{"id":7451,"date":"2013-06-17T07:42:45","date_gmt":"2013-06-17T07:42:45","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/les-celmlules-ljuguen-a-empaitar-ser-per-determinar-la-direccio-del-seu-moviment-durant-el-desenvolupament-embrionari\/"},"modified":"2015-01-08T10:10:53","modified_gmt":"2015-01-08T10:10:53","slug":"les-celmlules-ljuguen-a-empaitar-ser-per-determinar-la-direccio-del-seu-moviment-durant-el-desenvolupament-embrionari","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/les-celmlules-ljuguen-a-empaitar-ser-per-determinar-la-direccio-del-seu-moviment-durant-el-desenvolupament-embrionari\/","title":{"rendered":"Les c\u00e8l\u00b7lules \u00abjuguen a empaitar-se\u00bb per determinar la direcci\u00f3 del seu moviment durant el desenvolupament embrionari"},"content":{"rendered":"<p>Cient\u00edfics de l\u2019IBEC i la Facultat de Medicina de la UB, juntament amb investigadors del King\u2019s College i l\u2019University College de Londres, han examinat les c\u00e8l\u00b7lules de la cresta neural, una estructura embrion\u00e0ria dels vertebrats formada per c\u00e8l\u00b7lules migrat\u00f2ries que generen les c\u00e8l\u00b7lules del sistema nervi\u00f3s perif\u00e8ric i altres tipus de c\u00e8l\u00b7lules del sistema cardiovascular, aix\u00ed com les c\u00e8l\u00b7lules pigment\u00e0ries de la pell i gran part del teixit connectiu del cap, els ossos i els cart\u00edlags. Els experts van observar que, durant el seu desenvolupament, les c\u00e8l\u00b7lules de la cresta neural \u00abpersegueixen\u00bb altres tipus de c\u00e8l\u00b7lules, les dels placodes (l\u00e0mines que formen els \u00f2rgans sensorials), les quals, al seu torn, fugen quan estan a punt de ser atrapades. Aquesta persecuci\u00f3 d\u00f3na lloc a un moviment coordinat i direccional necessari per al correcte desenvolupament embrionari.<\/p>\n<p>Segons Xavier Trepat, investigador ICREA de l\u2019IBEC i de la UB, \u00ab\u00e9s com un ruc que empaita una pastanaga: les c\u00e8l\u00b7lules de la cresta neural s\u00f3n el ruc, que persegueix, per\u00f2 mai no obt\u00e9, la pastanaga, les c\u00e8l\u00b7lules dels placodes\u00bb. \u00abLa \u201cpersecuci\u00f3\u201d es produeix en pres\u00e8ncia d\u2019una prote\u00efna de senyalitzaci\u00f3, la Sdf1, mentre que la \u201cfugida\u201d la provoca una altra prote\u00efna, la N-cadherina\u00bb, afegeix Trepat.<\/p>\n<p>Els resultats de la recerca aporten noves dades sobre el proc\u00e9s de la migraci\u00f3 cel\u00b7lular, essencial en el desenvolupament i la regeneraci\u00f3 de teixits. Entendre millor el funcionament de la migraci\u00f3 cel\u00b7lular permetria con\u00e8ixer millor com les  c\u00e8l\u00b7lules canceroses envaeixen els teixits ve\u00efns.<\/p>\n<p class=\"caption\">Traject\u00f2ries de les c\u00e8l\u00b7lules de la cresta neural (en blau), que empaiten les dels placodes (en p\u00farpura). (\u00a9 UCL)<\/p>\n<p>&#8212;<\/p>\n<p>E Theveneau, B Steventon, E Scarpa, S Garcia, X Trepat, A Streit &amp; R Mayor  (2013). &#8216;<a href=\"http:\/\/www.nature.com\/ncb\/journal\/vaop\/ncurrent\/full\/ncb2772.html\" target=\"_blank\">Chase-and-run between adjacent cell populations promotes directional collective migration<\/a>&#8216;. Nature Cell Biology, doi:10.1038\/ncb2772<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-7447 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2013\/06\/ncb2013.jpg\" border=\"0\" width=\"340\" height=\"210\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2013\/06\/ncb2013.jpg 340w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2013\/06\/ncb2013-300x185.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2013\/06\/ncb2013-242x150.jpg 242w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2013\/06\/ncb2013-150x92.jpg 150w\" data-sizes=\"(max-width: 340px) 100vw, 340px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 340px; --smush-placeholder-aspect-ratio: 340\/210;\" \/>Investigadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i la Universitat de Barcelona han estudiat el proc\u00e9s de migraci\u00f3 cel\u00b7lular col\u00b7lectiva en el qual les c\u00e8l\u00b7lules fan moviments sincronitzats en una direcci\u00f3 particular.<\/h3>\n<p>Sorprenentment, els investigadors van descobrir que les c\u00e8l\u00b7lules es movien com si s\u2019empaitessin les unes a les altres.<\/p>\n","protected":false},"author":4,"featured_media":7447,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-7451","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Les c\u00e8l\u00b7lules \u00abjuguen a empaitar-se\u00bb per determinar la direcci\u00f3 del seu moviment durant el desenvolupament embrionari - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/les-celmlules-ljuguen-a-empaitar-ser-per-determinar-la-direccio-del-seu-moviment-durant-el-desenvolupament-embrionari\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les c\u00e8l\u00b7lules \u00abjuguen a empaitar-se\u00bb per determinar la direcci\u00f3 del seu moviment durant el desenvolupament embrionari - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i la Universitat de Barcelona han estudiat el proc\u00e9s de migraci\u00f3 cel\u00b7lular col\u00b7lectiva en el qual les c\u00e8l\u00b7lules fan moviments sincronitzats en una direcci\u00f3 particular. 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