{"id":74037,"date":"2020-05-18T09:00:13","date_gmt":"2020-05-18T07:00:13","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=74037"},"modified":"2020-06-15T11:18:35","modified_gmt":"2020-06-15T09:18:35","slug":"investigadors-de-libec-expliquen-la-durotaxis-un-mecanisme-de-migracio-cel%c2%b7lular-amb-un-paper-potencial-en-diverses-malalties","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-expliquen-la-durotaxis-un-mecanisme-de-migracio-cel%c2%b7lular-amb-un-paper-potencial-en-diverses-malalties\/","title":{"rendered":"Investigadors de l’IBEC expliquen la “durotaxis”, un mecanisme de migraci\u00f3 cel\u00b7lular amb un paper potencial en diverses malalties"},"content":{"rendered":"

Les c\u00e8l\u00b7lules no s\u00f3n est\u00e0tiques, es mouen i poden dirigir la seva migraci\u00f3, normalment guiades per gradients espacials en una propietat fisicoqu\u00edmica del mico ambient cel\u00b7lular, com, per exemple, la concentraci\u00f3 de subst\u00e0ncies qu\u00edmiques, per\u00f2 tamb\u00e9 es guia per la rigidesa de la seva matriu extracel\u00b7lular (MEC).<\/p>\n

La durotaxis<\/em> es va presentar per primera vegada l’any 2000 i es defineix com la tend\u00e8ncia de les c\u00e8l\u00b7lules individuals a seguir els gradients de rigidesa. Des que es va descriure per primera vegada, s’han dut a terme diversos estudis, principalment in vitro<\/em>, ja que in vivo<\/em> segueix sent un fenomen poc estudiat. A mesura que els aven\u00e7os tecnol\u00f2gics porten noves eines per provar la rigidesa de la MEC en teixits vius, \u00e9s probable que sorgeixin nous rols per explicar i observar la durotaxis in vivo<\/em>.<\/p>\n

La durotaxis<\/em> \u00e9s normalment positiva, les c\u00e8l\u00b7lules es desplacen cap a regions de major rigidesa, per\u00f2 tamb\u00e9 s’ha observat en negatiu, de zones r\u00edgides a toves, exemples d’aix\u00f2 s’expliquen en aquesta pe\u00e7a<\/a> publicada a la revista Current Biology<\/em>.<\/p>\n

En aquest article, escrit per Xavier Trepat i Raimon Sunyer ofereixen una visi\u00f3 general sobre els m\u00e8todes utilitzats per estudiar la durotaxis<\/em> tant in vitro <\/em>com in vivo<\/em>, i sobre l’estat de l’art dels mecanismes que guien la durotaxis<\/em>, que segueix sense con\u00e8ixer-se del tot.<\/p>\n

Els investigadors tamb\u00e9 expliquen que alguns tipus de c\u00e8l\u00b7lules no mostren durotaxis <\/em>significativa quan migren de forma a\u00efllada, per\u00f2 s\u00ed quan actuen com a grups cohesionats. Els grups multicel\u00b7lulars poden comportar-se com una s\u00faper c\u00e8l\u00b7lula gegant, augmentant la seva sensibilitat als gradients mec\u00e0nics. No obstant aix\u00f2, la durotaxis<\/em> col\u00b7lectiva encara no s’ha demostrat in vivo<\/em>, per\u00f2 es creu que aquest fenomen podria guiar la migraci\u00f3 col\u00b7lectiva en processos patol\u00f2gics que impliquen canvis locals en la rigidesa de la roba. Per exemple, \u00e9s sabut que els tumors s\u00f2lids s\u00f3n m\u00e9s r\u00edgids que el teixit circumdant, el que pot afavorir o prevenir la invasi\u00f3 col\u00b7lectiva.<\/p>\n

A tall de conclusi\u00f3, els investigadors afirmen que la durotaxis<\/em> est\u00e0 emergint com un mecanisme robust per impulsar la migraci\u00f3 dirigida de c\u00e8l\u00b7lules individuals i en grups. Els components clau inclouen l’adhesi\u00f3 c\u00e8l\u00b7lula-MEC a trav\u00e9s d’agafades moleculars, la transmissi\u00f3 de for\u00e7a de llarg abast a trav\u00e9s del citoesquelet i les unions c\u00e8l\u00b7lula-c\u00e8l\u00b7lula. A m\u00e9s, s’espera que la durotaxis <\/em>sigui la causa de molts moviments migratoris in vivo <\/em>que actualment no s’expliquen.<\/p>\n

\n

Article de refer\u00e8ncia<\/strong>: Raimon Sunyer; Xavier Trepat,\u00a0Durotaxis<\/a>.\u00a0Current Biol.\u00a0<\/em>2020, 30, R383-R387<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Xavier Trepat, l\u00edder del grup de “Din\u00e0mica integrativa de c\u00e8l\u00b7lules i teixits” a l’IBEC juntament amb Raimon Sunyer, investigador s\u00e8nior en el laboratori de Trepat, han escrit un Primer a la revista Current Biology sobre la “Durotaxis”, un mecanisme de migraci\u00f3 cel\u00b7lular que podria tenir un paper en diverses malalties que impliquin l’enduriment dels teixits.<\/h3>\n

El desenvolupament embrionari, la progressi\u00f3 tumoral o la resposta immunol\u00f2gica contra pat\u00f2gens requereix la migraci\u00f3 cel\u00b7lular. <\/p>\n","protected":false},"author":4,"featured_media":74023,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1143],"post_formats":[],"class_list":["post-74037","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-xavier-trepat-ca"],"yoast_head":"\nInvestigadors de l'IBEC expliquen la "durotaxis", un mecanisme de migraci\u00f3 cel\u00b7lular amb un paper potencial en diverses malalties - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-expliquen-la-durotaxis-un-mecanisme-de-migracio-cel\u00b7lular-amb-un-paper-potencial-en-diverses-malalties\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors de l'IBEC expliquen la "durotaxis", un mecanisme de migraci\u00f3 cel\u00b7lular amb un paper potencial en diverses malalties - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Xavier Trepat, l\u00edder del grup de "Din\u00e0mica integrativa de c\u00e8l\u00b7lules i teixits" a l'IBEC juntament amb Raimon Sunyer, investigador s\u00e8nior en el laboratori de Trepat, han escrit un Primer a la revista Current Biology sobre la "Durotaxis", un mecanisme de migraci\u00f3 cel\u00b7lular que podria tenir un paper en diverses malalties que impliquin l'enduriment dels teixits. 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