{"id":77017,"date":"2020-09-01T16:23:46","date_gmt":"2020-09-01T14:23:46","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=77017"},"modified":"2020-09-10T14:59:28","modified_gmt":"2020-09-10T12:59:28","slug":"bioenginyera-contra-el-cancer-investigadors-ibec-reben-financament-de-la-caixa","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/bioenginyera-contra-el-cancer-investigadors-ibec-reben-financament-de-la-caixa\/","title":{"rendered":"Bioenginyera contra el c\u00e0ncer: investigadors IBEC reben finan\u00e7ament de La Caixa"},"content":{"rendered":"

\"\"<\/a><\/p>\n

Els pacients amb c\u00e0ncer colorectal tenen bones possibilitats de sobreviure, per\u00f2 si es desenvolupa met\u00e0stasis, les opcions de tractament s\u00f3n limitades i la resposta\u00a0del\u00a0pacient no \u00e9s f\u00e0cil de predir. Per tant, combatre efica\u00e7ment la met\u00e0stasi, responsable d’aproximadament el 90% de les morts per c\u00e0ncer, segueix sent un dels grans desafiaments i esperances en el camp de l’oncologia. La met\u00e0stasi involucra un conjunt d’esdeveniments complexos, amb c\u00e8l\u00b7lules malignes de tumors primaris que envaeixen els teixits circumdants i entren al torrent sanguini per finalment estendre a \u00f2rgans.<\/p>\n

Ara, dos projectes de l’Institut de Bioenginyeria de Catalunya (IBEC) es proposen utilitzar t\u00e8cniques innovadores que permetin desxifrar els mecanismes que promouen la met\u00e0stasi en c\u00e0ncer colorectal, contribuint a possibles solucions que aconsegueixin aturar o alentir aquest proc\u00e9s.<\/p>\n

El projecte PROMISE<\/b>, liderat per la Cap de Grup a l\u2019IBEC i Professora de la Universitat de Barcelona Elena Mart\u00ednez, t\u00e9 per objectiu el desenvolupament d’una nova plataforma que imitar\u00e0 el microambient vascular tumoral de pacients amb c\u00e0ncer colorectal metast\u00e0tic per aix\u00ed, ajudar els metges a trobar el millor enfocament terap\u00e8utic i monitoratge, tamb\u00e9, del curs de la malaltia. Aquesta innovadora plataforma fusionar\u00e0 t\u00e8cniques d’\u00faltima generaci\u00f3 com la bioimpressi\u00f3, els biomaterials i la microflu\u00eddica, per crear aix\u00ed un dispositiu que recrear\u00e0 l’ambient tumoral a partir de les c\u00e8l\u00b7lules canceroses derivades dels mateixos pacients, proporcionant informaci\u00f3 rellevant sobre els mecanismes subjacents de la met\u00e0stasi. Per aconseguir els seus objectius, l’equip d’Elena Mart\u00ednez a l\u2019IBEC comptar\u00e0 amb la col\u00b7laboraci\u00f3 del Laboratori Internacional de Nanotecnologia (INL) i de l’Institut de Recerca Oncol\u00f2gica de la Vall Hebron (VHIO).<\/p>\n

D’altra banda, el projecte Mech4Cancer<\/b>\u00a0dels investigadors Xavier Trepat i Pere Roca-Cusachs, buscar\u00e0 desenvolupar sensors que ajudin a visualitzar com les forces afecten les c\u00e8l\u00b7lules, i promouen la progressi\u00f3 del c\u00e0ncer colorectal. I \u00e9s que quan les c\u00e8l\u00b7lules tumorals envaeixen els \u00f2rgans i produeixen met\u00e0stasi, les forces f\u00edsiques es transmeten fins al nucli cel\u00b7lular, on afecten dr\u00e0sticament l’expressi\u00f3 g\u00e8nica i impulsen la progressi\u00f3 de la malaltia. El problema \u00e9s que els mecanismes subjacents a aquest proc\u00e9s s\u00f3n,\u00a0en gran mesura, desconeguts a causa de la falta d’una tecnologia capa\u00e7 de mesurar fins a quin punt el nucli es veu afectat per aquestes forces mec\u00e0niques.<\/p>\n

\u00c9s per aix\u00f2 que, els investigadors de l’IBEC\u00a0Xavier Trepat, Professor d’Investigaci\u00f3\u00a0ICREA, i Pere Roca-Cusachs, Professor Agregat de la Universitat de Barcelona, \u200b\u200bs’han proposat desenvolupar una nova tecnologia basada en la llum fluorescent emesa per mol\u00e8cules, que permeti arribar a una resoluci\u00f3 a escala cel\u00b7lular. Trepat i Roca-Cusachs, dos referents europeus en el camp de la disciplina coneguda\u00a0com a\u00a0mecanobiologia, que\u00a0se\u00a0centra en l’estudi de com les forces\u00a0afecten\u00a0processos com el c\u00e0ncer, validaran aquesta nova tecnologia en models animals amb c\u00e0ncer colorectal i c\u00e0ncer de mama al costat del seu col\u00b7laborador\u00a0Jacco\u00a0Van\u00a0Rhenen, del\u00a0Netherlands\u00a0Cancer\u00a0Institute\u00a0a Amsterdam. Els investigadors esperen que aquesta nova tecnologia reveli com les forces nuclears defineixen la identitat, el comportament i la destinaci\u00f3 de les c\u00e8l\u00b7lules que impulsen el creixement tumoral, la met\u00e0stasi, aix\u00ed com la resist\u00e8ncia a la ter\u00e0pia.<\/p>\n

Per assolir els seus objectius, els investigadors\u00a0de l’IBEC\u00a0reben finan\u00e7ament de la tercera edici\u00f3 de la convocat\u00f2ria “Health\u00a0Research\u00a0Call” de la Fundaci\u00f3 “La Caixa”.<\/p>\n

\n

M\u00e9s informaci\u00f3 sobre projectes finan\u00e7ats per la convocatoria \u201cHealth Research Call\u201d de la Fundaci\u00f3 \u201cLa Caixa\u201d:<\/b> https:\/\/fundacionlacaixa.org\/es\/proyectos-investigacion-salud-2020<\/a>.<\/p>\n

\u00a0<\/strong><\/p>\n

Not\u00edcies de refer\u00e8ncia sobre els investigadors IBEC:<\/b><\/p>\n

https:\/\/ibecbarcelona.eu\/tres-investigadores-del-ibec-premiados-con-becas-de-la-caixa-por-sus-proyectos-de-investigacion-pionera-y-de-gran-impacto-social\/<\/a><\/p>\n

https:\/\/ibecbarcelona.eu\/five-ibec-researchers-awarded-la-caixa-grants-at-ceremony\/<\/a><\/p>\n

 <\/p>\n

Contacte per a peticions d\u2019entrevistes amb els investigadors:<\/b> alopez@ibecbarcelona.eu<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Els investigadors de l’IBEC Elena Mart\u00ednez, Xavier Trepat i Pere Roca-Cusachs es proposen entendre els processos que promouen la met\u00e0stasi en c\u00e0ncer colorectal utilitzant innovadores eines de bioenginyeria, com la bioimpressi\u00f3 i la microsc\u00f2pia capa\u00e7 de revelar forces a escala cel\u00b7lular. <\/h3>\n

Els resultats es traduiran en un dispositiu que recrear\u00e0 l’ambient tumoral a partir de les c\u00e8l\u00b7lules canceroses derivades dels mateixos pacients, aix\u00ed com una nova tecnologia que permetr\u00e0 visualitzar com les forces f\u00edsiques afecten els nuclis de les c\u00e8l\u00b7lules en met\u00e0stasi. Per aix\u00f2, els investigadors reben finan\u00e7ament de la tercera edici\u00f3 de la convocat\u00f2ria “Health Research Call” de la Fundaci\u00f3 “La Caixa”.<\/p>\n","protected":false},"author":4,"featured_media":77012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[820,1143],"post_formats":[],"class_list":["post-77017","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-elena-martinez-ca","tag-xavier-trepat-ca"],"yoast_head":"\nBioenginyera contra el c\u00e0ncer: investigadors IBEC reben finan\u00e7ament de La Caixa - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/bioenginyera-contra-el-cancer-investigadors-ibec-reben-financament-de-la-caixa\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bioenginyera contra el c\u00e0ncer: investigadors IBEC reben finan\u00e7ament de La Caixa - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Els investigadors de l'IBEC Elena Mart\u00ednez, Xavier Trepat i Pere Roca-Cusachs es proposen entendre els processos que promouen la met\u00e0stasi en c\u00e0ncer colorectal utilitzant innovadores eines de bioenginyeria, com la bioimpressi\u00f3 i la microsc\u00f2pia capa\u00e7 de revelar forces a escala cel\u00b7lular. 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