{"id":77119,"date":"2020-09-09T13:43:10","date_gmt":"2020-09-09T11:43:10","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=77119"},"modified":"2020-09-15T11:54:06","modified_gmt":"2020-09-15T09:54:06","slug":"un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/","title":{"rendered":"Un nou m\u00e8tode podria ajudar a trobar el millor tractament per a un c\u00e0ncer pedi\u00e0tric"},"content":{"rendered":"
\"\"
\u00das de l\u2019inhibidor S63845 per superar la resist\u00e8ncia a la vincristina en c\u00e8l\u00b7lules canceroses de Rabdomiosarcoma<\/figcaption><\/figure>\n

El Rabdomiosarcoma (RMS) \u00e9s un c\u00e0ncer molt maligne que t\u00edpicament es desenvolupa a partir de c\u00e8l\u00b7lules musculars esquel\u00e8tiques i que pot sorgir en diferents parts del cos. \u00c9s m\u00e9s freq\u00fcent en nens i representa el 5% de tots els tumors pedi\u00e0trics. Els tractaments actuals pel RMS inclouen quimioter\u00e0pia, radiaci\u00f3 i cirurgia. No obstant aix\u00f2, les taxes de superviv\u00e8ncia dels pacients d’alt risc no han millorat en les \u00faltimes d\u00e8cades, i els pacients recalcitrants\/amb recaiguda presenten un mal pron\u00f2stic, ja que la seva resposta als tractaments actuals \u00e9s sovint insuficient per evitar el desenvolupament del c\u00e0ncer.<\/p>\n

Ara, els investigadors de l’IBEC Clara Alcon, Albert Manzano, Josep Samitier i Joan Montero, del grup Nanobioenginyeria, juntament amb investigadors dels instituts VHIR, IDIBELL i IRSJD, associats a hospitals, publiquen a Cell Death & Disease<\/em>, una revista del grup editorial Nature, un estudi que troba una nova combinaci\u00f3 seq\u00fcencial de medicaments efectiva per a aquesta malaltia. L’agent quimioterap\u00e8utic vincristine, actualment utilitzat per tractar el RMS, amb el S63845, que mimetitza el BH3, van ser efectius tant in vitro<\/em> com in vivo<\/em> contra el RMS. Aquesta estrat\u00e8gia augmenta l’efic\u00e0cia dels tractaments actuals a la vegada que disminueix la toxicitat indu\u00efda per la ter\u00e0pia.<\/p>\n

La clau d’un tractament efica\u00e7 \u00e9s afavorir la mort per apoptosi en les c\u00e8l\u00b7lules canceroses<\/strong><\/h4>\n

La ter\u00e0pia causa la mort de les c\u00e8l\u00b7lules canceroses principalment per apoptosi, un proc\u00e9s controlat per la fam\u00edlia de prote\u00efnes BCL-2. No obstant aix\u00f2, l’evasi\u00f3 de l’apoptosi \u00e9s una caracter\u00edstica dels c\u00e0ncers humans, i sovint \u00e9s promoguda per un augment de l’expressi\u00f3 de prote\u00efnes antiapopt\u00f2tiques de la fam\u00edlia BCL-2. La cerca de prote\u00efnes antiapopt\u00f2tiques representa un enfocament terap\u00e8utic prometedor per tractar pacients RMS d’alt risc o amb reincid\u00e8ncia. En aquest sentit, una nova classe de ter\u00e0pies que inhibeixen amb precisi\u00f3 les prote\u00efnes antiapop\u00f2tiques BCL-2, les anomenades BH3 mim\u00e8tiques, podrien ser utilitzades per superar la resist\u00e8ncia al tractament. Aquest enfocament t\u00e9 un gran potencial terap\u00e8utic, per\u00f2 el principal repte \u00e9s guiar de manera efectiva l’\u00fas de BH3 mim\u00e8tics a la cl\u00ednica.<\/p>\n

Per resoldre aquest problema, en aquest recent treball els investigadors de l’IBEC han utilitzat perfils BH3 din\u00e0mics (DBP) – un biomarcador predictiu funcional – per identificar adaptacions antiapopt\u00f2tiques en el tractament. Utilitzant aquesta tecnologia, els autors podrien determinar la sensibilitat a la BH3 mim\u00e8tica, i superar la resist\u00e8ncia RMS a la quimioter\u00e0pia. Espec\u00edficament, van trobar que l’inhibidor MCL-1 S63845 millora de forma sin\u00e8rgica l’efecte de la vincristina, un dels medicaments m\u00e9s utilitzats cl\u00ednicament per tractar el RMS tant in vitro<\/em> com in vivo<\/em>.<\/p>\n

Els p\u00e8ptids sint\u00e8tics poden predir quan les c\u00e8l\u00b7lules tumorals deixaran de respondre al tractament<\/strong><\/h4>\n

En aquest treball els investigadors han estudiat l’\u00fas de BH3 mim\u00e8tics per augmentar la sensibilitat del RMS a la quimioter\u00e0pia actual. Van identificar adaptacions antiapopt\u00f2tiques a ter\u00e0pies comunes com la vincristina i la doxorubicina i les van provar en combinaci\u00f3 amb BH3 mim\u00e8tics. Van aconseguir una alta citotoxicitat, al voltant del 80%, disminuint deu vegades la seva concentraci\u00f3,\u00a0 i per tant els seus possibles efectes secundaris a la cl\u00ednica.<\/p>\n

Els autors van trobar tres noves combinacions de f\u00e0rmacs actualment utilitzats per tractar el RMS (que indueixen l’apoptosi) amb inhibidors antiapopt\u00f2tics espec\u00edfics, que van matar c\u00e8l\u00b7lules canceroses sense afectar les sanes. A m\u00e9s, aquestes combinacions quan s’aplicaven de forma seq\u00fcencial actuaven sin\u00e8rgicament, cosa que permetia una reducci\u00f3 de la dosi. Aquest \u00e9s un aspecte clau de l\u2019estudi, ja que els efectes secundaris derivats de l’administraci\u00f3 de quimioter\u00e0pia en nens s\u00f3n greus i poden incloure infertilitat, cardiomiopatia o l’aparici\u00f3 d’altres c\u00e0ncers. Utilitzant aquesta nova metodologia, el temps i la dosi de l’administraci\u00f3 de medicaments es poden optimitzar per a reduir aquests efectes secundaris no desitjats.<\/strong><\/p>\n

 <\/p>\n

\n

Utilitzant la nostra t\u00e8cnica vam ser capa\u00e7os de mesurar l’efectivitat d’un tractament, i el m\u00e9s important, vam poder detectar adaptacions de resist\u00e8ncia en c\u00e8l\u00b7lules tumorals que promouen la superviv\u00e8ncia del c\u00e0ncer.<\/p>\n

 <\/p>\n

Clara Alcon, investigadora de l’IBEC i primera autora de l’estudi.<\/p>\n<\/blockquote>\n

Aquesta estrat\u00e8gia va ser validada in vivo<\/em> en un model xen\u00f2graf derivat d\u2019un pacient amb RMS, on algunes c\u00e8l\u00b7lules del tumor del pacient van ser implantades i ampliades en ratolins. Aquesta t\u00e8cnica proporciona m\u00e9s material per ser utilitzat al laboratori i \u00e9s avantatjosa en la recerca precl\u00ednica, ja que recapitula la resposta terap\u00e8utica dels pacients. Els autors van observar in vitro<\/em> una reducci\u00f3 en el creixement del tumor despr\u00e9s de la combinaci\u00f3 seq\u00fcencial de l’inhibidor de la vincristina i de l’inhibidor MCL-1 S63845 en comparaci\u00f3 amb el tractament amb un sol agent.<\/p>\n

 <\/p>\n

\n

Aquestes troballes, juntament amb els esfor\u00e7os actuals amb els inhibidors de MCL-1, actualment explorats en assaigs cl\u00ednics, demostren la import\u00e0ncia de combinar racionalment agents anticancerosos amb BH3 mim\u00e8tics. Aquestes noves estrat\u00e8gies terap\u00e8utiques podrien millorar el tractament dels pacients RMS a la cl\u00ednica, incloent-hi els que presenten recaigudes, si es guien per un biomarcador funcional predictiu efectiu com ara un perfil de BH3 din\u00e0mic.<\/p>\n

\u00a0Joan Montero, cap del grup Nanobioenginyeria i investigador responsable de l\u2019estudi.<\/p>\n

 <\/p><\/blockquote>\n

Article de refer\u00e8ncia:<\/strong> Clara Alcon, Albert Manzano-Mu\u00f1oz, Estela Prada, Jaume Mora, Aroa Soriano, Gabriela Guill\u00e9n, Soledad Gallego, Josep Roma, Josep Samitier, Alberto Villanueva, Joan Montero. \u00a0Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat Rabdomiosarcoma and avoid resistance.<\/a> Cell Death and Disease (2020) 11:634.<\/p>\n

Aquest treball es va fer en col\u00b7laboraci\u00f3 amb el Laboratori de la Biologia del Desenvolupament del Tumor, Institut de Recerca Sant Joan de D\u00e9u; Departament d’Hematologia i Oncologia, Hospital Sant Joan de D\u00e9u; Grup de Recerca translacional en c\u00e0ncer en la inf\u00e0ncia i l’adolesc\u00e8ncia, Institut de Recerca Vall d’Hebron (VHIR); Departament de Cirurgia, Universitat Aut\u00f2noma de Barcelona (UAB); Departament d’Electr\u00f2nica i Enginyeria Biom\u00e8dica, Universitat de Barcelona; Programa contra la Resist\u00e8ncia Terap\u00e8utica al C\u00e0ncer (ProCURE), IDIBELL, Institut Catal\u00e0 d’Oncologia; Xenopat S.L., Business Bioincubator. El laboratori de Nanobioenginyeria forma part de la xarxa CIBER-BBN.<\/p>\n","protected":false},"excerpt":{"rendered":"

Un estudi dirigit per investigadors a l\u2019IBEC del Grup de Nanobioenginyeria en col\u00b7laboraci\u00f3 amb altres instituts de recerca i hospitals de Barcelona, utilitza un biomarcador predictiu per anticipar l\u2019efecte dels tractaments contra el Rabdomiosarcoma, el c\u00e0ncer de teixit tou m\u00e9s com\u00fa que afecta la inf\u00e0ncia i l’adolesc\u00e8ncia.<\/h3>\n

Aquest avan\u00e7 pot ajudar a predir l’efici\u00e8ncia del tractament, evitant la resist\u00e8ncia tumoral, i reduint els efectes secundaris no desitjats.<\/p>\n","protected":false},"author":4,"featured_media":77123,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[745,1136,1234,1237],"post_formats":[],"class_list":["post-77119","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-joan-montero-ca","tag-josep-samitier-ca","tag-rabdomiosarcoma","tag-tractament"],"yoast_head":"\nUn nou m\u00e8tode podria ajudar a trobar el millor tractament per a un c\u00e0ncer pedi\u00e0tric - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un nou m\u00e8tode podria ajudar a trobar el millor tractament per a un c\u00e0ncer pedi\u00e0tric - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudi dirigit per investigadors a l\u2019IBEC del Grup de Nanobioenginyeria en col\u00b7laboraci\u00f3 amb altres instituts de recerca i hospitals de Barcelona, utilitza un biomarcador predictiu per anticipar l\u2019efecte dels tractaments contra el Rabdomiosarcoma, el c\u00e0ncer de teixit tou m\u00e9s com\u00fa que afecta la inf\u00e0ncia i l'adolesc\u00e8ncia. Aquest avan\u00e7 pot ajudar a predir l'efici\u00e8ncia del tractament, evitant la resist\u00e8ncia tumoral, i reduint els efectes secundaris no desitjats.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2020-09-09T11:43:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-09-15T09:54:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-e1599651357776.png\" \/>\n\t<meta property=\"og:image:width\" content=\"950\" \/>\n\t<meta property=\"og:image:height\" content=\"585\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Un nou m\u00e8tode podria ajudar a trobar el millor tractament per a un c\u00e0ncer pedi\u00e0tric\",\"datePublished\":\"2020-09-09T11:43:10+00:00\",\"dateModified\":\"2020-09-15T09:54:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\\\/\"},\"wordCount\":1113,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/09\\\/imagen-e1599651357776.png\",\"keywords\":[\"Joan Montero\",\"Josep Samitier\",\"rabdomiosarcoma\",\"tractament\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\\\/\",\"name\":\"Un nou m\u00e8tode podria ajudar a trobar el millor tractament per a un c\u00e0ncer pedi\u00e0tric - Institute for Bioengineering of Catalonia\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/09\\\/imagen-e1599651357776.png\",\"datePublished\":\"2020-09-09T11:43:10+00:00\",\"dateModified\":\"2020-09-15T09:54:06+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\\\/#breadcrumb\"},\"inLanguage\":\"ca\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\\\/#primaryimage\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/09\\\/imagen-e1599651357776.png\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/09\\\/imagen-e1599651357776.png\",\"width\":950,\"height\":585},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Un nou m\u00e8tode podria ajudar a trobar el millor tractament per a un c\u00e0ncer pedi\u00e0tric\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"name\":\"Institute for Bioengineering of Catalonia\",\"description\":\"Bioengineering Solutions for Health\",\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ibecbarcelona.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ca\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\",\"name\":\"Institute for Bioengineering of Catalonia\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"width\":696,\"height\":257,\"caption\":\"Institute for Bioengineering of Catalonia\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\",\"name\":\"\u00c0ngels L\u00f3pez\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"caption\":\"\u00c0ngels L\u00f3pez\"},\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/author\\\/alopez\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Un nou m\u00e8tode podria ajudar a trobar el millor tractament per a un c\u00e0ncer pedi\u00e0tric - Institute for Bioengineering of Catalonia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/","og_locale":"ca_ES","og_type":"article","og_title":"Un nou m\u00e8tode podria ajudar a trobar el millor tractament per a un c\u00e0ncer pedi\u00e0tric - Institute for Bioengineering of Catalonia","og_description":"Un estudi dirigit per investigadors a l\u2019IBEC del Grup de Nanobioenginyeria en col\u00b7laboraci\u00f3 amb altres instituts de recerca i hospitals de Barcelona, utilitza un biomarcador predictiu per anticipar l\u2019efecte dels tractaments contra el Rabdomiosarcoma, el c\u00e0ncer de teixit tou m\u00e9s com\u00fa que afecta la inf\u00e0ncia i l'adolesc\u00e8ncia. Aquest avan\u00e7 pot ajudar a predir l'efici\u00e8ncia del tractament, evitant la resist\u00e8ncia tumoral, i reduint els efectes secundaris no desitjats.","og_url":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/","og_site_name":"Institute for Bioengineering of Catalonia","article_published_time":"2020-09-09T11:43:10+00:00","article_modified_time":"2020-09-15T09:54:06+00:00","og_image":[{"width":950,"height":585,"url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-e1599651357776.png","type":"image\/png"}],"author":"\u00c0ngels L\u00f3pez","twitter_card":"summary_large_image","twitter_misc":{"Escrit per":"\u00c0ngels L\u00f3pez","Temps estimat de lectura":"5 minuts"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/#article","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/"},"author":{"name":"\u00c0ngels L\u00f3pez","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/c212c6b589546130be67986b9290e2b8"},"headline":"Un nou m\u00e8tode podria ajudar a trobar el millor tractament per a un c\u00e0ncer pedi\u00e0tric","datePublished":"2020-09-09T11:43:10+00:00","dateModified":"2020-09-15T09:54:06+00:00","mainEntityOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/"},"wordCount":1113,"publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-e1599651357776.png","keywords":["Joan Montero","Josep Samitier","rabdomiosarcoma","tractament"],"articleSection":["Not\u00edcies de recerca"],"inLanguage":"ca"},{"@type":"WebPage","@id":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/","url":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/","name":"Un nou m\u00e8tode podria ajudar a trobar el millor tractament per a un c\u00e0ncer pedi\u00e0tric - Institute for Bioengineering of Catalonia","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/#primaryimage"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-e1599651357776.png","datePublished":"2020-09-09T11:43:10+00:00","dateModified":"2020-09-15T09:54:06+00:00","breadcrumb":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/#breadcrumb"},"inLanguage":"ca","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/"]}]},{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/#primaryimage","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-e1599651357776.png","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-e1599651357776.png","width":950,"height":585},{"@type":"BreadcrumbList","@id":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-metode-podria-ajudar-a-trobar-el-millor-tractament-per-a-un-cancer-pediatric\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ibecbarcelona.eu\/ca\/"},{"@type":"ListItem","position":2,"name":"Un nou m\u00e8tode podria ajudar a trobar el millor tractament per a un c\u00e0ncer pedi\u00e0tric"}]},{"@type":"WebSite","@id":"https:\/\/ibecbarcelona.eu\/#website","url":"https:\/\/ibecbarcelona.eu\/","name":"Institute for Bioengineering of Catalonia","description":"Bioengineering Solutions for Health","publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibecbarcelona.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ca"},{"@type":"Organization","@id":"https:\/\/ibecbarcelona.eu\/#organization","name":"Institute for Bioengineering of Catalonia","url":"https:\/\/ibecbarcelona.eu\/","logo":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","width":696,"height":257,"caption":"Institute for Bioengineering of Catalonia"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/c212c6b589546130be67986b9290e2b8","name":"\u00c0ngels L\u00f3pez","image":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","caption":"\u00c0ngels L\u00f3pez"},"url":"https:\/\/ibecbarcelona.eu\/ca\/author\/alopez\/"}]}},"AFP_featured_media_urls":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-e1599651357776.png",950,585,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-e1599651357776-150x150.png",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-e1599651357776-300x185.png",300,185,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-e1599651357776-768x473.png",768,473,true],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-e1599651357776.png",950,585,false]},"AFP_attachments":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen.jpg",960,720,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-150x150.jpg",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-300x225.jpg",300,225,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen-768x576.jpg",768,576,true],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/imagen.jpg",960,720,false]},"AFP_videos":[],"AFP_video_blocks":"","AFP_category_names":["Not\u00edcies de recerca"],"_links":{"self":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/77119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/comments?post=77119"}],"version-history":[{"count":22,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/77119\/revisions"}],"predecessor-version":[{"id":77268,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/77119\/revisions\/77268"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media\/77123"}],"wp:attachment":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media?parent=77119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/categories?post=77119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tags?post=77119"},{"taxonomy":"post_format","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/post_formats?post=77119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}