{"id":87018,"date":"2021-09-08T12:04:21","date_gmt":"2021-09-08T10:04:21","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=87018"},"modified":"2021-09-08T13:01:53","modified_gmt":"2021-09-08T11:01:53","slug":"un-nou-model-muscular-3d-permetra-estudiar-lenvelliment-i-avaluar-farmacs-i-cosmetics","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/un-nou-model-muscular-3d-permetra-estudiar-lenvelliment-i-avaluar-farmacs-i-cosmetics\/","title":{"rendered":"Un nou model muscular 3D permetr\u00e0 estudiar l’envelliment i avaluar f\u00e0rmacs i cosm\u00e8tics"},"content":{"rendered":"

\"\"<\/p>\n

Els estudis que utilitzen models\u00a0<\/span><\/span>in vitro<\/span><\/span><\/em>\u00a0de teixits musculars, sigui en biomedicina o en la ind\u00fastria cosm\u00e8tica, depenen en gran m<\/span>anera<\/span>\u00a0de models 2D de creixement cel\u00b7lular, que no representen el que realment succeeix en el cos hum\u00e0. Hi ha, per tant, una gran necessitat de models tridimensionals que permetin realitzar estudis fiables i reprodu\u00efbles en camps com l’enginyeria de teixits, la modelitzaci\u00f3 de malalties i l’assaig de nous f\u00e0rmacs, i la rob\u00f2tica bio-h\u00edbrida (combinaci\u00f3 de teixits vius i robots).\u00a0<\/span><\/span>\u00a0<\/span><\/p>\n

 <\/p>\n

Ara, gr\u00e0cies a l’enginyeria de teixits i la\u00a0<\/span>bioimpressi\u00f3<\/span>\u00a03D, investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC) liderats per Samuel S\u00e1nchez, professor d’investigaci\u00f3 ICREA i investigador principal del grup “<\/span><\/span>Nano-Bio\u00a0<\/span>Smart<\/span>\u00a0<\/span>Devices<\/span><\/span><\/a>“, han desenvolupat una nova plataforma 3D amb m\u00fasculs esquel\u00e8tics humans que imiten teixits reals.<\/span>\u00a0<\/span><\/span>Aquest nou enfocament permetr\u00e0 estudiar amb detall tant el desenvolupament dels m\u00fasculs com les malalties que pateixen, aix\u00ed com permetre una avaluaci\u00f3 fiable de f\u00e0rmacs i cosm\u00e8tics<\/strong>.<\/span><\/span>\u00a0El treball s’ha realitzat en col\u00b7laboraci\u00f3 amb l’empresa\u00a0<\/span><\/span>Lubrizol<\/span><\/span><\/a>\u00a0i s’<\/span>ha publicat recentment<\/span>\u00a0a la revista\u00a0<\/span><\/span>Biofabrication<\/span><\/span><\/a>.\u00a0\u00a0\u00a0<\/span><\/span>\u00a0<\/span><\/p>\n

El nou model muscular en 3D<\/span><\/span>\u00a0<\/span> <\/strong><\/h2>\n

El nou model tridimensional de teixit muscular desenvolupat per investigadors de l’IBEC \u00e9s capa\u00e7 d’imitar l’estructura 3D del teixit natiu. A m\u00e9s, proporciona\u00a0<\/span>informaci\u00f3 quantitativa sobre la generaci\u00f3 de for\u00e7a i patrons de contracci\u00f3 muscular a trav\u00e9s d’est\u00edmuls el\u00e8ctrics amb el\u00e8ctrodes de carboni fabricats pels\u00a0<\/span>mateixos<\/span>\u00a0investigadors.\u00a0\u00a0<\/span><\/span>\u00a0<\/span><\/p>\n

Per generar el nou m\u00fascul, els investigadors van comen\u00e7ar a partir de mioblasts, precursors de c\u00e8l\u00b7lules musculars<\/span>,<\/span>\u00a0juntament amb una barreja de diferents components que simula el medi extracel\u00b7lular i ajuda a\u00a0<\/span>donar f<\/span>orma i estructura 3D\u00a0<\/span>al<\/span>\u00a0nou teixit.<\/span><\/span>\u00a0<\/span><\/p>\n

\"\"
Esquema per generar el m\u00fascul en 3D.<\/figcaption><\/figure>\n

L’\u00fas de c\u00e8l\u00b7lules humanes en la nova plataforma, a m\u00e9s de proporcionar fiabilitat i precisi\u00f3, t\u00e9 altres avantatges com la possibilitat de personalitzaci\u00f3 a partir de c\u00e8l\u00b7lules pacients, i de prescindir de l’\u00fas d’animals per a l’experimentaci\u00f3, eliminant les implicacions \u00e8tiques que comporta.<\/span>\u00a0<\/span><\/p>\n

Aquest model ofereix la versatilitat i flexibilitat necess\u00e0ries en enfocaments multidisciplinaris per entendre el desenvolupament muscular i la seva resposta a diferents tractaments.<\/span>\u00a0<\/span><\/p>\n

La nova plataforma \u00e9s ideal per avaluar f\u00e0rmacs i cosm\u00e8tics i entendre com afecten el m\u00fascul i controlar el seu comportament<\/span>.<\/span><\/strong><\/p>\n

Rafael Mestre, primer coautor de l’estudi<\/span><\/span> (IBEC).\u00a0<\/strong><\/p>\n<\/blockquote>\n

Prova de concepte: l\u2019envelliment muscular<\/span><\/span>\u00a0<\/span><\/strong><\/h2>\n

La possibilitat d’estudiar l’envelliment muscular en una plataforma 3D t\u00e9 molta rellev\u00e0ncia per a la ind\u00fastria cosm\u00e8tica, ja que est\u00e0 estretament relacionada amb alteracions funcionals i fisiol\u00f2giques dels m\u00fasculs facials. En la prova de concepte per simular l’envelliment muscular, els investigadors van utilitzar el factor de necrosi tumoral \u03b1 (TNF-\u03b1), una petita prote\u00efna del grup de\u00a0les\u00a0citocines, relacionada, entre d’altres, amb la p\u00e8rdua de massa muscular i\u00a0el\u00a0to.\u00a0En tractar el m\u00fascul amb TNF-\u03b1, els investigadors van observar canvis en la relaxaci\u00f3 muscular i una reducci\u00f3 de la for\u00e7a muscular, similar al que\u00a0s\u2019observa\u00a0en un proc\u00e9s real d’envelliment.\u00a0\u00a0<\/span>\u00a0<\/span><\/p>\n

Finalment, per avaluar la funcionalitat muscular i l’efecte de nous compostos, els investigadors van realitzar proves en col\u00b7laboraci\u00f3 amb l’empresa\u00a0Lubrizol.\u00a0La nova plataforma va permetre corroborar l’efic\u00e0cia d’un nou producte cosm\u00e8tic\u00a0antiarrugues,\u00a0Argireline\u00ae\u00a0Amplified\u00a0peptide, que va mostrar una reducci\u00f3 en la for\u00e7a de contracci\u00f3 muscular i una major relaxaci\u00f3. Des de llavors, el p\u00e8ptid ha estat introdu\u00eft en el mercat amb una velocitat excepcional, creant un inter\u00e8s massiu en clients de tot el m\u00f3n, i aconseguint ser present ja en alguns productes finals del mercat.<\/span>\u00a0<\/span><\/p>\n

Amb el nostre model muscular en 3D podrem comprendre aspectes clau de la funci\u00f3 muscular durant l’envelliment i estudiar els processos fisiol\u00f2gics que contribueixen a l’aparici\u00f3 de les arrugues d’expressi\u00f3, aix\u00ed com les vies necess\u00e0ries per a reduir-les<\/span><\/span>.<\/strong><\/p>\n

Mauricio Valerio-Santiago, Lubrizol.\u00a0<\/strong><\/p>\n<\/blockquote>\n

\u00a0<\/span><\/p>\n

\n
\n

Article de refer\u00e8ncia:<\/strong>\u00a0Rafael Mestre, Nerea Garc\u00eda, Tania Pati\u00f1o,\u00a0Maria\u00a0Guix, Judith Fuentes, Mauricio Valerio-Santiago, N\u00faria\u00a0Almi\u00f1ana, Samuel S\u00e1nchez.\u00a0<\/span>3D-bioengineered model of human skeletal muscle tissue with phenotypic features of aging for drug testing purposes<\/span><\/a>.\u00a0Biofabrication\u00a013 (2021) 045011.<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l’IBEC desenvolupen un model tridimensional de teixit muscular utilitzant t\u00e8cniques de bioimpressi\u00f3 i bioenginyeria de teixits que permet reproduir els seus perfils de for\u00e7a, contracci\u00f3 i envelliment. El nou model tindr\u00e0 potencials aplicacions en camps com la biomedicina, la cosm\u00e8tica i la rob\u00f2tica. <\/h3>\n","protected":false},"author":4,"featured_media":87006,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1536,1535,1140],"post_formats":[],"class_list":["post-87018","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-lubrizol-ca","tag-model-muscular-3d","tag-samuel-sanchez-ca"],"yoast_head":"\nUn nou model muscular 3D permetr\u00e0 estudiar l'envelliment i avaluar f\u00e0rmacs i cosm\u00e8tics - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/un-nou-model-muscular-3d-permetra-estudiar-lenvelliment-i-avaluar-farmacs-i-cosmetics\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un nou model muscular 3D permetr\u00e0 estudiar l'envelliment i avaluar f\u00e0rmacs i cosm\u00e8tics - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l'IBEC desenvolupen un model tridimensional de teixit muscular utilitzant t\u00e8cniques de bioimpressi\u00f3 i bioenginyeria de teixits que permet reproduir els seus perfils de for\u00e7a, contracci\u00f3 i envelliment. 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