{"id":8374,"date":"2014-08-04T07:23:56","date_gmt":"2014-08-04T07:23:56","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/investigadors-de-libec-descobreixen-un-nou-mecanisme-de-curacio-de-ferides\/"},"modified":"2015-10-19T15:54:55","modified_gmt":"2015-10-19T15:54:55","slug":"investigadors-de-libec-descobreixen-un-nou-mecanisme-de-curacio-de-ferides","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-descobreixen-un-nou-mecanisme-de-curacio-de-ferides\/","title":{"rendered":"Investigadors de l\u2019IBEC descobreixen un nou mecanisme de curaci\u00f3 de ferides"},"content":{"rendered":"
Descripci\u00f3: Mapa de les forces f\u00edsiques que les c\u00e8l\u00b7lules exerceixen durant la curaci\u00f3 d\u2019una ferida. Les c\u00e8l\u00b7lules estan marcades en blau, les forces en vermell i groc, i la\u00a0ferida \u00e9s la zona fosca al centre de la imatge<\/h6>\n

Quan pensem en la curaci\u00f3 de les ferides, normalment pensem en les ferides de la nostra pell, per\u00f2 tamb\u00e9 hi ha ferides en tota mena de teixits i \u00f2rgans a l\u2019interior del nostre cos que poden estar relacionades amb malalties cr\u00f2niques, com la diabetis o l\u2019asma. Les ferides internes tamb\u00e9 poden afavorir la progressi\u00f3 del c\u00e0ncer, ja que proporcionen un entorn f\u00edsic i qu\u00edmic que promou la invasi\u00f3 de c\u00e8l\u00b7lules malignes.<\/p>\n

Des de fa temps se sap que hi ha dos mecanismes diferents que contribueixen a la curaci\u00f3 de les ferides. En el primer mecanisme es forma un anell de prote\u00efnes contr\u00e0ctils a la vora de la ferida i la contracci\u00f3 d\u2019aquest anell la tanca de la mateixa manera que ho fa una bossa quan n\u2019estirem els cordills. En l\u2019altre m\u00e8tode, que es denomina \u2018migraci\u00f3 cel\u00b7lular\u2019, les mateixes c\u00e8l\u00b7lules estenenuns \u2018bra\u00e7os microm\u00e8trics\u2019 ,coneguts com a \u2018lamelipodis\u2019, que els permeten arrossegar-se fins a tancar la ferida. En algunes ferides els dos mecanismes poden funcionar simult\u00e0niament, mentre que en d\u2019altres nom\u00e9s se n\u2019utilitza un dels dos.<\/p>\n

El grup de l\u2019IBEC, en col\u00b7laboraci\u00f3 amb l\u2019Institut de Recerca Biom\u00e8dica (IRB), la Universitat Polit\u00e8cnica de Catalunya (UPC), la Universitat de Barcelona (UB), la Universitat de Paris-Diderot, el Mechanobiology Institute de Singapur i la Universitat de Waterloo de Canad\u00e0, ha desenvolupat per primera vegada, una t\u00e8cnica per mesurar a la nano-escala les forces que hi ha al darrere del proc\u00e9s de curaci\u00f3 de les ferides, y fent aix\u00f2, han descobert que els dos mecanismes acceptats actualment no s\u00f3n suficients per explicar el fenomen. De forma inesperada han trobat un nou mecanisme en el qual les c\u00e8l\u00b7lules generen arcs contr\u00e0ctils supracel\u00b7lulars que comprimeixen el teixit sota la ferida. Combinant experiments i models computacionals, els autors han demostrat que les contraccions derivades d\u2019aquests arcs permeten la curaci\u00f3 de les ferides d\u2019una manera m\u00e9s r\u00e0pida i resistent.<\/p>\n

\u201cDes de fa temps sab\u00edem que la curaci\u00f3 de les ferides no es podia entendre completament sense una mesura directa de les forces que impulsen el moviment de les c\u00e8l\u00b7lules\u201d, explica Xavier Trepat, investigador principal del grup de Din\u00e0mica Integrativa de C\u00e8l\u00b7lules i de Teixits de l\u2019IBEC i professor investigador ICREA. \u201cSom els primers investigadors a desenvolupar la tecnologia per fer aquestes mesures, per\u00f2 no esper\u00e0vem ensopegar amb un mecanisme tan integratiu en el qual les c\u00e8l\u00b7lules ve\u00efnes coordinessin el seu treball f\u00edsic amb tanta precisi\u00f3\u201d.<\/p>\n

 <\/p>\n

Article de refer\u00e8ncia:<\/em> <\/strong>Agust\u00ed Brugu\u00e9s, Ester Anon, Vito Conte, Jim H. Veldhuis, Mukund Gupta, Julien Colombelli, Jos\u00e9 J. Mu\u00f1oz, G. Wayne Brodland, Benoit Ladoux, Xavier Trepat (2014). Forces driving epithelial wound healing<\/a>. Nature Physics <\/em>10, 683\u2013690<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Un grup investigador de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) ha desenvolupat una nova tecnologia per desxifrar els mecanismes de curaci\u00f3 de les ferides. Gr\u00e0cies a aquesta tecnologia han descobert com les c\u00e8l\u00b7lules es mouen i treballen conjuntament per tancar una lesi\u00f3 en un teixit.<\/h3>\n

L\u2019estudi, publicat avui a Nature Physics<\/em>, significa un gran pas endavant per comprendre el misteri de la reparaci\u00f3 de les ferides podent ajudar a desenvolupar tractaments per accelerar-ne la curaci\u00f3, ja que optimitzar la reparaci\u00f3 de teixits \u00e9s una necessitat important per al tractament de malalties agudes i cr\u00f2niques. El descobriment del mecanisme b\u00e0sic demostrat en aquest estudi tamb\u00e9 \u00e9s un pas important per aconseguir una regeneraci\u00f3 efica\u00e7 d\u2019\u00f2rgans.<\/p>\n","protected":false},"author":4,"featured_media":8370,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-8374","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nInvestigadors de l\u2019IBEC descobreixen un nou mecanisme de curaci\u00f3 de ferides - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-descobreixen-un-nou-mecanisme-de-curacio-de-ferides\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors de l\u2019IBEC descobreixen un nou mecanisme de curaci\u00f3 de ferides - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un grup investigador de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) ha desenvolupat una nova tecnologia per desxifrar els mecanismes de curaci\u00f3 de les ferides. 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