{"id":8415,"date":"2014-09-03T09:40:48","date_gmt":"2014-09-03T09:40:48","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/new\/cientifics-desenvolupen-el-primer-farmac-regulat-per-llum-dirigit-a-les-proteines-mes-comunes\/"},"modified":"2015-08-24T14:13:21","modified_gmt":"2015-08-24T14:13:21","slug":"cientifics-desenvolupen-el-primer-farmac-regulat-per-llum-dirigit-a-les-proteines-mes-comunes","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/cientifics-desenvolupen-el-primer-farmac-regulat-per-llum-dirigit-a-les-proteines-mes-comunes\/","title":{"rendered":"Cient\u00edfics desenvolupen el primer f\u00e0rmac regulat per llum dirigit a les prote\u00efnes m\u00e9s comunes"},"content":{"rendered":"
A dalt: Alloswitch-1 \u00e9s el primer modulador de llum al\u00b7lost\u00e8ric <\/span>controlada \u00a0per un receptor acoblat a la prote\u00efna G. \u00c9s selectiu per al receptor de glutamat metabotr\u00f3pic (mGlu5) i permet el control \u00f2ptic de senyalitzaci\u00f3 mGlu5 in vivo.<\/h6>\n

Els investigadors, del IBEC, IQAC-CSIC, UAB i IDIBELL a Barcelona i del IGF-CNRS de Montpellier, Fran\u00e7a, han desenvolupat una petita mol\u00e8cula agent terap\u00e8utic que en unir-se espec\u00edficament en el lloc no-actiu, o lloc al\u2022lost\u00e8ric, de la prote\u00efna diana \u00e9s capa\u00e7 de modular els seus receptors. Els moduladors al\u2022lost\u00e8rics tenen nombrosos avantatges comparats amb els f\u00e0rmacs tradicionals, ofereixen una major selectivitat per unir-se als receptors espec\u00edfics, s\u2019alliberen de forma sincronitzada d\u2019acord amb l\u2019activitat de la prote\u00efna i el seu potencial de toxicitat \u00e9s menor.<\/p>\n

\u201cPer a construir un modulador fotocontrolable per a un receptor acoblat a prote\u00efna G hem hagut de desenvolupar un nou concepte de disseny qu\u00edmic en el qual el fotoconmutable no est\u00e0 unit al f\u00e0rmac sin\u00f3 que est\u00e0 insertat en el farmac\u00f2for, que \u00e9s el gruo d\u2019\u00e0toms d\u2019una mol\u00e8cula d\u2019un f\u00e0rmac que s\u00f3n responsables de la seva acci\u00f3,\u201d explica Pau Gorostiza, investigador principal del grup de Nanosondes i Nanoconmutadors del IBEC. \u201cTamb\u00e9 hem tingut una mica de sort perqu\u00e8 no nom\u00e9s hem obtingut un lligand fotoconmutable per a aquestes prote\u00efnes, sin\u00f3 que tamb\u00e9 \u00e9s un dels moduladors al\u2022lost\u00e8rics m\u00e9s potents i selectius del de la seva classe\u201d.<\/p>\n

Els efectes d\u2019aquest compost \u2018opta farmacol\u00f2gic\u2019 poden ser controlades remotament en l\u2019espai i el temps en organismes vius. Aquest \u00e9s un avantatge en comparaci\u00f3 amb les manipulacions opto gen\u00e8tiques que requereixen la sobreexpressi\u00f3 de gens utilitzant virus, per exemple.<\/p>\n

Petites mol\u00e8cules agents terap\u00e8utics com Aloswitch-1, si s\u2019aconsegueix disposar d\u2019ells per via oral, podrien oferir un avantatge competitiu respecte als f\u00e0rmacs tradicionals que moltes vegades afecten \u00f2rgans i teixits no diana portant a conseq\u00fc\u00e8ncies indesitjades que poden comprometre els seus efectes beneficiosos.<\/p>\n

—<\/p>\n

Article de refer\u00e8ncia:<\/em> <\/strong>Silvia Pittolo, Xavier G\u00f3mez-Santacana, Kay Eckelt, Xavier Rovira, James Dalton, Cyril Goudet, Jean-Philippe Pin, Artur Llobet, Jes\u00fas Giraldo, Amadeu Llebaria & Pau Gorostiza (2014). An allosteric modulator to control endogenous G protein-coupled receptors with light.<\/a>. Nature Chemical Biology<\/em>, 10, 813\u2013815<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Els investigadors del grup de Nanosondes i Nanocommutadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i els seus col\u2022laboradors han anunciat el desenvolupament del primer agent terap\u00e8utic controlat per llum els efectes del qual es focalitzen espec\u00edficament en la classe m\u00e9s gran de prote\u00efnes que s\u00f3n diana de f\u00e0rmacs \u2013 els receptors acoblats a prote\u00efnes G.<\/h3>\n

A la revista Nature Chemical Biology<\/em> els cient\u00edfics descriuen Alloswitch-1, l\u2019\u00faltim avan\u00e7 en la seva recerca en f\u00e0rmacs fotocommutables (o regulats per llum). Controlar l\u2019activitat d\u2019un f\u00e0rmac mitjan\u00e7ant la llum significa que els agents terap\u00e8utics poden ser alliberats amb precisi\u00f3 a un nivell local, d\u2019aquesta manera es redueix el seu efecte en altres \u00e0rees i conseq\u00fcentment es redueixen tamb\u00e9 els efectes secundaris, el que al seu torn ajuda a reduir la dosis requerida.<\/p>\n","protected":false},"author":4,"featured_media":8413,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"post_formats":[],"class_list":["post-8415","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca"],"yoast_head":"\nCient\u00edfics desenvolupen el primer f\u00e0rmac regulat per llum dirigit a les prote\u00efnes m\u00e9s comunes - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/cientifics-desenvolupen-el-primer-farmac-regulat-per-llum-dirigit-a-les-proteines-mes-comunes\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cient\u00edfics desenvolupen el primer f\u00e0rmac regulat per llum dirigit a les prote\u00efnes m\u00e9s comunes - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Els investigadors del grup de Nanosondes i Nanocommutadors de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) i els seus col\u2022laboradors han anunciat el desenvolupament del primer agent terap\u00e8utic controlat per llum els efectes del qual es focalitzen espec\u00edficament en la classe m\u00e9s gran de prote\u00efnes que s\u00f3n diana de f\u00e0rmacs \u2013 els receptors acoblats a prote\u00efnes G. 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