{"id":73761,"date":"2020-04-28T10:48:28","date_gmt":"2020-04-28T08:48:28","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=73761"},"modified":"2020-04-28T10:49:22","modified_gmt":"2020-04-28T08:49:22","slug":"pericord-el-bioimplant-capac-de-reparar-el-teixit-cardiac-en-pacients","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/pericord-el-bioimplant-capac-de-reparar-el-teixit-cardiac-en-pacients\/","title":{"rendered":"PeriCord, el bioimplant capa\u00e7 de reparar el teixit card\u00edac en pacients"},"content":{"rendered":"

M\u00e9s concretament, els metges van introduir un bioimplant anomenat PeriCord<\/em> a un pacient de 63 anys que havia patit un infart.<\/p>\n

Tres mesos m\u00e9s tard, la mida de la cicatriu provocada per l\u2019infart s\u2019havia redu\u00eft significativament \u2013al voltant d\u2019un 9%-, tal com havien previst els experts basant-se en estudis precl\u00ednics amb porcs.<\/p>\n

Els detalls d\u2019aquesta nova ter\u00e0pia es recullen en un article cient\u00edfic publicat recentment a la revista EBioMedicine<\/em> de la prestigiosa The Lancet<\/em>. En aquest document, els autors exposen que per a l\u2019elaboraci\u00f3 del bioimplant -batejat amb el nom de PeriCord<\/em> en honor als dos components que el formen: el pericardi i el cord\u00f3 umbilical- van haver d\u2019incorporar les c\u00e8l\u00b7lules mare dins una matriu de pericardi que havia d\u2019actuar com a vehicle que permet\u00e9s l\u2019aplicaci\u00f3 de les c\u00e8l\u00b7lules que contenia directament sobre la zona infartada.<\/p>\n

Aquest bioimplant presenta una duresa comparable amb la d\u2019un ventricle, est\u00e0 format de pericardi hum\u00e0 descel\u00b7lularitzat i enriquit amb c\u00e8l\u00b7lules mare mesenquim\u00e0tiques, que procedeixen del cord\u00f3 umbilical. Aquestes c\u00e8l\u00b7lules es caracteritzen per posseir, a m\u00e9s d\u2019una gran plasticitat i propietats immunomoduladores i antiinflamat\u00f2ries importants, la capacitat de regenerar els teixits, el que explica la reducci\u00f3 de la mida de la cicatriu provocada per l\u2019infart.<\/p>\n

\"\"<\/a><\/p>\n

Segons els experts, liderats pel professor de la UB Daniel Navajas, que encap\u00e7ala el Grup de Biomec\u00e0nica Cel\u00b7lular i Respirat\u00f2ria de l\u2019IBEC, el gran repte era transformar un prototip de 2 cm2 utilitzat en el model precl\u00ednic provat amb porcs en un bioimplant de 16 cm2 i complir tots els requisits de seguretat i normatives per al seu \u00fas en humans.<\/p>\n

Un infart de miocardi pot condicionar la capacitat del pacient de dur a terme activitats de la vida di\u00e0ria, aix\u00ed com la seva qualitat i esperan\u00e7a de vida. En casos extrems, es pot arribar a necessitar un trasplantament de cor, si b\u00e9 el m\u00e9s freq\u00fcent \u00e9s que quedi una cicatriu residual que dilata el cor i fa que el pacient evolucioni cap a una insufici\u00e8ncia card\u00edaca. Aquest perfil de malalts s\u00f3n els que es podrien beneficiar de manera significativa d\u2019aquesta nova tecnologia.<\/p>\n

Aquest projecte ha estat possible gr\u00e0cies al suport del Departament de Salut de la Generalitat de Catalunya mitjan\u00e7ant les ajudes PERIS, El Instituto de Salud Carlos III i \u201cla Caixa\u201d.<\/p>\n

\n

Article de refer\u00e8ncia<\/strong>: C. Prat-Vidal et al. First-in-human PeriCord cardiac bioimplant: Scalability and GMP manufacturing of an allogeneic engineered tissue graft, EBioMedicine<\/a>, Abril 2020. DOI: https:\/\/doi.org\/10.1016\/j.ebiom.2020.102729<\/p>\n

 <\/p>\n

M\u00e9s informaci\u00f3: Bioenginyers de l\u2019IBEC contribueixen a crear un implant per al cor<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"La revista \u201cEBioMedicine\u201d de \u201cThe Lancet\u201d acaba de publicar el procediment que va permetre la creaci\u00f3, l\u2019any passat, del \u201cPeriCord\u201d, el primer bioimplant card\u00edac hum\u00e0, en l\u2019elaboraci\u00f3 del qual l\u2019Institut de Bioenginyeria de Catalunya (IBEC) va tenir un paper clau.<\/h3>\n

El mes de maig de 2019, una col\u00b7laboraci\u00f3 entre l\u2019Hospital Germans Trias i Pujol de Badalona, el Banc de Sang i Teixits (BST) i l\u00b4IBEC va fer possible a Barcelona un nou aven\u00e7 per als pacients card\u00edacs gr\u00e0cies a una f\u00f3rmula senzilla: combinar medicina, ci\u00e8ncia i enginyeria.<\/p>\n","protected":false},"author":4,"featured_media":73771,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[762,759,978],"post_formats":[],"class_list":["post-73761","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-bioimplant","tag-daniel-navajas-ca","tag-regeneracio"],"yoast_head":"\nPeriCord, el bioimplant capa\u00e7 de reparar el teixit card\u00edac en pacients - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/pericord-el-bioimplant-capac-de-reparar-el-teixit-cardiac-en-pacients\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PeriCord, el bioimplant capa\u00e7 de reparar el teixit card\u00edac en pacients - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"La revista \u201cEBioMedicine\u201d de \u201cThe Lancet\u201d acaba de publicar el procediment que va permetre la creaci\u00f3, l\u2019any passat, del \u201cPeriCord\u201d, el primer bioimplant card\u00edac hum\u00e0, en l\u2019elaboraci\u00f3 del qual l\u2019Institut de Bioenginyeria de Catalunya (IBEC) va tenir un paper clau. 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