{"id":85064,"date":"2021-06-15T10:26:29","date_gmt":"2021-06-15T08:26:29","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=85064"},"modified":"2021-06-25T10:09:27","modified_gmt":"2021-06-25T08:09:27","slug":"la-bioenginyeria-contra-la-covid-19-accelera-gracies-a-la-marato","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/la-bioenginyeria-contra-la-covid-19-accelera-gracies-a-la-marato\/","title":{"rendered":"La Bioenginyeria contra la COVID-19 accelera gr\u00e0cies a &#8220;La Marat\u00f3&#8221;\u00a0"},"content":{"rendered":"<p><img decoding=\"async\" class=\"alignleft wp-image-85066 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-300x161.png\" alt=\"\" width=\"878\" height=\"471\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-300x161.png 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-1024x550.png 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-768x412.png 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-1536x825.png 1536w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-150x81.png 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture.png 1991w\" data-sizes=\"(max-width: 878px) 100vw, 878px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 878px; --smush-placeholder-aspect-ratio: 878\/471;\" \/><\/p>\n<p><span data-contrast=\"none\">La bioenginyeria d&#8217;avantguarda que es realitza a l&#8217;IBEC estar\u00e0 present en tres dels projectes que buscaran solucions contra la COVID-19 gr\u00e0cies a les aportacions rebudes de &#8220;La Marat\u00f3 de TV3- per la COVID-19&#8221;. Aquests projectes amb lideratge, o participaci\u00f3 de l&#8217;IBEC, han estat seleccionats per a formar part dels 36 projectes financiables, entre 229 candidatures presentades, a trav\u00e9s l&#8217;\u00faltima edici\u00f3 de la popular campanya de recaptaci\u00f3 de fons, que va aconseguir reuniren total, prop de 14 milions d&#8217;euros .<\/span><\/p>\n<p><strong>N\u00faria Montserrat, professora d&#8217;investigaci\u00f3 ICREA i l\u00edder de el grup &#8220;<a href=\"https:\/\/ibecbarcelona.eu\/ipscs\">Pluripot\u00e8ncia\u00a0per a la Regeneraci\u00f3 d&#8217;\u00d2rgans<\/a>&#8221; a l&#8217;Institut de Bioenginyeria de Catalunya (IBEC), rebr\u00e0 398.000 \u20ac de l&#8217;edici\u00f3 2020 de &#8220;La Marat\u00f3&#8221; per liderar el projecte &#8220;SYSTORG&#8221;, amb el que explorar\u00e0 les condicions que desencadenen en casos greus de COVID-19.\u00a0<\/strong><\/p>\n<p><span data-contrast=\"none\">Montserrat i el seu equip fusionaran t\u00e8cniques de la bioenginyeria i l&#8217;edici\u00f3 gen\u00e8tica per crear organoides de rony\u00f3 (cultius cel\u00b7lulars que a escala mil\u00b7lim\u00e8trica recullen certes caracter\u00edstiques de l&#8217;\u00f2rgan natiu). Mitjan\u00e7ant aquests abordatges el projecte SYSTORG far\u00e0 servir, a m\u00e9s, plataformes d&#8217;\u00f2rgan en un xip (de l&#8217;angl\u00e8s organ-on-a-xip) per tal d&#8217;emular condicions fisiol\u00f2giques que poden empitjorar el curs de la COVID-19. D&#8217;aquesta manera SYSTORG podr\u00e0 explorar de manera fidedigna els canvis que es produeixen a nivell molecular i funcional en organoides renals, vasculars i g\u00e0strics utilitzant tecnologies com la seq\u00fcenciaci\u00f3 de RNA a nivell de c\u00e8l\u00b7lula \u00fanica (de l&#8217;angl\u00e8s single cell RNA seq).<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Juntament amb l&#8217;equip de N\u00faria Montserrat a l\u00b4IBEC, col\u00b7laboren en aquest projecte dos socis internacionals; l&#8217;equip dirigit per Josef Penninger de l&#8217;Institut fuer Molekulare Biotechnologie GmbH (IMBA), i Ali Mirazimi, del Karolinska Institutet. Tots ells han col\u00b7laborat anteriorment en altres projectes de recerca en coronavirus, sent pioners en la derivaci\u00f3 i l&#8217;\u00fas de c\u00e8l\u00b7lules mare pluripotents humanes (organoides) per modelar i estudiar els primers passos de la infecci\u00f3 per SARSCoV-2.<\/span><span data-contrast=\"none\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<blockquote><p><strong>&#8220;Gr\u00e0cies a la Marat\u00f3 de TV3 podrem desenvolupar tecnologies que s\u00f3n necess\u00e0ries per a aprofundir en q\u00fcestions complexes en la malaltia de la COVID-19. En aquest sentit volem investigar els mecanismes moleculars que explicarien perqu\u00e8 condicions sist\u00e8miques com la diabetis o la hiperlip\u00e8mia s&#8217;associen amb un pitjor pron\u00f2stic de la COVID-19 desenvolupant per a aix\u00f2 organoides renals, vasculars o g\u00e0strics\u201d.<\/strong><\/p>\n<p><strong>Nuria Montserrat, Professora de Recerca ICREA i Cap de Grup a l\u00b4IBEC<\/strong><\/p><\/blockquote>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Per altra banda,\u00a0<\/span><a href=\"https:\/\/ibecbarcelona.eu\/sensingsys\"><span data-contrast=\"none\">Santiago Marco<\/span><\/a><span data-contrast=\"auto\">, l\u00edder del grup de <a href=\"https:\/\/ibecbarcelona.eu\/sensingsys\">\u201c<\/a><\/span><a href=\"https:\/\/ibecbarcelona.eu\/sensingsys\"><span data-contrast=\"none\">Processament de senyals i informaci\u00f3 per sistemes de sensors<\/span><\/a><span data-contrast=\"auto\">\u201d a l\u2019IBEC, i Professor de la Universitat de Barcelona (UB), tamb\u00e9 rebr\u00e0 finan\u00e7ament de La Marat\u00f3 per desenvolupar el projecte \u201cCoRespirOmics\u201d. El grup de Santiago Marco juntament amb la Fundaci\u00f3 Institut Hospital del Mar d\u2019Investigacions M\u00e8diques, que lidera el projecte, pretenen millorar els processos d\u2019atenci\u00f3 al pacient i tamb\u00e9, determinar quines intervencions poden millorar l\u2019estat dels pacients infectats per coronavirus.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Per aix\u00f2, comptaran amb un finan\u00e7ament de 95.800 euros durant dos anys per poder fer una predicci\u00f3 del pron\u00f2stic respiratori en pacients greus de COVID-19. L\u2019evoluci\u00f3 cl\u00ednica respirat\u00f2ria de COVID-19 \u00e9s poc coneguda, per tant, identificar les vies metab\u00f2liques que es veuen alterades i la seva associaci\u00f3 amb el frac\u00e0s de les estrat\u00e8gies de suport ventilatori no invasiu (NIS) \u00e9s crucial per comprendre la fisiopatologia de la COVID-19, per orientar les decisions cl\u00edniques i determinar tractaments terap\u00e8utics.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><span data-contrast=\"auto\">Diferents patrons metab\u00f2lics de vies espec\u00edfiques poden predir el frac\u00e0s del suport ventilatori no invasiu (NIS) en pacients amb pneum\u00f2nia COVID-19. Aquests patrons podrien estar associats a alteracions en la mec\u00e0nica respirat\u00f2ria en la s\u00edndrome de l&#8217;angoixa respirat\u00f2ria aguda (SARD). L&#8217;objectiu del projecte \u00e9s poder crear un algoritme de decisi\u00f3 diagn\u00f2stica i terap\u00e8utica basat en els diferents patrons metab\u00f2lics de pacients cr\u00edtics de COVID-19 que necessiten NIS a causa del SDA.\u00a0\u00a0<\/span><\/p>\n<blockquote><p><strong><i>&#8220;En aquest projecte utilitzarem t\u00e8cniques estad\u00edstiques i d&#8217;intel\u00b7lig\u00e8ncia artificial per descobrir patrons metab\u00f2lits caracter\u00edstics que ens permetin entendre millor la fisiopatologia de la malaltia, i individualitzar i adaptar el suport\u00a0ventilatori\u00a0segons l&#8217;evoluci\u00f3 temporal d&#8217;aquests\u00a0biomarcadors.&#8221;<\/i>\u00a0<\/strong><\/p>\n<p><strong>Professor Santi Marco, Cap de Grup a l\u2019IBEC\u00a0<\/strong><\/p><\/blockquote>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Finalment, l\u00b4investigadora s\u00e8nior Beatriz F. Giraldo, del Grup de Processament i Interpretaci\u00f3 de Senyals Biom\u00e8diques a l&#8217;IBEC, i Professora de la Universitat Polit\u00e8cnica de Catalunya (UPC) participar\u00e0 en un projecte Coordinat, liderat per la doctora Arantxa Mas de l&#8217; IDIBELL i el Consorci Sanitari Integrat, que es proposa determinar biomarcadors respiratoris com a predictors din\u00e0mics de la mala evoluci\u00f3 en pacients amb COVID-19. Amb Aix\u00f2 \u00e9s pret\u00e8n fer un seguiment m\u00e9s prec\u00eds que permet\u00ed predir l&#8217;evoluci\u00f3 \u00a0i avancar en el tractament de pacients amb problemes de pneum\u00f2nia derivada de COVID-19.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<blockquote><p><strong>&#8220;Volem recollir la millor informaci\u00f3 possible sobre la resposta de el cos al coronavirus, a partir de senyals fisiol\u00f2giques relacionades amb els pulmons, el cor i la temperatura, per poder tenir\u00a0biomarcadors\u00a0que ens ajudin a predir l&#8217;evoluci\u00f3 de la malaltia i definir possibles tractaments. &#8220;<\/strong><\/p>\n<p><strong>Beatriz F.\u00a0Giraldo, investigadora S\u00e8nior a l\u00b4IBEC<\/strong><\/p><\/blockquote>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<h3>\n<p>Tres projectes amb contribuci\u00f3 de l&#8217;Institut de Bioenginyeria de Catalunya (IBEC) rebran finan\u00e7ament de &#8220;la Marat\u00f3 de TV3&#8221; per investigar diferents aspectes de la COVID19. Gr\u00e0cies a les aportacions rebudes, els experts aprofundiran en la comprensi\u00f3 de la malaltia i les seves possibles solucions terap\u00e8utiques, estudiaran millores en els processos d&#8217;atenci\u00f3 a\u00a0l&#8217;pacient, i desenvoluparan un sistema per predir l&#8217;evoluci\u00f3 de sistema respiratori, i per avan\u00e7ar en el tractament de pacients amb pneum\u00f2nia derivada de COVID19.\u00a0<\/h3><\/p>\n","protected":false},"author":4,"featured_media":85066,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[923,1123,1116,1118],"post_formats":[],"class_list":["post-85064","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-covid-ca","tag-nuria-montserrat-ca-2","tag-raimon-jane-ca","tag-santiago-marco-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>La Bioenginyeria contra la COVID-19 accelera gr\u00e0cies a &quot;La Marat\u00f3&quot;\u00a0 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/la-bioenginyeria-contra-la-covid-19-accelera-gracies-a-la-marato\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La Bioenginyeria contra la COVID-19 accelera gr\u00e0cies a &quot;La Marat\u00f3&quot;\u00a0 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Tres projectes amb contribuci\u00f3 de l&#039;Institut de Bioenginyeria de Catalunya (IBEC) rebran finan\u00e7ament de &quot;la Marat\u00f3 de TV3&quot; per investigar diferents aspectes de la COVID19. Gr\u00e0cies a les aportacions rebudes, els experts aprofundiran en la comprensi\u00f3 de la malaltia i les seves possibles solucions terap\u00e8utiques, estudiaran millores en els processos d&#039;atenci\u00f3 a\u00a0l&#039;pacient, i desenvoluparan un sistema per predir l&#039;evoluci\u00f3 de sistema respiratori, i per avan\u00e7ar en el tractament de pacients amb pneum\u00f2nia derivada de COVID19.\u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/la-bioenginyeria-contra-la-covid-19-accelera-gracies-a-la-marato\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-15T08:26:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-06-25T08:09:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/06\/cover-picture-1024x550.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"550\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/la-bioenginyeria-contra-la-covid-19-accelera-gracies-a-la-marato\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/la-bioenginyeria-contra-la-covid-19-accelera-gracies-a-la-marato\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"La Bioenginyeria contra la COVID-19 accelera gr\u00e0cies a &#8220;La Marat\u00f3&#8221;\u00a0\",\"datePublished\":\"2021-06-15T08:26:29+00:00\",\"dateModified\":\"2021-06-25T08:09:27+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/la-bioenginyeria-contra-la-covid-19-accelera-gracies-a-la-marato\\\/\"},\"wordCount\":879,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/la-bioenginyeria-contra-la-covid-19-accelera-gracies-a-la-marato\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2021\\\/06\\\/cover-picture.png\",\"keywords\":[\"COVID-19\",\"Nuria Montserrat\",\"Raimon Jane\",\"Santiago Marco\"],\"articleSection\":[\"Not\u00edcies institucionals\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/la-bioenginyeria-contra-la-covid-19-accelera-gracies-a-la-marato\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/la-bioenginyeria-contra-la-covid-19-accelera-gracies-a-la-marato\\\/\",\"name\":\"La Bioenginyeria contra la COVID-19 accelera gr\u00e0cies a \\\"La Marat\u00f3\\\"\u00a0 - 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