{"id":84231,"date":"2021-05-07T09:39:40","date_gmt":"2021-05-07T07:39:40","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=84231"},"modified":"2021-05-07T10:00:45","modified_gmt":"2021-05-07T08:00:45","slug":"noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/","title":{"rendered":"Noves mol\u00e8cules permeten activar i desactivar circuits neuronals utilitzant llum"},"content":{"rendered":"
\"\"
Transmissi\u00f3 sin\u00e0ptica, sistema nervi\u00f3s hum\u00e0, renderitzat 3D<\/figcaption><\/figure>\n

El sistema nervi\u00f3s\u00a0<\/span>dels v<\/span>ertebrat<\/span>s<\/span>, incloent<\/span>-hi<\/span>\u00a0els circuits neuronals de la medul\u00b7la espinal i\u00a0<\/span>d<\/span>el tronc de\u00a0<\/span>l\u2019enc<\/span>\u00e8<\/span>fal<\/span>,<\/span>\u00a0es basen entre d’altres, en el correcte funcionament dels receptors de glicina (<\/span>GlyR<\/span>). Aquests receptors estan implicats en la locomoci\u00f3, la sensaci\u00f3 de dolor, la respiraci\u00f3 i la funci\u00f3 auditiva i molt sovint el seu mal funcionament est\u00e0 relacionat amb el desenvolupament de trastorns neurol\u00f2gics greus. S’han descrit molt pocs medicaments fins al moment\u00a0<\/span>capa\u00e7os de<\/span>\u00a0modular els receptors de glicina i,\u00a0<\/span>malauradament<\/span>, no s\u00f3n molt espec\u00edfics i causen efectes secundaris.<\/span>\u00a0<\/span><\/p>\n

Ara, un consorci europeu\u00a0<\/span>(<\/span>Modulightor<\/span>)\u00a0<\/span>coordinat pel professor d’investigaci\u00f3 ICREA Pau\u00a0<\/span>Gorostiza<\/span>, l\u00edder del grup “<\/span>Nanoprobes<\/span>\u00a0i\u00a0<\/span>Nanoswitches<\/span><\/a>” a\u00a0<\/span>l\u2019<\/span>IBEC i membre del Centre de Xarxes d’Investigaci\u00f3 Biom\u00e8dica en\u00a0<\/span>B<\/span>ioenginyeria,\u00a0<\/span>B<\/span>iomaterials i\u00a0<\/span>N<\/span>anomedicina<\/span>\u00a0(CIBER-BBN), ha desenvolupat, per primera vegada, mol\u00e8cules org\u00e0niques que\u00a0<\/span>confereixen<\/span>\u00a0als\u00a0<\/span>GlyR<\/span>s<\/span>\u00a0<\/span>sensibilitat\u00a0<\/span>a\u00a0<\/span>la llum<\/span>,\u00a0<\/span>anomenades\u00a0<\/span>Glyght<\/span>\u00a0i Azo-NZ1.\u00a0<\/span>El treball<\/span>, public<\/span>at<\/span>\u00a0en dos<\/span>\u00a0articles en les\u00a0<\/span>revistes\u00a0<\/span>eNeuro<\/span><\/i><\/a>\u00a0i\u00a0<\/span>Cell\u00a0<\/span><\/i>Chemical<\/span><\/i>\u00a0<\/span><\/i>Biology<\/span><\/i><\/a>, mostra un control efectiu i espec\u00edfic sobre l’activitat de\u00a0<\/span>GlyR<\/span>\u00a0<\/span>in vitro<\/span><\/i>\u00a0i\u00a0<\/span>in\u00a0<\/span><\/i>vivo<\/span><\/i>. Aquestes mol\u00e8cules org\u00e0niques\u00a0<\/span>fotocr\u00f2miques<\/span>\u00a0poden ser controlades per la llum d’una manera no invasiva i permeten una selectivitat espacial i temporal precisa, afavorint l’acci\u00f3 espec\u00edfica de\u00a0<\/span>medicaments<\/span>. Els altres laboratoris del consorci estan dirigits per Carme Rovira (Universitat de Barcelona), Piotr\u00a0<\/span>Bregestovski<\/span>\u00a0(Universitat\u00a0<\/span>Aix-Marseille<\/span>), i\u00a0<\/span>Burkhard<\/span>\u00a0K<\/span>\u00f6<\/span>nig<\/span>\u00a0(Universitat de\u00a0<\/span>Regensburg<\/span>).<\/span>\u00a0<\/span><\/p>\n

Glyght<\/span><\/span>\u00a0i Azo-NZ1 confereixen als receptors de glicina<\/span><\/span>\u00a0<\/span><\/span>la\u00a0<\/span><\/span>capacita<\/span><\/span>t de resposta a la llum<\/span><\/span>\u00a0<\/span><\/span>\u00a0<\/span> <\/strong><\/h2>\n

Els receptors de glicina (<\/span>GlyRs<\/span>) s\u00f3n receptors inhibidors \u00e0mpliament distribu\u00efts en el sistema nervi\u00f3s central dels vertebrats i\u00a0<\/span>jug<\/span>ue<\/span>n<\/span>\u00a0un paper clau en la regulaci\u00f3 (inhibici\u00f3) de la transmissi\u00f3 dels senyals a trav\u00e9s de les neurones. Estan involucrats en trastorns com la\u00a0<\/span>hiperekplexia<\/span>\u00a0(resposta excessiva<\/span>\u00a0a<\/span>l sobresalt<\/span>),\u00a0<\/span>la\u00a0<\/span>sensi<\/span>bilitzaci\u00f3 al<\/span>\u00a0dolor inflamatori, l’autisme, l’epil\u00e8psia del l\u00f2bul temporal, trastorns respiratoris, l’alcoholisme i malalti<\/span>es relacionades amb\u00a0<\/span>les neurones motores. Fins avui, nom\u00e9s\u00a0<\/span>s\u2019han descrit<\/span>\u00a0<\/span>alguns<\/span>\u00a0medicaments\u00a0<\/span>amb les\u00a0<\/span>GlyR<\/span>s<\/span>\u00a0com diana<\/span>, revelant les limitacions de la farmacologia tradicional. Un dels principals reptes en el tractament d’aquests trastorns \u00e9s trobar compostos que actu<\/span>\u00ef<\/span>n d’una manera espacial i temporal afinada per obtenir una acci\u00f3 espec\u00edfica de<\/span>l medicament<\/span>\u00a0i desenvolupar futures ter\u00e0pies amb efectes secundaris redu\u00efts.<\/span>\u00a0<\/span><\/p>\n

En els \u00faltims anys, el desenvolupament de la\u00a0<\/span>fotofarmacologia<\/span>, un camp que combina enfocaments biol\u00f2gics amb m\u00e8todes de fotoqu\u00edmica, apareix com una alternativa al disseny de ter\u00e0pies m\u00e9s segures i eficients basades en mol\u00e8cules\u00a0<\/span>fotocr\u00f2miques<\/span>, que utilitzen la llum per controlar els processos biol\u00f2gics i\u00a0<\/span>estudiar<\/span>\u00a0la din\u00e0mica de prote\u00efnes.<\/span>\u00a0<\/span><\/p>\n

\"\"<\/p>\n

Glyght<\/span><\/span>\u00a0(<\/span><\/span>de<\/span><\/span>\u00a0<\/span><\/span>l<\/span><\/span>\u2019<\/span><\/span>angl\u00e8s\u00a0<\/span><\/span>GlyR<\/span><\/span>\u00a0<\/span><\/span>controlled<\/span><\/span>\u00a0<\/span><\/span>by<\/span><\/span>\u00a0light<\/span><\/span>) i Azo-NZ1 (compost\u00a0<\/span><\/span>fotocr\u00f2mic<\/span><\/span>\u00a0basat en l’azobenz\u00e8-nitrazepam), les noves mol\u00e8cules desenvolupades pels investigadors de l’IBEC i els seus col\u00b7laboradors, poden controlar l’activitat dels\u00a0<\/span><\/span>GlyR<\/span><\/span>s<\/span><\/span>\u00a0d’una manera dependent de la llum. Quan s’il\u00b7luminen amb llum ultraviolada, canvien la seva configuraci\u00f3 i s’uneixen a una regi\u00f3 espec\u00edfica del\u00a0<\/span><\/span>GlyR<\/span><\/span>, inhibint la seva funci\u00f3. A l’inrev\u00e9s,\u00a0<\/span><\/span>la uni\u00f3\u00a0<\/span><\/span>es pot invertir amb llum blava.<\/span><\/span>\u00a0<\/span><\/p>\n

La seva activitat<\/span><\/span>\u00a0d\u2019inhibici\u00f3 de\u00a0<\/span><\/span>l’acci\u00f3 de\u00a0<\/span><\/span>GlyRs<\/span><\/span>, r<\/span><\/span>ecolzada per\u00a0<\/span><\/span>models\u00a0<\/span><\/span>in\u00a0<\/span><\/span>silico<\/span><\/span>,\u00a0<\/span><\/span>es va demostrar\u00a0<\/span><\/span>in vitro<\/span><\/span>\u00a0en c\u00e8l\u00b7lules\u00a0<\/span><\/span>d\u2019<\/span><\/span>ovaris de\u00a0<\/span><\/span>hamster<\/span><\/span>\u00a0i talls cerebrals de ratolins, i\u00a0<\/span><\/span>in\u00a0<\/span><\/span>vivo<\/span><\/span>\u00a0en peix zebra. En els experiments\u00a0<\/span><\/span>in\u00a0<\/span><\/span>vivo<\/span><\/span>, els investigadors\u00a0<\/span><\/span>van poder o<\/span><\/span>bservar clarament l’efecte d’engegar i desactivar els moduladors de\u00a0<\/span><\/span>GlyR<\/span><\/span>\u00a0sobre el comportament dels peixos. En conjunt, els resultats mostren que aquestes mol\u00e8cules poden ser eines \u00fatils per controlar els circuits neuronals en diferents parts del sistema nervi\u00f3s, com la medul\u00b7la espinal,<\/span><\/span>\u00a0el<\/span><\/span>\u00a0<\/span><\/span>tronc de\u00a0<\/span><\/span>l\u2019enc<\/span><\/span>\u00e8<\/span><\/span>fal<\/span><\/span>\u00a0<\/span><\/span>i<\/span><\/span>\u00a0el<\/span><\/span>\u00a0cerebel.<\/span><\/span>\u00a0<\/span><\/p>\n

Els lligands\u00a0<\/span><\/span>amb resposta a la llum\u00a0<\/span><\/span>permeten controlar directament l’activitat dels receptors end\u00f2gens sense necessitat de manipulaci\u00f3 gen\u00e8tica. Es poden aplicar als teixits intactes, fent possible les fototer\u00e0pies basades en f\u00e0rmacs<\/span><\/span>.\u00a0\u00a0<\/strong><\/p>\n

Galyna Maleeva, primera autora del\u00a0<\/span><\/span>treball publicat a\u00a0<\/span><\/span>eNeuro<\/span><\/span>.\u00a0<\/strong><\/p>\n<\/blockquote>\n

Els receptors de<\/span><\/span>\u00a0<\/span><\/span>glicina s\u00f3n clau\u00a0<\/span><\/span>en el\u00a0<\/span><\/span>sistema nervi\u00f3s<\/span><\/span> <\/strong><\/h2>\n

Els\u00a0<\/span>GlyRs<\/span>\u00a0<\/span>s\u00f3n canals\u00a0<\/span>d’ions<\/span>\u00a0<\/span>regulats per\u00a0<\/span>lligands<\/span>\u00a0i estan<\/span>\u00a0presents a la membrana de les neurones<\/span>,\u00a0<\/span>jugant<\/span>\u00a0<\/span>un\u00a0<\/span>paper important en la\u00a0<\/span>inhibici\u00f3 de la\u00a0<\/span>neurotransmissi\u00f3<\/span>\u00a0<\/span>a<\/span>\u00a0la medul\u00b7la espinal i el tronc cerebral. Els\u00a0<\/span>GlyRs<\/span>\u00a0tamb\u00e9 s\u00f3n\u00a0<\/span>fonamentals<\/span>\u00a0en altres processos fisiol\u00f2gics i regulen l’excitabilitat en la retina, l’hipocamp i\u00a0<\/span>l\u2019am\u00edgdala<\/span>, i participen en el control de moviment, la respiraci\u00f3 i el processament de la informaci\u00f3 sensorial. Quan s’activa per glicina, un amino\u00e0cid i neurotransmissor,\u00a0<\/span>GlyR<\/span>\u00a0genera un corrent de clorur\u00a0<\/span>a la membrana\u00a0<\/span>que inhibeix la transmissi\u00f3 dels senyals a trav\u00e9s de les neurones.<\/span>\u00a0<\/span><\/p>\n

Tant Azo-NZ1 com\u00a0<\/span>Glyght<\/span>\u00a0causen una forta inhibici\u00f3 dels corrents indu\u00efts per la glicina i representen una eina prometedora per a les aplicacions farmacol\u00f2giques, aix\u00ed com per a la regulaci\u00f3 espec\u00edfica de la plasticitat neuronal i l’excitabilitat controlada per la llum en les diferents regions cerebrals.<\/span>\u00a0<\/span><\/p>\n

La possibilitat de controlar aquests receptors amb llum \u00e9s una manera prometedora d’entendre els circuits neuronals que controlen<\/span><\/span>,<\/span><\/span>\u00a0i\u00a0<\/span><\/span>de\u00a0<\/span><\/span>desenvolupar<\/span><\/span>,<\/span><\/span>\u00a0en animals intactes<\/span><\/span>,<\/span><\/span>\u00a0<\/span><\/span>fototer\u00e0pies basades en f\u00e0rmacs<\/span><\/span>.\u00a0<\/strong><\/p>\n

Alexandre Gomila, primer autor\u00a0<\/span><\/span>treball publicat a\u00a0<\/span><\/span>Cell\u00a0<\/span><\/span>Chemical<\/span><\/span>\u00a0<\/span><\/span>Biology<\/span><\/span> \u00a0<\/strong><\/p>\n<\/blockquote>\n

Aquestes noves mol\u00e8cules\u00a0<\/span><\/span>obren<\/span><\/span>\u00a0el cam\u00ed al desenvolupament de medicaments que poden modular espec\u00edficament els receptors en cada malaltia, reduint els efectes secundaris i augmentant l’efectivitat del<\/span><\/span>s<\/span><\/span>\u00a0tractament<\/span><\/span>s<\/span><\/span>.<\/span><\/span>\u00a0<\/span><\/p>\n

\n
\n

Articles de refer\u00e8ncia: <\/span><\/b>\u00a0<\/span><\/p>\n

Galyna<\/span>\u00a0<\/span>Maleeva<\/span>, Alba Nin-Hill, Karin\u00a0<\/span>Rustler<\/span>, Elena\u00a0<\/span>Petukhova<\/span>, Daria\u00a0<\/span>Ponomareva<\/span>, Elvira\u00a0<\/span>Mukhametova<\/span>, Alexandre MJ Gomila, Daniel\u00a0<\/span>Wutz<\/span>, Mercedes Alfonso-Prieto,\u00a0<\/span>Burkhard<\/span>\u00a0<\/span>K\u00f6nig<\/span>, Pau Gorostiza and Piotr\u00a0<\/span>Bregestovski<\/span>.\u00a0<\/span>Subunit-Specific Photocontrol of Glycine Receptors by Azobenzene-Nitrazepam\u00a0<\/span>Photoswitcher<\/span><\/a>.\u00a0<\/span>eNeuro<\/span>\u00a0(202<\/span>1<\/span>) 8 (1)<\/span>\u00a01-17<\/span>.<\/span>\u00a0<\/span><\/p>\n

Alexandre M.J. Gomila, Karin Rustler, Galyna\u00a0<\/span>Maleeva<\/span>, Alba Nin-Hill, Daniel Wutz, Antoni Bautista-<\/span>Barrufet<\/span>, Xavier Rovira, Miquel Bosch, Elvira\u00a0<\/span>Mukhametova<\/span>, Marat\u00a0<\/span>Mukhamedyarov<\/span>, Frank\u00a0<\/span>Peiretti<\/span>, Mercedes Alfonso-Prieto, Carme Rovira, Burkhard K\u00f6nig, Piotr\u00a0<\/span>Bregestovski<\/span>, Pau Gorostiza<\/span>. Photocontrol of endogenous glycine receptors in vivo.<\/span><\/a>\u00a0<\/span>Cell Chemical Biology\u00a0<\/span>(2020), 27 (11), 1425-1433.\u00a0<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l\u2019IBEC, en col\u00b7laboraci\u00f3 amb un equip internacional, descriuen les primeres mol\u00e8cules capaces de regular els receptors de glicina amb llum: Glyght i Azo-NZ1. Una manera d’estudiar els circuits neuronals, desenvolupar fototer\u00e0pies basades en f\u00e0rmacs de forma no invasiva, i comprendre els trastorns neurol\u00f2gics relacionats amb el funcionament incorrecte dels receptors de glicina. <\/h3>\n","protected":false},"author":4,"featured_media":84223,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1492,1491,1150],"post_formats":[],"class_list":["post-84231","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-azo-nz1-ca","tag-glyght-ca","tag-pau-gorostiza-ca"],"yoast_head":"\nNoves mol\u00e8cules permeten activar i desactivar circuits neuronals utilitzant llum - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Noves mol\u00e8cules permeten activar i desactivar circuits neuronals utilitzant llum - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l\u2019IBEC, en col\u00b7laboraci\u00f3 amb un equip internacional, descriuen les primeres mol\u00e8cules capaces de regular els receptors de glicina amb llum: Glyght i Azo-NZ1. Una manera d'estudiar els circuits neuronals, desenvolupar fototer\u00e0pies basades en f\u00e0rmacs de forma no invasiva, i comprendre els trastorns neurol\u00f2gics relacionats amb el funcionament incorrecte dels receptors de glicina.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-07T07:39:40+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-05-07T08:00:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/synaptic-transmission-human-nervous-system_500.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Noves mol\u00e8cules permeten activar i desactivar circuits neuronals utilitzant llum\",\"datePublished\":\"2021-05-07T07:39:40+00:00\",\"dateModified\":\"2021-05-07T08:00:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\\\/\"},\"wordCount\":1044,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2021\\\/05\\\/synaptic-transmission-human-nervous-system_500.jpg\",\"keywords\":[\"Azo-NZ1\",\"Glyght\",\"Pau Gorostiza\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\\\/\",\"name\":\"Noves mol\u00e8cules permeten activar i desactivar circuits neuronals utilitzant llum - Institute for Bioengineering of Catalonia\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2021\\\/05\\\/synaptic-transmission-human-nervous-system_500.jpg\",\"datePublished\":\"2021-05-07T07:39:40+00:00\",\"dateModified\":\"2021-05-07T08:00:45+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\\\/#breadcrumb\"},\"inLanguage\":\"ca\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\\\/#primaryimage\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2021\\\/05\\\/synaptic-transmission-human-nervous-system_500.jpg\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2021\\\/05\\\/synaptic-transmission-human-nervous-system_500.jpg\",\"width\":500,\"height\":500,\"caption\":\"Synaptic transmission, human nervous system, 3d rendering\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Noves mol\u00e8cules permeten activar i desactivar circuits neuronals utilitzant llum\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"name\":\"Institute for Bioengineering of Catalonia\",\"description\":\"Bioengineering Solutions for Health\",\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ibecbarcelona.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ca\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\",\"name\":\"Institute for Bioengineering of Catalonia\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"width\":696,\"height\":257,\"caption\":\"Institute for Bioengineering of Catalonia\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\",\"name\":\"\u00c0ngels L\u00f3pez\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"caption\":\"\u00c0ngels L\u00f3pez\"},\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/author\\\/alopez\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Noves mol\u00e8cules permeten activar i desactivar circuits neuronals utilitzant llum - Institute for Bioengineering of Catalonia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/","og_locale":"ca_ES","og_type":"article","og_title":"Noves mol\u00e8cules permeten activar i desactivar circuits neuronals utilitzant llum - Institute for Bioengineering of Catalonia","og_description":"Investigadors de l\u2019IBEC, en col\u00b7laboraci\u00f3 amb un equip internacional, descriuen les primeres mol\u00e8cules capaces de regular els receptors de glicina amb llum: Glyght i Azo-NZ1. Una manera d'estudiar els circuits neuronals, desenvolupar fototer\u00e0pies basades en f\u00e0rmacs de forma no invasiva, i comprendre els trastorns neurol\u00f2gics relacionats amb el funcionament incorrecte dels receptors de glicina.","og_url":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/","og_site_name":"Institute for Bioengineering of Catalonia","article_published_time":"2021-05-07T07:39:40+00:00","article_modified_time":"2021-05-07T08:00:45+00:00","og_image":[{"width":500,"height":500,"url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/synaptic-transmission-human-nervous-system_500.jpg","type":"image\/jpeg"}],"author":"\u00c0ngels L\u00f3pez","twitter_card":"summary_large_image","twitter_misc":{"Escrit per":"\u00c0ngels L\u00f3pez","Temps estimat de lectura":"5 minuts"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/#article","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/"},"author":{"name":"\u00c0ngels L\u00f3pez","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/c212c6b589546130be67986b9290e2b8"},"headline":"Noves mol\u00e8cules permeten activar i desactivar circuits neuronals utilitzant llum","datePublished":"2021-05-07T07:39:40+00:00","dateModified":"2021-05-07T08:00:45+00:00","mainEntityOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/"},"wordCount":1044,"publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/synaptic-transmission-human-nervous-system_500.jpg","keywords":["Azo-NZ1","Glyght","Pau Gorostiza"],"articleSection":["Not\u00edcies de recerca"],"inLanguage":"ca"},{"@type":"WebPage","@id":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/","url":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/","name":"Noves mol\u00e8cules permeten activar i desactivar circuits neuronals utilitzant llum - Institute for Bioengineering of Catalonia","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/#primaryimage"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/synaptic-transmission-human-nervous-system_500.jpg","datePublished":"2021-05-07T07:39:40+00:00","dateModified":"2021-05-07T08:00:45+00:00","breadcrumb":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/#breadcrumb"},"inLanguage":"ca","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/"]}]},{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/#primaryimage","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/synaptic-transmission-human-nervous-system_500.jpg","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/synaptic-transmission-human-nervous-system_500.jpg","width":500,"height":500,"caption":"Synaptic transmission, human nervous system, 3d rendering"},{"@type":"BreadcrumbList","@id":"https:\/\/ibecbarcelona.eu\/ca\/noves-molecules-permeten-activar-i-desactivar-circuits-neuronals-utilitzant-llum\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ibecbarcelona.eu\/ca\/"},{"@type":"ListItem","position":2,"name":"Noves mol\u00e8cules permeten activar i desactivar circuits neuronals utilitzant llum"}]},{"@type":"WebSite","@id":"https:\/\/ibecbarcelona.eu\/#website","url":"https:\/\/ibecbarcelona.eu\/","name":"Institute for Bioengineering of Catalonia","description":"Bioengineering Solutions for Health","publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibecbarcelona.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ca"},{"@type":"Organization","@id":"https:\/\/ibecbarcelona.eu\/#organization","name":"Institute for Bioengineering of Catalonia","url":"https:\/\/ibecbarcelona.eu\/","logo":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","width":696,"height":257,"caption":"Institute for Bioengineering of Catalonia"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/c212c6b589546130be67986b9290e2b8","name":"\u00c0ngels L\u00f3pez","image":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","caption":"\u00c0ngels L\u00f3pez"},"url":"https:\/\/ibecbarcelona.eu\/ca\/author\/alopez\/"}]}},"AFP_featured_media_urls":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/synaptic-transmission-human-nervous-system_500.jpg",500,500,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/synaptic-transmission-human-nervous-system_500-150x150.jpg",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/synaptic-transmission-human-nervous-system_500-300x300.jpg",300,300,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/synaptic-transmission-human-nervous-system_500.jpg",500,500,false],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/synaptic-transmission-human-nervous-system_500.jpg",500,500,false]},"AFP_attachments":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/imagen-esquema-scaled.jpg",2560,2560,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/imagen-esquema-150x150.jpg",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/imagen-esquema-300x300.jpg",300,300,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/imagen-esquema-768x768.jpg",768,768,true],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/05\/imagen-esquema-1024x1024.jpg",1024,1024,true]},"AFP_videos":[],"AFP_video_blocks":"","AFP_category_names":["Not\u00edcies de recerca"],"_links":{"self":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/84231","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/comments?post=84231"}],"version-history":[{"count":5,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/84231\/revisions"}],"predecessor-version":[{"id":84236,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/84231\/revisions\/84236"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media\/84223"}],"wp:attachment":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media?parent=84231"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/categories?post=84231"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tags?post=84231"},{"taxonomy":"post_format","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/post_formats?post=84231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}