{"id":8132,"date":"2014-03-25T12:17:21","date_gmt":"2014-03-25T12:17:21","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/ajudant-al-cervell-a-autoregenerar-se\/"},"modified":"2015-01-08T09:01:14","modified_gmt":"2015-01-08T09:01:14","slug":"ajudant-al-cervell-a-autoregenerar-se","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/ajudant-al-cervell-a-autoregenerar-se\/","title":{"rendered":"Ajudant al cervell a autoregenerar-se"},"content":{"rendered":"<p>En l\u2019estudi, liderat per la Dra. Soledad Alc\u00e1ntara del Grup de Desenvolupament Neural de la UB, els cient\u00edfics han descobert que aquests implants biodegradables fets de nanofibres d\u2019\u00e0cid polil\u00e0ctic (PLA) reprodueixen alguns aspectes de l&#8217;entorn natural del cervell embrionari i estimulen la regeneraci\u00f3 del teixit.<\/p>\n<p class=\"caption\" style=\"width: 300px; float: left;\"><em><span style=\"color: #888888;\">Imatge: Bastides de nanofibres aleat\u00f2ries (Esquerra) i alineades (dreta) despr\u00e9s d\u2019una setmana de la implantaci\u00f3 en el c\u00f2rtex cerebral de ratolins. Les c\u00e8l\u2022lules glials (verd)  i els vasos sanguinis (vermell) penetren a l\u2019andami alineat i no en les fibres aleat\u00f2ries (ratlles blanques).<\/span><\/em><\/p>\n<p>Aquests implants, coneguts en enginyeria de teixits com a &#8220;bastides&#8221;, alliberen L-lactat, una mol\u00e8cula que actua com a senyal cel\u2022lular com\u00fa per induir l\u2019 angiog\u00e8nesis (formaci\u00f3 de vasos sanguinis nous). Tamb\u00e9 reprodueixen el n\u00ednxol neurog\u00e8nic, \u00e9s a dir, l\u2019entorn en el qual els progenitors neurals generen noves neurones i c\u00e8l\u2022lules de glia, que migren de la mateixa manera que durant el desenvolupament cerebral.<\/p>\n<p>\u201cLes lesions cerebrals s\u00f3n la causa comuna de moltes discapacitats, a causa de la p\u00e8rdua de teixit nervi\u00f3s i a la formaci\u00f3 de cavitats que inhibeixen el creixement de les c\u00e8l\u2022lules neuronals,\u201d diu Zaida \u00c1lvarez membre del grup de Biomaterials per a ter\u00e0pies regeneratives de l&#8217;IBEC i del grup de Desenvolupament Neural de la UB i autora principal de l\u2019article. \u201cPer trobar estrat\u00e8gies regeneratives efectives que promoguin la recuperaci\u00f3 del cervell despr\u00e9s d\u2019una lesi\u00f3 traum\u00e0tica hem de focalitzar-nos a resoldre els obstacles actuals: la d\u00e8bil integraci\u00f3 del implant i la superviv\u00e8ncia cel\u2022lular.\u201d<\/p>\n<p>Quan les bastides de PLA dissenyades al IBEC van ser implantades en ratolins nounats, el L-lactat alliberat durant la degradaci\u00f3 va actuar com a &#8220;font d&#8217;energia&#8221; alternativa motivant el creixement de les neurones i activant als progenitors end\u00f2gens. Les fibres utilitzades per construir &#8220;l&#8217;estructura&#8221; reprodu\u00efen l\u2019organitzaci\u00f3 natural en 3D, aix\u00ed com la topologia de la glia radial embrion\u00e0ria, la qual cosa va afavorir la migraci\u00f3 neuronal i la vascularitzaci\u00f3 durant el creixement cerebral.\u201d<\/p>\n<p>\u201cMitjan\u00e7ant la millora de biomaterials ha estat possible regular els par\u00e0metres biof\u00edsics i metab\u00f2lics que lideren la restauraci\u00f3 de la funci\u00f3 del teixit nervi\u00f3s despr\u00e9s d\u2019una lesi\u00f3, sense la necessitat de c\u00e8l\u2022lules ex\u00f2genes, factors de creixement o manipulacions gen\u00e8tiques,\u201d diu Zaida \u00c1lvarez. \u201cEncara que queda un llarg cam\u00ed per rec\u00f3rrer abans que aquests experiments es puguin traslladar a la cl\u00ednica &#8211; hem de veure si hi ha una resposta regenerativa similar en ratolins adults- els nostres resultats obren perspectives esperan\u00e7adores i apassionants en el disseny de dispositius implantables lliures de c\u00e8l\u2022lules&#8221;<\/p>\n<p> <\/p>\n<p><em>&#8212;<\/em><\/p>\n<p> <strong>Article de Referencia: <\/strong>\u00c1lvarez, Z., Casta\u00f1o, O., Castells, A.A., Mateos-Timoneda, M.A., Planell, J.A., Engel, E. &amp; Alc\u00e1ntara, S. (2014). <a href=\"http:\/\/dx.doi.org\/10.1016\/j.biomaterials.2014.02.051\" target=\"_blank\">Neurogenesis and vascularization of the damaged brain using a lactate-releasing biomimetic scaffold.<\/a> <em>Biomaterials<\/em>, 35, 17, 4769\u20134781<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-8128 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/03\/brain.jpg\" border=\"0\" width=\"400\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/03\/brain.jpg 340w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/03\/brain-300x185.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/03\/brain-242x150.jpg 242w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/03\/brain-150x92.jpg 150w\" data-sizes=\"(max-width: 340px) 100vw, 340px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 340px; --smush-placeholder-aspect-ratio: 340\/210;\" \/> Una nova estrat\u00e8gia en medicina regenerativa pot promoure la recuperaci\u00f3 de les lesions cerebrals<\/h3>\n<p>Investigadors en regeneraci\u00f3 de teixits del Institut de Bioenginyeria de Catalunya (IBEC), de la Universitat de Barcelona (UB) i de la Universitat Polit\u00e8cnica de Catalunya (UPC) han desenvolupat un implant que estimula la regeneraci\u00f3 del teixit cerebral, especialment en casos de lesions pre- i postnatals.<\/p>\n","protected":false},"author":4,"featured_media":8128,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-8132","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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