{"id":8218,"date":"2014-05-05T07:29:20","date_gmt":"2014-05-05T07:29:20","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/researchers-uncover-a-fundamental-mechanism-in-breast-cancer-2\/"},"modified":"2015-08-24T12:45:30","modified_gmt":"2015-08-24T12:45:30","slug":"researchers-uncover-a-fundamental-mechanism-in-breast-cancer-2","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/researchers-uncover-a-fundamental-mechanism-in-breast-cancer-2\/","title":{"rendered":"Investigadors descobreixen un mecanisme fonamental en la formaci\u00f3 del c\u00e0ncer de mama"},"content":{"rendered":"
Imatge: Visualitzaci\u00f3 del moviment de les estructures que utilitzen les c\u00e8l\u00b7lules per aplicar for\u00e7a sobre el seu entorn.<\/h6>\n

Un s\u00edmptoma que indica un possible tumor de mama incipient \u00e9s la pres\u00e8ncia de n\u00f2duls durs al teixit mamari, que es poden identificar mitjan\u00e7ant la palpaci\u00f3 del pit. Aquest m\u00e8tode de diagn\u00f2stic \u00e9s \u00fatil precisament perqu\u00e8 la formaci\u00f3 de tumors est\u00e0 associada a l\u2019enduriment del teixit. Tanmateix, fins ara es desconeixia com les c\u00e8l\u00b7lules s\u00f3n capaces de detectar la rigidesa del teixit, i perqu\u00e8 reaccionen de forma diferent en condicions sanes o tumorals.<\/p>\n

Investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC), juntament amb els seus col\u00b7laboradors del Barts Cancer Institute de la Queen Mary University (Londres), han demostrat com les mol\u00e8cules que les c\u00e8l\u00b7lules utilitzen per adherir-se al seu entorn, anomenades integrines, permeten a les c\u00e8l\u00b7lules detectar i adaptar-se a la rigidesa del teixit.<\/p>\n

Aquest \u00e9s un del projectes que impulsa l\u2019Obra Social \u201cla Caixa\u201d en el camp de la investigaci\u00f3 d\u2019excel\u00b7l\u00e8ncia de valoraci\u00f3 i transfer\u00e8ncia de coneixement.<\/p>\n

El paper de les integrines<\/strong>
\n“Hem observat que en c\u00e8l\u00b7lules de mama sanes, les propietats adhesives de les integrines fan que les c\u00e8l\u00b7lules redueixin la for\u00e7a que apliquen al seu entorn si aquest \u00e9s m\u00e9s r\u00edgid del normal” diu en Pere Roca-Cusachs, investigador principal de l’IBEC i professor lector de la Universitat de Barcelona, que ha liderat l\u2019estudi. “Donat que una reducci\u00f3 de forces tamb\u00e9 redueix la rigidesa del teixit, aquest mecanisme pot prevenir l\u2019enduriment del teixit\u201d.<\/p>\n

D\u2019altra banda, les c\u00e8l\u00b7lules cancer\u00edgenes de mama expressen un tipus diferent d\u2019integrines, amb unes propietats adhesives modificades. Aquestes altres integrines fan que les c\u00e8l\u00b7lules apliquin m\u00e9s for\u00e7a a mesura que la rigidesa del teixit augmenta, creant, d’aquesta manera, un mecanisme de retroalimentaci\u00f3 que finalment podria conduir a la formaci\u00f3 dels n\u00f2duls durs caracter\u00edstics dels tumors de mama.<\/p>\n

Evitar l\u2019enduriment dels teixits, una possible eina per combatre el c\u00e0ncer <\/strong>
\n“El nostre estudi \u00e9s el primer que descriu un mecanisme molecular de detecci\u00f3 de la rigidesa del teixit, i a m\u00e9s ho demostrem en c\u00e8l\u00b7lules humanes sanes i cancer\u00edgenes”, diu en Pere Roca-Cusachs. “De fet, el m\u00e9s fascinant \u00e9s que l\u2019enduriment anormal del teixit es presenta no nom\u00e9s en c\u00e0ncer de mama, sin\u00f3 tamb\u00e9 en molts altres tipus de c\u00e0ncer que tamb\u00e9 tenen alteracions en els nivells de diverses integrines. Aix\u00f2 significa que els canvis mec\u00e0nics indu\u00efts per l\u2019expressi\u00f3 d\u2019integrines podrien ser clau en l’aparici\u00f3 de diverses malalties”.<\/p>\n

Despr\u00e9s d\u2019aquest descobriment, el seg\u00fcent pas del grup de recerca \u00e9s investigar si la regulaci\u00f3 d\u2019integrines \u00e9s un mecanisme general de control mec\u00e0nic dels teixits, tant sans com malalts. Si \u00e9s aix\u00ed, aix\u00f2 tindr\u00e0 un gran potencial per al desenvolupament de ter\u00e0pies encaminades a prevenir les alteracions malignes en la rigidesa del teixit.<\/p>\n

—<\/p>\n

Reference article:<\/strong> Elosegui-Artola, A., Bazelli\u00e8res, E., Allen, M.D., Andreu, I., Oria, R., Sunyer, R., Gomm, J.J., Marshall, J.F., Jones, J.L., Trepat, X., Roca-Cusachs, P. (2014). Rigidity sensing and adaptation through regulation of integrin types.<\/a> Nature Materials<\/em>, 13, 631\u2013637<\/p>\n","protected":false},"excerpt":{"rendered":"

Un estudi de l’Institut de Bioenginyeria de Catalunya (IBEC) publicat el diumenge en Nature Materials, revela com les c\u00e8l\u00b7lules mam\u00e0ries detecten l’enduriment del teixit, cosa que \u00e9s clau en el desenvolupament del c\u00e0ncer de mama.<\/h3>\n

Aconseguir controlar la rigidesa dels teixits podria obrir una nova via per combatre tumors com el de mama. <\/h3>\n

Aquest enduriment anormal del teixit es presenta tamb\u00e9 en molts altres tipus de c\u00e0ncer. El mecanisme descobert podria ser clau en la detecci\u00f3 de diverses malalties.<\/h3>\n","protected":false},"author":4,"featured_media":8216,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-8218","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nInvestigadors descobreixen un mecanisme fonamental en la formaci\u00f3 del c\u00e0ncer de mama - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/researchers-uncover-a-fundamental-mechanism-in-breast-cancer-2\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors descobreixen un mecanisme fonamental en la formaci\u00f3 del c\u00e0ncer de mama - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudi de l'Institut de Bioenginyeria de Catalunya (IBEC) publicat el diumenge en Nature Materials, revela com les c\u00e8l\u00b7lules mam\u00e0ries detecten l'enduriment del teixit, cosa que \u00e9s clau en el desenvolupament del c\u00e0ncer de mama. 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