{"id":8165,"date":"2014-04-07T11:07:58","date_gmt":"2014-04-07T11:07:58","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/diagnostic-mes-rapid-i-precis-per-a-infeccions-del-tracte-respiratori-inferior\/"},"modified":"2015-01-08T09:01:05","modified_gmt":"2015-01-08T09:01:05","slug":"diagnostic-mes-rapid-i-precis-per-a-infeccions-del-tracte-respiratori-inferior","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/diagnostic-mes-rapid-i-precis-per-a-infeccions-del-tracte-respiratori-inferior\/","title":{"rendered":"Diagn\u00f2stic m\u00e9s r\u00e0pid i prec\u00eds per a infeccions del tracte respiratori inferior"},"content":{"rendered":"

<\/em> <\/p>\n

Un estudi en el qual han participat investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC), de la Universitat de Barcelona (UB) i de l\u2019empresa catalana Biokit SA descriu el desenvolupament d\u2019un dispositiu \u2018en-un-xip\u2019 que \u00e9s capa\u00e7 de dur a terme una extracci\u00f3 autom\u00e0tica de mostres humanes i fer probes per material gen\u00e8tic bacteri\u00e0 o v\u00edric (ADN o ARN).<\/p>\n

El dispositiu en miniatura est\u00e0 especialment focalitzat cap a les infeccions del tracte respiratori inferior com la pneum\u00f2nia o la bronquitis. El dispositiu fa la preparaci\u00f3 total de la mostra i extreu l\u2019ADN o l\u2019ARN purificat de pat\u00f2gens de les vies respirat\u00f2ries de mostres reals de manera m\u00e9s efectiva que els m\u00e8todes existents. Tamb\u00e9 ofereix una operaci\u00f3 de mans lliures, dades autoexplicatives i resultats fiables incl\u00fas si l\u2019utilitza una persona no experta.<\/p>\n

\u201cLes infeccions del tracte respiratori inferior causen 3,4 milions de morts a l’any a tot el m\u00f3n. Els agents causants d\u2019aquestes malalties poden ser bacteris o virus, per\u00f2 els metges no poden determinar quin \u00e9s l\u2019agent basant-se \u00fanicament en els s\u00edmptomes cl\u00ednics,\u201d explica l\u2019Antoni Homs del grup de Nanobioenginyeria de l’IBEC. \u201cEls tests de diagn\u00f2stic tradicionals requereixen almenys 48 hores i els laboratoris de diagn\u00f2stic habitualment no estan dirigits als pacients amb aquests s\u00edmptomes que s\u2019atenen als centres d\u2019atenci\u00f3 prim\u00e0ria. Com a resultat existeix la incertesa sobre quina mena de bacteri o virus est\u00e0 causant els s\u00edmptomes. De manera que el nostre repte clau era dissenyar alguna cosa que fos capa\u00e7 d\u2019exercir tot el proc\u00e9s de preparaci\u00f3 d\u2019una mostra cl\u00ednica, tant de pat\u00f2gens respiratoris bacterians com v\u00edrics, i que a\u00eflli i recuperi el material gen\u00e8tic d\u2019una forma f\u00e0cil i r\u00e0pida”.<\/p>\n

La miniaturitzaci\u00f3 i la integraci\u00f3 dels procediments complets de preparaci\u00f3 de la mostra representen un important pas per a l\u2019aplicaci\u00f3 en un dispositiu de diagn\u00f2stic immediat d\u2019aquestes malalties. \u201cA m\u00e9s, sabent que les infeccions del tracte respiratori s\u00f3n la ra\u00f3 m\u00e9s habitual per a prescriure antibi\u00f2tics i que la resist\u00e8ncia a antibi\u00f2tics est\u00e0 altament correlacionada amb el consum d\u2019antibi\u00f2tics, podem assegurar que millorar els diagn\u00f2stics en aquest camp ajudar\u00e0 a frenar la resist\u00e8ncia als antibi\u00f2tics,\u201d afegeix l\u2019Antoni Homs.<\/p>\n

La recerca, que va ser duta a terme com a part del projecte theraEDGE, finan\u00e7at per la Uni\u00f3 Europea, i en un acord de col\u00b7laboraci\u00f3 entre l\u2019IBEC i Biokit SA (Grup Werfen), tamb\u00e9 a involucrat a investigadors de l\u2019Institut f\u00fcr MIkrotechnik Mainz GmbH (IMM) d\u2019Alemanya i de la Universitat d\u2019Antwerp de B\u00e8lgica i la resta d\u2019un consorci que inclou a 16 empreses i institucions europees.<\/p>\n

— <\/p>\n

Van Heirstraeten, L., Spang, P., Schwind, C., Drese, K. S., Ritzi-Lehnert, M., Nieto, B., Camps, M., Landgraf, B., Guasch, F., Homs Corbera, A., Samitier, J., Goossens, H., Malhotra-Kumar, S. & Roeser, T. (2014). Integrated DNA and RNA extraction and purification on an automated microfluidic cassette from bacterial and viral pathogens causing community-acquired lower respiratory tract infections.<\/a> Lab Chip<\/em>, 14, 1519-1526<\/p>\n","protected":false},"excerpt":{"rendered":"

Una col\u00b7laboraci\u00f3 entre investigaci\u00f3 i industria desenvolupa una plataforma de diagn\u00f2stic en miniatura per a les infeccions respirat\u00f2ries com la pneum\u00f2nia o la bronquitis infecciosa<\/h3>\n

<\/em><\/h3>\n

La investigaci\u00f3 est\u00e0 destacada a la portada de l\u2019\u00faltim n\u00famero de Lab on a Chip<\/em><\/h3>\n","protected":false},"author":4,"featured_media":8161,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-8165","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nDiagn\u00f2stic m\u00e9s r\u00e0pid i prec\u00eds per a infeccions del tracte respiratori inferior - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/diagnostic-mes-rapid-i-precis-per-a-infeccions-del-tracte-respiratori-inferior\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" 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