{"id":74334,"date":"2020-05-26T10:00:20","date_gmt":"2020-05-26T08:00:20","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=74334"},"modified":"2020-06-15T11:18:15","modified_gmt":"2020-06-15T09:18:15","slug":"investigadors-de-libec-descobreixen-una-nova-manera-de-transportar-eficacment-farmacs-al-cervell","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-descobreixen-una-nova-manera-de-transportar-eficacment-farmacs-al-cervell\/","title":{"rendered":"Investigadors de l&#8217;IBEC descobreixen una nova manera de transportar efica\u00e7ment f\u00e0rmacs al cervell"},"content":{"rendered":"<p>Poc despr\u00e9s de la seva administraci\u00f3 en ratolins de laboratori, les nanopart\u00edcules recobertes amb aquest antic\u00f2s havien aconseguit arribar al cervell travessant la barrera hematoencef\u00e0lica, que separa el torrent sanguini d&#8217;aquest teixit i es caracteritza per tenir una permeabilitat altament selectiva.<\/p>\n<p>La barrera hematoencef\u00e0lica actua de manera efica\u00e7 a l&#8217;hora de protegir el cervell de pat\u00f2gens i subst\u00e0ncies t\u00f2xiques que puguin circular en la sang, el que fa que les malalties que afecten el cervell siguin dif\u00edcils de tractar, ja que el 98% dels f\u00e0rmacs no poden creuar-la. En canvi, subst\u00e0ncies naturals com els nutrients, les hormones i les c\u00e8l\u00b7lules del sistema immune s\u00ed que poden travessar-la i entrar al cervell des del flux sanguini.<\/p>\n<p>L&#8217;estrat\u00e8gia dissenyada pel grup de la Dra. Muro per superar aquesta barrera es basa precisament en l&#8217;\u00fas d&#8217;ICAM-1, que \u00e9s una de les dianes utilitzades per les c\u00e8l\u00b7lules del sistema immune per travessar la barrera hematoencef\u00e0lica.<\/p>\n<p>Segons apunten els investigadors de l&#8217;IBEC i la Universitat de Maryland, es tracta d&#8217;un descobriment molt significatiu, ja que podria ajudar a optimitzar l&#8217;alliberament de f\u00e0rmacs a trav\u00e9s de l&#8217;endoteli, que \u00e9s el teixit que recobreix la part interna dels vasos sanguinis. D&#8217;aquesta manera, els f\u00e0rmacs podrien penetrar efica\u00e7ment la barrera hematoencef\u00e0lica i entrar al cervell.<\/p>\n<p>&#8220;Hem descobert una nova estrat\u00e8gia que ajuda a transportar fins al cervell d&#8217;animals d&#8217;experimentaci\u00f3 un f\u00e0rmac que per si sol no podria arribar fins a aquest \u00f2rgan, el que podria oferir un nou tractament, per exemple, per a la malaltia de Niemann-Pick tipus A, una s\u00edndrome neurodegenerativa cong\u00e8nita i incurable que actualment no t\u00e9 tractament, exposa S\u00edlvia Muro, l&#8217;autora principal de l\u2019estudi.<\/p>\n<p>En aquest sentit, l&#8217;experta afegeix que &#8220;seguint la mateixa estrat\u00e8gia, el sistema es podria adaptar per alliberar altres f\u00e0rmacs i ajudar a pacients d&#8217;altres malalties que afecten el cervell, com l&#8217;Alzheimer, el Parkinson, la meningitis o el glioblastoma&#8221;. De fet, la investigadora est\u00e0 actualment immersa en un projecte de l&#8217;IBEC que t\u00e9 com a objectiu obtenir nous anticossos per avan\u00e7ar aquesta estrat\u00e8gia cap a la cl\u00ednica.<\/p>\n<p>La Professora S\u00edlvia Muro es va incorporar a l&#8217;IBEC a finals del 2017 per liderar el grup &#8216;Targeted Therapeutics and Nanodevices&#8217;, que investiga com dissenyar nanotransportadores carregats amb medicaments que poden fer servir les rutes naturals de transport de l&#8217;organisme per tractar malalties neurodegeneratives, cardiovasculars, metab\u00f2liques o el c\u00e0ncer.<\/p>\n<p><strong>Article de refer\u00e8ncia: <\/strong>Rachel L.Manthe, Maximilian Loeck, Tridib Bhowmick, Melani Solomon, Silvia Muro. <span data-contrast=\"auto\">\u00ab<\/span>Intertwined mechanisms define transport of anti-ICAM nanocarriers across the endothelium and brain delivery of a therapeutic enzyme<span data-contrast=\"auto\">\u00bb.\u00a0<em>Journal of Controlled Release,\u00a0<\/em>August 2020. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.jconrel.2020.05.009\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1016\/j.jconrel.2020.05.009\u00a0<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"alignnone size-full wp-image-55930 lazyload\" data-src=\"http:\/\/www.ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1.jpg\" alt=\"\" width=\"500\" height=\"369\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1.jpg 500w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1-300x221.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1-176x130.jpg 176w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1-150x111.jpg 150w\" data-sizes=\"(max-width: 500px) 100vw, 500px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/369;\" \/>Un grup internacional d&#8217;investigadors liderats per la professora ICREA S\u00edlvia Muro de l&#8217;Institut de Bioenginyeria de Catalunya (IBEC) i la Universitat de Maryland (Estats Units) ha descobert una nova manera de transportar f\u00e0rmacs al cervell, un dels grans desafiaments de la ci\u00e8ncia farmac\u00e8utica actual, el que podria ajudar a dissenyar nous tractaments per a malalties neurol\u00f2giques com ho s\u00f3n el Parkinson o l&#8217;Alzheimer.<\/h3>\n<p>Els resultats d&#8217;aquesta investigaci\u00f3 es recullen en un article cient\u00edfic publicat aquesta setmana a la prestigiosa revista Journal of Controlled Release. Per a l&#8217;elaboraci\u00f3 del treball, els investigadors van unir un antic\u00f2s capa\u00e7 de recon\u00e8ixer la prote\u00efna ICAM-1 -una mol\u00e8cula expressada en la superf\u00edcie dels vasos sanguinis- a una s\u00e8rie de nanopart\u00edcules polim\u00e8riques capaces de transportar un f\u00e0rmac i injectar-lo per via intravenosa.<\/p>\n","protected":false},"author":4,"featured_media":63795,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1125],"post_formats":[],"class_list":["post-74334","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-silvia-muro-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigadors de l&#039;IBEC descobreixen una nova manera de transportar efica\u00e7ment f\u00e0rmacs al cervell - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-descobreixen-una-nova-manera-de-transportar-eficacment-farmacs-al-cervell\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors de l&#039;IBEC descobreixen una nova manera de transportar efica\u00e7ment f\u00e0rmacs al cervell - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un grup internacional d&#039;investigadors liderats per la professora ICREA S\u00edlvia Muro de l&#039;Institut de Bioenginyeria de Catalunya (IBEC) i la Universitat de Maryland (Estats Units) ha descobert una nova manera de transportar f\u00e0rmacs al cervell, un dels grans desafiaments de la ci\u00e8ncia farmac\u00e8utica actual, el que podria ajudar a dissenyar nous tractaments per a malalties neurol\u00f2giques com ho s\u00f3n el Parkinson o l&#039;Alzheimer. Els resultats d&#039;aquesta investigaci\u00f3 es recullen en un article cient\u00edfic publicat aquesta setmana a la prestigiosa revista Journal of Controlled Release. Per a l&#039;elaboraci\u00f3 del treball, els investigadors van unir un antic\u00f2s capa\u00e7 de recon\u00e8ixer la prote\u00efna ICAM-1 -una mol\u00e8cula expressada en la superf\u00edcie dels vasos sanguinis- a una s\u00e8rie de nanopart\u00edcules polim\u00e8riques capaces de transportar un f\u00e0rmac i injectar-lo per via intravenosa.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-descobreixen-una-nova-manera-de-transportar-eficacment-farmacs-al-cervell\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2020-05-26T08:00:20+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-15T09:18:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2017\/11\/silviamuro1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"369\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-descobreixen-una-nova-manera-de-transportar-eficacment-farmacs-al-cervell\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-descobreixen-una-nova-manera-de-transportar-eficacment-farmacs-al-cervell\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Investigadors de l&#8217;IBEC descobreixen una nova manera de transportar efica\u00e7ment f\u00e0rmacs al cervell\",\"datePublished\":\"2020-05-26T08:00:20+00:00\",\"dateModified\":\"2020-06-15T09:18:15+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-descobreixen-una-nova-manera-de-transportar-eficacment-farmacs-al-cervell\\\/\"},\"wordCount\":479,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-descobreixen-una-nova-manera-de-transportar-eficacment-farmacs-al-cervell\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2017\\\/11\\\/silviamuro1.jpg\",\"keywords\":[\"Silvia Muro\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-descobreixen-una-nova-manera-de-transportar-eficacment-farmacs-al-cervell\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/investigadors-de-libec-descobreixen-una-nova-manera-de-transportar-eficacment-farmacs-al-cervell\\\/\",\"name\":\"Investigadors de l'IBEC descobreixen una nova manera de transportar efica\u00e7ment f\u00e0rmacs al cervell - 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