{"id":8349,"date":"2014-07-07T07:06:49","date_gmt":"2014-07-07T07:06:49","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/lheparina-mostra-una-doble-activitat-contra-la-malaria\/"},"modified":"2015-10-20T14:04:23","modified_gmt":"2015-10-20T14:04:23","slug":"lheparina-mostra-una-doble-activitat-contra-la-malaria","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/lheparina-mostra-una-doble-activitat-contra-la-malaria\/","title":{"rendered":"L&#8217;heparina mostra una doble activitat contra la mal\u00e0ria"},"content":{"rendered":"<p>L&#8217;heparina, adsorbida electrost\u00e0ticament sobre els liposomes amb c\u00e0rrega positiva i carregats amb primaquina, medicament antimal\u00e0ric, va ser capa\u00e7 de triplicar l&#8217;activitat en cultius de<em> P. falciparum<\/em> del f\u00e0rmac encapsulat. En concentracions inferiors a les que indueixen anticoagulaci\u00f3 de la sang de ratol\u00ed <em>in vivo<\/em>, l&#8217;activitat parasiticida va resultar ser la suma de les activitats separades d&#8217;heparina lliure com antimal\u00e0ric i d&#8217;heparina unida al liposoma com a element vectoritzador per a la primaquina encapsulada.<\/p>\n<p>Els investigadors van observar mitjan\u00e7ant imatges de fluoresc\u00e8ncia confocal i de microsc\u00f2pia electr\u00f2nica que al cap de 30 minuts d&#8217;haver tractat gl\u00f2buls vermells infectats per Plasmodium amb heparina, aquesta havia penetrat els par\u00e0sits intracel\u2022lulars.<\/p>\n<p>Xavier Fern\u00e1ndez-Busquets, investigador ISGlobal i IBEC i coordinador de l&#8217;estudi, comenta que &#8220;aquests resultats obren la porta a millorar el tractament amb heparina contra la mal\u00e0ria degut a la seva activitat additiva com a f\u00e0rmac i com a element vectoritzador espec\u00edfic d&#8217;altres antimal\u00e0rics; per\u00f2, ser\u00e0 necessari realitzar m\u00e9s investigaci\u00f3 a nivell cl\u00ednic per comprovar el paper de l&#8217;heparina en pacients infectats per <em>Plasmodium<\/em>&#8221;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Refer\u00e8ncia de l&#8217;article:<\/strong> Marques J, Moles E, Urb\u00e1n P, Prohens R, Busquets MA, Sevrin C, Grandfils C, Fern\u00e0ndez-Busquets X. (2014). &#8220;<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1549963414003141\" target=\"_blank\">Application of heparin as a dual agent with antimalarial and liposome targeting activities towards Plasmodium-infected red blood cells.<\/a>&#8221; <em>Nanomedicine<\/em>, 10, 8, p1719\u20131728<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<h3><img decoding=\"async\" class=\"left size-full wp-image-8345 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/07\/heparin2014.jpg\" border=\"0\" width=\"340\" height=\"210\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/07\/heparin2014.jpg 340w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/07\/heparin2014-300x185.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/07\/heparin2014-242x150.jpg 242w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/07\/heparin2014-150x92.jpg 150w\" data-sizes=\"(max-width: 340px) 100vw, 340px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 340px; --smush-placeholder-aspect-ratio: 340\/210;\" \/>Una recerca publicada a Nanomedicine i portada a terme per cient\u00edfics del IBEC, ISGlobal i la UB obre la porta a millorar el tractament de la mal\u00e0ria mitjan\u00e7ant heparina.<\/h3>\n<p>L&#8217;estudi publicat a Nanomedicine explora si l&#8217;heparina (esquerra), que ha mostrat tenir activitat contra la mal\u00e0ria i afinitat d&#8217;uni\u00f3 espec\u00edfica per als gl\u00f2buls vermells infectats per <em>Plasmodium falciparum<\/em> respecte els gl\u00f2buls no infectats, pot mostrar ambdues propietats i unir-les en una estrat\u00e8gia d&#8217;administraci\u00f3 de f\u00e0rmacs contra la mal\u00e0ria. En aquest cas l&#8217;heparina tindria un doble paper com antimal\u00e0ric i com a element de focalitzaci\u00f3 de les nanopart\u00edcules carregades amb f\u00e0rmacs que actuarien en unir-se als gl\u00f2buls vermells infectats. Aquest estudi, dut a terme per investigadors del CRESIB, centre d&#8217;investigaci\u00f3 d&#8217;ISGlobal, l&#8217;Institut de Bioenginyeria de Catalunya (IBEC) i de la Universitat de Barcelona, ha estat publicat en Nanomedicine.<\/p>\n","protected":false},"author":4,"featured_media":8347,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-8349","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>L&#039;heparina mostra una doble activitat contra la mal\u00e0ria - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/lheparina-mostra-una-doble-activitat-contra-la-malaria\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L&#039;heparina mostra una doble activitat contra la mal\u00e0ria - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Una recerca publicada a Nanomedicine i portada a terme per cient\u00edfics del IBEC, ISGlobal i la UB obre la porta a millorar el tractament de la mal\u00e0ria mitjan\u00e7ant heparina. L&#039;estudi publicat a Nanomedicine explora si l&#039;heparina (esquerra), que ha mostrat tenir activitat contra la mal\u00e0ria i afinitat d&#039;uni\u00f3 espec\u00edfica per als gl\u00f2buls vermells infectats per Plasmodium falciparum respecte els gl\u00f2buls no infectats, pot mostrar ambdues propietats i unir-les en una estrat\u00e8gia d&#039;administraci\u00f3 de f\u00e0rmacs contra la mal\u00e0ria. En aquest cas l&#039;heparina tindria un doble paper com antimal\u00e0ric i com a element de focalitzaci\u00f3 de les nanopart\u00edcules carregades amb f\u00e0rmacs que actuarien en unir-se als gl\u00f2buls vermells infectats. Aquest estudi, dut a terme per investigadors del CRESIB, centre d&#039;investigaci\u00f3 d&#039;ISGlobal, l&#039;Institut de Bioenginyeria de Catalunya (IBEC) i de la Universitat de Barcelona, ha estat publicat en Nanomedicine.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/lheparina-mostra-una-doble-activitat-contra-la-malaria\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2014-07-07T07:06:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-10-20T14:04:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2014\/07\/heparin2014.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"340\" \/>\n\t<meta property=\"og:image:height\" content=\"210\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minut\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/lheparina-mostra-una-doble-activitat-contra-la-malaria\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/lheparina-mostra-una-doble-activitat-contra-la-malaria\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"L&#8217;heparina mostra una doble activitat contra la mal\u00e0ria\",\"datePublished\":\"2014-07-07T07:06:49+00:00\",\"dateModified\":\"2015-10-20T14:04:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/lheparina-mostra-una-doble-activitat-contra-la-malaria\\\/\"},\"wordCount\":242,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/lheparina-mostra-una-doble-activitat-contra-la-malaria\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2014\\\/07\\\/heparin2014.jpg\",\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/lheparina-mostra-una-doble-activitat-contra-la-malaria\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/lheparina-mostra-una-doble-activitat-contra-la-malaria\\\/\",\"name\":\"L'heparina mostra una doble activitat contra la mal\u00e0ria - 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