{"id":74696,"date":"2020-06-02T18:13:43","date_gmt":"2020-06-02T16:13:43","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new-chemical-lego-blocks-for-health-solutions\/"},"modified":"2020-06-15T11:17:50","modified_gmt":"2020-06-15T09:17:50","slug":"new-chemical-lego-blocks-for-health-solutions","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/new-chemical-lego-blocks-for-health-solutions\/","title":{"rendered":"Nous blocs qu\u00edmics de “lego” per a solucions de salut"},"content":{"rendered":"

Fa m\u00e9s d’un any, el Grup d’Albertazzi<\/span>\u00a0a l’IBEC<\/span>\u00a0va comen\u00e7ar una fruct\u00edfera col\u00b7laboraci\u00f3 amb el Grup d’Ilja<\/span>\u00a0Voets<\/span>\u00a0a l’ICMS<\/span><\/a>, a la Universitat T\u00e8cnica d’Eindhoven. Per\u00f2 no nom\u00e9s aix\u00f2, altres dos grups d’experts es van unir a aquesta col\u00b7laboraci\u00f3: el grup de\u00a0Nanosondes<\/span>\u00a0i\u00a0Nanocommutadors<\/span><\/a>\u00a0dirigit per Pau\u00a0Gorostiza<\/span>\u00a0a l’IBEC<\/span>\u00a0i el grup de “Qu\u00edmica de pol\u00edmers i Materials” dirigit per Jos\u00e9\u00a0Berrocal<\/span>\u00a0a l’Adolphe<\/span>\u00a0Merkle<\/span>\u00a0Institute<\/span>\u00a0a Su\u00efssa. Com a resultat d’aquest gran equip, els investigadors han publicat recentment un article destacat al\u00a0Journal<\/span>\u00a0of<\/span>\u00a0the<\/span>\u00a0American<\/span>\u00a0Society<\/span>\u00a0of<\/span>\u00a0Chemistry<\/span>\u00a0(JACS<\/span>).<\/p>\n

La mol\u00e8cula en forma de disc, es va sintetitzar a Barcelona i se li va incorporar una part pept\u00eddica feta de lisina (sensible al pH), una cadena d’oct\u00e0-etilenglicol sensible a la temperatura i una part d’azobenz\u00e8 que respon als est\u00edmuls de llum. Els investigadors han observat que en combinar aquestes parts en una sola mol\u00e8cula, el compost final mant\u00e9 la capacitat de resposta, canviant la seva c\u00e0rrega i la seva forma. I, el que \u00e9s encara m\u00e9s fascinant, aquests canvis poden promoure que les mol\u00e8cules en forma de disc s’apilin una damunt de l’altra formant una pila de mol\u00e8cules.<\/p>\n

Segons els investigadors: “El nostre sistema respon de manera controlada i reversible a la llum, la temperatura, el pH i la for\u00e7a i\u00f2nica, modulant l’equilibri d’acoblament i desmuntatge. Aix\u00f2 \u00e9s especialment interessant per a aplicacions biol\u00f2giques, com l’administraci\u00f3 de f\u00e0rmacs o l’enginyeria de teixits, on controlar el rendiment del\u00a0material\u00a0en un entorn complex \u00e9s tot un\u00a0desafiament<\/strong>“. Edgar Fonts, primer autor de l’article\u00a0va passar una setmana a Eindhoven, treballant directament amb el Grup\u00a0Voets<\/span>, gr\u00e0cies a l’acord de col\u00b7laboraci\u00f3\u00a0IBEC<\/span>–ICMS<\/span>\u00a0<\/a>explica la import\u00e0ncia de la troballa d’una manera molt integral:<\/p>\n

Hem desenvolupat unes “peces de Lego” molt petites que es comporten com un interruptor capa\u00e7 de canviar amb la llum o altres condicions ambientals. Per\u00f2 el m\u00e9s fascinant \u00e9s el seg\u00fcent: sota certes condicions, aquestes petites peces poden interactuar espont\u00e0niament amb moltes altres peces, formant objectes fibrosos a l’aigua, 10000 vegades m\u00e9s primes que un cabell.<\/strong><\/p>\n

Edgar Fuentes, primer autor de l’article<\/em><\/strong><\/p><\/blockquote>\n

\n

Art\u00edcle de refer\u00e8ncia: <\/strong>Fuentes, M. Gerth, J. A. Berrocal, C. Matera, P. Gorostiza, I. K. Voets, S. Pujals and L. Albertazzi. An Azobenzene-Based Single-Component Supramolecular Polymer Responsive to Multiple Stimuli in Water.<\/a> JACS, 2020.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"Investigadors de l’IBEC desenvolupen noves mol\u00e8cules de resposta m\u00faltiple capaces d’autoassemblar-se en l’aigua formant estructures fibroses. Les anomenades mol\u00e8cules disc\u00f2tiques mostren sensibilitat a la temperatura, la llum, el pH i la for\u00e7a i\u00f2nica i poden mostrar un gran potencial per a aplicacions m\u00e8diques com sistemes d’administraci\u00f3 de medicaments, diagn\u00f2stic o enginyeria de teixits.<\/h3>\n

Edgar Fuentes \u00e9s un estudiant de doctorat al grup de Nanoscopia per a la Nanomedicina<\/a> dirigit per Lorenzo Albertazzi a l’Institut de Bioenginyeria de Catalunya (IBEC). Dins d’aquest grup, Edgar i els seus col\u00b7legues se centren en la s\u00edntesi de nous materials supramoleculars intel\u00b7ligents per a l’administraci\u00f3 de medicaments.<\/p>\n","protected":false},"author":4,"featured_media":74693,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1051,1052,1150,1054],"post_formats":[],"class_list":["post-74696","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-icms-ca","tag-lorenzo-albertazzi-ca","tag-pau-gorostiza-ca","tag-tue-ca"],"yoast_head":"\nNous blocs qu\u00edmics de "lego" per a solucions de salut - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/new-chemical-lego-blocks-for-health-solutions\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nous blocs qu\u00edmics de "lego" per a solucions de salut - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l'IBEC desenvolupen noves mol\u00e8cules de resposta m\u00faltiple capaces d'autoassemblar-se en l'aigua formant estructures fibroses. Les anomenades mol\u00e8cules disc\u00f2tiques mostren sensibilitat a la temperatura, la llum, el pH i la for\u00e7a i\u00f2nica i poden mostrar un gran potencial per a aplicacions m\u00e8diques com sistemes d'administraci\u00f3 de medicaments, diagn\u00f2stic o enginyeria de teixits. Edgar Fuentes \u00e9s un estudiant de doctorat al grup de Nanoscopia per a la Nanomedicina dirigit per Lorenzo Albertazzi a l'Institut de Bioenginyeria de Catalunya (IBEC). 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