{"id":8313,"date":"2014-06-26T13:30:56","date_gmt":"2014-06-26T11:30:56","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/molecular-mechanisms-that-regulate-the-migration-of-cajal-retzius-cells-during-brain-development-shown-for-the-first-time-2\/"},"modified":"2016-06-27T21:22:32","modified_gmt":"2016-06-27T19:22:32","slug":"molecular-mechanisms-that-regulate-the-migration-of-cajal-retzius-cells-during-brain-development-shown-for-the-first-time-2","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/molecular-mechanisms-that-regulate-the-migration-of-cajal-retzius-cells-during-brain-development-shown-for-the-first-time-2\/","title":{"rendered":"Es demostra per primera vegada el mecanisme molecular que regula la migraci\u00f3 de les c\u00e8l\u00b7lules implicades en el desenvolupament cerebral"},"content":{"rendered":"<p>La distribuci\u00f3 de les c\u00e8l\u00b7lules Cajal-Retzius al c\u00f2rtex \u00e9s fonamental perqu\u00e8, en humans, si hi ha alteracions en la seva distribuci\u00f3 o b\u00e9 no hi ha expressi\u00f3 d\u2019algunes de les mol\u00e8cules produ\u00efdes per les c\u00e8l\u00b7lules Cajal-Retzius es desenvolupa Lissencef\u00e0lia de tipus I, una malaltia en en la qual el c\u00f2rtex cerebral \u00e9s llis, sense circumvolucions, el que porta retard mental i alteracions en el control del moviment.<\/p>\n<p>Les c\u00e8l\u00b7lules Cajal-Retzius es generen en tres punts diferents del cervell i durant les etapes inicials del seu desenvolupament migren en paral\u00b7lel en relaci\u00f3 amb la superf\u00edcie cerebral fins cobrir tota la superf\u00edcie del c\u00f2rtex cerebral, la denominada capa I. Aquestes c\u00e8l\u00b7lules tenen un paper cr\u00edtic en la migraci\u00f3 de les neurones del c\u00f2rtex cerebral i en la posterior formaci\u00f3 de les diferents capes el formen. Per a aix\u00f2, han de migrar de forma coordinada en tota l\u2019extensi\u00f3 de la capa I, el que implica una correcta senyalitzaci\u00f3 molecular que les gui\u00ef fins al seu dest\u00ed.<\/p>\n<p>La migraci\u00f3 de les c\u00e8l\u00b7lules Cajal-Retzius al seu torn est\u00e0 regulada per un sistema molecular d\u2019atracci\u00f3, el CXCL12\/CXCR4. Aquest sistema \u00e9s b\u00e0sic per l\u2019atracci\u00f3 de les c\u00e8l\u00b7lules des dels seus punts d\u2019origen fins a la superf\u00edcie del c\u00f2rtex cerebral per\u00f2, per si sol, no els pot indicar quan han de deixar de migrar per aix\u00ed distribuir-se en tot el c\u00f2rtex.<\/p>\n<p>En el seu estudi, publicat avui a Nature Communications, es demostra per primera vegada l\u2019exist\u00e8ncia d\u2019una mol\u00e8cula senyal, la Semaforina 3E (Sema3E) que, al unir-se a Plexina D1 (el seu receptor espec\u00edfic que presenten les c\u00e8l\u00b7lules Cajal-Retzius) \u00e9s capa\u00e7 de modular l\u2019acci\u00f3 del sistema CXCL12\/CXCR4.<\/p>\n<p>\u201cEl sistema Sema3E\/PlexinaD1 \u00e9s el que indica a les c\u00e8l\u00b7lules Cajal-Retzius quan han de parar\u201d comenta el Dr. Jos\u00e9 Antonio del R\u00edo, investigador principal del grup de Neurobotecnologia Molecular i Cel\u00b7lular de l\u2019IBEC i catedr\u00e0tic del Departament de Biologia Cel\u00b7lular de la UB. \u201cAl sistema nervi\u00f3s en desenvolupament, la Sema3E pot exercir funcions d\u2019inhibici\u00f3 o d\u2019atracci\u00f3 segons el receptor que presenten les c\u00e8l\u00b7lules diana. En aquest cas, les c\u00e8l\u00b7lules Cajal-Retzius presenten \u00fanicament el receptor PlexinaD1 i al unir-se amb la mol\u00e8cula Sema 3E la migraci\u00f3 cel\u00b7lular es veu frenada\u201d.<\/p>\n<p>Aquest treball constitueix la primera demostraci\u00f3 de les funcions d\u2019un sistema de senyalitzaci\u00f3 (Sema3E\/PlexinaD1), que ja es coneix que t\u00e9 implicacions molt importants en vascularitzaci\u00f3 i en c\u00e0ncer, durant el proc\u00e9s de migraci\u00f3 neuronal i la formaci\u00f3 del sistema nervi\u00f3s\u201d. Els investigadors han demostrat l\u2019acci\u00f3 del sistema Sema3E\/PlexinaD1 sobre les c\u00e8l\u00b7lules de Cajal-Retzius en embrions de ratol\u00ed, per\u00f2 encara falten m\u00e9s estudis per veure si es tracta d\u2019un proc\u00e9s com\u00fa en altres organismes, inclosos els humans. Com a resultat, el grup del IBEC col\u00b7labora amb l\u2019Hospital Vall d\u2019Hebron de Barcelona per treballar conjuntament en estudis futurs utilitzant el seu banc de teixits.<\/p>\n<p>&nbsp;<\/p>\n<p><em><strong>Reference article: <\/strong><\/em>Ana Bribi\u00e1n, Sara Nocentini, Franc Llorens, Vanessa Gil, Erik Mire, Diego Reginensi, Yutaka Yoshida, Fanny Mann, Jos\u00e9 Antonio del R\u00edo (2014). Sema3E\/PlexinD1 regulates the migration of hem-derived Cajal-Retzius cells in developing cerebral cortex. <em>Nat. Commun.<\/em>, \u00a05, 4265<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-8309 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/06\/imagedelrio_web.jpg\" border=\"0\" width=\"340\" height=\"210\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/06\/imagedelrio_web.jpg 340w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/06\/imagedelrio_web-300x185.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/06\/imagedelrio_web-242x150.jpg 242w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/06\/imagedelrio_web-150x92.jpg 150w\" data-sizes=\"(max-width: 340px) 100vw, 340px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 340px; --smush-placeholder-aspect-ratio: 340\/210;\" \/>Investigadors del Institut de Bioenginyeria de Catalunya (IBEC) i de la Universitat de Barcelona (UB) en col\u00b7laboraci\u00f3 amb l\u2019institut de Marseille Luminy de la Universitat de la Mediterr\u00e0nia de Fran\u00e7a i el Children\u2019s Hospital de Cincinnati, Estats Units, han identificat per primera vegada el mecanisme molecular que regula la migraci\u00f3 de les c\u00e8l\u00b7lules Cajal-Retzius en els primers estadis del desenvolupament del c\u00f2rtex cerebral, la capa m\u00e9s superficial del cervell.<\/h3>\n","protected":false},"author":4,"featured_media":8311,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-8313","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Es demostra per primera vegada 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