{"rendered":"<p>En aquests organoides generats mitjan\u00e7ant t\u00e8cniques de bioingenier\u00eda s&#8217;ha desxifrat com el SARS-Co-V2 interacciona i infecta les c\u00e8l\u00b7lules humanes del rony\u00f3.<\/p>\n<p><span style=\"font-family: Yantramanav;\">Per a l&#8217;elaboraci\u00f3 d&#8217;aquest estudi que s&#8217;ha publicat avui en la prestigiosa revista Cell, i en el qual ha participat l&#8217;Institut Karolinska de Su\u00e8cia, el Institute of Molecular Biotechnology de\u00a0 la Austrian Academy of Sciences i el Life Sciences Institute (LSI) de la\u00a0 Universitat of British Columbia, entre altres, \u00a0els investigadors han\u00a0 utilitzat minirronyons desenvolupats a partir de c\u00e8l\u00b7lules mare humanes generats a l&#8217;IBEC per l&#8217;equip de N\u00faria Montserrat. Aquests organoides, creats mitjan\u00e7ant t\u00e8cniques de bioenginyeria, recullen la complexitat de l&#8217;\u00f2rgan real, la qual cosa els ha perm\u00e8s desxifrar com el SARS-Co-V2 interacciona i infecta les c\u00e8l\u00b7lules humanes del rony\u00f3, a m\u00e9s d&#8217;identificar una ter\u00e0pia dirigida a reduir la seva c\u00e0rrega viral.<\/span><\/p>\n<p>\u201cL&#8217;\u00fas d\u2019organoides humans ens permet provar de manera molt \u00e0gil els tractaments que ja s&#8217;estan utilitzant per a altres malalties o que estan prop de ser validats. En aquests moments en els quals el temps constreny, aquestes estructures 3D estalvien dr\u00e0sticament el temps que destinar\u00edem a provar un nou medicament en humans\u201d, destaca els avantatges N\u00faria Montserrat.<\/p>\n<h3><strong>L&#8217;estudi del paper del receptor ACE2 en la infecci\u00f3<\/strong><\/h3>\n<p>Publicacions recents han demostrat que, per a infectar una c\u00e8l\u00b7lula, els\u00a0coronavirus\u00a0utilitzen una prote\u00efna, denominada S, que s&#8217;uneix a un receptor de les c\u00e8l\u00b7lules humanes denominat ACE2 (enzim convertidor d&#8217;angiotensina 2). Tenint en compte que aquesta uni\u00f3 s&#8217;ha detectat com a porta d&#8217;entrada del virus a l&#8217;organisme, evitar-la podria constituir una possible diana terap\u00e8utica.<\/p>\n<p>Seguint aquesta estrat\u00e8gia, els investigadors s&#8217;han centrat en entendre el paper del receptor ACE2 en organoides humans perqu\u00e8 mimetitzen en pocs mil\u00b7l\u00edmetres moltes de les caracter\u00edstiques dels \u00f2rgans reals. L&#8217;estudi proporciona nous coneixements sobre aspectes clau del SARS-CoV-2 i les seves interaccions a nivell cel\u00b7lular, aix\u00ed com sobre com el virus pot infectar els vasos sanguinis i els ronyons.<\/p>\n<p>A m\u00e9s del pulm\u00f3, el receptor ACE2 tamb\u00e9 s&#8217;expressa en altres teixits, entre els quals s&#8217;inclou el cor, els vasos sanguinis, l&#8217;intest\u00ed i els ronyons, la qual cosa explicaria la disfunci\u00f3 multiorg\u00e0nica que s&#8217;observa en els pacients infectats per SARS-Co-V2. El fet que aquest receptor s&#8217;expressi fortament en els ronyons i que el SARS-Co-V2 es trobi en l&#8217;orina, \u00e9s el que ha portat a aquest equip d&#8217;investigadors a utilitzar els organoides renals com a model de prova, la creaci\u00f3 de les quals Montserrat \u00e9s referent internacional.<\/p>\n<figure id=\"attachment_73156\" aria-describedby=\"caption-attachment-73156\" style=\"width: 490px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/ibecbarcelona.eu\/ca\/experts-de-libec-contribueixen-a-identificar-un-farmac-en-fase-clinica-que-bloqueja-els-efectes-de-la-malaltia-del-coronavirus\/organoid_web-2\/#main\" rel=\"attachment wp-att-73156\"><img decoding=\"async\" class=\"wp-image-73156 size-full lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web.jpg\" alt=\"\" width=\"500\" height=\"500\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web.jpg 500w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web-300x300.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web-150x150.jpg 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web-45x45.jpg 45w\" data-sizes=\"(max-width: 500px) 100vw, 500px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/500;\" \/><\/a><figcaption id=\"caption-attachment-73156\" class=\"wp-caption-text\">Imatge de microscopia confocal d\u2019un organoid de rony\u00f3 generat in vitro a partir de c\u00e8l.lules mare pluripotents humanes que han estat diferenciades durant 20 dies mitjan\u00e7ant cultius tridimensionals. Aquests organoids de rony\u00f3 contenen estructures renals que inclouen t\u00fabuls proximals (marcatsamb LTL, en verd) i la expressi\u00f3 de col.l\u00e8gen IV en la membrana basal (en vermell). Aquestes estructures s\u2019assemblen en part a les estructures renals del rony\u00f3 hum\u00e0.<\/figcaption><\/figure>\n<h3><strong>La identificaci\u00f3 d&#8217;un f\u00e0rmac inhibidor de la infecci\u00f3<\/strong><\/h3>\n<p>En primer lloc els investigadors van demostrar que els\u00a0organoides\u00a0renals contenien diferents grups de c\u00e8l\u00b7lules que expressaven ACE2 de manera similar a la que s&#8217;observa en el teixit natiu, i despr\u00e9s, van procedir a infectar-lo amb\u00a0SARS-Co-V2. Una vegada van obtenir aquests\u00a0minirronyons\u00a0infectats, van aplicar diferents ter\u00e0pies, concloent, com a resultat de l&#8217;estudi, que el\u00a0hrsACE2\u00a0(ACE2 hum\u00e0 recombinant soluble), un f\u00e0rmac que ja ha superat les proves cl\u00edniques de fase 1 (en voluntaris sans) i de fase 2 (en pacients amb s\u00edndrome de dificultat respirat\u00f2ria aguda), inhibeix significativament les infeccions per\u00a0SARS-Co-V2\u00a0i redueix la seva c\u00e0rrega viral.<\/p>\n<p>\u201cAquestes troballes s\u00f3n prometedores com a tractament capa\u00e7 d&#8217;aturar la infecci\u00f3 primerenca del nou coronavirus que, a 30 de mar\u00e7, ha afectat a m\u00e9s de 750,000 persones i s&#8217;ha cobrat la vida de 36,000 persones a tot el m\u00f3n\u201d, conclou N\u00faria Montserrat.<\/p>\n<p>Troballes com aquesta\u00a0posen de manifest que les t\u00e8cniques de\u00a0bioenginyeria\u00a0s\u00f3n imprescindibles per a la medicina del futur. Fins ara, han perm\u00e8s la creaci\u00f3\u00a0d\u2019organoides\u00a0i \u00f2rgans en un xip, entre altres. Aix\u00ed mateix, l&#8217;enginyeria molecular, que est\u00e0 molt lligada a la\u00a0bioenginyeria, porta anys demostrant la seva capacitat de preveure l&#8217;efic\u00e0cia de tractaments experimentals i reduir l&#8217;experimentaci\u00f3 amb animals. Ara, aquestes eines es posen a disposici\u00f3 de la societat una vegada m\u00e9s, per a intentar trobar solucions a la crisi provocada pel\u00a0coronavirus.<\/p>\n<p>N\u00faria Montserrat lidera el grup de Pluripot\u00e8ncia per a la regeneraci\u00f3 d&#8217;\u00f2rgans de l&#8217;IBEC i \u00e9s membre del Centre de Recerca Biom\u00e8dica en Xarxa en Bioenginyeria, Biomaterials i Nanomedicina (CIBER BBN), en aquest treball ha comptat amb la participaci\u00f3 de les investigadores Elena Garreta, Patricia Prado i Carmen Hurtado, entre d&#8217;altres.<\/p>\n<p><strong>Article de refer\u00e8ncia:\u00a0<\/strong>Monteil et al, Inhibition of SARS-CoV-2 infections in engineered human<br \/>\ntissues using clinical-grade soluble human ACE2, <em>Cell\u00a0<\/em>2020, DOI: <a href=\"https:\/\/www.cell.com\/pb-assets\/products\/coronavirus\/CELL_CELL-D-20-00739.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.cell.2020.04.004<\/a><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<p>Per a m\u00e9s informaci\u00f3 sobre aquesta noticia:<\/p>\n<p>\u00c0ngels L\u00f3pez \u00b7 alopez@ibecbarcelona.eu \u00b7 639 989 670<br \/>\nOficina de premsa, Comunicaci\u00f3<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p><img decoding=\"async\" class=\"alignnone size-full wp-image-73158 lazyload\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/Nmont_web.jpg\" alt=\"\" width=\"500\" height=\"333\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/Nmont_web.jpg 500w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/Nmont_web-300x200.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/Nmont_web-150x100.jpg 150w\" data-sizes=\"(max-width: 500px) 100vw, 500px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/333;\" \/><\/p>\n<h3>Investigadors de l&#8217;IBEC liderats per la Professora d&#8217;investigaci\u00f3 ICREA N\u00faria Montserrat, en col\u00b7laboraci\u00f3 amb experts internacionals, han identificat un f\u00e0rmac capa\u00e7 de bloquejar els efectes del virus SARS-Co-V2, origen de la malaltia del Coronavirus 2019.<\/h3>\n<p>El tractament, que des d&#8217;avui es podr\u00e0 provar en dos-cents pacients de Covid-19, ha demostrat la seva efic\u00e0cia en minirronyons generats a partir de c\u00e8l\u00b7lules mare humanes.<\/p>\n","protected":false},"author":4,"featured_media":73159,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[891,158,539,1123],"post_formats":[],"class_list":["post-73138","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-coronavirus-ca","tag-ibec-ca","tag-ibec-es-ca","tag-nuria-montserrat-ca-2"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Experts de l&#039;IBEC contribueixen a identificar un f\u00e0rmac en fase cl\u00ednica que bloqueja els efectes del virus SARS-Co-V2 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/experts-de-libec-contribueixen-a-identificar-un-farmac-en-fase-clinica-que-bloqueja-els-efectes-de-la-malaltia-del-coronavirus\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Experts de l&#039;IBEC contribueixen a identificar un f\u00e0rmac en fase cl\u00ednica que bloqueja els efectes del virus SARS-Co-V2 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l&#039;IBEC liderats per la Professora d&#039;investigaci\u00f3 ICREA N\u00faria Montserrat, en col\u00b7laboraci\u00f3 amb experts internacionals, han identificat un f\u00e0rmac capa\u00e7 de bloquejar els efectes del virus SARS-Co-V2, origen de la malaltia del Coronavirus 2019.  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