{"id":81550,"date":"2021-02-08T10:41:58","date_gmt":"2021-02-08T09:41:58","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/?p=81550"},"modified":"2021-02-09T11:42:03","modified_gmt":"2021-02-09T10:42:03","slug":"premi-per-a-doctorat-sobre-mecanobiologia-a-libec","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/premi-per-a-doctorat-sobre-mecanobiologia-a-libec\/","title":{"rendered":"Premi per a doctorat sobre mecanobiologia a l\u00b4IBEC"},"content":{"rendered":"

El treball premiat ha estat dirigit per Pere Roca-Cusachs, investigador principal a l\u2019IBEC, i\u202fProfessor Agregat de la Facultat de Medicina i Ci\u00e8ncies de la Salut de la UB.<\/p>\n

\"\"
Roger Oria, guanyador del XXIV Premi Claustre de Doctors de la UB.<\/figcaption><\/figure>\n

La tesi doc<\/span>toral amb el t\u00edtol <\/span>Cell <\/span><\/i>sensing<\/span><\/i> of <\/span><\/i>the<\/span><\/i> extracellular<\/span><\/i> environment<\/span><\/i>: Roles of <\/span><\/i>matrix<\/span><\/i> rigidity<\/span><\/i>, <\/span><\/i>ligand<\/span><\/i> density<\/span><\/i>, <\/span><\/i>and<\/span><\/i> ligand<\/span><\/i> distribution<\/span><\/i><\/a>,<\/span><\/i>\u202fgira a<\/span>l<\/span> voltant d<\/span>\u00b4una<\/span> hip\u00f2tesi<\/span> sobre<\/span> com les c\u00e8l\u00b7lules s\u00f3n capaces de percebre informaci\u00f3 espacial i f\u00edsica a escala <\/span>nanom\u00e8tric<\/span>a<\/span>. Fins ara, la hip\u00f2tesi m\u00e9s acceptada defensava que les c\u00e8l\u00b7lules podrien emprar algun tipus de mol\u00e8cula patr\u00f3 en aquest proc\u00e9s. <\/span>E<\/span>l treball doctoral<\/span> realitzat pel <\/span>Dr.<\/span> Roger <\/span>Oria<\/span> constata<\/span> que el mecanisme que fan servir per percebre el medi extracel\u00b7lular est\u00e0 regulat per la detecci\u00f3 de forces que depenen de la distribuci\u00f3 espacial de<\/span> mol\u00e8cules<\/span> anomena<\/span>des<\/span> lligands<\/span>. <\/span>Aquesta l\u00ednia de recerca dins de la innovadora disciplina de la <\/span>mecanobiologia<\/span> pot contribuir a identificar noves eines per frenar patologies que s\u2019associen amb la rigidesa dels teixits, com per exemple, el c\u00e0ncer.\u202f<\/span>\u202f<\/span>\u00a0<\/span><\/p>\n

Mecanobiologia: una nova perspectiva dels processos biol\u00f2gics\u202f\u00a0<\/strong><\/h2>\n

La <\/span>mecanobiologia<\/span> \u00e9s un camp emergent que ha anat prenent for\u00e7a durant les \u00faltimes d<\/span>\u00e8<\/span>cades. Cada cop m\u00e9s cient\u00edfics han comen\u00e7at a <\/span>donar<\/span> atenci\u00f3 a la import\u00e0ncia de la <\/span>f\u00edsica en el desenvolupament d\u2019\u00f2rgans i organismes<\/span>,<\/span> i han comen\u00e7at a definir els mecanismes pels quals les c\u00e8l\u00b7lules detecten, responen i generen forces. A l\u2019IBEC, varis grups de recerca<\/span>, entre ells el del Professor Pere Roca-Cusachs,<\/span> s<\/span>\u00f3<\/span>n pioners en aquest camp, que a m\u00e9s a m\u00e9s, \u00e9s un dels quatre eixos de recerca a l\u2019institut.\u202f<\/span>\u202f<\/span>\u00a0<\/span><\/p>\n

Les c\u00e8l\u00b7lules s\u00f3n capaces de percebre el seu entorn i aquesta capacitat \u00e9s essencial per mantenir la funci\u00f3 dels teixits i detectar-hi canvis (creixement cel\u00b7lular, proliferaci\u00f3 tumoral, etc.). A trav\u00e9s de les adhesions focals, que s\u00f3n estructures formades per prote\u00efnes <\/span>transmembrana<\/span> i tamb\u00e9 adaptadores, les c\u00e8l\u00b7lules s\u2019adapten i detecten les propietats f\u00edsiques de la matriu extracel\u00b7lular.<\/span>\u202f<\/span>\u00a0<\/span><\/p>\n

Les adhesions focals actuen com una mena de \u201csabates cel\u00b7lulars\u201d, que proporcionen tracci\u00f3 i ancoratge als teixits del voltant. Aix\u00ed mateix, les c\u00e8l\u00b7lules tamb\u00e9 canvien les adhesions focals per poder adaptar-se als diferents teixits i les seves caracter\u00edstiques com, per exemple, els creixements tumorals.\u00a0<\/strong><\/p>\n

Roger Oria\u202f\u00a0<\/strong><\/p>\n<\/blockquote>\n

\n

Sobre el premi\u202f<\/strong>
\n<\/span>El Premi Claustre de Doctors es va crear el 1997 per distingir les tesis doctorals llegides i defensades a la Universitat de Barcelona que representessin les aportacions m\u00e9s rellevants en el camp del coneixement hum\u00e0 i del progr\u00e9s de la ci\u00e8ncia. Amb car\u00e0cter anual, el premi vol donar a con\u00e8ixer i potenciar els treballs dels joves doctors de la UB i col\u00b7laborar aix\u00ed en la difusi\u00f3 del prestigi acad\u00e8mic i social del t\u00edtol de doctor, m\u00e0xim grau acad\u00e8mic que poden assolir els estudiants dins la instituci\u00f3 universit\u00e0ria.<\/span>\u202f<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Roger Oria guanya el XXIV Premi Claustre de Doctors de la Universitat de Barcelona (UB) per la seva tesi sobre mecanobiologia, una disciplina emergent que pot contribuir a identificar noves eines per frenar patologies que s\u2019associen amb la rigidesa dels teixits, com per exemple, el c\u00e0ncer.\u202f\u202f <\/h3>\n","protected":false},"author":4,"featured_media":81561,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1134,1399],"post_formats":[],"class_list":["post-81550","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-pere-roca-cusachs-ca","tag-roger-oria"],"yoast_head":"\nPremi per a doctorat sobre mecanobiologia a l\u00b4IBEC - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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