{"id":86498,"date":"2021-06-15T14:29:31","date_gmt":"2021-06-15T12:29:31","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=86498"},"modified":"2021-07-26T10:09:27","modified_gmt":"2021-07-26T08:09:27","slug":"els-mini-organs-de-bioenginyeria-avancen-en-la-lluita-contra-el-cancer-gracies-a-laecc","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/els-mini-organs-de-bioenginyeria-avancen-en-la-lluita-contra-el-cancer-gracies-a-laecc\/","title":{"rendered":"Els mini-\u00f2rgans de bioenginyeria avancen en la lluita contra el cancer gr\u00e0cies a l\u2019AECC"},"content":{"rendered":"<p><span data-contrast=\"auto\"><img decoding=\"async\" class=\"alignleft wp-image-85927 lazyload\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/Organoids-per-AECC.png\" alt=\"\" width=\"821\" height=\"386\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/Organoids-per-AECC.png 602w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/Organoids-per-AECC-300x141.png 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/07\/Organoids-per-AECC-150x71.png 150w\" data-sizes=\"(max-width: 821px) 100vw, 821px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 821px; --smush-placeholder-aspect-ratio: 821\/386;\" \/><\/span><\/p>\n<p><span data-contrast=\"none\">El carcinoma de\u00a0c\u00e8l\u00b7lules\u00a0renals\u00a0\u00e9s\u00a0un\u00a0tipus\u00a0agressiu\u00a0de\u00a0c\u00e0ncer,\u00a0on\u00a0el\u00a0subtipus\u00a0de\u00a0c\u00e8l\u00b7lula\u00a0clara (CcRCC)\u00a0\u00e9s\u00a0el\u00a0m\u00e9s\u00a0freq\u00fcent.\u00a0Segons\u00a0les\u00a0dades\u00a0acumulades\u00a0durant\u00a0l&#8217;\u00faltima\u00a0d\u00e8cada,\u00a0m\u00e9s\u00a0del 50%\u00a0dels\u00a0tumors\u00a0malignes\u00a0renals\u00a0es detecten\u00a0accidentalment\u00a0a causa de\u00a0l&#8217;\u00fas\u00a0generalitzat\u00a0de la\u00a0imatge\u00a0abdominal. Per\u00a0tant, un\u00a0m\u00e8tode\u00a0de\u00a0detecci\u00f3\u00a0preco\u00e7\u00a0\u00e9s\u00a0crucial per poder tractar\u00a0aquest\u00a0tipus\u00a0de\u00a0malaltia\u00a0i\u00a0facilitarien\u00a0el\u00a0desenvolupament\u00a0d&#8217;estrat\u00e8gies\u00a0d&#8217;intervenci\u00f3\u00a0primerenca.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Fins al moment, no existien models humans basats en la generaci\u00f3 d&#8217;organoides renals per a aquest tipus de c\u00e0ncer renal. \u00c9s per aix\u00f2 que la investigadora N\u00faria Montserrat i el seu grup de recerca a l&#8217;IBEC, juntament amb els seus col\u00b7laboradors a Vall d&#8217;Hebron Institut d&#8217;Oncologia, ICO-IDIBELL i Hospital Cl\u00ednic de Barcelona, van rebre, el 2017, 300.000 euros de l&#8217;Associaci\u00f3 espanyola Contra el c\u00e0ncer per a la recerca en c\u00e0ncer renal utilitzant organoides. Els organoides de rony\u00f3 s\u00f3n agregats de c\u00e8l\u00b7lules cultivades que constitueixen teixits d&#8217;una grand\u00e0ria redu\u00efda (de micr\u00f2metres a cent\u00edmetres), dotats de les caracter\u00edstiques estructurals i funcionals al rony\u00f3 hum\u00e0. Aquest m\u00e8tode permet estudiar de manera m\u00e9s fidel i precisa la malaltia, pel que fa als cultius cel\u00b7lulars tradicionals. A m\u00e9s, aquest abordatge permet identificar nous marcadors de la iniciaci\u00f3 de la malaltia. <strong>Durant aquest temps, els investigadors han desenvolupat organoides de rony\u00f3 a partir de c\u00e8l\u00b7lules mare pluripotents humanes que els ha perm\u00e8s assolir dos objectius: observar com es desenvolupa el teixit en aquest \u00f2rgan, i, d&#8217;altra banda, gr\u00e0cies a t\u00e8cniques d&#8217;edici\u00f3 gen\u00e8tica, manipular aquests minirronyons perqu\u00e8 presentin mutacions per a aquest tipus de c\u00e0ncer poden identificar, aix\u00ed, signes primerencs de desenvolupament per a aquesta malaltia.<\/strong><\/span><strong>\u00a0<\/strong><\/p>\n<p><span data-contrast=\"none\">Aquest projecte ha assegut, a m\u00e9s, les bases per a la generaci\u00f3 c\u00e8l\u00b7lules progenitores de rony\u00f3 i que capturen el rerefons gen\u00e8tic del CcRCC Gr\u00e0cies als aven\u00e7os d&#8217;aquest estudi, en un futur els investigadors creuen possible la realitzaci\u00f3 d&#8217;una plataforma d&#8217;alt rendiment per a l&#8217;estudi de la iniciaci\u00f3 de CcRCC utilitzant organoides de rony\u00f3 que serien de gran utilitat per a la ind\u00fastria farmac\u00e8utica.<\/span><\/p>\n<hr \/>\n<p><strong>Sobre les &#8220;Ajudes\u00a0LAB&#8221;\u00a0<\/strong><\/p>\n<p><span data-contrast=\"none\">Les &#8220;Ajudes\u00a0LAB&#8221;\u00a0financen\u00a0a\u00a0grups\u00a0emergents\u00a0per\u00a0dur\u00a0a\u00a0terme\u00a0projectes\u00a0en\u00a0c\u00e0ncer\u00a0que\u00a0tenen\u00a0moltes\u00a0possibilitats\u00a0de ser\u00a0traslladats\u00a0a la\u00a0pr\u00e0ctica\u00a0cl\u00ednica. Es consideren\u00a0grups\u00a0emergents\u00a0fins\u00a0cinc\u00a0anys\u00a0despr\u00e9s\u00a0d&#8217;haver\u00a0iniciat\u00a0una\u00a0l\u00ednia\u00a0d&#8217;investigaci\u00f3\u00a0independent\u00a0acreditada per la\u00a0seva\u00a0producci\u00f3\u00a0cient\u00edfica i\/o\u00a0projectes\u00a0finan\u00e7ats.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<h3>Un projecte capitanejat per la Professora d&#8217;Investigaci\u00f3 ICREA a IBEC, N\u00faria Montserrat, ha dedicat tres anys a la investigaci\u00f3 a l&#8217;estudi del c\u00e0ncer renal utilitzant organoides de laboratori, gr\u00e0cies als ajuts &#8220;LAB 2017&#8221; de l&#8217;Associaci\u00f3 Espanyola Contra el C\u00e0ncer (AECC). Els investigadors han aconseguit crear el primer model animal basat en organoides renals per a aquest tipus de c\u00e0ncer, i comen\u00e7ar a identificar signes primerencs del desenvolupament de la malaltia.<\/h3>\n","protected":false},"author":4,"featured_media":85928,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1123],"post_formats":[],"class_list":["post-86498","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-nuria-montserrat-ca-2"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Els mini-\u00f2rgans de bioenginyeria avancen en la lluita contra el cancer gr\u00e0cies a l\u2019AECC - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/els-mini-organs-de-bioenginyeria-avancen-en-la-lluita-contra-el-cancer-gracies-a-laecc\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Els mini-\u00f2rgans de bioenginyeria avancen en la lluita contra el cancer gr\u00e0cies a l\u2019AECC - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un projecte capitanejat per la Professora d&#039;Investigaci\u00f3 ICREA a IBEC, N\u00faria Montserrat, ha dedicat tres anys a la investigaci\u00f3 a l&#039;estudi del c\u00e0ncer renal utilitzant organoides de laboratori, gr\u00e0cies als ajuts &quot;LAB 2017&quot; de l&#039;Associaci\u00f3 Espanyola Contra el C\u00e0ncer (AECC). 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