{"id":80008,"date":"2020-11-16T17:55:35","date_gmt":"2020-11-16T16:55:35","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=80008"},"modified":"2020-11-26T13:59:31","modified_gmt":"2020-11-26T12:59:31","slug":"desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/","title":{"rendered":"Desxifrant el potencial dels organoides humans a trav\u00e9s de la bioenginyeria"},"content":{"rendered":"
\"\"
Mini rony\u00f3 generat al laboratori de la N\u00faria Montserrat al IBEC<\/span><\/span>\u00a0<\/span><\/figcaption><\/figure>\n

Els\u00a0<\/span><\/span>organoides<\/span><\/span>\u00a0es conceben com micro-teix<\/span><\/span>its dissenyats al laboratori que s\u2019usen per ajudar-nos a comprendre el desenvolupament i les malalties dels humans. No obstant aix\u00f2, aquests models no tenen caracter\u00edstiques importants que s\u00ed que tenen els \u00f2rgans originals, com la seva maduresa o esperan\u00e7a<\/span><\/span>\u00a0de la vida.\u00a0<\/span><\/span>En aquesta revisi\u00f3, els autors discuteixen la manera com la bioenginyeria pot proporcionar informaci\u00f3 sobre les propietats biof\u00edsiques del teixit original i aix\u00ed reproduir-les en els\u00a0<\/span><\/span>organoides<\/span><\/span><\/strong>.<\/span><\/span>\u00a0Els autors recalquen la import\u00e0ncia que especial<\/span><\/span>istes en \u00e8tica, enginyers i bi\u00f2legs experts en c\u00e8l\u00b7lules mare treballin\u00a0<\/span><\/span>conjuntament. Segons afirmen, aquesta col\u00b7laboraci\u00f3 \u00e9s clau per avan\u00e7ar en el camp dels\u00a0<\/span><\/span>organoides<\/span><\/span>\u00a0derivats de c\u00e8l\u00b7lules mare pluripotents humanes (<\/span><\/span>hPSCs<\/span><\/span>).<\/span><\/span>\u00a0<\/span><\/p>\n

Els\u00a0<\/span>organoides<\/span>\u00a0s\u00f3n agregats<\/span>\u00a0de c\u00e8l\u00b7lules cultivades que constitueixen teixits d’una grand\u00e0ria redu\u00efda (de micr\u00f2metres a cent\u00edmetres), dotats de les caracter\u00edstiques estructurals i funcionals dels \u00f2rgans humans. Durant les \u00faltimes dues d\u00e8cades, els aven\u00e7os en les t\u00e8cniques de creixem<\/span>ent de\u00a0<\/span>hPSCs<\/span>\u00a0han perm\u00e8s el desenvolupament de procediments per generar estructures similars a petits \u00f2rgans a demanda. Fins ara, els cient\u00edfics han generat\u00a0<\/span>organoides<\/span>\u00a0propis d<\/span>el cervell, rony\u00f3, intest\u00ed, pulm\u00f3, retina, o\u00efda interna, fetge, etc., a partir\u00a0<\/span>de c\u00e8l\u00b7lules mare. Aquestes plataformes de cultiu cel\u00b7lular han perm\u00e8s l’estudi de programes\u00a0<\/span>morfogen\u00e8tics<\/span>\u00a0inicials<\/span>\u00a0que impulsen l’especificaci\u00f3 i la diferenciaci\u00f3 de teixits, i han donat lloc a una nova classe de cultius tridimensionals segurs i assequi<\/span>bles per a aplicacions a la recerca biom\u00e8dica. No obstant aix\u00f2, encara hi ha limitacions importants, com ara la seva maduresa i vida limitada, que impedeixen aplicar els\u00a0<\/span>organoides<\/span>\u00a0en medicina regenerativa.<\/span>\u00a0<\/span><\/p>\n

En aquest punt, les investigadores de l’IBEC\u00a0<\/span>Nuria Montserrat<\/span><\/a>\u202fi\u202f<\/span>Elena Garreta<\/span><\/a>\u202fhan estudiat el passat i el present dels sistemes de culti<\/span>u de\u00a0<\/span>hPSCs<\/span>\u00a0i l’impacte d’aquests av<\/span>e<\/span>n\u00e7os\u00a0<\/span>en<\/span>\u00a0la recerca centrada en els\u00a0<\/span>organoides<\/span>, en un esfor\u00e7 per destacar les estrat\u00e8gies de bioenginyeria assequibles per superar les actuals limitacions. En aquest article de revisi\u00f3 publicat a\u00a0<\/span>Nature<\/span><\/i>\u00a0Materials<\/span><\/i><\/a>, i escrit<\/span>\u00a0en col\u00b7laboraci\u00f3 amb altres experts internacionals, inclosos Xavier Trepat de l’IBEC, Roger D.\u00a0<\/span>Kamm<\/span>\u00a0i\u00a0<\/span>Ron<\/span>\u00a0<\/span>Weiss<\/span>\u00a0de MIT als EE. UU., Susana M\u00a0<\/span>Chuva<\/span>\u00a0de Sousa\u00a0<\/span>Lopes<\/span>\u00a0de LUMC dels pa\u00efsos Baixos,\u00a0<\/span>Madeline<\/span>\u00a0A. Lancaster de MRC al Regne Unit i\u00a0<\/span>Insoo<\/span>\u00a0<\/span>Hyun<\/span>\u00a0de la Uni<\/span>versitat de Casi\u00a0<\/span>West<\/span>\u00a0<\/span>Research<\/span>\u00a0University als EE. UU., les investigadores destaquen el paper crucial que juguen la bioenginyeria i l’\u00e8tica en l’impuls d<\/span>el desenvolupament futur de aquests sistemes.<\/span>\u00a0<\/span><\/p>\n

La converg\u00e8ncia entre\u00a0<\/span><\/span>organoides<\/span><\/span>\u00a0i bioenginyeria t\u00e9 el\u00a0<\/span><\/span>potencial de revolucionar la biomedicina, ja que permetr\u00e0 als investigadors estudiar patologies amb una precisi\u00f3 sense precedents.<\/span><\/span>\u00a0<\/span><\/strong><\/p><\/blockquote>\n

Els reptes des de fa un segle<\/span><\/span>\u00a0<\/span><\/strong><\/h2>\n

a abans dels anys 1900, els bi\u00f2legs havien comen\u00e7at a a\u00efllar i cultivar teixits i c\u00e8l\u00b7lules de diversos organismes, com esponges, pollastres o ratolins. M\u00e9s endavant, es va aconseguir l’a\u00efllament de c\u00e8l\u00b7lules mare embrion\u00e0ries humanes i la reprogramaci\u00f3 de c\u00e8l\u00b7lules som\u00e0tiques en c\u00e8l\u00b7lules mare pluripotents indu\u00efdes. Aix\u00f2 va permetre\u00a0<\/span>obtenir<\/span>\u00a0c\u00e8l\u00b7lules amb propietats similars a les que trobem durant les etapes de desenvolupament. Durant l’\u00faltima d\u00e8cada, la possibilitat de generar versions microm\u00e8triques d’\u00f2rgans humans ha perm\u00e8s la creaci\u00f3 de models que reprodueixen les caracter\u00edstiques fonamentals dels \u00f2rgans originals. Entre elles, la forma en qu\u00e8 les c\u00e8l\u00b7lules s’organitzen espacialment i la seva resposta funcional davant de situacions adverses com les que es donen despr\u00e9s d’un trasplantament\u00a0<\/span>in\u00a0<\/span><\/i>vivo<\/span><\/i>.<\/span>\u00a0<\/span><\/p>\n

Fins al moment, els\u00a0<\/span>organoides<\/span>\u00a0derivats de\u00a0<\/span>hPSCs<\/span>\u00a0han conservat les propietats inherents d’aquestes fonts cel\u00b7lulars \u00faniques, inclosa la seva capacitat per\u00a0<\/span>autoorganitzar<\/span>-se<\/span>\u00a0o diferenciar-se en qualsevol tipus de c\u00e8l\u00b7lula del nostre cos en resposta a senyals externs.\u00a0<\/span>No obstant aix\u00f2, e<\/span>l poc control sobre els est\u00edmuls externs\u00a0<\/span>rebuts<\/span>, provoca respostes no desitjades com ara la manca de maduresa o una curta vida \u00fatil.<\/span>\u00a0<\/span>En aquest sentit, els experts descriuen diversos enfocaments orientats a proporcionar un component vascular capa\u00e7 de desenvolupar\u00a0<\/span>organoides<\/span>\u00a0a partir de c\u00e8l\u00b7lules mare i<\/span>\u00a0<\/span>a dissenyar xarxes vasculars que permetin la generaci\u00f3 de\u00a0<\/span>organoides<\/span>\u00a0m\u00e9s grans i viables, utilitzant solucions com sistemes de\u00a0<\/span>microfluids<\/span>, sistemes de\u00a0<\/span>cocultiu<\/span>\u00a0o\u00a0<\/span>bioimpresi\u00f3n<\/span>\u00a03D.<\/span>\u00a0<\/span><\/p>\n

Creant l’entorn adequat<\/span><\/span>\u00a0<\/span><\/strong><\/h2>\n

Una altra limitaci\u00f3 dels\u00a0<\/span>organoides<\/span>\u00a0\u00e9s la naturalesa aleat\u00f2ria i descontrolada del seu creixement. Fins i tot dins de les mateixes l\u00ednies de c\u00e8l\u00b7lules mare, s’observa poca homogene\u00eftat, el que significa que actualment no s\u00f3n el reflex m\u00e9s fidel dels sistemes originals en qu\u00e8 es basen. Els\u00a0<\/span>microambients<\/span>\u00a0dissenyats<\/span>\u00a0amb\u00a0<\/span>bioingenyeria<\/span>\u00a0podrien proporcionar als\u00a0<\/span>organoides<\/span>\u00a0les instruccions que necessiten per cr\u00e9ixer d’una manera m\u00e9s organitzada i consistent; un exemple el trobar\u00edem en els sistemes din\u00e0mics d’hidrogel activats per llum.<\/span>\u00a0<\/span><\/p>\n

Cal no oblidar la import\u00e0ncia de recrear les interaccions teixit-teixit i les condicions fisiol\u00f2giques que experimenten els \u00f2rgans originals. En aquest sentit, s’han utilitzat dispositius de\u00a0<\/span>microingenyeria<\/span>\u00a0per crear diversos tipus de “\u00f2rgan en un xip” que imiten aspectes clau de la fisiologia dels \u00f2rgans. Una tecnologia que ja ha estat usada per a desenvolupar models\u00a0<\/span>organoides<\/span>\u00a0amb certes malalties, com la diabetis tipus 2 i l’esclerosi lateral\u00a0<\/span>amiotr\u00f2fica<\/span>\u00a0(ELA).<\/span>\u00a0<\/span><\/p>\n

Tot i que la creaci\u00f3 dels\u00a0<\/span>microambients<\/span>\u00a0ideals per a la producci\u00f3, el creixement i la funcionalitat dels\u00a0<\/span>organoides<\/span>\u00a0queda encara una mica lluny, la tecnologia dels\u00a0<\/span>organoides<\/span>\u00a0ja est\u00e0 revolucionant la biomedicina en \u00e0rees com la biologia del desenvolupament, la generaci\u00f3 de f\u00e0rmacs, el modelatge de malalties i la medicina personalitzada. No hi ha cap dubte que les estrat\u00e8gies de bioenginyeria s\u00f3n una poderosa eina per aconseguir la creaci\u00f3 d’aquests\u00a0<\/span>microambients<\/span>. No obstant aix\u00f2, segons els autors, tal revoluci\u00f3 requerir\u00e0 una estreta col\u00b7laboraci\u00f3 entre bi\u00f2legs experts en c\u00e8l\u00b7lules mare, bioenginyers i especialistes en \u00e8tica. Est\u00e0 en les mans de les universitats, els instituts i les administracions assignar recursos per garantir que aix\u00ed sigui.<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Sobre l’IBEC<\/span><\/b>
\n<\/span>L’Institut de Bioenginyeria de Catalunya (IBEC) \u00e9s un centre CERCA, reconegut en dues ocasions com a centre d’Excel\u00b7l\u00e8ncia Severo Ochoa i membre de l’Institut de Ci\u00e8ncia i Tecnologia de Barcelona (BIST). IBEC duu a terme recerca interdisciplin\u00e0ria d’excel\u00b7l\u00e8ncia en la frontera de l’enginyeria i les ci\u00e8ncies de la vida per tal de generar nou coneixement, integrant camps com la\u00a0<\/span>nanomedicina<\/span>, la biof\u00edsica, la biotecnologia l’enginyeria de teixits i les aplicacions de tecnologia de la informaci\u00f3 en l’\u00e0mbit de la salut. L’IBEC va ser creat el 2005 per la Generalitat de Catalunya, la Universitat de Barcelona (UB) i la Universitat Polit\u00e8cnica de Catalunya (UPC).<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

En una revisi\u00f3 publicada a la prestigiosa revista cient\u00edfica Nature Materials, investigadors de l’IBEC debaten al costat d’experts internacionals dels EE. UU. i Europa la forma d’utilitzar la bioenginyeria per tal de guiar millor l’autoorganitzaci\u00f3 i diferenciaci\u00f3 de les c\u00e8l\u00b7lules mare pluripotents humanes (hPSCs) i aix\u00ed poder generar organoides de m\u00e9s qualitat.<\/h3>\n","protected":false},"author":4,"featured_media":73156,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1244,1123],"post_formats":[],"class_list":["post-80008","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-bioengineering-ca","tag-nuria-montserrat-ca-2"],"yoast_head":"\nDesxifrant el potencial dels organoides humans a trav\u00e9s de la bioenginyeria - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Desxifrant el potencial dels organoides humans a trav\u00e9s de la bioenginyeria - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"En una revisi\u00f3 publicada a la prestigiosa revista cient\u00edfica Nature Materials, investigadors de l'IBEC debaten al costat d'experts internacionals dels EE. UU. i Europa la forma d'utilitzar la bioenginyeria per tal de guiar millor l'autoorganitzaci\u00f3 i diferenciaci\u00f3 de les c\u00e8l\u00b7lules mare pluripotents humanes (hPSCs) i aix\u00ed poder generar organoides de m\u00e9s qualitat.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-16T16:55:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-26T12:59:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Desxifrant el potencial dels organoides humans a trav\u00e9s de la bioenginyeria\",\"datePublished\":\"2020-11-16T16:55:35+00:00\",\"dateModified\":\"2020-11-26T12:59:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\\\/\"},\"wordCount\":1205,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/04\\\/organoid_web.jpg\",\"keywords\":[\"bioengineering\",\"Nuria Montserrat\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\\\/\",\"name\":\"Desxifrant el potencial dels organoides humans a trav\u00e9s de la bioenginyeria - Institute for Bioengineering of Catalonia\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/04\\\/organoid_web.jpg\",\"datePublished\":\"2020-11-16T16:55:35+00:00\",\"dateModified\":\"2020-11-26T12:59:31+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\\\/#breadcrumb\"},\"inLanguage\":\"ca\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\\\/#primaryimage\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/04\\\/organoid_web.jpg\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2020\\\/04\\\/organoid_web.jpg\",\"width\":500,\"height\":500,\"caption\":\"Imatge de microscopia confocal d\u2019un organoid de rony\u00f3 generat in vitro a partir de c\u00e8l.lules mare pluripotents humanes que han estat diferenciadesdurant 20 diesmitjan\u00e7antcultiustridimensionals. Aquestsorganoids de rony\u00f3contenen estructures renals que inclouent\u00fabulsproximals (marcatsamb LTL, en verd) i la expressi\u00f3 de col.l\u00e8gen IV en la membrana basal (en vermell). Aquestes estructures s\u2019assemblen en part a les estructures renals del rony\u00f3hum\u00e0.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Desxifrant el potencial dels organoides humans a trav\u00e9s de la bioenginyeria\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"name\":\"Institute for Bioengineering of Catalonia\",\"description\":\"Bioengineering Solutions for Health\",\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ibecbarcelona.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ca\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\",\"name\":\"Institute for Bioengineering of Catalonia\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"width\":696,\"height\":257,\"caption\":\"Institute for Bioengineering of Catalonia\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\",\"name\":\"\u00c0ngels L\u00f3pez\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"caption\":\"\u00c0ngels L\u00f3pez\"},\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/author\\\/alopez\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Desxifrant el potencial dels organoides humans a trav\u00e9s de la bioenginyeria - Institute for Bioengineering of Catalonia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/","og_locale":"ca_ES","og_type":"article","og_title":"Desxifrant el potencial dels organoides humans a trav\u00e9s de la bioenginyeria - Institute for Bioengineering of Catalonia","og_description":"En una revisi\u00f3 publicada a la prestigiosa revista cient\u00edfica Nature Materials, investigadors de l'IBEC debaten al costat d'experts internacionals dels EE. UU. i Europa la forma d'utilitzar la bioenginyeria per tal de guiar millor l'autoorganitzaci\u00f3 i diferenciaci\u00f3 de les c\u00e8l\u00b7lules mare pluripotents humanes (hPSCs) i aix\u00ed poder generar organoides de m\u00e9s qualitat.","og_url":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/","og_site_name":"Institute for Bioengineering of Catalonia","article_published_time":"2020-11-16T16:55:35+00:00","article_modified_time":"2020-11-26T12:59:31+00:00","og_image":[{"width":500,"height":500,"url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web.jpg","type":"image\/jpeg"}],"author":"\u00c0ngels L\u00f3pez","twitter_card":"summary_large_image","twitter_misc":{"Escrit per":"\u00c0ngels L\u00f3pez","Temps estimat de lectura":"6 minuts"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/#article","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/"},"author":{"name":"\u00c0ngels L\u00f3pez","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/c212c6b589546130be67986b9290e2b8"},"headline":"Desxifrant el potencial dels organoides humans a trav\u00e9s de la bioenginyeria","datePublished":"2020-11-16T16:55:35+00:00","dateModified":"2020-11-26T12:59:31+00:00","mainEntityOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/"},"wordCount":1205,"publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web.jpg","keywords":["bioengineering","Nuria Montserrat"],"articleSection":["Not\u00edcies de recerca"],"inLanguage":"ca"},{"@type":"WebPage","@id":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/","url":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/","name":"Desxifrant el potencial dels organoides humans a trav\u00e9s de la bioenginyeria - Institute for Bioengineering of Catalonia","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/#primaryimage"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web.jpg","datePublished":"2020-11-16T16:55:35+00:00","dateModified":"2020-11-26T12:59:31+00:00","breadcrumb":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/#breadcrumb"},"inLanguage":"ca","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/"]}]},{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/#primaryimage","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web.jpg","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web.jpg","width":500,"height":500,"caption":"Imatge de microscopia confocal d\u2019un organoid de rony\u00f3 generat in vitro a partir de c\u00e8l.lules mare pluripotents humanes que han estat diferenciadesdurant 20 diesmitjan\u00e7antcultiustridimensionals. Aquestsorganoids de rony\u00f3contenen estructures renals que inclouent\u00fabulsproximals (marcatsamb LTL, en verd) i la expressi\u00f3 de col.l\u00e8gen IV en la membrana basal (en vermell). Aquestes estructures s\u2019assemblen en part a les estructures renals del rony\u00f3hum\u00e0."},{"@type":"BreadcrumbList","@id":"https:\/\/ibecbarcelona.eu\/ca\/desxifrant-el-potencial-dels-organoides-humans-a-traves-de-la-bioenginyeria\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ibecbarcelona.eu\/ca\/"},{"@type":"ListItem","position":2,"name":"Desxifrant el potencial dels organoides humans a trav\u00e9s de la bioenginyeria"}]},{"@type":"WebSite","@id":"https:\/\/ibecbarcelona.eu\/#website","url":"https:\/\/ibecbarcelona.eu\/","name":"Institute for Bioengineering of Catalonia","description":"Bioengineering Solutions for Health","publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibecbarcelona.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ca"},{"@type":"Organization","@id":"https:\/\/ibecbarcelona.eu\/#organization","name":"Institute for Bioengineering of Catalonia","url":"https:\/\/ibecbarcelona.eu\/","logo":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","width":696,"height":257,"caption":"Institute for Bioengineering of Catalonia"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/c212c6b589546130be67986b9290e2b8","name":"\u00c0ngels L\u00f3pez","image":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","caption":"\u00c0ngels L\u00f3pez"},"url":"https:\/\/ibecbarcelona.eu\/ca\/author\/alopez\/"}]}},"AFP_featured_media_urls":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web.jpg",500,500,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web-150x150.jpg",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web-300x300.jpg",300,300,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web.jpg",500,500,false],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/04\/organoid_web.jpg",500,500,false]},"AFP_attachments":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/11\/HL27ZOT26FGPXFGJNEZ4NFWVTY.jpg",1500,1500,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/11\/HL27ZOT26FGPXFGJNEZ4NFWVTY-150x150.jpg",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/11\/HL27ZOT26FGPXFGJNEZ4NFWVTY-300x300.jpg",300,300,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/11\/HL27ZOT26FGPXFGJNEZ4NFWVTY-768x768.jpg",768,768,true],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2020\/11\/HL27ZOT26FGPXFGJNEZ4NFWVTY-1024x1024.jpg",1024,1024,true]},"AFP_videos":[],"AFP_video_blocks":"","AFP_category_names":["Not\u00edcies de recerca"],"_links":{"self":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/80008","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/comments?post=80008"}],"version-history":[{"count":3,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/80008\/revisions"}],"predecessor-version":[{"id":80011,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/80008\/revisions\/80011"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media\/73156"}],"wp:attachment":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media?parent=80008"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/categories?post=80008"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tags?post=80008"},{"taxonomy":"post_format","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/post_formats?post=80008"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}


\nArticle de refer\u00e8ncia:<\/span><\/b>
\n<\/span>Elena Garreta, Roger D.\u00a0<\/span>Kamm<\/span>, Susana M\u00a0<\/span>Chuva<\/span>\u00a0de Sousa\u00a0<\/span>Lopes<\/span>,\u00a0<\/span>Madeline<\/span>\u00a0A. Lancaster,\u00a0<\/span>Ron<\/span>\u00a0<\/span>Weiss<\/span>, Xavier Trepat,\u00a0<\/span>Insoo<\/span>\u00a0<\/span>Hyun<\/span>\u00a0<\/span>and<\/span>\u00a0Nuria Montserrat (2020) \u201c<\/span>Rethinking<\/span><\/i>\u00a0<\/span><\/i>organoid<\/span><\/i>\u00a0<\/span><\/i>technology<\/span><\/i>\u00a0<\/span><\/i>through<\/span><\/i>\u00a0<\/span><\/i>bioengineering<\/span><\/i><\/a>.<\/span><\/i>\u201d\u00a0<\/span>Nature<\/span>\u00a0Materials, 2020.<\/span>\u00a0<\/span><\/p>\n