{"id":86353,"date":"2021-07-21T14:17:54","date_gmt":"2021-07-21T12:17:54","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=86353"},"modified":"2021-09-02T12:37:50","modified_gmt":"2021-09-02T10:37:50","slug":"investigadors-de-libec-i-crg-reben-financament-de-la-fundacio-la-caixa-per-a-lluitar-contra-la-demencia","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-i-crg-reben-financament-de-la-fundacio-la-caixa-per-a-lluitar-contra-la-demencia\/","title":{"rendered":"Investigadors de l&#8217;IBEC i CRG reben finan\u00e7ament de la Fundaci\u00f3 \u201cla Caixa\u201d per a lluitar contra la dem\u00e8ncia"},"content":{"rendered":"<p><img decoding=\"async\" class=\"alignnone wp-image-86356 size-large lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/dementia-1024x617.png\" alt=\"\" width=\"900\" height=\"542\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/dementia-1024x617.png 1024w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/dementia-300x181.png 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/dementia-768x463.png 768w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/dementia-150x90.png 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/dementia.png 1279w\" data-sizes=\"(max-width: 900px) 100vw, 900px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 900px; --smush-placeholder-aspect-ratio: 900\/542;\" \/><\/p>\n<p class=\"xmsonormal\" style=\"text-align: justify; line-height: 150%;\"><span style=\"font-size: 12.0pt; line-height: 150%; font-family: 'Arial',sans-serif;\">Les malalties neurodegeneratives estan associades amb l&#8217;acumulaci\u00f3 patol\u00f2gica d&#8217;unes certes prote\u00efnes en el cervell. Aquestes venen en diverses formes, com a plaques de beta-amiloide en l&#8217;Alzheimer, alfa-sinucle\u00edna en el Parkinson i prote\u00efnes Tau en la dem\u00e8ncia frontotemporal. Els investigadors han observat que unes certes mutacions acceleren la formaci\u00f3 de dip\u00f2sits de prote\u00efnes en el cervell, portant al desenvolupament de formes rares i m\u00e9s agressives d&#8217;aquestes malalties. No obstant aix\u00f2, es necessita un coneixement m\u00e9s profund per a desenvolupar m\u00e8todes predictius capa\u00e7os d&#8217;identificar aquestes mutacions i desenvolupar ter\u00e0pies eficients.<\/span><\/p>\n<p class=\"xmsonormal\" style=\"text-align: justify; line-height: 150%;\"><span style=\"font-size: 12.0pt; line-height: 150%; font-family: 'Arial',sans-serif;\">Ara, la recerca liderada per la J\u00fanior Group Leader <b>Benedetta Bolognesi<\/b> a l&#8217;Institut de Bioenginyeria de Catalunya (IBEC), i pel professor de recerca ICREA <b>Ben Lehner<\/b> en el Centre de Regulaci\u00f3 Gen\u00f2mica (CRG), t\u00e9 com a objectiu comprendre millor les variants que causen aquestes malalties neurodegeneratives i desenvolupar m\u00e8todes per a predir si una persona \u00e9s m\u00e9s susceptible a la dem\u00e8ncia. Els cient\u00edfics tamb\u00e9 volen desenvolupar noves estrat\u00e8gies per a prevenir o tractar la dem\u00e8ncia. Per a aconseguir aquests objectius, els investigadors combinaran la seva experi\u00e8ncia en mutagenesis profunda i aprenentatge autom\u00e0tic per a mapear com totes les possibles mutacions en aquestes prote\u00efnes poden conduir a la dem\u00e8ncia.<\/span><span style=\"font-size: 12.0pt; line-height: 150%; font-family: 'Arial',sans-serif;\">\u00a0<\/span><\/p>\n<p style=\"margin: 0in; text-align: justify; line-height: 150%;\"><span style=\"font-size: 12.0pt; line-height: 150%; font-family: 'Arial',sans-serif;\">Investigadors de l&#8217;IBEC i CRG uniran forces contra la dem\u00e8ncia gr\u00e0cies a un pressupost total de prop d&#8217;un mili\u00f3 d&#8217;euros, finan\u00e7at per l&#8217;\u00faltima convocat\u00f2ria del programa CaixaResearch de Recerca en Salut. Segons Bolognesi: \u201cL&#8217;impacte del projecte \u00e9s almenys doble. Primer, tenim la possibilitat de saber de manera preventiva si alguna mutaci\u00f3 en aquestes prote\u00efnes conduir\u00e0 a la dem\u00e8ncia. En segon lloc, podem inferir la &#8220;forma&#8221; que han d&#8217;adoptar per a iniciar el proc\u00e9s d&#8217;agregaci\u00f3, que \u00e9s la diana a la qual hem de dirigir-nos si volem evitar el proc\u00e9s per complet\u201d.<\/span><\/p>\n<p><span style=\"font-size: 12.0pt; line-height: 150%; font-family: 'Arial',sans-serif;\">I afegeix: \u201cM&#8217;agrada especialment aquest projecte perqu\u00e8 cap dels nostres laboratoris podria dur-lo a terme de manera independent, per la qual cosa realment tots estem guanyant molt amb aquesta col\u00b7laboraci\u00f3\u201d.<\/span><\/p>\n<p>&nbsp;<\/p>\n<blockquote><p><img decoding=\"async\" class=\"wp-image-61269 alignleft lazyload\" style=\"--smush-placeholder-width: 279px; --smush-placeholder-aspect-ratio: 279\/186;font-size: 13px; font-style: normal;\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/09\/benedetta_news-300x200.jpg\" alt=\"\" width=\"279\" height=\"186\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/09\/benedetta_news-300x200.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/09\/benedetta_news-195x130.jpg 195w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/09\/benedetta_news-150x100.jpg 150w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2018\/09\/benedetta_news.jpg 500w\" data-sizes=\"(max-width: 279px) 100vw, 279px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><\/p>\n<p style=\"text-align: left;\"><strong>El problema amb l&#8217;agregaci\u00f3 de prote\u00efnes que afecta les malalties neurodegeneratives \u00e9s que una vegada s&#8217;inicia, no hi ha volta enrere. Amb aquest projecte, podem recopilar coneixements mec\u00e0nics sobre el primer pas de l&#8217;agregaci\u00f3 de prote\u00efnes.<\/strong><\/p>\n<p style=\"text-align: right;\"><strong>Benedetta Bolognesi (IBEC)<\/strong><\/p>\n<\/blockquote>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12.0pt; line-height: 150%; font-family: 'Arial',sans-serif;\">El programa CaixaResearch de Recerca en Salut finan\u00e7a iniciatives de recerca d&#8217;avantguarda que aborden reptes sanitaris en els \u00e0mbits de les malalties cardiovasculars, infeccioses i oncol\u00f2giques, aix\u00ed com de les neuroci\u00e8ncies. Enguany s&#8217;han seleccionat trenta projectes a Espanya i Portugal d&#8217;un total de 644 propostes.<\/span><span style=\"font-size: 12.0pt; line-height: 150%; font-family: 'Arial',sans-serif;\">\u00a0<\/span><\/p>\n<p><span style=\"font-size: 12.0pt; line-height: 150%; font-family: 'Arial',sans-serif;\">La Fundaci\u00f3 \u201cla Caixa\u201d ha destinat al voltant de 72 milions d&#8217;euros a un total de 105 iniciatives des de 2018.<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<h3>La Fundaci\u00f3 \u201cla Caixa\u201d finan\u00e7ar\u00e0 un ampli i innovador projecte de recerca codirigit per Benedetta Bolognesi, J\u00fanior Group Leader a l&#8217;IBEC, i pel professor de recerca ICREA Ben Lehner del CRG, l&#8217;objectiu del qual \u00e9s con\u00e8ixer millor les causes gen\u00e8tiques que condueixen a malalties neurodegeneratives. Els investigadors combinaran t\u00e8cniques de \u201cmutagenesis profunda\u201d i aprenentatge autom\u00e0tic per a produir un \u201cmapa de la dem\u00e8ncia\u201d com a m\u00e8tode per a predir si una persona \u00e9s m\u00e9s susceptible a patir aquestes malalties.<\/h3>\n","protected":false},"author":24,"featured_media":61269,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[98],"tags":[1107],"post_formats":[],"class_list":["post-86353","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-institucionals","tag-benedetta-bolognesi-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigadors de l&#039;IBEC i CRG reben finan\u00e7ament de la Fundaci\u00f3 \u201cla Caixa\u201d per a lluitar contra la dem\u00e8ncia - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/investigadors-de-libec-i-crg-reben-financament-de-la-fundacio-la-caixa-per-a-lluitar-contra-la-demencia\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors de l&#039;IBEC i CRG reben finan\u00e7ament de la Fundaci\u00f3 \u201cla Caixa\u201d per a lluitar contra la dem\u00e8ncia - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"La Fundaci\u00f3 \u201cla Caixa\u201d finan\u00e7ar\u00e0 un ampli i innovador projecte de recerca codirigit per Benedetta Bolognesi, J\u00fanior Group Leader a l&#039;IBEC, i pel professor de recerca ICREA Ben Lehner del CRG, l&#039;objectiu del qual \u00e9s con\u00e8ixer millor les causes gen\u00e8tiques que condueixen a malalties neurodegeneratives. 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