{"id":7985,"date":"2014-01-13T09:28:32","date_gmt":"2014-01-13T09:28:32","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/una-dosis-doble-dexit-del-european-research-council-per-a-un-investigador-de-linstitut-de-bioenginyeria-de-catalunya\/"},"modified":"2015-01-07T15:26:59","modified_gmt":"2015-01-07T15:26:59","slug":"una-dosis-doble-dexit-del-european-research-council-per-a-un-investigador-de-linstitut-de-bioenginyeria-de-catalunya","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/una-dosis-doble-dexit-del-european-research-council-per-a-un-investigador-de-linstitut-de-bioenginyeria-de-catalunya\/","title":{"rendered":"Doble dosi d\u2019\u00e8xit del European Research Council per a un investigador de l&#8217;Institut de Bioenginyeria de Catalunya"},"content":{"rendered":"<\/h3>\n<p>El projecte \u201cControl de tensi\u00f3: Regulaci\u00f3 a multiescala de la tensi\u00f3 epitelial\u201d d\u2019en Xavier Trepat, investigador del l&#8217;IBEC, rebr\u00e0 1,98 milions d\u2019Euros al llarg de cinc anys gr\u00e0cies al premi Consolidator Grant (destinat a investigadors amb talent i potencial acreditat) i que es va convocar per primera vegada el 2013. Aquest premi constitueix un tercer bra\u00e7 de finan\u00e7ament b\u00e0sic d\u2019aquest organisme i que es suma als altres dos, el Starting Grant i el Advanced Grant (ajudes a joves investigadors amb carrera cient\u00edfica prometedora i a projectes pioners d&#8217;alt risc, respectivament). Les subvencions del ERC es consideren el guard\u00f3 a la recerca m\u00e9s prestigi\u00f3s d\u2019Europa.<\/p>\n<p>L\u2019objectiu del projecte de Xavier Trepat \u00e9s proporcionar mesures i models a multiescala de la regulaci\u00f3 de la tensi\u00f3 mec\u00e0nica en monocapes cel\u2022lulars epitelials. L\u2019objectiu final \u00e9s aprofundir el nostre coneixement de la interacci\u00f3 entre est\u00edmuls qu\u00edmics i f\u00edsics durant el creixement i la remodelaci\u00f3 dels teixits vius. \u201cEntre aquests est\u00edmuls, la tensi\u00f3 mec\u00e0nica emergeix com un regulador central del dest\u00ed i de la funci\u00f3 cel\u2022lular\u201d, diu en Xavier trepat, qui tamb\u00e9 \u00e9s professor i investigador de la Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA). \u201cEstudiarem dos mecanismes concurrents a microescala per regular la tensi\u00f3 mec\u00e0nica \u2013 flu\u00efditzaci\u00f3 vs. refor\u00e7 i divisi\u00f3 cel\u2022lular vs. apoptosi \u2013 i analitzarem com els processos i les interaccions locals donen lloc a patrons globals de tensi\u00f3.\u201d<\/p>\n<p>Per a aix\u00f2, els investigadors han desenvolupat un muntatge experimental per mesurar i pertorbar la tensi\u00f3 de les monocapes a diferents escales de longitud. Utilitzen t\u00e8cniques com per exemple la microsc\u00f2pia d\u2019estr\u00e8s en monocapa, que van desenvolupar i patentar el 2011 en col\u2022laboraci\u00f3 amb investigadors de Harvard. El grup de Trepat espera que aquest muntatge desvetlli el repertori complert de mecanismes que utilitzen els teixits epitelials per a regular la tensi\u00f3 i la din\u00e0mica i, d&#8217;aquesta manera, aclarir els processos subjacents del creixement tissular en regeneraci\u00f3 i c\u00e0ncer.<\/p>\n<p>El grup d\u2019en Xavier Trepat rebr\u00e0 tamb\u00e9 149 mil Euros del ERC per al seu projecte \u201cGels de poliacrilamida amb micro-gradients per a l\u2019an\u00e0lisi d\u2019electroforesi d\u2019alt rendiment (MICROGRADIENTPAGE)\u201d sota l\u2019estrat\u00e8gia de finan\u00e7ament complementari del 2013 Proof of Concept. Aquest projecte proposa un m\u00e8tode millorat per a la preparaci\u00f3 de gels d\u2019electroforesi en miniatura, que s\u00f3n \u00e0mpliament emprats en la recerca en ci\u00e8ncies de la vida. Aquesta nova tecnologia, si es converteix en una eina com\u00fa per a la quantificaci\u00f3 de prote\u00efnes amb alt rendiment, pot generar ingressos considerables en el mercat de la recerca farmac\u00e8utica, cl\u00ednica o de recerca b\u00e0sica aix\u00ed com en la medicina personalitzada.<\/p>\n<p>\u201cAquest projecte \u00e9s el resultat de l&#8217;esfor\u00e7 d\u2019equip de dos membres del meu propi grup, d&#8217;en Raimon Sunyer i en Xavier Serra, aix\u00ed com dels serveis de suport de l\u2019IBEC\u201d, diu en Xavier Trepat, qui a m\u00e9s d\u2019aquestes dues subvencions ja contava amb un Starting Grant del ERC, el que fa d\u2019ell un dels pocs i m\u00e9s joves investigadors a Europa en rebre tres ajudes consecutives d\u2019aquest prestigi\u00f3s organisme independent de finan\u00e7ament.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-7981 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/01\/trepat.jpg\" border=\"0\" width=\"400\" height=\"318\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/01\/trepat.jpg 400w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/01\/trepat-300x238.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/01\/trepat-188x150.jpg 188w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/01\/trepat-150x119.jpg 150w\" data-sizes=\"(max-width: 400px) 100vw, 400px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/318;\" \/> El grup de &#8220;Din\u00e0mica integrativa de c\u00e8l\u2022lules i teixits&#8221; de l&#8217;Institut de Bioenginyeria de Catalunya (IBEC) ha comen\u00e7at l\u2019any amb molt bones not\u00edcies del European Research Council (ERC); li han atorgat dos premis, el Consolidator Grant i el Proof of Concept.     <\/p>\n","protected":false},"author":4,"featured_media":7981,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[],"post_formats":[],"class_list":["post-7985","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Doble dosi d\u2019\u00e8xit del European Research Council per a un investigador de l&#039;Institut de Bioenginyeria de Catalunya - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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