{"id":7457,"date":"2013-06-18T15:48:33","date_gmt":"2013-06-18T15:48:33","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/avenc-pioner-de-la-nanoenginyeria-quimica-per-dissenyar-farmacs-regulats-amb-llum\/"},"modified":"2015-01-08T10:10:45","modified_gmt":"2015-01-08T10:10:45","slug":"avenc-pioner-de-la-nanoenginyeria-quimica-per-dissenyar-farmacs-regulats-amb-llum","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/avenc-pioner-de-la-nanoenginyeria-quimica-per-dissenyar-farmacs-regulats-amb-llum\/","title":{"rendered":"Aven\u00e7 pioner de la nanoenginyeria qu\u00edmica per dissenyar f\u00e0rmacs regulats amb llum"},"content":{"rendered":"

L\u2019article, portada i \u201cVery Important Paper\u201d d\u2019Angewandte Chemie, \u00e9s un resultat destacat del projecte europeu \u201cOpticalBullet\u201d finan\u00e7at pel Consell Europeu de Recerca (ERC) en el que col\u00b7laboren ambd\u00f3s instituts.<\/p>\n

Imatge:\u00a0Investigadors de l’IRB Barcelona i l’IBEC dissenyen els primers p\u00e8ptids regulats amb llum per modulatar processos biol\u00f2gics. Autora: Laura Nevola<\/span><\/em><\/p>\n

La cooperaci\u00f3 cient\u00edfica entre qu\u00edmics, biotecn\u00f2legs, farmac\u00f2legs i f\u00edsics de diverses institucions catalanes, liderats per Pau Gorostiza, de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i Ernest Giralt, de l\u2019Institut de Recerca Biom\u00e8dica (IRB Barcelona) ha donat com a fruit un avan\u00e7ament que afavorir\u00e0 el desenvolupament de mol\u00e8cules terap\u00e8utiques regulades amb llum. El treball que es publica avui online a la revista alemanya de refer\u00e8ncia internacional en qu\u00edmica, Angewandte Chemie, ha rebut la consideraci\u00f3 de \u201cVery Important Paper\u201d, que \u00fanicament reben el 5% dels articles acceptats. A m\u00e9s, l\u2019article ser\u00e0 portada del proper n\u00famero de la revista al juliol.<\/p>\n

El laboratori de \u201cDisseny, s\u00edntesi i estructura de p\u00e8ptids i prote\u00efnes<\/a>\u201d liderat pel Dr. Giralt, tamb\u00e9 catedr\u00e0tic de la Universitat de Barcelona i Premi Nacional de Recerca el 2011, ha creat dos p\u00e8ptids (prote\u00efnes petites) que al ser irradiats amb llum canvien de forma permetent o evitant la interacci\u00f3 entre dues prote\u00efnes. L\u2019associaci\u00f3 d\u2019aquestes dues prote\u00efnes \u00e9s necess\u00e0ria per a que es doni l\u2019endocitosi, proc\u00e9s pels qual les c\u00e8l\u00b7lules permeten l\u2019acc\u00e9s de components cap al seu interior a trav\u00e9s de la membrana cel\u00b7lular. La cient\u00edfica italiana Laura Nevola, postdoc al laboratori del Dr. Giralt, i Andr\u00e9s Mart\u00edn-Quir\u00f3s, estudiant de doctorat al laboratori del Dr. Gorostiza, han treballat durant quatre anys en el disseny dels p\u00e8ptids fotosensibles i s\u00f3n co-autors de l\u2019article.<\/p>\n

\u201cEls p\u00e8ptids fotosensibles actuen com a sem\u00e0fors que a voluntat nostra donen llum verd o frenen l\u2019endocitosi cel\u00b7lular. S\u00f3n, des de ja, una eina molt potent per a la biologia cel\u00b7lular\u201d explica el Dr. Giralt. \u201cAquestes mol\u00e8cules ens permeten usar llum focalitzada com si fos una \u201cvareta m\u00e0gica\u201d per controlar processos biol\u00f2gics i interrogar-los\u201d, afegeix el f\u00edsic Pau Gorostiza, professor ICREA i cap del grup \u201cNanosondes i nanocommutadors<\/a>\u201d a l\u2019IBEC.<\/p>\n

Els investigadors destaquen l\u2019aplicabilitat immediata per estudiar, per exemple, l\u2019endocitosi in vitro en c\u00e8l\u00b7lules canceroses -on aquest proc\u00e9s est\u00e0 descontrolat- el que permetria inhibir selectivament la proliferaci\u00f3 de les c\u00e8l\u00b7lules. Tamb\u00e9 per estudiar la biologia del desenvolupament -on les c\u00e8l\u00b7lules requereixen de l\u2019endocitosi per modelar la seva morfologia i funci\u00f3 cel\u00b7lular, processos que estan orquestrats amb gran precisi\u00f3 espacio-temporal. En aquest context, els p\u00e8ptids fotosensibles permetran manipular amb patrons de llum el complex proc\u00e9s de desenvolupament d\u2019un organisme multicel\u00b7lular. \u201cA la vista dels resultats ara treballem per obtenir una recepta general per dissenyar p\u00e8ptids inhibidors fotocommutables aplicable a altres interaccions entre prote\u00efnes per manipular-les amb llum dins de les c\u00e8l\u00b7lules\u201d, avancen els investigadors.<\/p>\n

Cap a l\u2019optofarmacologia o les mol\u00e8cules terap\u00e8utiques regulades amb llum<\/strong><\/p>\n

\u201cAquest primer \u00e8xit ens permetr\u00e0 generar el mateix tipus de p\u00e8ptids per a treballs amb una orientaci\u00f3 de qu\u00edmica m\u00e8dica\u201d, diu Giralt. El Dr. Gorostiza \u00e9s qui proposa la idea de manipular amb llum processos biol\u00f2gics i farmacol\u00f2gics despr\u00e9s de cinc anys d\u2019especialitzaci\u00f3 a la Universitat de Calif\u00f2rnia a Berkeley. Coordinador del projecte ERC Starting Grant \u201cOpticalBullet\u201d (Bala \u00d2ptica) i de l\u2019ERC Proof of Concept \u201cTheralight\u201d, en els quals col\u00b7labora amb el laboratori de qu\u00edmica de Giralt, explica que \u201cles aplicacions terap\u00e8utiques m\u00e9s immediates les podr\u00edem esperar per a patologies de teixits superficials com la pell, la retina o les mucoses m\u00e9s externes\u201d.<\/p>\n

La manipulaci\u00f3 de processos biol\u00f2gics amb llum est\u00e0 generant eines revolucion\u00e0ries per a la biologia i la medicina i obre nous camps d\u2019estudi com l\u2019optofarmacologia i l\u2019optogen\u00e8tica. La combinaci\u00f3 de f\u00e0rmacs amb dispositius externs de control de llum pot contribuir al desenvolupament de la medicina personalitzada en la que les ter\u00e0pies es poden modular en funci\u00f3 de cada pacient, restringir a regions localitzades per un temps determinat, reduint sensiblement els efectes no desitjats.<\/p>\n

Millores en l\u00e0sers i en enginyeria qu\u00edmica<\/strong><\/p>\n

Per avan\u00e7ar en el desenvolupament de f\u00e0rmacs fotosensibles, cal millorar la resposta fotoqu\u00edmica dels compostos i poder estimular amb longituds d\u2019ona visibles. \u201cLa il\u00b7luminaci\u00f3 prolongada amb llum ultraviolada \u00e9s t\u00f2xica per a les c\u00e8l\u00b7lules i \u00e9s una limitaci\u00f3 evident, al que cal afegir la poca capacitat de penetraci\u00f3 al teixit\u201d, d\u00f3na com exemple Giralt. Tamb\u00e9 cal fer passes cap una millor fotoconversi\u00f3 dels compostos i cap a l\u2019estabilitat en la foscor per a \u201csegons interessi, dissenyar-los de modus que es relaxin r\u00e0pidament quan es deixi d\u2019irradiar llum o per a que \u201crecordin\u201d durant hores o dies la llum que els ha il\u00b7luminat\u201d, afegeix Gorostiza.<\/p>\n

En aquest treball tamb\u00e9 han col\u00b7laborat investigadors de la Plataforma de Microsc\u00f2pia Digital Avan\u00e7ada<\/a> de l\u2019IRB Barcelona, que han dissenyat un programa adhoc per poder validar qualitativament i quantitativa l\u2019acci\u00f3 dels p\u00e8ptids dins de les c\u00e8l\u00b7lules en temps real. Aix\u00ed mateix, l\u2019equip ha comptat amb el recolzament en biologia del grup del Dr. Artur Llobet de l\u2019IDIBELL.<\/p>\n

—<\/p>\n

Article de refer\u00e8ncia: \u2028Light-regulated Stapled Peptides to Inhibit Protein-protein Interactions Involved in Clathrin-mediated Endocytosis<\/a>. Laura Nevola, Andr\u00e9s Mart\u00edn-Quir\u00f3s, Kay Eckelt, N\u00faria Camarero, S\u00e9bastien Tosi, Artur Llobet, Ernest Giralt and Pau Gorostiza. \u2028Angewandte Chemie (2013) DOI: 10.1002\/anie.201303324<\/p>\n

—<\/p>\n

>> IBEC als mitjans:<\/strong><\/p>\n

http:\/\/www.telecinco.es\/informativos\/sociedad\/Logran-cientifico-disenar-farmacos-regulados_0_1622250299.html<\/a><\/p>\n

http:\/\/www.diariosigloxxi.com\/texto-ep\/mostrar\/20130618133250\/logran-un-avance-cientifico-para-disenar-farmacos-regulados-con-luz
<\/a>
http:\/\/www.nanowerk.com\/news2\/newsid=30941.php<\/a><\/p>\n

http:\/\/phys.org\/news\/2013-06-breakthrough-chemical-nanoengineering-drugs.html<\/a><\/p>\n

http:\/\/www.bioopticsworld.com\/articles\/2013\/06\/photo-switchable-molecules-could-lead-to-drugs-controlled-by-light.html<\/a>

http:\/\/www.photonics.com\/Article.aspx?AID=54182<\/a><\/p>\n

http:\/\/www.healthcanal.com\/medical-breakthroughs\/39918-pioneering-breakthrough-of-chemical-nanoengineering-to-design-drugs-controlled-by-light.html<\/a><\/p>\n

http:\/\/www.medgadget.com\/2013\/06\/light-used-to-control-a-pair-of-peptides-may-lead-to-fine-targeting-of-drug-activity.html<\/a><\/p>\n

http:\/\/www.jano.es\/jano\/actualidad\/ultimas\/noticias\/janoes\/cientificos\/espanoles\/sientan\/bases\/disenar\/farmacos\/regulados\/luz\/_f-11+iditem-19979+idtabla-1<\/a><\/p>\n

http:\/\/herenciageneticayenfermedad.blogspot.com.es\/2013\/06\/cientificos-espanoles-sientan-las-bases.html<\/a>

http:\/\/www.sciencedaily.com\/releases\/2013\/06\/130618101516.htm<\/a>

http:\/\/www.lescienze.it\/lanci\/2013\/06\/18\/news\/irb_barcelona_farmaci_regolati_con_la_luce_italiana_partecipa_a_una_pioneristica_ricerca_in_nanoingegneria_chimica-1707152\/<\/a>

http:\/\/www.agi.it\/research-e-sviluppo\/notizie\/201306181454-eco-rt10207-salute_farmaci_regolati_con_la_luce_italiana_nel_team<\/a> <\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

Investigadors de l\u2019IRB Barcelona i l\u2019IBEC aconsegueixen mol\u00e8cules fotocommutables (photoswitchable) per controlar de forma remota i no invasiva la interacci\u00f3 entre prote\u00efnes.<\/h3>\n

Aquestes eines serviran de prototipus per desenvolupar medicaments fotocommutables, el benefici dels quals seria restringir a una regi\u00f3 i temps determinats l\u2019efecte d\u2019un compost, reduint els efectes secundaris en altres regions.<\/p>\n","protected":false},"author":4,"featured_media":7453,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-7457","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nAven\u00e7 pioner de la nanoenginyeria qu\u00edmica per dissenyar f\u00e0rmacs regulats amb llum - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/avenc-pioner-de-la-nanoenginyeria-quimica-per-dissenyar-farmacs-regulats-amb-llum\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aven\u00e7 pioner de la nanoenginyeria qu\u00edmica per dissenyar f\u00e0rmacs regulats amb llum - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l\u2019IRB Barcelona i l\u2019IBEC aconsegueixen mol\u00e8cules fotocommutables (photoswitchable) per controlar de forma remota i no invasiva la interacci\u00f3 entre prote\u00efnes. Aquestes eines serviran de prototipus per desenvolupar medicaments fotocommutables, el benefici dels quals seria restringir a una regi\u00f3 i temps determinats l\u2019efecte d\u2019un compost, reduint els efectes secundaris en altres regions.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/avenc-pioner-de-la-nanoenginyeria-quimica-per-dissenyar-farmacs-regulats-amb-llum\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2013-06-18T15:48:33+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-01-08T10:10:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2013\/06\/lightpeptides_angchjune2013.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"340\" \/>\n\t<meta property=\"og:image:height\" content=\"210\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/avenc-pioner-de-la-nanoenginyeria-quimica-per-dissenyar-farmacs-regulats-amb-llum\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/avenc-pioner-de-la-nanoenginyeria-quimica-per-dissenyar-farmacs-regulats-amb-llum\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Aven\u00e7 pioner de la nanoenginyeria qu\u00edmica per dissenyar f\u00e0rmacs regulats amb llum\",\"datePublished\":\"2013-06-18T15:48:33+00:00\",\"dateModified\":\"2015-01-08T10:10:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/avenc-pioner-de-la-nanoenginyeria-quimica-per-dissenyar-farmacs-regulats-amb-llum\\\/\"},\"wordCount\":1123,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/avenc-pioner-de-la-nanoenginyeria-quimica-per-dissenyar-farmacs-regulats-amb-llum\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2013\\\/06\\\/lightpeptides_angchjune2013.jpg\",\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/avenc-pioner-de-la-nanoenginyeria-quimica-per-dissenyar-farmacs-regulats-amb-llum\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/avenc-pioner-de-la-nanoenginyeria-quimica-per-dissenyar-farmacs-regulats-amb-llum\\\/\",\"name\":\"Aven\u00e7 pioner de la nanoenginyeria qu\u00edmica per dissenyar f\u00e0rmacs regulats amb llum - 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