{"id":76861,"date":"2020-08-26T10:53:25","date_gmt":"2020-08-26T08:53:25","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=76861"},"modified":"2020-08-26T12:43:21","modified_gmt":"2020-08-26T10:43:21","slug":"ladhesio-cel%c2%b7lular-a-nanoescala-es-un-factor-clau-per-a-la-produccio-de-cartilag-in-vitro","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/ladhesio-cel%c2%b7lular-a-nanoescala-es-un-factor-clau-per-a-la-produccio-de-cartilag-in-vitro\/","title":{"rendered":"L’adhesi\u00f3 cel\u00b7lular a nanoescala \u00e9s un factor clau per a la producci\u00f3 de cart\u00edlag in vitro"},"content":{"rendered":"

\"\"<\/p>\n

L’<\/span>Organitzaci\u00f3 Mundial de la Salut<\/span><\/a> estima que m\u00e9s de 300 milions de persones en el m\u00f3n pateixen artrosi cada any. Aquesta malaltia comporta un<\/span> trencament progressiu<\/span> i la degradaci\u00f3 del cart\u00edlag en les articulacions, que condueix <\/span>a un<\/span> dolor cr\u00f2nic i a <\/span>una<\/span> mobilitat redu\u00efda. Un dels m\u00e8todes que actualment existeixen per reparar aquestes lesions \u00e9s <\/span>la implantaci\u00f3 de<\/span> c<\/span>ondr\u00f2cits (c\u00e8l\u00b7lules de cart\u00edlag<\/span>) extret<\/span>e<\/span>s del pacient. No obstant aix\u00f2, aquesta t\u00e8cnica est\u00e0 limitada pe<\/span>r l\u2019etapa <\/span>d’expansi\u00f3 cel\u00b7lular<\/span> requeri<\/span>da <\/span>per generar teixits de mida <\/span>suficientment <\/span>gran per omplir la lesi\u00f3, ja que molt sovint els condr\u00f2cits es <\/span>des<\/span>diferencien<\/span> en <\/span>el cultiu<\/span>. Ara, el grup d’investigaci\u00f3 <\/span>Nanobioengineering<\/span> del IBEC<\/span>, dirigit pel professor Josep <\/span>Samitier<\/span>, publica <\/span>a la revista <\/span>International <\/span><\/i>Journal<\/span><\/i> of Molecular <\/span><\/i>Sciences<\/span><\/i> un estudi que tracta de la generaci\u00f3 de cart\u00edlag <\/span>in vitro<\/span><\/i> utilitzant c\u00e8l\u00b7lules mare <\/span>mesenquimals<\/span> humanes (<\/span>MSCs<\/span>). <\/span>Aquestes c\u00e8l\u00b7lules <\/span><\/b>s\u2019<\/span><\/b>han de <\/span><\/b>pre<\/span><\/b>-diferenciar <\/span><\/b>in vitro<\/span><\/i><\/b> per guiar amb \u00e8x<\/span><\/b>it la<\/span><\/b> diferenciaci\u00f3 cap a co<\/span><\/b>ndr<\/span><\/b>\u00f2cits quan s’insereixen<\/span><\/b> en el pacient, un proc\u00e9s que es pot controlar mitjan\u00e7ant l’ajust prec\u00eds de l’<\/span><\/b>adhesi\u00f3 cel\u00b7lular al substrat durant el cultiu<\/span><\/b> cel\u00b7lular.<\/span><\/b>\u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n

En el grup desenvolupem eines per modular les interaccions substrat<\/span>-c\u00e8<\/span>l\u00b7lula a la <\/span>nanoescala<\/span> per desxifrar el seu impacte en la generaci\u00f3 de teixits i en el desenvolupament de malalties. <\/span><\/p>\n

Ignasi <\/span>Casanellas<\/span>, <\/span><\/p>\n

primer autor de<\/span>l treball <\/span>i estudiant de doctorat al laboratori del professor Josep <\/span>Samitier<\/span>.<\/span>\u00a0<\/span><\/p>\n<\/blockquote>\n

\u00a0<\/span><\/p>\n

L’estructura del <\/span><\/b>nanopatr\u00f3<\/span><\/b> determina la correcta formaci\u00f3 del cart\u00edlag<\/span><\/b>\u00a0<\/span><\/p>\n

Les <\/span>MSC<\/span>s<\/span> s\u00f3n c\u00e8l\u00b7lules <\/span>multipotents<\/span> que es diferen<\/span>cien, entre d’altres, en condr<\/span>\u00f2cits. La formaci\u00f3 de cart\u00edlag comen\u00e7a amb la condensaci\u00f3 de les c\u00e8l\u00b7lules <\/span>mesenquimals<\/span> que migren unes envers les altres per formar agregats cel\u00b7lulars tridimensionals. En aquest treball, la condensaci\u00f3 <\/span>mesenquimal<\/span> es <\/span>va <\/span>millora<\/span>r<\/span> ajustant el nivell d’adher\u00e8ncia entre <\/span>MSCs<\/span> i el substrat a la <\/span>nanoescala<\/span>. Aix\u00f2 promou la migraci\u00f3 direccional de c\u00e8l\u00b7lules, contribueix a l’estabilitat mec\u00e0nica dels agregats cel\u00b7lulars i millora les interaccions c\u00e8l\u00b7lula- c\u00e8l\u00b7lula, conduint a una millor formaci\u00f3 del cart\u00edlag <\/span>in vitro<\/span><\/i>. Els investigadors van <\/span>utilitzar<\/span> MSCs<\/span> derivades<\/span> de teixit adip\u00f3s hum\u00e0, una font f\u00e0cilment accessible per a potencials<\/span> aplicacions<\/span> cl\u00edniques.<\/span>\u00a0<\/span><\/p>\n

L’objectiu d’aquest treball \u00e9s poder reparar les lesions del cart\u00edlag usant <\/span>MSC<\/span>s<\/span> f\u00e0cilment extret<\/span>es<\/span> del pacient, que <\/span>s\u2019inseriran<\/span> al lloc de la lesi\u00f3 despr\u00e9s de passar <\/span>p<\/span>el proc\u00e9s de precondicionament in vitro<\/i>.<\/span><\/p>\n

Anna <\/span>Lagunas<\/span>,<\/span><\/span><\/p>\n

investigadora s\u00e8nior del grup <\/span>Nanobioengineering<\/span> de l’IBEC.<\/span>\u00a0<\/span><\/span><\/p>\n<\/blockquote>\n

\u00a0<\/span><\/p>\n

El grup del professor <\/span>Samitier<\/span> ha utilitzat <\/span>nanopatrons<\/span>, substrats per a la cultura cel\u00b7lular, de RGD (una seq\u00fc\u00e8ncia <\/span>tripeptidica<\/span> que existeix en diverses prote\u00efnes de la matriu extracel\u00b7lular i \u00e9s responsable de l’adhesi\u00f3 cel\u00b7lular) per controlar i modificar l’adhesi\u00f3 de les <\/span>MSCs<\/span> durant les primeres etapes de la formaci\u00f3 del cart\u00edlag. Mitjan\u00e7ant la modificaci\u00f3 de la quantitat i l’espai entre els motius RGD en els <\/span>nanopatrons<\/span>, <\/span>van determinar que hi ha m\u00e9s diferenciaci\u00f3 quan s’utilitzen <\/span><\/b>nanopatrons<\/span><\/b> S<\/span><\/b>90<\/span><\/b> (aquells que presenten el 90% de la seva superf\u00edcie amb una dist\u00e0ncia entre els motius RGD inferior a 70 <\/span>nm<\/span>). Aquests <\/span>nanopatrons<\/span> biocompatibles<\/span>, pr\u00e8viament desenvolupats en col\u00b7laboraci\u00f3 amb el <\/span>Laboratorio<\/span> de <\/span>Dendr\u00edmeros<\/span> Biomim\u00e9ticos<\/span> y <\/span>Fot\u00f3nica<\/span> del Centro <\/span>Andaluz<\/span> de <\/span>Nanomedicina<\/span> y <\/span>Biotecnolog\u00eda<\/span> (<\/span>Bionand<\/span>), permeten ajustar l’adhesi\u00f3 c\u00e8<\/span>l\u00b7lula-substrat i es poden generar en grans superf\u00edcies, sent <\/span>doncs<\/span> compatible amb <\/span>el cultiu de teixits<\/span>. R<\/span>esul<\/span>tats anteriors del grup indica<\/span>n que els <\/span>nanopatrons<\/span> S<\/span>90<\/span> tamb\u00e9 promouen el proc\u00e9s de diferenciaci\u00f3 <\/span>in vitro<\/span><\/i>. Les noves troballes mostren que es necessiten nivells d’adhesi\u00f3 alts per promoure la condensaci\u00f3 i viabilitat dels agregats <\/span>de <\/span>MSC<\/span>s<\/span>, destacant la impor<\/span>t\u00e0ncia de controlar l’adhesi\u00f3 c\u00e8<\/span>l\u00b7lula-substrat en les estrat\u00e8gies d’enginyeria de teixits per a la reparaci\u00f3 del cart\u00edlag.<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span>L’estudi es va realitzar en col\u00b7laboraci\u00f3 amb diferents grups de la<\/span> xarxa<\/span> CIBER-B<\/span>B<\/span>N (<\/span>Centro de <\/span>Investigaci\u00f3n<\/span> Biom\u00e9dica<\/span> en Red <\/span>\u2013<\/span> Bioingenier\u00eda<\/span>,<\/span> Biomateriales<\/span> y <\/span>Nanomedicina<\/span>)<\/span>: <\/span>Laboratorio<\/span> de <\/span>Bioingenier\u00eda<\/span> y <\/span>Regeneraci\u00f3n<\/span> Tisular<\/span>, <\/span>Universidad<\/span> de <\/span>Ma<\/span>laga<\/span> (LABRET-UMA).<\/span>\u00a0<\/span><\/p>\n

Article de refer\u00e8ncia: <\/span><\/b>Ignasi <\/span>Casanellas<\/span>, Anna <\/span>Lagunas<\/span>, Yolanda Vida, Ezequiel P\u00e9rez-<\/span>Inestrosa<\/span>, Jos\u00e9 A. Andrades, Jos\u00e9 <\/span>Becerra<\/span>, Josep <\/span>Samitier<\/span>. <\/span>The<\/span> Janus<\/span> Role<\/span> of <\/span>Adhesion<\/span> in <\/span>Chondrogenesis<\/span>.<\/span><\/a> Int. J. Mol. <\/span><\/i>Sci<\/span><\/i>. 2020.<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC) desenvolupen una metodologia basada en estructures de nanopatrons que milloren la diferenciaci\u00f3 de c\u00e8l\u00b7lules mare mesenquimals en cart\u00edlag in vitro. Aquest avan\u00e7 es podr\u00e0 aplicar a les t\u00e8cniques de regeneraci\u00f3 del cart\u00edlag amb l’objectiu de tractar lesions. <\/h3>\n","protected":false},"author":4,"featured_media":76840,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1136,978,1219],"post_formats":[],"class_list":["post-76861","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-josep-samitier-ca","tag-regeneracio","tag-salut"],"yoast_head":"\nL'adhesi\u00f3 cel\u00b7lular a nanoescala \u00e9s un factor clau per a la producci\u00f3 de cart\u00edlag in vitro - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/ladhesio-cel\u00b7lular-a-nanoescala-es-un-factor-clau-per-a-la-produccio-de-cartilag-in-vitro\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'adhesi\u00f3 cel\u00b7lular a nanoescala \u00e9s un factor clau per a la producci\u00f3 de cart\u00edlag in vitro - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l'Institut de Bioenginyeria de Catalunya (IBEC) desenvolupen una metodologia basada en estructures de nanopatrons que milloren la diferenciaci\u00f3 de c\u00e8l\u00b7lules mare mesenquimals en cart\u00edlag in vitro. 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