{"id":75808,"date":"2020-06-25T21:48:29","date_gmt":"2020-06-25T19:48:29","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new-biodegradable-nanomotors-for-biomedical-applications\/"},"modified":"2020-06-30T11:46:09","modified_gmt":"2020-06-30T09:46:09","slug":"new-biodegradable-nanomotors-for-biomedical-applications","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/new-biodegradable-nanomotors-for-biomedical-applications\/","title":{"rendered":"Nous nanomotors biodegradables per a aplicacions biom\u00e8diques"},"content":{"rendered":"

\"\"<\/p>\n

Els nanomotors s\u00f3n dispositius moleculars o d’escala nanom\u00e8trica capa\u00e7os de moure\u2019s a trav\u00e9s d’un mitj\u00e0 biol\u00f2gic mitjan\u00e7ant la conversi\u00f3 d’energia qu\u00edmica en moviment. Aquests artefactes poden usar-se per fer arribar medicaments a parts espec\u00edfiques del cos. Normalment els nanomotors fan servir biomol\u00e8cules per propulsar-se. No obstant, aquestes mol\u00e8cules es degraden al entrar en contacte amb el cos del pacient. \u00c9s per aix\u00f2 que l’\u00fas de part\u00edcules motoritzades, biocompatibles i biodegradables que transporten medicaments a el teixit malalt \u00e9s actualment una \u00e0rea de recerca emergent en el camp de la biomedicina.<\/p>\n

Investigadors de l‘Institute for Complex Molecular Systems<\/a><\/em> (ICMS) de la Eindhoven University of Technology<\/em> (TU\/e), juntament amb investigadors de la Soochow University, Swansea University<\/em>, i l’Institut de Bioenginyeria de Catalunya (IBEC) han desenvolupat una nova manera de sintetitzar nanomotors biodegradables. Aquesta via emmagatzema al nanomotor nanopart\u00edcules inorg\u00e0niques capaces de promoure en la propulsi\u00f3. L’estudi ha estat publicat a la revista Nano Letters<\/em>.<\/p>\n

Un innovador nanomotor<\/h3>\n

Aquest innovador dispositiu h\u00edbrid est\u00e0 format per una estructura anomenada estomatocit, tamb\u00e9 coneguda com poly(ethylene glycol)-block-poly(D,L-lactide) (PEG\u2212PDLLA), amb un motor que es carrega amb di\u00f2xid de mangan\u00e8s. Els estomatocits s\u00f3n c\u00e8l\u00b7lules en forma de bol amb una cavitat interna buida amb una petita obertura a l’exterior. Estudis previs han demostrat com aquestes part\u00edcules s\u00f3n capaces de confinar i protegir el motor o combustible dins de la cavitat i, posteriorment, catalitzar permetent el seu moviment a trav\u00e9s d’entorns biol\u00f2gics complexos. Com a prova de concepte, els investigadors han aconseguit fer penetrar dels nanomotors h\u00edbrids en tumors, garantint aix\u00ed la seva funcionalitat en contextos biol\u00f2gics i evidenciant el seu potencial en aplicacions biom\u00e8diques.<\/p>\n

\u00a0<\/strong>Un propulsor sintetitzat dins el nanomotor<\/h3>\n

L’enfocament innovador d’aquest treball consisteix en que la propulsi\u00f3 a partir de di\u00f2xid de mangan\u00e8s es genera en el mateix nanomotor. Quan aquest compost inorg\u00e0nic reacciona amb el per\u00f2xid d’hidrogen, genera “nanobombolles” d’oxigen que al ser expulsades per la petita obertura de l’estomatocit impulsen l’estructura en la direcci\u00f3 oposada. El per\u00f2xid d’hidrogen, un compost t\u00f2xic per a les c\u00e8l\u00b7lules, \u00e9s com\u00fa en microambients tumorals. A m\u00e9s, els estomatocitos poden ser reutilitzats sempre que el combustible emmagatzemat en la cavitat es mantingui funcional. En cas de no estar en funcionament, el combustible no es “s’escapa” a trav\u00e9s de l’obertura, almenys durant tres mesos.<\/p>\n

L’estructura h\u00edbrida descrita a l’estudi \u00e9s totalment biocompatible i biodegradable, gr\u00e0cies al seu exterior org\u00e0nic. A m\u00e9s, els nanomotors es podrien fer servir com a plataformes multimodals i les seves part\u00edcules tenen potencial per ser controlades de forma remota mitjan\u00e7ant senyals externs (camps magn\u00e8tics o llum, per exemple). En altres paraules, aquests nous compostos h\u00edbrids combinen les millors caracter\u00edstiques de les nano-estructures inorg\u00e0niques i de les org\u00e0niques. Aquest estudi obre nous camins en la recerca de nanomotors aut\u00f2noms aix\u00ed com en les seves nombroses aplicacions en biomedicina.<\/p>\n

Col\u00b7laboraci\u00f3 ICMS-IBEC<\/h3>\n

Al 2018, l‘IBEC i el ICMS van sembrar la llavor<\/a> del que fins ara ha estat una alian\u00e7a molt prometedora. Aquest 2020, ambdues institucions ahn signat un nou acord de col\u00b7laboraci\u00f3<\/a>. Actualment, dos l\u00edders de grup de l’IBEC, Vito Conte i Lorenzo Albertazzi, compten amb una segona afiliaci\u00f3 a l\u2019ICMS. A continuaci\u00f3, pots llegir un altre estudi recent derivat de la col\u00b7laboraci\u00f3 cient\u00edfica IBEC-ICMS sobre mol\u00e8cules de resposta m\u00faltiple capaces de autoensamblarse<\/a> i una revisi\u00f3 sobre com sistemes artificials imiten la forma en qu\u00e8 les c\u00e8l\u00b7lules es mouen i es comuniquen<\/a>.<\/p>\n

\n

Article de referencia: <\/strong>Imke A. B. Pijpers, Shoupeng Cao, Antoni Llopis-Lorente, Jianzhi Zhu, Shidong Song, Rick R. M. Joosten, Fenghua Meng, Heiner Friedrich, David S. Williams, Samuel S\u00e1nchez, Jan C. M. van Hest, and Loai K. E. A. Abdelmohsen \u201cHybrid Biodegradable Nanomotors through Compartmentalized Synthesis<\/a>\u201d Nano Letters. DOI: 10.1021\/acs.nanolett.0c01268.<\/p>\n","protected":false},"excerpt":{"rendered":"

Un article publicat a Nano Letters descriu el disseny i la funcionalitat d’un nanomotor biocompatible i biodegradable. Aquesta estructura h\u00edbrida dotada d’un exterior org\u00e0nic s\u2019autopropulsa utilitzant una nanopart\u00edcula inorg\u00e0nica que els investigadors han estat capa\u00e7os de sintetitzar dins del nanomotor.<\/h3>\n<\/p>\n

L’estudi l\u2019han dirigit Jan van Hest i Laoi Abdelmohsen de l’Institute of Complex Molecular Systems at TU\/e en col\u00b7laboraci\u00f3 amb Samuel S\u00e1nchez de l’Institut de Bioingenieria de Catalunya (IBEC) a Barcelona, i investigadors residents a la Xina i el Regne Unit.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1140],"post_formats":[],"class_list":["post-75808","post","type-post","status-publish","format-standard","hentry","category-noticies-de-recerca","tag-samuel-sanchez-ca"],"yoast_head":"\nNous nanomotors biodegradables per a aplicacions biom\u00e8diques - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/new-biodegradable-nanomotors-for-biomedical-applications\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nous nanomotors biodegradables per a aplicacions biom\u00e8diques - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un article publicat a Nano Letters descriu el disseny i la funcionalitat d'un nanomotor biocompatible i biodegradable. 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