{"id":8337,"date":"2014-07-01T15:14:23","date_gmt":"2014-07-01T15:14:23","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/why-alzheimers-patients-have-no-memory-loss-when-the-disease-starts-2\/"},"modified":"2015-08-31T08:58:47","modified_gmt":"2015-08-31T08:58:47","slug":"why-alzheimers-patients-have-no-memory-loss-when-the-disease-starts-2","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/why-alzheimers-patients-have-no-memory-loss-when-the-disease-starts-2\/","title":{"rendered":"Es descobreix perqu\u00e8 els pacients d\u2019Alzheimer no presenten p\u00e8rdua de mem\u00f2ria a l\u2019inici de la malaltia"},"content":{"rendered":"

[br][br]<\/p>\n

Image: A section of brain cortex with hyperphosphorylated tau showing in black; (inset) a model of the PRPc protein<\/em><\/h6>\n

L\u2019Alzheimer \u00e9s una malaltia neurodegenerativa que es caracteritza per una p\u00e8rdua gradual de la mem\u00f2ria i d\u2019altres funcions mentals, a mesura que les neurones moren, diferents zones del cervell< s\u2019atrofien. Aquesta malaltia \u00e9s la forma de dem\u00e8ncia m\u00e9s comuna i apareix amb major freq\u00fc\u00e8ncia en la poblaci\u00f3 major de 65 anys (1,5 casos\/1000 persones-any a Europa, arribant a 69,2 casos\/1000 persones-any en la poblaci\u00f3 d\u2019edat superior a 90 anys). En aquesta malaltia es diferencien dues etapes: una inicial on els s\u00edmptomes no s\u00f3n clars i una segona fase on els s\u00edmptomes estan ben definits.<\/p>\n

L\u2019Alzheimer s\u2019atribueix principalment a dues causes; la pres\u00e8ncia d\u2019uns agregats extracel\u00b7lulars en forma de plaques, formats majorit\u00e0riament per un compost conegut com a p\u00e8ptid beta-amiloide; i una acumulaci\u00f3 de la forma hiperfosoforilada de la prote\u00efna tau, que forma petits cabdells a l\u2019interior de les neurones afectades. Fins avui es coneixia que la formaci\u00f3 dels cabdells de tau en les neurones depenia de l\u2019acci\u00f3 t\u00f2xica del p\u00e8ptid beta-amiloide, per\u00f2 el mecanisme d\u2019aquesta interacci\u00f3 entre els dos es desconeixia.<\/p>\n

Els investigadors -que van treballar en col\u00b7laboraci\u00f3 amb membres del Ciberned, del Centro de Biologia Molecular de Madrid i de l\u2019Institut de Neuropatologia de l\u2019IDIBELL-Hospital Universitari de Bellvitge- descriuen la relaci\u00f3 entre el p\u00e8ptid beta-amiloide i la fosforilaci\u00f3 de tau i la pres\u00e8ncia d\u2019una altra prote\u00efna en les neurones afectades, la prote\u00efna cel\u00b7lular pri\u00f3nica (PRPc). Els resultats mostren que quan els nivells neuronals de PRPc s\u00f3n elevats hi ha menor quantitat de prote\u00efna tau fosforilada a l\u2019interior cel\u00b7lular, encara que hi hagi pres\u00e8ncia del p\u00e8ptid beta-amiloide.<\/p>\n

\u201cEn estudis anteriors s\u2019havia investigat sobre els nivells de PRPc en estadis avan\u00e7ats de la malaltia\u201d, explica el Dr. Jos\u00e9 Antonio del R\u00edo, investigador principal del grup de Neurobiotecnologia Molecular i Cel\u00b7lular de l\u2019IBEC i catedr\u00e0tic del Departament de Biologia Cel\u00b7lular de la UB. \u201cPer\u00f2 el nostre nou estudi mostra, en cervells de ratolins i d\u2019humans afectats d\u2019Alzheimer, un increment de la prote\u00efna PRPc en els primers estadis asimptom\u00e0tics de la malaltia i com aquests nivells de PRPc van disminuint a mesura que avan\u00e7a la malaltia\u201d.<\/p>\n

Quan els nivells de PRPc s\u00f3n baixos la quantitat de tau -i la seva forma fosforilada formant cabdells a l\u2019interior cel\u00b7lular- augmenta, cosa que contribueix a la deterioraci\u00f3 cerebral observada en pacients d\u2019Alzheimer. \u201cCom a resultat, \u00e9s raonable considerar que la sobreexpressi\u00f3 de PRPc observada en l\u2019inici de la malaltia forma part d\u2019una resposta protectora del sistema nervi\u00f3s en un intent de reprimir l\u2019avan\u00e7 de la mateixa\u201d, diu el Dr. del R\u00edo \u201cConseq\u00fcentment, els pacients d\u2019Alzheimer no mostren d\u00e8ficits de mem\u00f2ria fins als estats avan\u00e7ats de la malaltia.\u201d<\/p>\n

Reference article:<\/strong> Cristina Vergara, Lara Ord\u00f3\u00f1ez-Guti\u00e9rrez, Francisco Wandosell, Isidre Ferrer, Jos\u00e9 Antonio del R\u00edo, Rosalina Gav\u00edn (2014). \u201cRole of PrPC expression in tau protein levels and phosphorylation in Alzheimer’s disease evolution\u201d<\/a>. Molecular Neurobiology<\/em>, Volume 51<\/span>, Issue 3<\/span>, pp 1206-1220<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i de la Universitat de Barcelona (UB) revelen, en un article publicat a la revista Molecular Neurobiology, que el nostre sistema nervi\u00f3s envia, de manera natural, una resposta protectora en un intent de reprimir l\u2019avan\u00e7 de l\u2019Alzheimer. <\/h3>\n

Aix\u00f2 contribuiria al fet que els pacients no mostren d\u00e8ficits de mem\u00f2ria en la primera etapa de la malaltia.<\/p>\n","protected":false},"author":4,"featured_media":8335,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-8337","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nEs descobreix perqu\u00e8 els pacients d\u2019Alzheimer no presenten p\u00e8rdua de mem\u00f2ria a l\u2019inici de la malaltia - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/why-alzheimers-patients-have-no-memory-loss-when-the-disease-starts-2\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Es descobreix perqu\u00e8 els pacients d\u2019Alzheimer no presenten p\u00e8rdua de mem\u00f2ria a l\u2019inici de la malaltia - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i de la Universitat de Barcelona (UB) revelen, en un article publicat a la revista Molecular Neurobiology, que el nostre sistema nervi\u00f3s envia, de manera natural, una resposta protectora en un intent de reprimir l\u2019avan\u00e7 de l\u2019Alzheimer. 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