{"id":78343,"date":"2020-10-16T13:06:52","date_gmt":"2020-10-16T11:06:52","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=78343"},"modified":"2020-10-26T20:50:57","modified_gmt":"2020-10-26T19:50:57","slug":"les-cel%c2%b7lules-poden-detectar-la-quantitat-despai-disponible-i-prendre-decisions-a-mida-utilitzant-el-seu-nucli","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/les-cel%c2%b7lules-poden-detectar-la-quantitat-despai-disponible-i-prendre-decisions-a-mida-utilitzant-el-seu-nucli\/","title":{"rendered":"Les c\u00e8l\u00b7lules poden detectar la quantitat d\u2019espai disponible i prendre decisions a mida utilitzant el seu nucli"},"content":{"rendered":"

\"\"Les c\u00e8l\u00b7lules que conformen els nostres \u00f2rgans i teixits s\u00f3n capaces de respondre a canvis de densitat cel\u00b7lular i espai en el seu entorn. Un dels exemples m\u00e9s rellevants el representen les c\u00e8l\u00b7lules del sistema immune, que poden escollir el pas de menor resist\u00e8ncia durant la seva migraci\u00f3, a trav\u00e9s del nostre organisme, per combatre infeccions. Existeixen multitut d\u2019exemples com aquest en el nostre cos que es donen tant en home\u00f2stasi com en processos cancerosos i del desenvolupament.<\/p>\n

No obstant aix\u00f2, la manera en qu\u00e8 aquestes i altres c\u00e8l\u00b7lules “mesuren” el seu entorn i responen en conseq\u00fc\u00e8ncia no es coneixia del tot. En un estudi publicat avui a la revista Science<\/a>, un grup internacional d’investigadors del Regne Unit, Alemanya, \u00c0ustria, Fran\u00e7a, EUA i Espanya, liderats pel King College de Londres, mostra que diferents tipus cel\u00b7lulars poden utilitzar el nucli cel\u00b7lular \u2013 l\u2019org\u00e0nul m\u00e9s r\u00edgid i volumin\u00f3s de la c\u00e8l\u00b7lula- per mesurar el nivell de confinament a qu\u00e8 estan sotmeses. Marc Molina, actual investigador de l’IBEC a Barcelona, \u200b\u200b\u00e9s coautor d’aquest article, per les seves aportacions a aquest durant el treball realitzat al laboratori iBCTM liderat pel Dr. Alexis J. Lomakin, al King\u00b4s College de Londres. Un altre estudi<\/a> publicat a la mateixa revista, amb participaci\u00f3 d’investigadors del CRG i de l’ICFO demostra, simult\u00e0niament, el mateix principi.<\/p>\n

\"\"Contribuir en un projecte aix\u00ed de gran, veure com totes les peces van encaixant i que finalment el teu treball es publica \u00e9s una sensaci\u00f3 indescriptible.<\/strong><\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

Marc Molina<\/strong><\/p>\n<\/blockquote>\n

 <\/p>\n

Utilitzant diverses t\u00e8cniques, que van des de pressionar diferents parts de les c\u00e8l\u00b7lules fins a fer circular per canals de diferent di\u00e0metre, els investigadors mostren que el nucli \u00e9s capa\u00e7 de produir una resposta cel\u00b7lular sota pressi\u00f3. En particular, quan les c\u00e8l\u00b7lules experimenten la deformaci\u00f3 del seu nucli per sobre d’un cert nivell, responen activant el seu citoesquelet generant for\u00e7a per contrarestar la compressi\u00f3. El paper del nucli en aquest proc\u00e9s \u00e9s imprescindible, ja que, en la seva abs\u00e8ncia les c\u00e8l\u00b7lules s\u00f3n incapaces d\u00b4engegar aquesta resposta. A m\u00e9s, les propietats mec\u00e0niques d’aquest org\u00e0nul s\u00f3n les que dicten a quin r\u00e8gim de confinament es desencadena el mecanisme.<\/p>\n

\"\"<\/a><\/p>\n

Una c\u00e8l\u00b7lula humana cancerosa travessa un estret pas. Font: Alexis Lomakin, Cancer Research Center Vienna.<\/h5>\n

 <\/p>\n

Aquests resultats s\u00f3n d’especial inter\u00e8s per a l’estudi de la migraci\u00f3 cel\u00b7lular tant en teixit sa com cancer\u00f3s. Aix\u00f2 \u00e9s degut al fet que dona resposta a per qu\u00e8 diferents tipus cel\u00b7lulars tenen major o menor susceptibilitat a diferents graus de confinament i el relaciona amb les caracter\u00edstiques mec\u00e0niques del nucli. D’aquesta manera \u00e9s possible comprendre com c\u00e8l\u00b7lules altament migrat\u00f2ries, com poden ser les del sistema immune, o altres metast\u00e0tiques, s\u00f3n capaces de despla\u00e7ar-se amb m\u00e9s facilitat i per espais m\u00e9s estrets que altres tipus cel\u00b7lulars.<\/p>\n

Aquest estudi atribueix un paper pr\u00e8viament desconegut al nucli cel\u00b7lular i descriu un nou mecanisme amb el qual les c\u00e8l\u00b7lules poden relacionar-se amb el seu entorn. Segons els investigadors, el seg\u00fcent pas ser\u00e0 esbrinar en detall quines prote\u00efnes del nucli estan a c\u00e0rrec d’aquest proc\u00e9s i aprofundir en els estadis immediatament posteriors a l’activaci\u00f3 d’aquest mecanisme.<\/p>\n

Article de refer\u00e8ncia: <\/strong>A. J. Lomakin, C. J. Cattin, D. Cuvelier, Z. Alraies, M. Molina, G. P. F. Nader, N. Srivastava, P. J. Saez, J. M. Garcia-Arcos, I.Y. Zhitnyak, A. Bhargava, M. K. Driscoll, E. S.Welf, R. Fiolka, R. J. Petrie, N. S. De Silva, J. M. Gonz\u00e1lez-Granado, N. Manel, A. M. Lennon-Dum\u00e9nil, D. J. M\u00fcller, M. Piel.\u00a0The nucleus acts as a ruler tailoring cell responses to spatial constraints<\/a><\/em>. Science, 2020.<\/p>\n","protected":false},"excerpt":{"rendered":"

Dos estudis publicats avui a la revista Science mostren que diferents tipus cel\u00b7lulars poden utilitzar el seu nucli \u2013 l\u2019org\u00e0nul m\u00e9s r\u00edgid i volumin\u00f3s de la c\u00e8l\u00b7lula \u2013 per mesurar el nivell de confinament al qual estan sotmeses. Aquests resultats s\u00f3n d\u2019especial inter\u00e8s per a l\u2019estudi de la migraci\u00f3 cel\u00b7lular, tant en teixit sa com cancer\u00f3s. Marc Molina, actual investigador de l\u2019IBEC, contribueix a un dels articles en Science pel seu treball realitzat durant la seva posici\u00f3 anterior al King\u2019s College de Londres.<\/h3>\n","protected":false},"author":4,"featured_media":78274,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1293],"post_formats":[],"class_list":["post-78343","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-marc-molina-ca"],"yoast_head":"\nLes c\u00e8l\u00b7lules poden detectar la quantitat d\u2019espai disponible i prendre decisions a mida utilitzant el seu nucli - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/cells-can-detect-the-amount-of-space-available-and-take-decisions-using-their-nuclei\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les c\u00e8l\u00b7lules poden detectar la quantitat d\u2019espai disponible i prendre decisions a mida utilitzant el seu nucli - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Dos estudis publicats avui a la revista Science mostren que diferents tipus cel\u00b7lulars poden utilitzar el seu nucli \u2013 l\u2019org\u00e0nul m\u00e9s r\u00edgid i volumin\u00f3s de la c\u00e8l\u00b7lula \u2013 per mesurar el nivell de confinament al qual estan sotmeses. 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