{"id":77610,"date":"2020-09-25T12:45:02","date_gmt":"2020-09-25T10:45:02","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=77610"},"modified":"2020-09-29T11:30:47","modified_gmt":"2020-09-29T09:30:47","slug":"selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/","title":{"rendered":"Selectivitat de rang: un nou concepte per administrar de manera eficient f\u00e0rmacs mitjan\u00e7ant nanopart\u00edcules."},"content":{"rendered":"

La troballa podria aplanar el cam\u00ed per al desenvolupament de ter\u00e0pies altament dirigides contra una s\u00e8rie de malalties. Aquest treball, un gran avan\u00e7 en la bioenginyeria molecular, va ser dirigit per Stefano Angioletti-Uberti de l’Imperial College de Londres i per l\u2019investigador Giuseppe Battaglia de l’Institut de Bioenginyeria de Catalunya (IBEC).<\/p>\n

\"\"
Representaci\u00f3 esquem\u00e0tica del sistema. Una nanopart\u00edcula recoberta de lligands (lligams verds i esferes taronges) interactua amb una superf\u00edcie recoberta de receptors (embuts verds).<\/figcaption><\/figure>\n

Una \u00e0rea de creixent inter\u00e8s en la bioenginyeria se centra en com la uni\u00f3 molecular observada en la naturalesa pot imitar-se sint\u00e8ticament per ajudar a l’administraci\u00f3 de f\u00e0rmacs. Si pogu\u00e9ssim crear un portador de medicaments que s’un\u00eds espec\u00edficament a les c\u00e8l\u00b7lules malaltes i als pat\u00f2gens sense danyar les c\u00e8l\u00b7lules sanes, podr\u00edem desenvolupar ter\u00e0pies altament dirigides amb molts menys efectes secundaris. Ara, gr\u00e0cies a un nou estudi amb coautoria del Professor d’Investigaci\u00f3 ICREA i l\u00edder del Grup de Bi\u00f2nica Molecular de l’IBEC Giuseppe Battaglia, estem\u00a0un pas m\u00e9s a prop d’assolir aquest objectiu. En aquest important treball, publicat recentment a la prestigiosa revista cient\u00edfica Nature Communications, els autors descriuen com van aconseguir el que anomenen “selectivitat de rang” en la uni\u00f3 biomolecular sint\u00e8tica. Investigadors de deu centres van contribuir en aquest estudi, inclosa la Universitat de Tecnologia Qu\u00edmica de Beijing i l’Imperial College de Londres.<\/p>\n

 <\/p>\n

 <\/p>\n

Imitant la natura<\/strong><\/h4>\n

La uni\u00f3 lligand-receptor \u00e9s el proc\u00e9s mitjan\u00e7ant el qual les c\u00e8l\u00b7lules reben senyals de l’entorn extern. Moltes biomol\u00e8cules s\u00f3n multivalents, el que significa que m\u00faltiples lligands en una mol\u00e8cula s’uneixen a m\u00faltiples receptors en una altra, simult\u00e0niament. Com a resultat, aquestes mol\u00e8cules s’uneixen amb exquisida selectivitat. Imitar aix\u00f2 amb \u00e8xit obriria un seguit de noves possibilitats en biomedicina, com el desenvolupament de portadors de f\u00e0rmacs de mida nanom\u00e8trica que nom\u00e9s alliberen la seva c\u00e0rrega terap\u00e8utica quan s’adhereixen a c\u00e8l\u00b7lules malaltes espec\u00edfiques. No obstant aix\u00f2, tal precisi\u00f3 selectiva continua sent un objectiu encara per complir en bioenginyeria.<\/p>\n

Ara, en aquesta nova publicaci\u00f3, els investigadors descriuen com construir nanopart\u00edcules que nom\u00e9s s’uneixen als receptors quan la densitat del receptor est\u00e0 dins d’un rang prec\u00eds, per\u00f2 no per sota ni per sobre, un fenomen que anomenen “selectivitat de rang”.<\/strong> Assenyalen que aix\u00f2 passa a causa d’un equilibri de forces atractives i repulsives a escala molecular. Passat un cert llindar, les forces repulsives superen les forces atractives, per la qual cosa \u00e9s molt menys probable que es produeixi la uni\u00f3.<\/p>\n

Utilitzant models mec\u00e0nics estad\u00edstics, van demostrar que certs par\u00e0metres podrien explotar-se per ajustar el l\u00edmit superior i inferior de la franja de selectivitat. Aix\u00ed, aquest estudi ens acosta un pas m\u00e9s cap a la creaci\u00f3 de nanopart\u00edcules sint\u00e8tiques que s’uneixin exclusivament als receptors diana.<\/p>\n

A m\u00e9s, ofereix una visi\u00f3 important que podria canviar la forma en qu\u00e8 es realitzaran els estudis futurs en aquest camp: augmentar el nombre de receptors no necess\u00e0riament augmenta la probabilitat d’uni\u00f3 i, de fet, pot provocar que disminueixi significativament.<\/p>\n

Cap a l’administraci\u00f3 dirigida de medicaments\u00a0<\/strong><\/h4>\n

Aquest treball no nom\u00e9s aplana el cam\u00ed per a una administraci\u00f3 de f\u00e0rmacs m\u00e9s dirigida\u00a0i\u00a0amb menys efectes secundaris, sin\u00f3 que tamb\u00e9 ofereix pistes que podrien explicar per qu\u00e8 els tumors evadeixen l’atac del sistema immunol\u00f2gic.\u00a0Les c\u00e8l\u00b7lules canceroses generalment sobre expressen receptors, que, per tant, s\u00f3n presents en una densitat molt alta en la seva superf\u00edcie, potencialment fora de la franja d’uni\u00f3 de les c\u00e8l\u00b7lules immunes.<\/p>\n

Els autors conclouen que s’han de realitzar m\u00e9s investigacions per comprendre millor com es poden explotar els diferents par\u00e0metres per ajustar la selectivitat de la franja i construir portadors de medicaments altament efectius.<\/p>\n

\n

Aquest important estudi ens acosta un pas m\u00e9s a assolir una precisi\u00f3 d’objectiu fins a la poblaci\u00f3 unicel\u00b7lular o fins i tot personalitzada per al pacient individual.<\/strong><\/p>\n

Beppe\u00a0Battaglia\u00a0<\/strong><\/p>\n<\/blockquote>\n

Article de refer\u00e8ncia:\u00a0<\/strong><\/p>\n

Meng\u00a0Liu,\u00a0Azzurra\u00a0Apriceno, Miguel Sipin,\u00a0Edoardo\u00a0Scarpa, Laura\u00a0Rodriguez-Arco, Alessandro Poma,\u00a0Gabriele\u00a0Marchello, Giuseppe\u00a0Battaglia,\u00a0and\u00a0Stefano\u00a0Angioletti-Uberti.\u00a0\u201cCombinatorial\u00a0entropy\u00a0behaviour\u00a0leads\u00a0to\u00a0range\u00a0selective\u00a0binding\u00a0in\u00a0ligand-receptor\u00a0interactions.\u201d<\/a>\u00a0Nature\u00a0Communications,\u00a011,\u00a04836 (2020).<\/p>\n","protected":false},"excerpt":{"rendered":"

En un nou estudi publicat a la revista cient\u00edfica Nature Communications, investigadors descriuen un nou concepte anomenat “selectivitat de rang”.<\/h3>\n

Explica per qu\u00e8 les nanopart\u00edcules biomim\u00e8tiques nom\u00e9s s’uneixen als receptors quan la seva densitat est\u00e0 dins d’un rang prec\u00eds.<\/p>\n","protected":false},"author":4,"featured_media":77562,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1104],"post_formats":[],"class_list":["post-77610","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-giuseppe-battaglia-ca"],"yoast_head":"\nSelectivitat de rang: un nou concepte per administrar de manera eficient f\u00e0rmacs mitjan\u00e7ant nanopart\u00edcules. - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Selectivitat de rang: un nou concepte per administrar de manera eficient f\u00e0rmacs mitjan\u00e7ant nanopart\u00edcules. - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"En un nou estudi publicat a la revista cient\u00edfica Nature Communications, investigadors descriuen un nou concepte anomenat "selectivitat de rang".Explica per qu\u00e8 les nanopart\u00edcules biomim\u00e8tiques nom\u00e9s s'uneixen als receptors quan la seva densitat est\u00e0 dins d'un rang prec\u00eds.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2020-09-25T10:45:02+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-09-29T09:30:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-e1601369377648.png\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"545\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Selectivitat de rang: un nou concepte per administrar de manera eficient f\u00e0rmacs mitjan\u00e7ant nanopart\u00edcules.\",\"datePublished\":\"2020-09-25T10:45:02+00:00\",\"dateModified\":\"2020-09-29T09:30:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\\\/\"},\"wordCount\":749,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/09\\\/Imagen_Nature-Comm-e1601369377648.png\",\"keywords\":[\"Giuseppe Battaglia\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\\\/\",\"name\":\"Selectivitat de rang: un nou concepte per administrar de manera eficient f\u00e0rmacs mitjan\u00e7ant nanopart\u00edcules. - Institute for Bioengineering of Catalonia\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/09\\\/Imagen_Nature-Comm-e1601369377648.png\",\"datePublished\":\"2020-09-25T10:45:02+00:00\",\"dateModified\":\"2020-09-29T09:30:47+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\\\/#breadcrumb\"},\"inLanguage\":\"ca\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\\\/#primaryimage\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/09\\\/Imagen_Nature-Comm-e1601369377648.png\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/09\\\/Imagen_Nature-Comm-e1601369377648.png\",\"width\":500,\"height\":545},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Selectivitat de rang: un nou concepte per administrar de manera eficient f\u00e0rmacs mitjan\u00e7ant nanopart\u00edcules.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"name\":\"Institute for Bioengineering of Catalonia\",\"description\":\"Bioengineering Solutions for Health\",\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ibecbarcelona.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ca\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\",\"name\":\"Institute for Bioengineering of Catalonia\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"width\":696,\"height\":257,\"caption\":\"Institute for Bioengineering of Catalonia\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\",\"name\":\"\u00c0ngels L\u00f3pez\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"caption\":\"\u00c0ngels L\u00f3pez\"},\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/author\\\/alopez\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Selectivitat de rang: un nou concepte per administrar de manera eficient f\u00e0rmacs mitjan\u00e7ant nanopart\u00edcules. - Institute for Bioengineering of Catalonia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/","og_locale":"ca_ES","og_type":"article","og_title":"Selectivitat de rang: un nou concepte per administrar de manera eficient f\u00e0rmacs mitjan\u00e7ant nanopart\u00edcules. - Institute for Bioengineering of Catalonia","og_description":"En un nou estudi publicat a la revista cient\u00edfica Nature Communications, investigadors descriuen un nou concepte anomenat \"selectivitat de rang\".Explica per qu\u00e8 les nanopart\u00edcules biomim\u00e8tiques nom\u00e9s s'uneixen als receptors quan la seva densitat est\u00e0 dins d'un rang prec\u00eds.","og_url":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/","og_site_name":"Institute for Bioengineering of Catalonia","article_published_time":"2020-09-25T10:45:02+00:00","article_modified_time":"2020-09-29T09:30:47+00:00","og_image":[{"width":500,"height":545,"url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-e1601369377648.png","type":"image\/png"}],"author":"\u00c0ngels L\u00f3pez","twitter_card":"summary_large_image","twitter_misc":{"Escrit per":"\u00c0ngels L\u00f3pez","Temps estimat de lectura":"4 minuts"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/#article","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/"},"author":{"name":"\u00c0ngels L\u00f3pez","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/c212c6b589546130be67986b9290e2b8"},"headline":"Selectivitat de rang: un nou concepte per administrar de manera eficient f\u00e0rmacs mitjan\u00e7ant nanopart\u00edcules.","datePublished":"2020-09-25T10:45:02+00:00","dateModified":"2020-09-29T09:30:47+00:00","mainEntityOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/"},"wordCount":749,"publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-e1601369377648.png","keywords":["Giuseppe Battaglia"],"articleSection":["Not\u00edcies de recerca"],"inLanguage":"ca"},{"@type":"WebPage","@id":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/","url":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/","name":"Selectivitat de rang: un nou concepte per administrar de manera eficient f\u00e0rmacs mitjan\u00e7ant nanopart\u00edcules. - Institute for Bioengineering of Catalonia","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/#primaryimage"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-e1601369377648.png","datePublished":"2020-09-25T10:45:02+00:00","dateModified":"2020-09-29T09:30:47+00:00","breadcrumb":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/#breadcrumb"},"inLanguage":"ca","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/"]}]},{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/#primaryimage","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-e1601369377648.png","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-e1601369377648.png","width":500,"height":545},{"@type":"BreadcrumbList","@id":"https:\/\/ibecbarcelona.eu\/ca\/selectivitat-de-rang-un-nou-concepte-per-administrar-de-manera-eficient-farmacs-mitjancant-nanoparticules\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ibecbarcelona.eu\/ca\/"},{"@type":"ListItem","position":2,"name":"Selectivitat de rang: un nou concepte per administrar de manera eficient f\u00e0rmacs mitjan\u00e7ant nanopart\u00edcules."}]},{"@type":"WebSite","@id":"https:\/\/ibecbarcelona.eu\/#website","url":"https:\/\/ibecbarcelona.eu\/","name":"Institute for Bioengineering of Catalonia","description":"Bioengineering Solutions for Health","publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibecbarcelona.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ca"},{"@type":"Organization","@id":"https:\/\/ibecbarcelona.eu\/#organization","name":"Institute for Bioengineering of Catalonia","url":"https:\/\/ibecbarcelona.eu\/","logo":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","width":696,"height":257,"caption":"Institute for Bioengineering of Catalonia"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/c212c6b589546130be67986b9290e2b8","name":"\u00c0ngels L\u00f3pez","image":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","caption":"\u00c0ngels L\u00f3pez"},"url":"https:\/\/ibecbarcelona.eu\/ca\/author\/alopez\/"}]}},"AFP_featured_media_urls":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-e1601369377648.png",500,545,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-150x150.png",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-275x300.png",275,300,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-e1601369377648.png",500,545,false],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-e1601369377648.png",500,545,false]},"AFP_attachments":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-e1601369377648.png",500,545,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-150x150.png",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-275x300.png",275,300,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-e1601369377648.png",500,545,false],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/09\/Imagen_Nature-Comm-e1601369377648.png",500,545,false]},"AFP_videos":[],"AFP_video_blocks":"","AFP_category_names":["Not\u00edcies de recerca"],"_links":{"self":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/77610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/comments?post=77610"}],"version-history":[{"count":16,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/77610\/revisions"}],"predecessor-version":[{"id":77640,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/77610\/revisions\/77640"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media\/77562"}],"wp:attachment":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media?parent=77610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/categories?post=77610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tags?post=77610"},{"taxonomy":"post_format","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/post_formats?post=77610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}